TGFB1 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	TGFB1
Entrez Gene ID	100873157
Full Name	transforming growth factor beta 1
Synonyms	TGF-beta4,TGFB4
General protein information	Preferred Names transforming growth factor beta 1 Names transforming growth factor beta-1 LOW QUALITY PROTEIN: transforming growth factor beta-1 TGF-beta-1 tissue growth factor-beta4 transforming growth factor beta 4
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
XM_025144453.1	XP_025000221.1	transforming growth factor beta-1 isoform X1
NM_001318456.1	NP_001305385.1	transforming growth factor beta-1 proprotein precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Cell-cycle-dependent TGF?-BMP antagonism regulates neural tube closure by modulating tight junctions.
Amarnath S, Agarwala S
Journal of cell science130(1)119-131(2017 01)

Staurosporine induces chondrogenesis of chick embryo wing bud mesenchyme in monolayer cultures through canonical and non-canonical TGF-? pathways.
Kim H, Kei K, Sonn JK
In vitro cellular & developmental biology. Animal52(1)120-9(2016 Jan)

Interaction of TGF-?4 and IL-17 with IgA secretion in the intestine of chickens fed with E. faecium AL41 and challenged with S. Enteritidis.
Karaffov? V, Bob?kov? K, Hus?kov? E, Levkut M, Herich R, Revajov? V, Levkutov? M, Levkut M
Research in veterinary science10075-9(2015 Jun)

Cooperative Effects of FOXL2 with the Members of TGF-? Superfamily on FSH Receptor mRNA Expression and Granulosa Cell Proliferation from Hen Prehierarchical Follicles.
Qin N, Fan XC, Xu XX, Tyasi TL, Li SJ, Zhang YY, Wei ML, Xu RF
PloS one10(10)e0141062(2015)

Over, and underexpression of endothelin 1 and TGF-beta family ligands and receptors in lung tissue of broilers with pulmonary hypertension.
Dominguez-Avila N, Ruiz-Casta?eda G, Gonz?lez-Ram?rez J, Fernandez-Jaramillo N, Escoto J, S?nchez-Mu?oz F, Marquez-Velasco R, Bojalil R, Espinosa-Cervantes R, S?nchez F
BioMed research international2013190382(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the interactions of BMP and TGFbeta with polarity proteins dynamically modulate median hinge point formation.
Title: Cell-cycle-dependent TGF?-BMP antagonism regulates neural tube closure by modulating tight junctions.

Taken together, these results suggest that staurosporine induces chondrogenesis through TGF-beta pathways including canonical Smads and non-canonical Akt and p38 MAPK signaling.
Title: Staurosporine induces chondrogenesis of chick embryo wing bud mesenchyme in monolayer cultures through canonical and non-canonical TGF-? pathways.

There was a beneficial effect of Enterococcus faecium on IgA production and secretion in chicken intestine. IgA also contributed in decrease of intestinal Salmonella Enteritidis, and cytokines TGF-beta4 and IL-17 contributed to increased IgA secretion.
Title: Interaction of TGF-?4 and IL-17 with IgA secretion in the intestine of chickens fed with E. faecium AL41 and challenged with S. Enteritidis.

Cooperative effects have been found of FOXL2 with the members of TGF-beta superfamily on FSH receptor mRNA expression and granulosa cell proliferation from hen prehierarchical follicles.
Title: Cooperative Effects of FOXL2 with the Members of TGF-? Superfamily on FSH Receptor mRNA Expression and Granulosa Cell Proliferation from Hen Prehierarchical Follicles.

mRNA expression of genes of the TGF beta family and endothelin 1 in lung samples from 4-week-old chickens with pulmonary hypertension, were determined.
Title: Over, and underexpression of endothelin 1 and TGF-beta family ligands and receptors in lung tissue of broilers with pulmonary hypertension.

The following TGFB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TGFB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa51408	NM_001318456.1 Latest version!	Gallus gallus transforming growth factor beta 1 (TGFB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OGa149551	XM_025144453.1 Latest version!	Gallus gallus transforming growth factor beta 1 (TGFB1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TGFB1 ( NM_001318456.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001305385.1 Gallus gallus transforming growth factor beta 1 (TGFB1), mRNA.

Price & Availability↑

CloneID	OGa51408
Clone ID Related Accession (Same CDS sequence)	NM_001318456.1
Accession Version	NM_001318456.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1179bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Gallus gallus(chicken)
Product	transforming growth factor beta-1 proprotein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JQ423909.1. On Jan 6, 2016 this sequence version replaced XM_015272489.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: JQ423909.1 [ECO:0000332] ##Evidence-Data-END##

ATGGATCCGT CGCCGCTGCT GGCGCTGCTG CTGCTGCTGC TGGGGGCCGC CCGCGCGCTC 
TCCACGTGCC AACGGCTGGA CCTGGAGGCG GCCAAAAAGA AACGCATCGA GGCGGTGCGG 
GGTCAAATCC TCAGCAAACT GCGTCTGACC GCGCCCCCCC CCGCCTCCGA GACCCCCCCC 
CGCCCCCTGC CCGACGACGT CCGGGCTCTG TACAACAGCA CCCAGGAGCT GCTGAAGCAG 
CGCGCCCGAC TGCGGCCCCC CCCGGATGGA CCCGATGAGT ATTGGGCCAA AGAGCTGCGG 
CGGATCCCCA TGGAGACCAC CTGGGACGGC CCCATGGAGC ATTGGCAGCC GCAGAGCCAC 
AGCATCTTCT TCGTGTTCAA CGTGTCCCGC GTGCGCGCAG AGGTGGGCGG CCGAGCGCTG 
CTGCACCGCG CCGAGCTGAG GATGCTGCGG CAAAAGGCGG CCGCCGACAG CGCCGGCACC 
GAACAGCGGC TGGAGCTGTA CCAGGGTTAC GGCAATGCCT CGTGGCGGTA CCTGCATGGC 
CGCTCCGTGC GCGCCACGGC CGACGATGAG TGGCTCTCCT TCGACGTCAC CGACGCCGTC 
CATCAGTGGC TGAGCGGCAG CGAGCTCCTG GGGGTCTTCA AGCTGAGCGT GCACTGTCCC 
TGTGAGATGG GCCCCGGCCA CGCCGACGAG ATGCGCATCT CCATCGAAGG CTTCGAGCAG 
CAGCGCGGGG ACATGCAGAG CATTGCCAAG AAGCACCGCC GCGTGCCGTA CGTCCTGGCC 
ATGGCGCTGC CGGCCGAGCG CGCCAATGAG CTGCACAGCG CCCGGCGGCG GCGCGACCTC 
GACACCGACT ACTGCTTCGG CCCCGGGACG GATGAGAAGA ACTGCTGCGT GCGGCCGCTC 
TACATCGACT TCCGCAAGGA TCTGCAGTGG AAGTGGATCC ACGAACCCAA AGGTTATATG 
GCCAACTTCT GCATGGGGCC GTGCCCGTAC ATCTGGAGCG CCGACACGCA GTACACCAAG 
GTGCTGGCGC TGTACAACCA ACACAACCCG GGGGCTTCGG CCGCTCCGTG CTGCGTCCCG 
CAGACCCTCG ACCCCCTCCC CATCATTTAC TACGTGGGCC GGAATGTGCG CGTGGAGCAG 
CTCTCCAATA TGGTGGTCCG TGCCTGCAAG TGCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001305385.1
CDS	162..1340
Translation	MDPSPLLALLLLLLGAARALSTCQRLDLEAAKKKRIEAVRGQILSKLRLTAPPPASETPPRPLPDDVRALYNSTQELLKQRARLRPPPDGPDEYWAKELRRIPMETTWDGPMEHWQPQSHSIFFVFNVSRVRAEVGGRALLHRAELRMLRQKAAADSAGTEQRLELYQGYGNASWRYLHGRSVRATADDEWLSFDVTDAVHQWLSGSELLGVFKLSVHCPCEMGPGHADEMRISIEGFEQQRGDMQSIAKKHRRVPYVLAMALPAERANELHSARRRRDLDTDYCFGPGTDEKNCCVRPLYIDFRKDLQWKWIHEPKGYMANFCMGPCPYIWSADTQYTKVLALYNQHNPGASAAPCCVPQTLDPLPIIYYVGRNVRVEQLSNMVVRACKCS

Target ORF information:

RefSeq Version	NM_001318456.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus transforming growth factor beta 1 (TGFB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318456.1

ORF Insert Sequence:

ATGGATCCGT CGCCGCTGCT GGCGCTGCTG CTGCTGCTGC TGGGGGCCGC CCGCGCGCTC 
TCCACGTGCC AACGGCTGGA CCTGGAGGCG GCCAAAAAGA AACGCATCGA GGCGGTGCGG 
GGTCAAATCC TCAGCAAACT GCGTCTGACC GCGCCCCCCC CCGCCTCCGA GACCCCCCCC 
CGCCCCCTGC CCGACGACGT CCGGGCTCTG TACAACAGCA CCCAGGAGCT GCTGAAGCAG 
CGCGCCCGAC TGCGGCCCCC CCCGGATGGA CCCGATGAGT ATTGGGCCAA AGAGCTGCGG 
CGGATCCCCA TGGAGACCAC CTGGGACGGC CCCATGGAGC ATTGGCAGCC GCAGAGCCAC 
AGCATCTTCT TCGTGTTCAA CGTGTCCCGC GTGCGCGCAG AGGTGGGCGG CCGAGCGCTG 
CTGCACCGCG CCGAGCTGAG GATGCTGCGG CAAAAGGCGG CCGCCGACAG CGCCGGCACC 
GAACAGCGGC TGGAGCTGTA CCAGGGTTAC GGCAATGCCT CGTGGCGGTA CCTGCATGGC 
CGCTCCGTGC GCGCCACGGC CGACGATGAG TGGCTCTCCT TCGACGTCAC CGACGCCGTC 
CATCAGTGGC TGAGCGGCAG CGAGCTCCTG GGGGTCTTCA AGCTGAGCGT GCACTGTCCC 
TGTGAGATGG GCCCCGGCCA CGCCGACGAG ATGCGCATCT CCATCGAAGG CTTCGAGCAG 
CAGCGCGGGG ACATGCAGAG CATTGCCAAG AAGCACCGCC GCGTGCCGTA CGTCCTGGCC 
ATGGCGCTGC CGGCCGAGCG CGCCAATGAG CTGCACAGCG CCCGGCGGCG GCGCGACCTC 
GACACCGACT ACTGCTTCGG CCCCGGGACG GATGAGAAGA ACTGCTGCGT GCGGCCGCTC 
TACATCGACT TCCGCAAGGA TCTGCAGTGG AAGTGGATCC ACGAACCCAA AGGTTATATG 
GCCAACTTCT GCATGGGGCC GTGCCCGTAC ATCTGGAGCG CCGACACGCA GTACACCAAG 
GTGCTGGCGC TGTACAACCA ACACAACCCG GGGGCTTCGG CCGCTCCGTG CTGCGTCCCG 
CAGACCCTCG ACCCCCTCCC CATCATTTAC TACGTGGGCC GGAATGTGCG CGTGGAGCAG 
CTCTCCAATA TGGTGGTCCG TGCCTGCAAG TGCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TGFB1 ( XM_025144453.1 ) cDNA ORF clone, Gallus gallus(chicken) -> XP_025000221.1 Gallus gallus transforming growth factor beta 1 (TGFB1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OGa149551
Clone ID Related Accession (Same CDS sequence)	XM_025144453.1
Accession Version	XM_025144453.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1179bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-16
Organism	Gallus gallus(chicken)
Product	transforming growth factor beta-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006119.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 104 Annotation Version :: 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATCCGT CGCCGCTGCT GGCGCTGCTG CTGCTGCTGC TGGGGGCCGC CCGCGCGCTC 
TCCACGTGCC AACGGCTGGA CCTGGAGGCG GCCAAAAAGA AACGCATCGA GGCGGTGCGG 
GGTCAAATCC TCAGCAAACT GCGTCTGACC GCGCCCCCCC CCGCCTCCGA GACCCCCCCC 
CGCCCCCTGC CCGACGACGT CCGGGCTCTG TACAACAGCA CCCAGGAGCT GCTGAAGCAG 
CGCGCCCGAC TGCGGCCCCC CCCGGATGGA CCCGATGAGT ATTGGGCCAA AGAGCTGCGG 
CGGATCCCCA TGGAGACCAC CTGGGACGGC CCCATGGAGC ATTGGCAGCC GCAGAGCCAC 
AGCATCTTCT TCGTGTTCAA CGTGTCCCGC GTGCGCGCAG AGGTGGGCGG CCGAGCGCTG 
CTGCACCGCG CCGAGCTGAG GATGCTGCGG CAAAAGGCGG CCGCCGACAG CGCCGGCACC 
GAACAGCGGC TGGAGCTATA CCAGGGTTAC GGCAATGCCT CGTGGCGGTA CCTGCATGGC 
CGCTCCGTGC GCGCCACGGC CGACGATGAG TGGCTCTCCT TCGACGTCAC CGACGCCGTC 
CATCAGTGGC TGAGCGGCAG CGAGCTCCTG GGGGTCTTCA AGCTGAGCGT GCACTGTCCC 
TGTGAGATGG GCCCCGGCCA CGCCGACGAG ATGCGCATCT CCATCGAAGG CTTCGAGCAG 
CAGCGCGGGG ACATGCAGAG CATTGCCAAG AAGCACCGCC GCGTGCCGTA CGTCCTGGCC 
ATGGCGCTGC CGGCCGAGCG CGCCAATGAG CTGCACAGCG CCCGGCGGCG GCGCGACCTC 
GACACCGACT ACTGCTTCGG CCCCGGGACG GATGAGAAGA ACTGCTGCGT GCGGCCGCTC 
TACATCGACT TCCGCAAGGA TCTGCAGTGG AAGTGGATCC ACGAACCCAA AGGTTATATG 
GCCAACTTCT GCATGGGGCC GTGCCCATAC ATCTGGAGCG CCGACACGCA GTACACCAAG 
GTGCTGGCGC TGTACAACCA ACACAACCCG GGGGCTTCGG CCGCTCCGTG CTGCGTCCCG 
CAGACCCTCG ACCCCCTCCC CATCATTTAC TACGTGGGCC GGAATGTGCG CGTGGAGCAG 
CTCTCCAATA TGGTGGTCCG TGCCTGCAAG TGCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_025000221.1
CDS	502..1680
Translation	MDPSPLLALLLLLLGAARALSTCQRLDLEAAKKKRIEAVRGQILSKLRLTAPPPASETPPRPLPDDVRALYNSTQELLKQRARLRPPPDGPDEYWAKELRRIPMETTWDGPMEHWQPQSHSIFFVFNVSRVRAEVGGRALLHRAELRMLRQKAAADSAGTEQRLELYQGYGNASWRYLHGRSVRATADDEWLSFDVTDAVHQWLSGSELLGVFKLSVHCPCEMGPGHADEMRISIEGFEQQRGDMQSIAKKHRRVPYVLAMALPAERANELHSARRRRDLDTDYCFGPGTDEKNCCVRPLYIDFRKDLQWKWIHEPKGYMANFCMGPCPYIWSADTQYTKVLALYNQHNPGASAAPCCVPQTLDPLPIIYYVGRNVRVEQLSNMVVRACKCS

Target ORF information:

RefSeq Version	XM_025144453.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus transforming growth factor beta 1 (TGFB1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_025144453.1

ORF Insert Sequence:

ATGGATCCGT CGCCGCTGCT GGCGCTGCTG CTGCTGCTGC TGGGGGCCGC CCGCGCGCTC 
TCCACGTGCC AACGGCTGGA CCTGGAGGCG GCCAAAAAGA AACGCATCGA GGCGGTGCGG 
GGTCAAATCC TCAGCAAACT GCGTCTGACC GCGCCCCCCC CCGCCTCCGA GACCCCCCCC 
CGCCCCCTGC CCGACGACGT CCGGGCTCTG TACAACAGCA CCCAGGAGCT GCTGAAGCAG 
CGCGCCCGAC TGCGGCCCCC CCCGGATGGA CCCGATGAGT ATTGGGCCAA AGAGCTGCGG 
CGGATCCCCA TGGAGACCAC CTGGGACGGC CCCATGGAGC ATTGGCAGCC GCAGAGCCAC 
AGCATCTTCT TCGTGTTCAA CGTGTCCCGC GTGCGCGCAG AGGTGGGCGG CCGAGCGCTG 
CTGCACCGCG CCGAGCTGAG GATGCTGCGG CAAAAGGCGG CCGCCGACAG CGCCGGCACC 
GAACAGCGGC TGGAGCTATA CCAGGGTTAC GGCAATGCCT CGTGGCGGTA CCTGCATGGC 
CGCTCCGTGC GCGCCACGGC CGACGATGAG TGGCTCTCCT TCGACGTCAC CGACGCCGTC 
CATCAGTGGC TGAGCGGCAG CGAGCTCCTG GGGGTCTTCA AGCTGAGCGT GCACTGTCCC 
TGTGAGATGG GCCCCGGCCA CGCCGACGAG ATGCGCATCT CCATCGAAGG CTTCGAGCAG 
CAGCGCGGGG ACATGCAGAG CATTGCCAAG AAGCACCGCC GCGTGCCGTA CGTCCTGGCC 
ATGGCGCTGC CGGCCGAGCG CGCCAATGAG CTGCACAGCG CCCGGCGGCG GCGCGACCTC 
GACACCGACT ACTGCTTCGG CCCCGGGACG GATGAGAAGA ACTGCTGCGT GCGGCCGCTC 
TACATCGACT TCCGCAAGGA TCTGCAGTGG AAGTGGATCC ACGAACCCAA AGGTTATATG 
GCCAACTTCT GCATGGGGCC GTGCCCATAC ATCTGGAGCG CCGACACGCA GTACACCAAG 
GTGCTGGCGC TGTACAACCA ACACAACCCG GGGGCTTCGG CCGCTCCGTG CTGCGTCCCG 
CAGACCCTCG ACCCCCTCCC CATCATTTAC TACGTGGGCC GGAATGTGCG CGTGGAGCAG 
CTCTCCAATA TGGTGGTCCG TGCCTGCAAG TGCAGCTGA