Dysb cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dysb
Entrez Gene ID	40052
Full Name	Dysbindin
Synonyms	CG6856,Ddysb,Dmel\CG6856,NP_649064,dysb
General protein information	Preferred Names Dysbindin Names CG6856 gene product from transcript CG6856-RA CG6856-PA CG6856-PB Dysb-PA Dysb-PB dysbindin dysbindin ortholog
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3L Map Location: 75E2-75E2

mRNA and Protein(s)

mRNA	Protein	Name
NM_001275094.1	NP_001262023.1	dysbindin, isoform B
NM_140807.4	NP_649064.1	dysbindin, isoform A

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results indicate that perturbations downstream of DTNBP1, confer susceptibility to copper, a metal that in excess is a neurotoxin and whose depletion constitutes a micronutrient deficiency.
Title: Neuronal copper homeostasis susceptibility by genetic defects in dysbindin, a schizophrenia susceptibility factor.

Loss-of-function alleles of dysbindin or Blos1 impaired neurotransmitter release and synaptic function and plasticity.
Title: Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity.

optimal binding ratio between Dysb and Ebony might contribute to such non-linear effects. Thus, Ddysb-dependent regulation of Ebony could be one of the mechanisms that mediate dopamine signal
Title: The ?-alanyl-monoamine synthase ebony is regulated by schizophrenia susceptibility gene dysbindin in Drosophila.

Ddysb regulates glutamatergic transmission through its neuronal function and regulates dopamine metabolism by regulating Ebony expression in glial cells
Title: Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila.

study found that dysbindin (CG6856) is required presynaptically for the retrograde, homeostatic modulation of neurotransmission, and functions in a dose-dependent manner downstream or independently of calcium influx
Title: The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis.

The following Dysb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dysb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa18896	NM_140807.4 Latest version!	Drosophila melanogaster dysbindin, transcript variant A (Dysb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OFa18896	NM_001275094.1 Latest version!	Drosophila melanogaster dysbindin, transcript variant B (Dysb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dysb ( NM_001275094.1 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001262023.1 Drosophila melanogaster dysbindin, transcript variant B (Dysb), mRNA.

Price & Availability↑

CloneID	OFa18896
Clone ID Related Accession (Same CDS sequence)	NM_001275094.1 , NM_140807.4
Accession Version	NM_001275094.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	dysbindin, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTTCGGGA ACCTGAAAAA GAAGCTTAGC AGTGCGATCC AGGAGGGCCT GGTGATCTCG 
GAGAATCTGC AACAGCAATA TCGCCAGCGT GTCAGTTCCG GAAACTCGGG GAGTAGCCAA 
GCCAGTGGGA TTACGACCCC CATTTCGCCA CTGGGCCTTA ACGAAAGTCT GTCGTCCAGC 
AGGAGCAGTA GCCTCTCCCT TAGTGCTCCC TTCCAGCTAA CCGATGGAGT GCCCAGTCAC 
CTAAATGTGG CAGCTGGTTG CAGTTTGCTT GCCAAATACG AGGATGATTG GCAGCAGATT 
CATGGCGCCA ACGAAAAGAA CGCGGAGAAG GCTGCGCAGA TTGCTAACCA AATCTCCGGC 
ATCCAAGACC AGGCCAGCCA TCAGCACAGG ATCATGAGTG AGCTGAACAG TAGTCTGGCG 
GGAATTCCCA CGTTGATAGC CCAACTGCAA AACAGCTCAC AGGTTCTTAA TTCCCTGGAG 
GAAATGGGTA AGCAGTTGGA GATTGAGCTC GAGAAGCTGG AGGATCTGCG CGAGGAGTGT 
GAGCTCCAAG AGTTCATCCT TGAGCAGCAG TTTCAGCTCT CCCGGCACAA GCAAAAGAAA 
CTGAACGAAC TGGAGCAGTA TCGCCAGCAA ATAGCCCAGA AACACCAATC CAAAATCAAG 
GATCAGGAGC AGACCCTCCT GAAGCTGCAG AGGGAACGAC AGGCTGTCTT CGACGACGCC 
TTCCGGGAGG ATATGGAGGA GTACAAACAG CGCGGCCAGC TGACAAAAAT TCAAACCACC 
AGCAACAAGT TGGCTCTGGA GGAAGTCGTC CTTGAAGCCA ACGAAGTGGA GACAAAGGAT 
GCTCTGGAAC AATTTCTAAA TGGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001262023.1
CDS	110..976
Translation	MFGNLKKKLSSAIQEGLVISENLQQQYRQRVSSGNSGSSQASGITTPISPLGLNESLSSSRSSSLSLSAPFQLTDGVPSHLNVAAGCSLLAKYEDDWQQIHGANEKNAEKAAQIANQISGIQDQASHQHRIMSELNSSLAGIPTLIAQLQNSSQVLNSLEEMGKQLEIELEKLEDLREECELQEFILEQQFQLSRHKQKKLNELEQYRQQIAQKHQSKIKDQEQTLLKLQRERQAVFDDAFREDMEEYKQRGQLTKIQTTSNKLALEEVVLEANEVETKDALEQFLNG

Target ORF information:

RefSeq Version	NM_001275094.1
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster dysbindin, transcript variant B (Dysb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001275094.1

ORF Insert Sequence:

ATGTTCGGGA ACCTGAAAAA GAAGCTTAGC AGTGCGATCC AGGAGGGCCT GGTGATCTCG 
GAGAATCTGC AACAGCAATA TCGCCAGCGT GTCAGTTCCG GAAACTCGGG GAGTAGCCAA 
GCCAGTGGGA TTACGACCCC CATTTCGCCA CTGGGCCTTA ACGAAAGTCT GTCGTCCAGC 
AGGAGCAGTA GCCTCTCCCT TAGTGCTCCC TTCCAGCTAA CCGATGGAGT GCCCAGTCAC 
CTAAATGTGG CAGCTGGTTG CAGTTTGCTT GCCAAATACG AGGATGATTG GCAGCAGATT 
CATGGCGCCA ACGAAAAGAA CGCGGAGAAG GCTGCGCAGA TTGCTAACCA AATCTCCGGC 
ATCCAAGACC AGGCCAGCCA TCAGCACAGG ATCATGAGTG AGCTGAACAG TAGTCTGGCG 
GGAATTCCCA CGTTGATAGC CCAACTGCAA AACAGCTCAC AGGTTCTTAA TTCCCTGGAG 
GAAATGGGTA AGCAGTTGGA GATTGAGCTC GAGAAGCTGG AGGATCTGCG CGAGGAGTGT 
GAGCTCCAAG AGTTCATCCT TGAGCAGCAG TTTCAGCTCT CCCGGCACAA GCAAAAGAAA 
CTGAACGAAC TGGAGCAGTA TCGCCAGCAA ATAGCCCAGA AACACCAATC CAAAATCAAG 
GATCAGGAGC AGACCCTCCT GAAGCTGCAG AGGGAACGAC AGGCTGTCTT CGACGACGCC 
TTCCGGGAGG ATATGGAGGA GTACAAACAG CGCGGCCAGC TGACAAAAAT TCAAACCACC 
AGCAACAAGT TGGCTCTGGA GGAAGTCGTC CTTGAAGCCA ACGAAGTGGA GACAAAGGAT 
GCTCTGGAAC AATTTCTAAA TGGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dysb ( NM_140807.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_649064.1 Drosophila melanogaster dysbindin, transcript variant A (Dysb), mRNA.

Price & Availability↑

CloneID	OFa18896
Clone ID Related Accession (Same CDS sequence)	NM_001275094.1 , NM_140807.4
Accession Version	NM_140807.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	dysbindin, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). On Jan 16, 2013 this sequence version replaced NM_140807.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTTCGGGA ACCTGAAAAA GAAGCTTAGC AGTGCGATCC AGGAGGGCCT GGTGATCTCG 
GAGAATCTGC AACAGCAATA TCGCCAGCGT GTCAGTTCCG GAAACTCGGG GAGTAGCCAA 
GCCAGTGGGA TTACGACCCC CATTTCGCCA CTGGGCCTTA ACGAAAGTCT GTCGTCCAGC 
AGGAGCAGTA GCCTCTCCCT TAGTGCTCCC TTCCAGCTAA CCGATGGAGT GCCCAGTCAC 
CTAAATGTGG CAGCTGGTTG CAGTTTGCTT GCCAAATACG AGGATGATTG GCAGCAGATT 
CATGGCGCCA ACGAAAAGAA CGCGGAGAAG GCTGCGCAGA TTGCTAACCA AATCTCCGGC 
ATCCAAGACC AGGCCAGCCA TCAGCACAGG ATCATGAGTG AGCTGAACAG TAGTCTGGCG 
GGAATTCCCA CGTTGATAGC CCAACTGCAA AACAGCTCAC AGGTTCTTAA TTCCCTGGAG 
GAAATGGGTA AGCAGTTGGA GATTGAGCTC GAGAAGCTGG AGGATCTGCG CGAGGAGTGT 
GAGCTCCAAG AGTTCATCCT TGAGCAGCAG TTTCAGCTCT CCCGGCACAA GCAAAAGAAA 
CTGAACGAAC TGGAGCAGTA TCGCCAGCAA ATAGCCCAGA AACACCAATC CAAAATCAAG 
GATCAGGAGC AGACCCTCCT GAAGCTGCAG AGGGAACGAC AGGCTGTCTT CGACGACGCC 
TTCCGGGAGG ATATGGAGGA GTACAAACAG CGCGGCCAGC TGACAAAAAT TCAAACCACC 
AGCAACAAGT TGGCTCTGGA GGAAGTCGTC CTTGAAGCCA ACGAAGTGGA GACAAAGGAT 
GCTCTGGAAC AATTTCTAAA TGGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_649064.1
CDS	110..976
Translation	MFGNLKKKLSSAIQEGLVISENLQQQYRQRVSSGNSGSSQASGITTPISPLGLNESLSSSRSSSLSLSAPFQLTDGVPSHLNVAAGCSLLAKYEDDWQQIHGANEKNAEKAAQIANQISGIQDQASHQHRIMSELNSSLAGIPTLIAQLQNSSQVLNSLEEMGKQLEIELEKLEDLREECELQEFILEQQFQLSRHKQKKLNELEQYRQQIAQKHQSKIKDQEQTLLKLQRERQAVFDDAFREDMEEYKQRGQLTKIQTTSNKLALEEVVLEANEVETKDALEQFLNG

Target ORF information:

RefSeq Version	NM_140807.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster dysbindin, transcript variant A (Dysb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_140807.4

ORF Insert Sequence:

ATGTTCGGGA ACCTGAAAAA GAAGCTTAGC AGTGCGATCC AGGAGGGCCT GGTGATCTCG 
GAGAATCTGC AACAGCAATA TCGCCAGCGT GTCAGTTCCG GAAACTCGGG GAGTAGCCAA 
GCCAGTGGGA TTACGACCCC CATTTCGCCA CTGGGCCTTA ACGAAAGTCT GTCGTCCAGC 
AGGAGCAGTA GCCTCTCCCT TAGTGCTCCC TTCCAGCTAA CCGATGGAGT GCCCAGTCAC 
CTAAATGTGG CAGCTGGTTG CAGTTTGCTT GCCAAATACG AGGATGATTG GCAGCAGATT 
CATGGCGCCA ACGAAAAGAA CGCGGAGAAG GCTGCGCAGA TTGCTAACCA AATCTCCGGC 
ATCCAAGACC AGGCCAGCCA TCAGCACAGG ATCATGAGTG AGCTGAACAG TAGTCTGGCG 
GGAATTCCCA CGTTGATAGC CCAACTGCAA AACAGCTCAC AGGTTCTTAA TTCCCTGGAG 
GAAATGGGTA AGCAGTTGGA GATTGAGCTC GAGAAGCTGG AGGATCTGCG CGAGGAGTGT 
GAGCTCCAAG AGTTCATCCT TGAGCAGCAG TTTCAGCTCT CCCGGCACAA GCAAAAGAAA 
CTGAACGAAC TGGAGCAGTA TCGCCAGCAA ATAGCCCAGA AACACCAATC CAAAATCAAG 
GATCAGGAGC AGACCCTCCT GAAGCTGCAG AGGGAACGAC AGGCTGTCTT CGACGACGCC 
TTCCGGGAGG ATATGGAGGA GTACAAACAG CGCGGCCAGC TGACAAAAAT TCAAACCACC 
AGCAACAAGT TGGCTCTGGA GGAAGTCGTC CTTGAAGCCA ACGAAGTGGA GACAAAGGAT 
GCTCTGGAAC AATTTCTAAA TGGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Dysb cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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