SELENOH cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	SELENOH
Entrez Gene ID	100858006
Full Name	selenoprotein H
Synonyms	C11orf31,C5H11orf31,SELH
General protein information	Preferred Names selenoprotein H Names selenoprotein H selenoprotein H-like
Gene Type	protein-coding
Organism	Gallus gallus(chicken)
Summary	This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, May 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001277865.1	NP_001264794.1	selenoprotein H

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	C11H11orf31	NP_001140163.1
	C14H11orf31	NP_001152973.1
Bos taurus (cattle)	C15H11orf31	NP_001157564.1
Mus musculus (house mouse)	2700094K13Rik	NP_001028338.1
Gallus gallus (chicken)	LOC100858006	NP_001264794.1
Canis lupus familiaris (dog)	C18H11orf31	NP_001157978.1
Homo sapiens (human)	C11orf31	NP_734467.1
Rattus norvegicus (Norway rat)	RGD1563348	NP_001108411.1
Danio rerio (zebrafish)	seph	NP_835234.2

Gene Ontology
Bibliography

Related articles in PubMed

Glutathione Peroxidase 1, Selenoprotein K, and Selenoprotein H May Play Important Roles in Chicken Testes in Response to Selenium Deficiency.
Gao Y, Zhang J, Huang X, Zhang G
Biological trace element research179(2)271-276(2017 Oct)

Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels.
Xu JX, Zhang C, Cao CY, Zhu SY, Li H, Sun YC, Li JL
Biological trace element research170(2)438-48(2016 Apr)

Characterization of mammalian selenoproteomes.
Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guig? R, Gladyshev VN
Science (New York, N.Y.)300(5624)1439-43(2003 May)

A comprehensive collection of chicken cDNAs.
Boardman PE, Sanz-Ezquerro J, Overton IM, Burt DW, Bosch E, Fong WT, Tickle C, Brown WR, Wilson SA, Hubbard SJ
Current biology : CB12(22)1965-9(2002 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Dietary low Se downregulated the mRNA expressions of Gpx1-4, Txnrd3, Sepn1, Selw, Sepx1, Selh, and SEPSECS.
Title: Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels.

The following SELENOH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SELENOH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa26502	NM_001277865.1 Latest version!	Gallus gallus selenoprotein H (SELENOH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SELENOH ( NM_001277865.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001264794.1 Gallus gallus selenoprotein H (SELENOH), mRNA.

Price & Availability↑

CloneID	OGa26502
Clone ID Related Accession (Same CDS sequence)	NM_001277865.1
Accession Version	NM_001277865.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 390bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-07-14
Organism	Gallus gallus(chicken)
Product	selenoprotein H
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX932816.2 and BU398637.1. On Apr 25, 2013 this sequence version replaced XM_003641330.1. Sequence Note: This RefSeq record was created from transcript data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BX932816.2, BX934208.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCCCC GCGGCAGGAA GCGCGCCGCG CGGCGCCCGG CCGAGCCGGA GGCGCGGGCG 
GATCCCCCCG AGAAGCGGCC CCGCGACGAG GCCGAGGGCA GCCCCGGGGA CGCCGGCGGC 
CCCCGCGTCG TCATCGAGCA CTGCCGTAGC TGACGCGTGT ACGGGCGCAA CGCGGCGGCG 
CTGAGCGAGG CCCTGCGCGG GGCCGTGGCC GCCCTGGCCG TAGAGATCAA CCCGCGGCAG 
CCCCGCAGGA ACAGCTTCGA GGTGTCCCTG GTGAAGGAAG ACGGCAGCAC CGTGCAGCTG 
TGGAGCGGCA TCGGGAAGGG GCCTCCCCGC AAGCTGAAGT TCCCCGAGCC CGCGGCCGTG 
GTGGAGGCTC TGCGGAGCAG CCTGGCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001264794.1
CDS	84..473
Translation	MAPRGRKRAARRPAEPEARADPPEKRPRDEAEGSPGDAGGPRVVIEHCRS*RVYGRNAAALSEALRGAVAALAVEINPRQPRRNSFEVSLVKEDGSTVQLWSGIGKGPPRKLKFPEPAAVVEALRSSLA

Target ORF information:

RefSeq Version	NM_001277865.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus selenoprotein H (SELENOH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001277865.1

ORF Insert Sequence:

ATGGCCCCCC GCGGCAGGAA GCGCGCCGCG CGGCGCCCGG CCGAGCCGGA GGCGCGGGCG 
GATCCCCCCG AGAAGCGGCC CCGCGACGAG GCCGAGGGCA GCCCCGGGGA CGCCGGCGGC 
CCCCGCGTCG TCATCGAGCA CTGCCGTAGC TGACGCGTGT ACGGGCGCAA CGCGGCGGCG 
CTGAGCGAGG CCCTGCGCGG GGCCGTGGCC GCCCTGGCCG TAGAGATCAA CCCGCGGCAG 
CCCCGCAGGA ACAGCTTCGA GGTGTCCCTG GTGAAGGAAG ACGGCAGCAC CGTGCAGCTG 
TGGAGCGGCA TCGGGAAGGG GCCTCCCCGC AAGCTGAAGT TCCCCGAGCC CGCGGCCGTG 
GTGGAGGCTC TGCGGAGCAG CCTGGCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Glutathione Peroxidase 1, Selenoprotein K, and Selenoprotein H May Play Important Roles in Chicken Testes in Response to Selenium Deficiency.
Biological trace element research179(2)271-276(2017 Oct)
Gao Y,Zhang J,Huang X,Zhang G

Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels.
Biological trace element research170(2)438-48(2016 Apr)
Xu JX,Zhang C,Cao CY,Zhu SY,Li H,Sun YC,Li JL

Characterization of mammalian selenoproteomes.
Science (New York, N.Y.)300(5624)1439-43(2003 May)
Kryukov GV,Castellano S,Novoselov SV,Lobanov AV,Zehtab O,Guig? R,Gladyshev VN

A comprehensive collection of chicken cDNAs.
Current biology : CB12(22)1965-9(2002 Nov)
Boardman PE,Sanz-Ezquerro J,Overton IM,Burt DW,Bosch E,Fong WT,Tickle C,Brown WR,Wilson SA,Hubbard SJ

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SELENOH cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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