| Gene Symbol | PGRP-SC2 |
| Entrez Gene ID | 35862 |
| Full Name | CG14745 gene product from transcript CG14745-RA |
| Synonyms | CG14745,CG14745 PGRP,Dmel\CG14745,PCRP-SC2,PGRP-SC,pgrp-sc2 |
| Gene Type | protein-coding |
| Organism | Drosophila melanogaster(fruit fly) |
| Genome |
ORF » Species Summary » Drosophila melanogaster » PGRP-SC2 cDNA ORF clone
| Gene Symbol | PGRP-SC2 |
| Entrez Gene ID | 35862 |
| Full Name | CG14745 gene product from transcript CG14745-RA |
| Synonyms | CG14745,CG14745 PGRP,Dmel\CG14745,PCRP-SC2,PGRP-SC,pgrp-sc2 |
| Gene Type | protein-coding |
| Organism | Drosophila melanogaster(fruit fly) |
| Genome |
| mRNA | Protein | Name |
|---|---|---|
| NM_136566.2 | NP_610410.1 | peptidoglycan recognition protein SC2 |
| Mus musculus (house mouse) | Pglyrp4 | NP_001159440.1 |
| Drosophila melanogaster (fruit fly) | PGRP-SC1b | NP_610409.1 |
| Anopheles gambiae (African malaria mosquito) | PGRPS2 | XP_316360.1 |
| Pan troglodytes (chimpanzee) | PGLYRP4 | XP_001137479.2 |
| Drosophila melanogaster (fruit fly) | PGRP-SC1a | NP_610407.1 |
| Xenopus tropicalis (tropical clawed frog) | pglyrp1 | NP_001015775.1 |
| Rattus norvegicus (Norway rat) | Pglyrp4 | NP_001178637.1 |
| Homo sapiens (human) | PGLYRP4 | NP_065126.2 |
| PGLYRP4 | XP_002801850.1 | |
| Drosophila melanogaster (fruit fly) | PGRP-SC2 | NP_610410.1 |
| Xenopus tropicalis (tropical clawed frog) | pglyrp1 | NP_001025626.1 |
| Bos taurus (cattle) | PGLYRP4 | XP_002686069.1 |
| Anopheles gambiae (African malaria mosquito) | PGRPS3 | XP_316359.1 |
Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The aging intestine of Drosophila, chronic activation of the transcription factor Foxo reduces expression of peptidoglycan recognition protein SC2 (PGRP-SC2), a negative regulator of IMD/Relish innate immune signaling, and homolog of the anti-inflammatory molecules PGLYRP1-4.
Title: PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan.
Report that PGRP-SC1/2-depleted flies present over-activation of the immune deficiency signaling pathway after bacterial challenge suggesting that these proteins act in the larval gut to prevent activation of this pathway following bacterial ingestion.
Title: Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2.
The following PGRP-SC2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PGRP-SC2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OFa12801 | |
| Clone ID Related Accession (Same CDS sequence) | NM_136566.2 | |
| Accession Version | NM_136566.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-24 | |
| Organism | Drosophila melanogaster(fruit fly) | |
| Product | peptidoglycan recognition protein SC2 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_136566.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END## | |
1 | ATGGCAAACA AAGCTCTCAT CCTTCTGGCC GTACTCTTCT GCGCCCAAGC CGTTCTCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_610410.1 |
| CDS | 18..572 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_136566.2 |
1 | ATGGCAAACA AAGCTCTCAT CCTTCTGGCC GTACTCTTCT GCGCCCAAGC CGTTCTCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data. |
Gene Model Annotations for Drosophila melanogaster: The Rule-Benders. |
Sequence finishing and mapping of Drosophila melanogaster heterochromatin. |
The Release 5.1 annotation of Drosophila melanogaster heterochromatin. |
Combined evidence annotation of transposable elements in genome sequences. |