HDAC3 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	HDAC3
Entrez Gene ID	44446
Full Name	Histone deacetylase 3
Synonyms	CG2128,DHDAC3,DmHDAC3,Dmel\CG2128,Dromel_CG2128_FBtr0078767_hdac3_mORF,HDAC,Hdac 3,Hdac3,dHDAC3,dmHDA402,hdac3
General protein information	Preferred Names Histone deacetylase 3 Names CG2128 gene product from transcript CG2128-RA CG2128-PA HDAC3-PA Hdac3 histone Deacetylase-3 histone deacetylase 3
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3R Map Location: 83A4-83A4

mRNA and Protein(s)

mRNA	Protein	Name
NM_143721.4	NP_651978.2	histone deacetylase 3

Pathways from BioSystems

Homologies

Oryza sativa (rice)	Os04g0409600	NP_001052725.1
Xenopus tropicalis (tropical clawed frog)	hdac3	NP_001016883.1
	HDAC3	XP_001094295.1
Canis lupus familiaris (dog)	HDAC3	XP_535219.2
Homo sapiens (human)	HDAC3	NP_003874.2
Gallus gallus (chicken)	HDAC3	NP_990078.1
Bos taurus (cattle)	HDAC3	NP_001193172.1
Mus musculus (house mouse)	Hdac3	NP_034541.2
Drosophila melanogaster (fruit fly)	Hdac3	NP_651978.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001143	XP_322018.5
Arabidopsis thaliana (thale cress)	HDA9	NP_190054.2
Pan troglodytes (chimpanzee)	HDAC3	XP_001151495.1
Rattus norvegicus (Norway rat)	Hdac3	NP_445900.1
Danio rerio (zebrafish)	hdac3	NP_957284.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Brm-HDAC3-Erm repressor complex suppresses dedifferentiation of intermediate neural progenitors back into type II neuroblasts.
Title: The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages.

Hdac3 served as an important regulator of the PI3K pathway and revealed a novel link between histone acetylation and growth control.
Title: Depletion of histone deacetylase 3 antagonizes PI3K-mediated overgrowth of Drosophila organs through the acetylation of histone H4 at lysine 16.

Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X tremor ataxia syndrome.
Title: Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.

Histone deacetylation is a repression mechanism in early Drosophila development.
Title: Drosophila Ebi mediates Snail-dependent transcriptional repression through HDAC3-induced histone deacetylation.

Mutant larvae display small imaginal discs, which result from abnormally elevated levels of apoptosis. This cell death occurs as a cell-autonomous response to HDAC3 loss and is accompanied by increased expression of the pro-apoptotic gene, hid.
Title: Drosophila histone deacetylase-3 controls imaginal disc size through suppression of apoptosis.

The following HDAC3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HDAC3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa06847	NM_143721.4 Latest version!	Drosophila melanogaster histone deacetylase 3 (HDAC3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HDAC3 ( NM_143721.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_651978.2 Drosophila melanogaster histone deacetylase 3 (HDAC3), mRNA.

Price & Availability↑

CloneID	OFa06847
Clone ID Related Accession (Same CDS sequence)	NM_143721.4
Accession Version	NM_143721.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1317bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	histone deacetylase 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jul 15, 2014 this sequence version replaced NM_143721.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGACGGACC GTAGGGTGTC GTACTTCTAC AACGCGGACG TGGGCAACTT CCACTATGGA 
GCCGGGCATC CCATGAAGCC GCAACGCCTG GCGGTCACTC ACAGCCTGGT AATGAACTAC 
GGACTGCACA AGAAAATGAA GATCTACAGG CCGTACAAGG CCAGTGCGCA GGACATGCTC 
CGCTTCCACA GCGACGAGTA CATCGCCTAC TTACAGCAGG TGACTCCACA AAACATTCAG 
TGCAATTCCG TGGCCTATAC GAAGTACCTG GCGCACTTCA GCGTAGGCGA GGACTGTCCC 
GTGTTCGATG GCCTCTTCGA CTTCTGTGCA ATGTACACGG GTGCCTCGCT GGAGGGAGCC 
CAGAAGCTGA ACCACAACCA CAGCGACATA TGCATAAACT GGTCGGGCGG ACTGCATCAC 
GCCAAGAAGT TCGAGGCAAG CGGATTCTGC TACGTGAATG ACATCGTCAT CGGCATTCTG 
GAGCTGCTTA AGTACCATCC TCGGGTGCTC TACATCGACA TCGATGTGCA CCACGGCGAC 
GGGGTGCAGG AGGCGTTCTA CCTTACGGAC CGAGTGATGA CGGCTTCGTT CCACAAATAC 
GGAAACTACT TTTTTCCCGG CACGGGAGAC ATGTACGAGA TAGGCGCCGA ATCGGGACGA 
TACTACAGCG TTAATGTGCC GCTAAAGGAG GGCATTGATG ACCAGAGCTA TTTTCAGGTG 
TTCAAACCCA TAATTTCTGC CATTATGGAC TTCTACCGGC CCACGGCTAT CGTTTTGCAG 
TGTGGCGCGG ATTCACTAGC TGGAGATCGA CTAGGTTGCT TCTCCCTGAG CACCAAGGGA 
CATGGTGAGT GTGTCAAATT TGTGAAGGAA CTGAACGTAC CCACATTGGT GGTCGGAGGC 
GGTGGCTACA CCTTACGGAA CGTGGCCCGC TGCTGGACGC ACGAGACCTC GCTGCTGGTG 
GACCAAGACA TTGAAAATGA CCTACCCGCC ACCGAGTATT ACGACTTTTT CGCCCCCGAC 
TTTACACTCC ATCCAGAGAT TAACTCACGC CAAGATAATG CTAACTCAAA GCAGTATCTT 
GAACTCATCG TTAAGCATGT GTATGAAAAC CTTAAGATGT GCCAGCACTC GCCCAGCGTC 
CAAATGGTGC AGACCCCGCC TGATGTGGAC TTGGAGGAGC TGCGCAGCAA CCGGGAGGAG 
GCGAGTGATC CCGACGTGCG AATATCCGTA GCCGATGAGG ACAAGCTGGT TGATGCTAAG 
AACGAGTTCT ACGACGGCGA TCAGGACCAA GACAAGCCCG ATTCGGCAGA AAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_651978.2
CDS	278..1594
Translation	MTDRRVSYFYNADVGNFHYGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYIAYLQQVTPQNIQCNSVAYTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDICINWSGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTASFHKYGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTAIVLQCGADSLAGDRLGCFSLSTKGHGECVKFVKELNVPTLVVGGGGYTLRNVARCWTHETSLLVDQDIENDLPATEYYDFFAPDFTLHPEINSRQDNANSKQYLELIVKHVYENLKMCQHSPSVQMVQTPPDVDLEELRSNREEASDPDVRISVADEDKLVDAKNEFYDGDQDQDKPDSAES

Target ORF information:

RefSeq Version	NM_143721.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster histone deacetylase 3 (HDAC3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_143721.4

ORF Insert Sequence:

ATGACGGACC GTAGGGTGTC GTACTTCTAC AACGCGGACG TGGGCAACTT CCACTATGGA 
GCCGGGCATC CCATGAAGCC GCAACGCCTG GCGGTCACTC ACAGCCTGGT AATGAACTAC 
GGACTGCACA AGAAAATGAA GATCTACAGG CCGTACAAGG CCAGTGCGCA GGACATGCTC 
CGCTTCCACA GCGACGAGTA CATCGCCTAC TTACAGCAGG TGACTCCACA AAACATTCAG 
TGCAATTCCG TGGCCTATAC GAAGTACCTG GCGCACTTCA GCGTAGGCGA GGACTGTCCC 
GTGTTCGATG GCCTCTTCGA CTTCTGTGCA ATGTACACGG GTGCCTCGCT GGAGGGAGCC 
CAGAAGCTGA ACCACAACCA CAGCGACATA TGCATAAACT GGTCGGGCGG ACTGCATCAC 
GCCAAGAAGT TCGAGGCAAG CGGATTCTGC TACGTGAATG ACATCGTCAT CGGCATTCTG 
GAGCTGCTTA AGTACCATCC TCGGGTGCTC TACATCGACA TCGATGTGCA CCACGGCGAC 
GGGGTGCAGG AGGCGTTCTA CCTTACGGAC CGAGTGATGA CGGCTTCGTT CCACAAATAC 
GGAAACTACT TTTTTCCCGG CACGGGAGAC ATGTACGAGA TAGGCGCCGA ATCGGGACGA 
TACTACAGCG TTAATGTGCC GCTAAAGGAG GGCATTGATG ACCAGAGCTA TTTTCAGGTG 
TTCAAACCCA TAATTTCTGC CATTATGGAC TTCTACCGGC CCACGGCTAT CGTTTTGCAG 
TGTGGCGCGG ATTCACTAGC TGGAGATCGA CTAGGTTGCT TCTCCCTGAG CACCAAGGGA 
CATGGTGAGT GTGTCAAATT TGTGAAGGAA CTGAACGTAC CCACATTGGT GGTCGGAGGC 
GGTGGCTACA CCTTACGGAA CGTGGCCCGC TGCTGGACGC ACGAGACCTC GCTGCTGGTG 
GACCAAGACA TTGAAAATGA CCTACCCGCC ACCGAGTATT ACGACTTTTT CGCCCCCGAC 
TTTACACTCC ATCCAGAGAT TAACTCACGC CAAGATAATG CTAACTCAAA GCAGTATCTT 
GAACTCATCG TTAAGCATGT GTATGAAAAC CTTAAGATGT GCCAGCACTC GCCCAGCGTC 
CAAATGGTGC AGACCCCGCC TGATGTGGAC TTGGAGGAGC TGCGCAGCAA CCGGGAGGAG 
GCGAGTGATC CCGACGTGCG AATATCCGTA GCCGATGAGG ACAAGCTGGT TGATGCTAAG 
AACGAGTTCT ACGACGGCGA TCAGGACCAA GACAAGCCCG ATTCGGCAGA AAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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HDAC3 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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