NOV cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	NOV
Entrez Gene ID	374135
Full Name	connective tissue growth factor
Synonyms	CCN2
General protein information	Preferred Names connective tissue growth factor Names connective tissue growth factor CCN family member 2
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_204274.1	NP_989605.1	connective tissue growth factor precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CTGF	XP_518744.2
Canis lupus familiaris (dog)	LOC476202	XP_003638817.1
Mus musculus (house mouse)	Ctgf	NP_034347.2
Gallus gallus (chicken)	CTGF	NP_989605.1
Xenopus tropicalis (tropical clawed frog)	ctgf	NP_001015042.1
Rattus norvegicus (Norway rat)	Ctgf	NP_071602.1
Homo sapiens (human)	CTGF	NP_001892.1
Bos taurus (cattle)	CTGF	NP_776455.1
Danio rerio (zebrafish)	ctgfa	NP_001015041.1

Gene Ontology
Bibliography

Related articles in PubMed

Compressive force-produced CCN2 induces osteocyte apoptosis through ERK1/2 pathway.
Hoshi K, Kawaki H, Takahashi I, Takeshita N, Seiryu M, Murshid SA, Masuda T, Anada T, Kato R, Kitaura H, Suzuki O, Takano-Yamamoto T
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research29(5)1244-57(2014)

Defining the earliest transcriptional steps of chondrogenic progenitor specification during the formation of the digits in the embryonic limb.
Lorda-Diez CI, Montero JA, Diaz-Mendoza MJ, Garcia-Porrero JA, Hurle JM
PloS one6(9)e24546(2011)

Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin.
Huang BL, Brugger SM, Lyons KM
The Journal of biological chemistry285(36)27702-12(2010 Sep)

Tendon healing in vivo: gene expression and production of multiple growth factors in early tendon healing period.
Chen CH, Cao Y, Wu YF, Bais AJ, Gao JS, Tang JB
The Journal of hand surgery33(10)1834-42(2008 Dec)

Posttranscriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation.
Mukudai Y, Kubota S, Kawaki H, Kondo S, Eguchi T, Sumiyoshi K, Ohgawara T, Shimo T, Takigawa M
Molecular and cellular biology28(19)6134-47(2008 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

application of exogenous CCN2 protein caused ERK1/2 activation, and the neutralizing CCN2 antibody inhibited loading-induced ERK1/2 activation.
Title: Compressive force-produced CCN2 induces osteocyte apoptosis through ERK1/2 pathway.

Ccn2 was expressed in the prehypertrophic cartilage of the digit rays and, with a lower intensity, in the developing joints. Interdigital implantation of beads bearing CCN2 exhibited the same effects as CCN1 but caused an additional moderate upregulation of Sox9, Activin beta-A and alpha 5 Integrin.
Title: Defining the earliest transcriptional steps of chondrogenic progenitor specification during the formation of the digits in the embryonic limb.

Differential occupancy of the TCF x LEF x Sox9 site by Sox9 versus beta-catenin restricts high levels of Ccn2 expression to hypertrophic chondrocytes.
Title: Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin.

CTGF genes and proteins are expressed at high or moderately high levels in healing tendon
Title: Tendon healing in vivo: gene expression and production of multiple growth factors in early tendon healing period.

The present study reveals a novel aspect of NPM/B23 as a key player in the posttranscriptional regulation of ccn2 mRNA during the differentiation of chondrocytes.
Title: Posttranscriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation.

The following NOV gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NOV cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa26645	NM_204274.1 Latest version!	Gallus gallus nephroblastoma overexpressed (NOV), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NOV ( NM_204274.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_989605.1 Gallus gallus nephroblastoma overexpressed (NOV), mRNA.

Price & Availability↑

CloneID	OGa26645
Clone ID Related Accession (Same CDS sequence)	NM_204274.1
Accession Version	NM_204274.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-11
Organism	Gallus gallus(chicken)
Product	connective tissue growth factor precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ298335.1. On Aug 30, 2004 this sequence version replaced XM_424540.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ298335.1, AF463517.1 [ECO:0000332] ##Evidence-Data-END##

ATGTCCCCCG CCAGCCTCGC CGTCGCCCTG CTGCTCGCCC TCCTCGGCCC GGAGGTGCGC 
GGCCAGGAGT GCAGCGGGCA GTGCCAGTGC GGCTCGGGGC CCGGCCCCAG CTGCCCCGCC 
GGCGTCTCCC TGGTGCTCGA TGGCTGCGGC TGCTGCCGCG TCTGCGCCAA GCAGCTGGGC 
GAGCTGTGCA CCGAGCGCGA CCCCTGCGAC CACCACAAAG GGCTCTTCTG CGACTTCGGC 
TCCCCCGCCA ACCGCCGCAT CGGCGTCTGC ACCGCTCGGG ACGGAGCGCC CTGCGTCTTC 
TCCGGCATGG TGTACCGGAG CGGCGAGTCC TTCCAGAGCA GCTGCAAGTA CCAGTGCACC 
TGCCTGGACG GCGCGGTGGG CTGCGTGCCC CTCTGCAGCA TGGACGTCCG CCTGCCCAGC 
CCTGACTGCC CCTACCCTCG GCGGGTGAAG CTCCCCGGCA AGTGCTGTGA GGAGTGGGTC 
TGCGACGAGG CCAAGGAGCA GACGGCGGTG GGACCCGCAC TGGCCGCCTA CAGACTGGAA 
GACACTTACG GCCCAGACCC CACCATGATG CGTGCCAATT GCCTGGTGCA GACTACTGAG 
TGGAGTGCTT GCTCCAAGAC CTGTGGCATG GGCATCTCGA CCAGGGTCAC CAACGATAAT 
GCTTTCTGCA GACTGGAGAA GCAGAGCAGA CTGTGCATGG TCAGACCTTG CGAAGCTGAC 
CTGGAGGAGA ACATCAAGAA AGGCAAAAAG TGCATTCGCA CCCCAAAAAT CTCCAAGCCC 
ATCAAGTTTG AGCTGTCTGG CTGCACCAGC GTGAAGACGT ACAGAGCTAA GTTCTGTGGT 
GTCTGCACTG ACGGGCGCTG CTGCACACCC CACAGAACAG CCACCCTCCC CGTGGAGTTC 
AAGTGCCCCG ATGGAGAGAT CATGAAAAGG AAAATGATGT TCATCAAGAC CTGCGCCTGC 
CACTACAACT GCCCTGGAGA CAATGACATC TTTGAGTCTC TGTACTACAG GAAGATGTAT 
GGAGACATGG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_989605.1
CDS	172..1206
Translation	MSPASLAVALLLALLGPEVRGQECSGQCQCGSGPGPSCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDHHKGLFCDFGSPANRRIGVCTARDGAPCVFSGMVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPYPRRVKLPGKCCEEWVCDEAKEQTAVGPALAAYRLEDTYGPDPTMMRANCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTATLPVEFKCPDGEIMKRKMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA

Target ORF information:

RefSeq Version	NM_204274.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus nephroblastoma overexpressed (NOV), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_204274.1

ORF Insert Sequence:

ATGTCCCCCG CCAGCCTCGC CGTCGCCCTG CTGCTCGCCC TCCTCGGCCC GGAGGTGCGC 
GGCCAGGAGT GCAGCGGGCA GTGCCAGTGC GGCTCGGGGC CCGGCCCCAG CTGCCCCGCC 
GGCGTCTCCC TGGTGCTCGA TGGCTGCGGC TGCTGCCGCG TCTGCGCCAA GCAGCTGGGC 
GAGCTGTGCA CCGAGCGCGA CCCCTGCGAC CACCACAAAG GGCTCTTCTG CGACTTCGGC 
TCCCCCGCCA ACCGCCGCAT CGGCGTCTGC ACCGCTCGGG ACGGAGCGCC CTGCGTCTTC 
TCCGGCATGG TGTACCGGAG CGGCGAGTCC TTCCAGAGCA GCTGCAAGTA CCAGTGCACC 
TGCCTGGACG GCGCGGTGGG CTGCGTGCCC CTCTGCAGCA TGGACGTCCG CCTGCCCAGC 
CCTGACTGCC CCTACCCTCG GCGGGTGAAG CTCCCCGGCA AGTGCTGTGA GGAGTGGGTC 
TGCGACGAGG CCAAGGAGCA GACGGCGGTG GGACCCGCAC TGGCCGCCTA CAGACTGGAA 
GACACTTACG GCCCAGACCC CACCATGATG CGTGCCAATT GCCTGGTGCA GACTACTGAG 
TGGAGTGCTT GCTCCAAGAC CTGTGGCATG GGCATCTCGA CCAGGGTCAC CAACGATAAT 
GCTTTCTGCA GACTGGAGAA GCAGAGCAGA CTGTGCATGG TCAGACCTTG CGAAGCTGAC 
CTGGAGGAGA ACATCAAGAA AGGCAAAAAG TGCATTCGCA CCCCAAAAAT CTCCAAGCCC 
ATCAAGTTTG AGCTGTCTGG CTGCACCAGC GTGAAGACGT ACAGAGCTAA GTTCTGTGGT 
GTCTGCACTG ACGGGCGCTG CTGCACACCC CACAGAACAG CCACCCTCCC CGTGGAGTTC 
AAGTGCCCCG ATGGAGAGAT CATGAAAAGG AAAATGATGT TCATCAAGAC CTGCGCCTGC 
CACTACAACT GCCCTGGAGA CAATGACATC TTTGAGTCTC TGTACTACAG GAAGATGTAT 
GGAGACATGG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Compressive force-produced CCN2 induces osteocyte apoptosis through ERK1/2 pathway.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research29(5)1244-57(2014)
Hoshi K,Kawaki H,Takahashi I,Takeshita N,Seiryu M,Murshid SA,Masuda T,Anada T,Kato R,Kitaura H,Suzuki O,Takano-Yamamoto T

Defining the earliest transcriptional steps of chondrogenic progenitor specification during the formation of the digits in the embryonic limb.
PloS one6(9)e24546(2011)
Lorda-Diez CI,Montero JA,Diaz-Mendoza MJ,Garcia-Porrero JA,Hurle JM

Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin.
The Journal of biological chemistry285(36)27702-12(2010 Sep)
Huang BL,Brugger SM,Lyons KM

Tendon healing in vivo: gene expression and production of multiple growth factors in early tendon healing period.
The Journal of hand surgery33(10)1834-42(2008 Dec)
Chen CH,Cao Y,Wu YF,Bais AJ,Gao JS,Tang JB

Posttranscriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation.
Molecular and cellular biology28(19)6134-47(2008 Oct)
Mukudai Y,Kubota S,Kawaki H,Kondo S,Eguchi T,Sumiyoshi K,Ohgawara T,Shimo T,Takigawa M

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NOV cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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