p38b cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	p38b
Entrez Gene ID	34780
Full Name	p38b MAP kinase
Synonyms	186F5S,BG:DS00797.3,CG7393,D-p38,D-p38 MAPK,D-p38b,Dm p38b,Dmel\CG7393,Dmp38b,Dp38,Dp38b,ESTS:186F5S,MAPK,Mpk34C,P38,anon-sts23,dp38b,p38,p38 MAPK,p38 beta,p38B,p38Kb,p38beta
General protein information	Preferred Names p38b MAP kinase Names CG7393 gene product from transcript CG7393-RA CG7393-PA p38 MAP kinase p38 mitogen-activated protein kinase p38b-PA stress-activated p38b MAP kinase
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2L Map Location: 34D1-34D1

mRNA and Protein(s)

mRNA	Protein	Name
NM_058013.5	NP_477361.1	p38b MAP kinase

Pathways from BioSystems

Homologies

Homo sapiens (human)	MAPK14	NP_001306.1
Saccharomyces cerevisiae (baker's yeast)	HOG1	NP_013214.1
Neurospora crassa	NCU07024	XP_962163.2
Canis lupus familiaris (dog)	MAPK14	NP_001003206.1
Rattus norvegicus (Norway rat)	Mapk14	NP_112282.2
Kluyveromyces lactis	KLLA0F20053g	XP_455981.1
Eremothecium gossypii	AGOS_AGR048C	NP_986713.1
Bos taurus (cattle)	MAPK14	NP_001095644.1
Drosophila melanogaster (fruit fly)	Mpk2	NP_001163711.1
Caenorhabditis elegans (roundworm)	pmk-1	NP_501365.1
Magnaporthe oryzae (rice blast fungus)	MGG_01822	XP_003714838.1
Oryza sativa (rice)	Os03g0285800	NP_001049770.1
Xenopus tropicalis (tropical clawed frog)	mapk14	NP_001005824.1
	LOC718976	XP_001112423.2
Mus musculus (house mouse)	Mapk14	NP_001161980.1
Gallus gallus (chicken)	MAPK14	XP_001232616.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012148	XP_320380.4
Schizosaccharomyces pombe (fission yeast)	sty1	NP_592843.1
Pan troglodytes (chimpanzee)	MAPK14	NP_001009065.1
Danio rerio (zebrafish)	mapk14a	NP_571797.1
Drosophila melanogaster (fruit fly)	p38b	NP_477361.1
Arabidopsis thaliana (thale cress)	MPK3	NP_190150.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results illustrate a novel pro-tumourigenic crosstalk between the p38 MAPK pathway and JAK signalling in a Drosophila model of Myeloproliferative neoplasms.
Title: A

ROS/JNK/p38/Upd stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Title: ROS-Induced JNK and p38 Signaling Is Required for Unpaired Cytokine Activation during Drosophila Regeneration.

data suggest that p38Kb may affect circadian locomotor rhythms through the regulation of multiple downstream pathways
Title: p38 MAP kinase regulates circadian rhythms in Drosophila.

Taken together, our findings indicate that the p38 MAP Kinase is an integral component of the core circadian clock of Drosophila in addition to playing a role in stress-input pathways.
Title: The MAP kinase p38 is part of Drosophila melanogaster's circadian clock.

Data show that the genetic interaction between p38b MAPK and Rack1 controls muscle aggregate formation, locomotor function, and longevity.
Title: In vivo interaction proteomics reveal a novel p38 mitogen-activated protein kinase/Rack1 pathway regulating proteostasis in Drosophila muscle.

The following p38b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the p38b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa16761	NM_058013.5 Latest version!	Drosophila melanogaster p38b MAP kinase (p38b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

p38b ( NM_058013.5 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_477361.1 Drosophila melanogaster p38b MAP kinase (p38b), mRNA.

Price & Availability↑

CloneID	OFa16761
Clone ID Related Accession (Same CDS sequence)	NM_058013.5
Accession Version	NM_058013.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	p38b MAP kinase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033779). On Jul 15, 2014 this sequence version replaced NM_058013.4. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTCGCGCA AAATGGCCAA ATTCTACAAG CTGGACATCA ATCGCACCGA GTGGGAAATC 
CCGGAAACAT ACCAGAACCT GCAACCCGTG GGTCAGGGTG CCTACGGCCA GGTCTGCAAG 
GCCGTGGTCC GCGGAACCAG CACGAAGGTG GCCATCAAGA AGCTTGCCAG GCCCTTCCAG 
TCGGCGGTCC ATGCGAAGCG CACCTATCGG GAACTGCGGC TGCTGAAGCA CATGGATCAC 
GAGAACGTTA TTGGTCTGCT GGATGTCTTT CATCCAGGAC AGCCCGCCGA TTCGCTGGAT 
CAGTTCCAGC AAGTGTACAT GGTGACCCAC TTGATGGACG CCGATCTGAA CAACATAATA 
CGCACGCAGA AACTGTCTGA TGATCATGTC CAGTTTCTGG TCTACCAAAT CCTGCGCGGT 
CTGAAGTACA TCCACAGCGC TGGGGTCATC CATCGTGATC TAAAGCCATC GAACATTGCG 
GTAAACGAGG ACTGTGAGCT TCGCATCCTG GATTTCGGTT TGGCCCGTCC CGCAGAAAGC 
GAGATGACCG GATACGTCGC AACGCGATGG TACCGGGCGC CTGAGATCAT GCTCAACTGG 
ATGCACTACA ACCAGACGGC GGACATCTGG TCGGTGGGCT GCATCATGGC TGAGCTGCTG 
ACTGGGCGCA CGCTGTTCCC TGGAACCGAT CACATCCATC AGCTGAACCT CATCATGGAA 
GTGCTGGGCA CGCCAGCTGA TGAGTTCATG AGCCGCATCT CCTCGGAGAG CGCTAGAAAC 
TATATTCGTT CACTGCCGGT GATGCCGCGC CGCAATTTCC GCGACATCTT CCGCGGTGCC 
AATCCGCTGG CCATCGATTT GCTGGAGAAG ATGCTGGAAC TTGACGCCGA CAAGCGCATA 
ACCGCCGAGC AGGCGCTGGC CCATCCGTAC ATGGAGAAGT ACCACGATCC AACCGATGAG 
CAGACCGCCG CGCTCTACGA CCAGAGCTTC GAGGAGAACG AGCTGCCGGT GGAGAAGTGG 
CGGGAGATGG TCTTCAGCGA GGTGACGGCC TTCAAGCCCA CAGCCGCCTT CGCTGAGCTC 
CTGCCCAAAG AGCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_477361.1
CDS	210..1307
Translation	MSRKMAKFYKLDINRTEWEIPETYQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIRTQKLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPAESEMTGYVATRWYRAPEIMLNWMHYNQTADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSESARNYIRSLPVMPRRNFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYMEKYHDPTDEQTAALYDQSFEENELPVEKWREMVFSEVTAFKPTAAFAELLPKEQ

Target ORF information:

RefSeq Version	NM_058013.5
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster p38b MAP kinase (p38b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_058013.5

ORF Insert Sequence:

ATGTCGCGCA AAATGGCCAA ATTCTACAAG CTGGACATCA ATCGCACCGA GTGGGAAATC 
CCGGAAACAT ACCAGAACCT GCAACCCGTG GGTCAGGGTG CCTACGGCCA GGTCTGCAAG 
GCCGTGGTCC GCGGAACCAG CACGAAGGTG GCCATCAAGA AGCTTGCCAG GCCCTTCCAG 
TCGGCGGTCC ATGCGAAGCG CACCTATCGG GAACTGCGGC TGCTGAAGCA CATGGATCAC 
GAGAACGTTA TTGGTCTGCT GGATGTCTTT CATCCAGGAC AGCCCGCCGA TTCGCTGGAT 
CAGTTCCAGC AAGTGTACAT GGTGACCCAC TTGATGGACG CCGATCTGAA CAACATAATA 
CGCACGCAGA AACTGTCTGA TGATCATGTC CAGTTTCTGG TCTACCAAAT CCTGCGCGGT 
CTGAAGTACA TCCACAGCGC TGGGGTCATC CATCGTGATC TAAAGCCATC GAACATTGCG 
GTAAACGAGG ACTGTGAGCT TCGCATCCTG GATTTCGGTT TGGCCCGTCC CGCAGAAAGC 
GAGATGACCG GATACGTCGC AACGCGATGG TACCGGGCGC CTGAGATCAT GCTCAACTGG 
ATGCACTACA ACCAGACGGC GGACATCTGG TCGGTGGGCT GCATCATGGC TGAGCTGCTG 
ACTGGGCGCA CGCTGTTCCC TGGAACCGAT CACATCCATC AGCTGAACCT CATCATGGAA 
GTGCTGGGCA CGCCAGCTGA TGAGTTCATG AGCCGCATCT CCTCGGAGAG CGCTAGAAAC 
TATATTCGTT CACTGCCGGT GATGCCGCGC CGCAATTTCC GCGACATCTT CCGCGGTGCC 
AATCCGCTGG CCATCGATTT GCTGGAGAAG ATGCTGGAAC TTGACGCCGA CAAGCGCATA 
ACCGCCGAGC AGGCGCTGGC CCATCCGTAC ATGGAGAAGT ACCACGATCC AACCGATGAG 
CAGACCGCCG CGCTCTACGA CCAGAGCTTC GAGGAGAACG AGCTGCCGGT GGAGAAGTGG 
CGGGAGATGG TCTTCAGCGA GGTGACGGCC TTCAAGCCCA CAGCCGCCTT CGCTGAGCTC 
CTGCCCAAAG AGCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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p38b cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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