HES4 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	HES4
Entrez Gene ID	395128
Full Name	hes family bHLH transcription factor 4
Synonyms	HAIRY1,HES1,c-hairy1A
General protein information	Preferred Names hes family bHLH transcription factor 4 Names transcription factor HES-4 C-HAIRY1 c-hairy1B hairy and enhancer of split 4 transcription factor HES-1
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_204472.3	NP_989803.1	transcription factor HES-4 isoform 2
NM_001005848.2	NP_001005848.1	transcription factor HES-4 isoform 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	HES1	NP_989803.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006699	XP_316733.3
Danio rerio (zebrafish)	her9	NP_571948.1
Drosophila melanogaster (fruit fly)	h	NP_523977.2
Xenopus tropicalis (tropical clawed frog)	hes4	NP_988870.1

Gene Ontology
Bibliography

Related articles in PubMed

Hairy1 acts as a node downstream of Wnt signaling to maintain retinal stem cell-like progenitor cells in the chick ciliary marginal zone.
Kubo F, Nakagawa S
Development (Cambridge, England)136(11)1823-33(2009 Jun)

Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1.
Bai G, Sheng N, Xie Z, Bian W, Yokota Y, Benezra R, Kageyama R, Guillemot F, Jing N
Developmental cell13(2)283-97(2007 Aug)

Chick Hairy1 protein interacts with Sap18, a component of the Sin3/HDAC transcriptional repressor complex.
Sheeba CJ, Palmeirim I, Andrade RP
BMC developmental biology783(2007 Jul)

Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index.
Carre W, Wang X, Porter TE, Nys Y, Tang J, Bernberg E, Morgan R, Burnside J, Aggrey SE, Simon J, Cogburn LA
Physiological genomics25(3)514-24(2006 May)

Correlation between Musashi-1 and c-hairy-1 expression and cell proliferation activity in the developing intestine and stomach of both chicken and mouse.
Asai R, Okano H, Yasugi S
Development, growth & differentiation47(8)501-10(2005 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hairy1 functions as a node downstream of Wnt signaling to maintain progenitor cells in the chick CMZ.
Title: Hairy1 acts as a node downstream of Wnt signaling to maintain retinal stem cell-like progenitor cells in the chick ciliary marginal zone.

These results indicate that Id proteins participate in NSC maintenance through sustaining Hes1 expression in early embryos.
Title: Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1.

Results indicate that during chick somitogenesis Hairy1 may mediate gene transcriptional repression by recruiting the Sin3/HDAC complex, through a direct interaction with the Sap18 adaptor molecule.
Title: Chick Hairy1 protein interacts with Sap18, a component of the Sin3/HDAC transcriptional repressor complex.

Expressed in embryonic proventriculus. After day 6, restricted to luminal epithelium.
Title: Correlation between Musashi-1 and c-hairy-1 expression and cell proliferation activity in the developing intestine and stomach of both chicken and mouse.

The following HES4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HES4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa00076	NM_001005848.2 Latest version!	Gallus gallus hes family bHLH transcription factor 4 (HES4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OGa00147	NM_204472.3 Latest version!	Gallus gallus hes family bHLH transcription factor 4 (HES4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HES4 ( NM_001005848.2 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001005848.1 Gallus gallus hes family bHLH transcription factor 4 (HES4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OGa00076
Clone ID Related Accession (Same CDS sequence)	NM_001005848.2
Accession Version	NM_001005848.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-20
Organism	Gallus gallus(chicken)
Product	transcription factor HES-4 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU452950.1, AY225439.1, CD731422.1, FD587606.1, BX259770.2 and BU474043.1. On Aug 13, 2013 this sequence version replaced NM_001005848.1. Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform 1). Sequence Note: This RefSeq record was created from transcript data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF032966.1, AY225439.1 [ECO:0000332] ##Evidence-Data-END##

ATGCCCGCCG ACACGGGCAT GGAAAAACCC ACCGCTTCCC CCATCGCGGG GGCACCGGCC 
AGCGCCAGCC ACACGCCGGA CAAACCTCGG AGCGCCAGCG AGCACCGGAA GTCCTCCAAA 
CCCATCATGG AGAAGCGACG GCGGGCGCGC ATCAACGAGA GCCTGGGGCA GCTGAAGATG 
CTCATCCTGG ACGCGTTGAA AAAAGACAGC TCTCGGCACT CCAAGCTGGA GAAGGCGGAC 
ATCCTGGAGA TGACGGTGAA GCACCTGAGG AACCTCCAGA GGGCACAGAT GGCAGCCGCT 
CTCAGCGCTG ACCCCAGCGT GCTGGGCAAA TACCGGGCTG GTTTCAATGA GTGCATGAAC 
GAGGTGACGA GGTTCCTGTC CACCTGCGAG GGGGTGAACG CCGACGTGCG AGCCCGCCTG 
CTGGGCCACC TCTCTGCTTG CCTGGGGCAG ATCGTGGCCA TGAACTACCT GCCACCCCCT 
CCTGCTGGCC AACCCGCACA TCTGGCTCAA CCCCTGCACG TCCAACTGCC TCCTACCACC 
ACCGGAGCGG TGCCGGTGCC GTGCAAGCTG GAACCGACCG AAGCTCTCTC CCCTAAAGTC 
TATGGGGGTT TCCAGCTCGT CCCGGCCACT GACGGTCAAT TCGCCTTCCT CATCCCCAAC 
CCTGCGTTCC CACCTGGCTC TGGACCGGTT ATCCCACTCT ACGCCAACGC CAACGTCCCA 
GTGTCCACAA GTGGAGGCTC TGGGAACGCG TCCACCACCC CATCAGCATC CCCGGTGCAG 
GGCTTGACAT CATTTGGGCA CAGCGTGGTG CCGGCATCCC AGGCAGGCAG CCCTATTGCT 
GAGCGCAGGG AGTCCGTCTG GAGGCCGTGG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001005848.1
CDS	3..875
Translation	MPADTGMEKPTASPIAGAPASASHTPDKPRSASEHRKSSKPIMEKRRRARINESLGQLKMLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMAAALSADPSVLGKYRAGFNECMNEVTRFLSTCEGVNADVRARLLGHLSACLGQIVAMNYLPPPPAGQPAHLAQPLHVQLPPTTTGAVPVPCKLEPTEALSPKVYGGFQLVPATDGQFAFLIPNPAFPPGSGPVIPLYANANVPVSTSGGSGNASTTPSASPVQGLTSFGHSVVPASQAGSPIAERRESVWRPW

Target ORF information:

RefSeq Version	NM_001005848.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus hes family bHLH transcription factor 4 (HES4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001005848.2

ORF Insert Sequence:

ATGCCCGCCG ACACGGGCAT GGAAAAACCC ACCGCTTCCC CCATCGCGGG GGCACCGGCC 
AGCGCCAGCC ACACGCCGGA CAAACCTCGG AGCGCCAGCG AGCACCGGAA GTCCTCCAAA 
CCCATCATGG AGAAGCGACG GCGGGCGCGC ATCAACGAGA GCCTGGGGCA GCTGAAGATG 
CTCATCCTGG ACGCGTTGAA AAAAGACAGC TCTCGGCACT CCAAGCTGGA GAAGGCGGAC 
ATCCTGGAGA TGACGGTGAA GCACCTGAGG AACCTCCAGA GGGCACAGAT GGCAGCCGCT 
CTCAGCGCTG ACCCCAGCGT GCTGGGCAAA TACCGGGCTG GTTTCAATGA GTGCATGAAC 
GAGGTGACGA GGTTCCTGTC CACCTGCGAG GGGGTGAACG CCGACGTGCG AGCCCGCCTG 
CTGGGCCACC TCTCTGCTTG CCTGGGGCAG ATCGTGGCCA TGAACTACCT GCCACCCCCT 
CCTGCTGGCC AACCCGCACA TCTGGCTCAA CCCCTGCACG TCCAACTGCC TCCTACCACC 
ACCGGAGCGG TGCCGGTGCC GTGCAAGCTG GAACCGACCG AAGCTCTCTC CCCTAAAGTC 
TATGGGGGTT TCCAGCTCGT CCCGGCCACT GACGGTCAAT TCGCCTTCCT CATCCCCAAC 
CCTGCGTTCC CACCTGGCTC TGGACCGGTT ATCCCACTCT ACGCCAACGC CAACGTCCCA 
GTGTCCACAA GTGGAGGCTC TGGGAACGCG TCCACCACCC CATCAGCATC CCCGGTGCAG 
GGCTTGACAT CATTTGGGCA CAGCGTGGTG CCGGCATCCC AGGCAGGCAG CCCTATTGCT 
GAGCGCAGGG AGTCCGTCTG GAGGCCGTGG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HES4 ( NM_204472.3 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_989803.1 Gallus gallus hes family bHLH transcription factor 4 (HES4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OGa00147
Clone ID Related Accession (Same CDS sequence)	NM_204472.3
Accession Version	NM_204472.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-20
Organism	Gallus gallus(chicken)
Product	transcription factor HES-4 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CV892644.1, BU223037.1, BU354696.1, BU296072.1, BX259770.2, FD587606.1, BG710631.1 and BU474043.1. On Aug 13, 2013 this sequence version replaced NM_204472.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is longer compared to isoform 1. Sequence Note: This RefSeq record was created from transcript data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CV892644.1, AY225440.1 [ECO:0000332] ##Evidence-Data-END##

ATGCCCGCCG ACACGGGCAT GGAAAAACCC ACCGCTTCCC CCATCGCGGG GGCACCGGCC 
AGCGCCAGCC ACACGCCGGA CAAACCTCGG AGCGCCAGCG AGCACCGGAA GGTAAATGGC 
AGCGGATGGC GGCGAGCCCG CGGCCGGGCC GAGTCCTCCA AACCCATCAT GGAGAAGCGA 
CGGCGGGCGC GCATCAACGA GAGCCTGGGG CAGCTGAAGA TGCTCATCCT GGACGCGTTG 
AAAAAAGACA GCTCTCGGCA CTCCAAGCTG GAGAAGGCGG ACATCCTGGA GATGACGGTG 
AAGCACCTGA GGAACCTCCA GAGGGCACAG ATGGCAGCCG CTCTCAGCGC TGACCCCAGC 
GTGCTGGGCA AATACCGGGC TGGTTTCAAT GAGTGCATGA ACGAGGTGAC GAGGTTCCTG 
TCCACCTGCG AGGGGGTGAA CGCCGACGTG CGAGCCCGCC TGCTGGGCCA CCTCTCTGCT 
TGCCTGGGGC AGATCGTGGC CATGAACTAC CTGCCACCCC CTCCTGCTGG CCAACCCGCA 
CATCTGGCTC AACCCCTGCA CGTCCAACTG CCTCCTACCA CCACCGGAGC GGTGCCGGTG 
CCGTGCAAGC TGGAACCGAC CGAAGCTCTC TCCCCTAAAG TCTATGGGGG TTTCCAGCTC 
GTCCCGGCCA CTGACGGTCA ATTCGCCTTC CTCATCCCCA ACCCTGCGTT CCCACCTGGC 
TCTGGACCGG TTATCCCACT CTACGCCAAC GCCAACGTCC CAGTGTCCAC AAGTGGAGGC 
TCTGGGAACG CGTCCACCAC CCCATCAGCA TCCCCGGTGC AGGGCTTGAC ATCATTTGGG 
CACAGCGTGG TGCCGGCATC CCAGGCAGGC AGCCCTATTG CTGAGCGCAG GGAGTCCGTC 
TGGAGGCCGT GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_989803.1
CDS	3..917
Translation	MPADTGMEKPTASPIAGAPASASHTPDKPRSASEHRKVNGSGWRRARGRAESSKPIMEKRRRARINESLGQLKMLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMAAALSADPSVLGKYRAGFNECMNEVTRFLSTCEGVNADVRARLLGHLSACLGQIVAMNYLPPPPAGQPAHLAQPLHVQLPPTTTGAVPVPCKLEPTEALSPKVYGGFQLVPATDGQFAFLIPNPAFPPGSGPVIPLYANANVPVSTSGGSGNASTTPSASPVQGLTSFGHSVVPASQAGSPIAERRESVWRPW

Target ORF information:

RefSeq Version	NM_204472.3
Organism	Gallus gallus(chicken)
Definition	Gallus gallus hes family bHLH transcription factor 4 (HES4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_204472.3

ORF Insert Sequence:

ATGCCCGCCG ACACGGGCAT GGAAAAACCC ACCGCTTCCC CCATCGCGGG GGCACCGGCC 
AGCGCCAGCC ACACGCCGGA CAAACCTCGG AGCGCCAGCG AGCACCGGAA GGTAAATGGC 
AGCGGATGGC GGCGAGCCCG CGGCCGGGCC GAGTCCTCCA AACCCATCAT GGAGAAGCGA 
CGGCGGGCGC GCATCAACGA GAGCCTGGGG CAGCTGAAGA TGCTCATCCT GGACGCGTTG 
AAAAAAGACA GCTCTCGGCA CTCCAAGCTG GAGAAGGCGG ACATCCTGGA GATGACGGTG 
AAGCACCTGA GGAACCTCCA GAGGGCACAG ATGGCAGCCG CTCTCAGCGC TGACCCCAGC 
GTGCTGGGCA AATACCGGGC TGGTTTCAAT GAGTGCATGA ACGAGGTGAC GAGGTTCCTG 
TCCACCTGCG AGGGGGTGAA CGCCGACGTG CGAGCCCGCC TGCTGGGCCA CCTCTCTGCT 
TGCCTGGGGC AGATCGTGGC CATGAACTAC CTGCCACCCC CTCCTGCTGG CCAACCCGCA 
CATCTGGCTC AACCCCTGCA CGTCCAACTG CCTCCTACCA CCACCGGAGC GGTGCCGGTG 
CCGTGCAAGC TGGAACCGAC CGAAGCTCTC TCCCCTAAAG TCTATGGGGG TTTCCAGCTC 
GTCCCGGCCA CTGACGGTCA ATTCGCCTTC CTCATCCCCA ACCCTGCGTT CCCACCTGGC 
TCTGGACCGG TTATCCCACT CTACGCCAAC GCCAACGTCC CAGTGTCCAC AAGTGGAGGC 
TCTGGGAACG CGTCCACCAC CCCATCAGCA TCCCCGGTGC AGGGCTTGAC ATCATTTGGG 
CACAGCGTGG TGCCGGCATC CCAGGCAGGC AGCCCTATTG CTGAGCGCAG GGAGTCCGTC 
TGGAGGCCGT GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hairy1 acts as a node downstream of Wnt signaling to maintain retinal stem cell-like progenitor cells in the chick ciliary marginal zone.
Development (Cambridge, England)136(11)1823-33(2009 Jun)
Kubo F,Nakagawa S

Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1.
Developmental cell13(2)283-97(2007 Aug)
Bai G,Sheng N,Xie Z,Bian W,Yokota Y,Benezra R,Kageyama R,Guillemot F,Jing N

Chick Hairy1 protein interacts with Sap18, a component of the Sin3/HDAC transcriptional repressor complex.
BMC developmental biology783(2007 Jul)
Sheeba CJ,Palmeirim I,Andrade RP

Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index.
Physiological genomics25(3)514-24(2006 May)
Carre W,Wang X,Porter TE,Nys Y,Tang J,Bernberg E,Morgan R,Burnside J,Aggrey SE,Simon J,Cogburn LA

Correlation between Musashi-1 and c-hairy-1 expression and cell proliferation activity in the developing intestine and stomach of both chicken and mouse.
Development, growth & differentiation47(8)501-10(2005 Oct)
Asai R,Okano H,Yasugi S

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HES4 cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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