POSH cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	POSH
Entrez Gene ID	36990
Full Name	Plenty of SH3s
Synonyms	155116_at,BEST:GM09451,CG4909,DPOSH,Dmel\CG4909,GM09451,dPOSH,l(2)k15815,posh
General protein information	Preferred Names Plenty of SH3s Names CG4909 gene product from transcript CG4909-RA CG4909-PA POSH-PA Plenty-of-SH3s plenty of SH3 domains plenty of SH3s
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2R Map Location: 54C9-54C9

mRNA and Protein(s)

mRNA	Protein	Name
NM_079052.4	NP_523776.1	plenty of SH3s

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011487	XP_317815.4
Drosophila melanogaster (fruit fly)	POSH	NP_523776.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The data data uncover Rab8, POSH, and TAK1 as regulators of synaptic growth responses and point to recycling endosome as a key compartment for synaptic growth regulation during neurodegenerative processes.
Title: Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia.

POSH promotes cell survival in Drosophila and in human rheumatoid arthritis synovial fibroblasts
Title: POSH promotes cell survival in Drosophila and in human RASF cells.

evidence that the JNK pathway scaffold protein, POSH, is involved in TNF (Eiger) signaling in Drosophila
Title: POSH is involved in Eiger-Basket (TNF-JNK) signaling and embryogenesis in Drosophila.

Phenotypic consequences of POSH expression were found to be dependent on Drosophila Nc, the caspase-9 homolog, but only partially on Tak1 and not at all on Slpr and Hep.
Title: POSH misexpression induces caspase-dependent cell death in Drosophila.

activates the JNK/SAPK signaling pathway, and that neural-specific overexpression of DPOSH extends the longevity of flies.
Title: Neural-specific overexpression of drosophila plenty of SH3s (DPOSH) extends the longevity of adult flies.

The following POSH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the POSH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa13064	NM_079052.4 Latest version!	Drosophila melanogaster plenty of SH3s (POSH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$510.30 $729.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

POSH ( NM_079052.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_523776.1 Drosophila melanogaster plenty of SH3s (POSH), mRNA.

Price & Availability↑

CloneID	OFa13064
Clone ID Related Accession (Same CDS sequence)	NM_079052.4
Accession Version	NM_079052.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2517bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	plenty of SH3s
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_079052.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGACGAGC ACACGTTAAA CGACCTGTTG GAGTGCTCCG TGTGTCTTGA GCGACTGGAC 
ACCACATCGA AGGTGCTGCC ATGCCAGCAC ACCTTCTGCC GCAAATGCTT GCAGGACATT 
GTGGCCAGTC AGCACAAGTT GCGATGCCCG GAGTGCCGCA TCCTGGTCTC TTGCAAAATT 
GATGAGCTGC CTCCAAACGT CTTGCTGATG CGAATCTTAG AAGGCATGAA ACAAAATGCA 
GCAGCTGGCA AAGGAGAAGA AAAGGGAGAG GAGACTGAAA CACAGCCGGA AAGGGCCAAA 
CCTCAGCCGC CAGCGGAATC AGTGGCCCCG CCTGACAACC AACTACTCCA GCTGCAGTCA 
CATCAGCAAT CTCATCAGCC GGCTCGTCAC AAGCAACGTC GATTTCTACT CCCCCACGCC 
TATGCCCTCT TTGACTTCGC CTCCGGTGAA GCCACCGATC TAAAGTTCAA GAAAGGGGAT 
CTGATACTGA TCAAGCATCG CATCGACAAC AACTGGTTTG TGGGTCAAGC GAATGGTCAG 
GAGGGCACAT TTCCCATCAA CTACGTCAAG GTATCGGTTC CGCTGCCCAT GCCGCAGTGC 
ATTGCCATGT ATGACTTTAA GATGGGGCCC AACGACGAGG AGGGATGCCT CGAATTTAAG 
AAAAGCACTG TAATACAGGT AATGCGCCGA GTTGATCATA ATTGGGCAGA AGGACGAATT 
GGCCAGACCA TCGGAATCTT TCCAATAGCA TTCGTTGAGC TGAATGCAGC GGCCAAAAAG 
CTGTTGGACA GCGGGCTACA CACCCATCCA TTCTGCCATC CACCGAAGCA ACAGGGGCAG 
CGGGCCCTTC CTCCGGTTCC AGTTATTGAT CCCACGGTGG TCACGGAATC CAGTTCGGGA 
TCCTCCAATT CCACGCCGGG CAGCAGCAAT TCAAGCTCCA CATCCAGCTC GAATAACTGC 
AGTCCGAATC ACCAAATCTC ACTGCCGAAT ACCCCCCAAC ATGTAGTAGC TTCCGGATCG 
GCGTCTGTTC GTTTCCGTGA CAAGGGAGCA AAGGAGAAAC GCCACTCACT AAATGCTTTG 
CTGGGAGGAG GAGCTCCATT AAGTCTGCTG CAGACCAACC GCCATTCGGC TGAAATTCTT 
AGCCTGCCCC ATGAACTAAG CCGCTTGGAA GTTTCCAGCT CAACAGCTCT AAAACCCACG 
TCAGCCCCAC AGACATCGCG TGTACTTAAG ACCACTGTTC AGCAGCAGAT GCAACCGAAT 
TTACCCTGGG GATACTTAGC CCTGTTCCCA TACAAACCAC GCCAAACGGA TGAGCTGGAA 
TTAAAAAAGG GTTGTGTTTA CATTGTGACC GAACGATGTG TGGACGGTTG GTTCAAGGGA 
AAAAACTGGT TGGACATCAC TGGAGTGTTC CCGGGCAACT ACCTGACGCC CCTGCGCGCC 
CGCGACCAGC AGCAGTTAAT GCATCAATGG AAATATGTTC CCCAAAATGC AGACGCCCAG 
ATGGCACAAG TACAGCAGCA TCCAGTTGCA CCAGATGTGC GACTCAACAA CATGCTGTCC 
ATGCAACCGC CTGATTTGCC ACCTCGTCAG CAGCAGGCTA CCGCCACGAC CACCAGTTGC 
TCTGTGTGGT CGAAACCAGT GGAGGCGCTG TTCAGCAGAA AATCGGAGCC CAAGCCTGAA 
ACTGCCACAG CTTCGACTAC GAGCAGCAGT TCCTCTGGAG CAGTGGGACT TATGAGGAGA 
TTAACTCACA TGAAAACACG CTCCAAATCT CCGGGAGCGT CCTTGCAGCA AGTTCCGAAA 
GAAGCTATTA GCACAAATGT GGAATTTACA ACAAACCCAT CAGCTAAATT GCATCCAGTA 
CATGTAAGAT CCGGCTCGTG CCCCAGTCAG CTGCAGCACA GTCAACCGCT CAATGAAACT 
CCAGCAGCCA AGACAGCGGC ACAACAACAG CAGTTCCTAC CCAAGCAGCT GCCTTCCGCT 
TCTACGAACA GCGTTTCGTA CGGATCGCAA CGCGTGAAAG GAAGCAAGGA ACGTCCTCAC 
TTGATTTGCG CGAGACAATC ATTAGATGCA GCTACATTTC GCAGTATGTA CAACAATGCC 
GCGTCGCCGC CGCCACCTAC TACTTCCGTG GCCCCAGCTG TCTACGCCGG CGGTCAGCAA 
CAGGTGATTC CTGGAGGTGG AGCGCAATCC CAGTTGCATG CCAATATGAT TATTGCACCC 
AGCCATCGGA AGTCGCACAG CCTAGATGCG AGTCATGTGC TGAGTCCCAG CAGCAATATG 
ATCACGGAGG CGGCCATTAA GGCCAGCGCC ACCACTAAGT CTCCTTACTG CACGAGGGAA 
AGTCGATTCC GCTGCATTGT GCCGTATCCA CCAAACAGTG ACATTGAACT AGAGCTACAT 
TTGGGCGACA TTATCTACGT CCAGCGGAAG CAGAAGAACG GCTGGTATAA GGGCACCCAT 
GCCCGTACCC ACAAAACCGG GCTGTTCCCC GCCTCCTTTG TTGAACCGGA TTGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_523776.1
CDS	333..2849
Translation	MDEHTLNDLLECSVCLERLDTTSKVLPCQHTFCRKCLQDIVASQHKLRCPECRILVSCKIDELPPNVLLMRILEGMKQNAAAGKGEEKGEETETQPERAKPQPPAESVAPPDNQLLQLQSHQQSHQPARHKQRRFLLPHAYALFDFASGEATDLKFKKGDLILIKHRIDNNWFVGQANGQEGTFPINYVKVSVPLPMPQCIAMYDFKMGPNDEEGCLEFKKSTVIQVMRRVDHNWAEGRIGQTIGIFPIAFVELNAAAKKLLDSGLHTHPFCHPPKQQGQRALPPVPVIDPTVVTESSSGSSNSTPGSSNSSSTSSSNNCSPNHQISLPNTPQHVVASGSASVRFRDKGAKEKRHSLNALLGGGAPLSLLQTNRHSAEILSLPHELSRLEVSSSTALKPTSAPQTSRVLKTTVQQQMQPNLPWGYLALFPYKPRQTDELELKKGCVYIVTERCVDGWFKGKNWLDITGVFPGNYLTPLRARDQQQLMHQWKYVPQNADAQMAQVQQHPVAPDVRLNNMLSMQPPDLPPRQQQATATTTSCSVWSKPVEALFSRKSEPKPETATASTTSSSSSGAVGLMRRLTHMKTRSKSPGASLQQVPKEAISTNVEFTTNPSAKLHPVHVRSGSCPSQLQHSQPLNETPAAKTAAQQQQFLPKQLPSASTNSVSYGSQRVKGSKERPHLICARQSLDAATFRSMYNNAASPPPPTTSVAPAVYAGGQQQVIPGGGAQSQLHANMIIAPSHRKSHSLDASHVLSPSSNMITEAAIKASATTKSPYCTRESRFRCIVPYPPNSDIELELHLGDIIYVQRKQKNGWYKGTHARTHKTGLFPASFVEPDC

Target ORF information:

RefSeq Version	NM_079052.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster plenty of SH3s (POSH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_079052.4

ORF Insert Sequence:

ATGGACGAGC ACACGTTAAA CGACCTGTTG GAGTGCTCCG TGTGTCTTGA GCGACTGGAC 
ACCACATCGA AGGTGCTGCC ATGCCAGCAC ACCTTCTGCC GCAAATGCTT GCAGGACATT 
GTGGCCAGTC AGCACAAGTT GCGATGCCCG GAGTGCCGCA TCCTGGTCTC TTGCAAAATT 
GATGAGCTGC CTCCAAACGT CTTGCTGATG CGAATCTTAG AAGGCATGAA ACAAAATGCA 
GCAGCTGGCA AAGGAGAAGA AAAGGGAGAG GAGACTGAAA CACAGCCGGA AAGGGCCAAA 
CCTCAGCCGC CAGCGGAATC AGTGGCCCCG CCTGACAACC AACTACTCCA GCTGCAGTCA 
CATCAGCAAT CTCATCAGCC GGCTCGTCAC AAGCAACGTC GATTTCTACT CCCCCACGCC 
TATGCCCTCT TTGACTTCGC CTCCGGTGAA GCCACCGATC TAAAGTTCAA GAAAGGGGAT 
CTGATACTGA TCAAGCATCG CATCGACAAC AACTGGTTTG TGGGTCAAGC GAATGGTCAG 
GAGGGCACAT TTCCCATCAA CTACGTCAAG GTATCGGTTC CGCTGCCCAT GCCGCAGTGC 
ATTGCCATGT ATGACTTTAA GATGGGGCCC AACGACGAGG AGGGATGCCT CGAATTTAAG 
AAAAGCACTG TAATACAGGT AATGCGCCGA GTTGATCATA ATTGGGCAGA AGGACGAATT 
GGCCAGACCA TCGGAATCTT TCCAATAGCA TTCGTTGAGC TGAATGCAGC GGCCAAAAAG 
CTGTTGGACA GCGGGCTACA CACCCATCCA TTCTGCCATC CACCGAAGCA ACAGGGGCAG 
CGGGCCCTTC CTCCGGTTCC AGTTATTGAT CCCACGGTGG TCACGGAATC CAGTTCGGGA 
TCCTCCAATT CCACGCCGGG CAGCAGCAAT TCAAGCTCCA CATCCAGCTC GAATAACTGC 
AGTCCGAATC ACCAAATCTC ACTGCCGAAT ACCCCCCAAC ATGTAGTAGC TTCCGGATCG 
GCGTCTGTTC GTTTCCGTGA CAAGGGAGCA AAGGAGAAAC GCCACTCACT AAATGCTTTG 
CTGGGAGGAG GAGCTCCATT AAGTCTGCTG CAGACCAACC GCCATTCGGC TGAAATTCTT 
AGCCTGCCCC ATGAACTAAG CCGCTTGGAA GTTTCCAGCT CAACAGCTCT AAAACCCACG 
TCAGCCCCAC AGACATCGCG TGTACTTAAG ACCACTGTTC AGCAGCAGAT GCAACCGAAT 
TTACCCTGGG GATACTTAGC CCTGTTCCCA TACAAACCAC GCCAAACGGA TGAGCTGGAA 
TTAAAAAAGG GTTGTGTTTA CATTGTGACC GAACGATGTG TGGACGGTTG GTTCAAGGGA 
AAAAACTGGT TGGACATCAC TGGAGTGTTC CCGGGCAACT ACCTGACGCC CCTGCGCGCC 
CGCGACCAGC AGCAGTTAAT GCATCAATGG AAATATGTTC CCCAAAATGC AGACGCCCAG 
ATGGCACAAG TACAGCAGCA TCCAGTTGCA CCAGATGTGC GACTCAACAA CATGCTGTCC 
ATGCAACCGC CTGATTTGCC ACCTCGTCAG CAGCAGGCTA CCGCCACGAC CACCAGTTGC 
TCTGTGTGGT CGAAACCAGT GGAGGCGCTG TTCAGCAGAA AATCGGAGCC CAAGCCTGAA 
ACTGCCACAG CTTCGACTAC GAGCAGCAGT TCCTCTGGAG CAGTGGGACT TATGAGGAGA 
TTAACTCACA TGAAAACACG CTCCAAATCT CCGGGAGCGT CCTTGCAGCA AGTTCCGAAA 
GAAGCTATTA GCACAAATGT GGAATTTACA ACAAACCCAT CAGCTAAATT GCATCCAGTA 
CATGTAAGAT CCGGCTCGTG CCCCAGTCAG CTGCAGCACA GTCAACCGCT CAATGAAACT 
CCAGCAGCCA AGACAGCGGC ACAACAACAG CAGTTCCTAC CCAAGCAGCT GCCTTCCGCT 
TCTACGAACA GCGTTTCGTA CGGATCGCAA CGCGTGAAAG GAAGCAAGGA ACGTCCTCAC 
TTGATTTGCG CGAGACAATC ATTAGATGCA GCTACATTTC GCAGTATGTA CAACAATGCC 
GCGTCGCCGC CGCCACCTAC TACTTCCGTG GCCCCAGCTG TCTACGCCGG CGGTCAGCAA 
CAGGTGATTC CTGGAGGTGG AGCGCAATCC CAGTTGCATG CCAATATGAT TATTGCACCC 
AGCCATCGGA AGTCGCACAG CCTAGATGCG AGTCATGTGC TGAGTCCCAG CAGCAATATG 
ATCACGGAGG CGGCCATTAA GGCCAGCGCC ACCACTAAGT CTCCTTACTG CACGAGGGAA 
AGTCGATTCC GCTGCATTGT GCCGTATCCA CCAAACAGTG ACATTGAACT AGAGCTACAT 
TTGGGCGACA TTATCTACGT CCAGCGGAAG CAGAAGAACG GCTGGTATAA GGGCACCCAT 
GCCCGTACCC ACAAAACCGG GCTGTTCCCC GCCTCCTTTG TTGAACCGGA TTGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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POSH cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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