ctbp2l cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	ctbp2l
Entrez Gene ID	548605
Full Name	C-terminal binding protein 2, like
General protein information	Preferred Names C-terminal binding protein 2, like Names C-terminal-binding protein 2 ribeye b protein
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001015064.1	NP_001015064.1	C-terminal-binding protein 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CTBP2	XP_508100.3
Danio rerio (zebrafish)	ctbp2a	NP_001182420.1
Homo sapiens (human)	CTBP2	NP_073713.2
Canis lupus familiaris (dog)	LOC100684514	XP_005637947.1
Danio rerio (zebrafish)	ctbp2l	NP_001015064.1
Xenopus tropicalis (tropical clawed frog)	ctbp2	NP_001008196.1
Mus musculus (house mouse)	Ctbp2	NP_001164215.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003893	XP_003436652.1
Gallus gallus (chicken)	CTBP2	XP_004942401.1
	CTBP2	XP_001084570.2
Bos taurus (cattle)	CTBP2	NP_783643.1
Rattus norvegicus (Norway rat)	Ctbp2	NP_445787.1
Drosophila melanogaster (fruit fly)	CtBP	NP_001262524.1

Gene Ontology
Bibliography

Related articles in PubMed

Ribeye protein is intrinsically dynamic but is stabilized in the context of the ribbon synapse.
Chen Z, Chou SW, McDermott BM Jr
The Journal of physiology(2017 Oct)

In Vivo Ribbon Mobility and Turnover of Ribeye at Zebrafish Hair Cell Synapses.
Graydon CW, Manor U, Kindt KS
Scientific reports7(1)7467(2017 Aug)

Enlargement of Ribbons in Zebrafish Hair Cells Increases Calcium Currents But Disrupts Afferent Spontaneous Activity and Timing of Stimulus Onset.
Sheets L, He XJ, Olt J, Schreck M, Petralia RS, Wang YX, Zhang Q, Beirl A, Nicolson T, Marcotti W, Trapani JG, Kindt KS
The Journal of neuroscience : the official journal of the Society for Neuroscience37(26)6299-6313(2017 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In zebrafish hair cells exogenous Ribeye B-domain and CtBP1 localize to the basal ends of synaptic ribbons.
Title: Characterization of Ribeye subunits in zebrafish hair cells reveals that exogenous Ribeye B-domain and CtBP1 localize to the basal ends of synaptic ribbons.

These findings reveal two distinct functions of Ribeye in ribbon synapse formation--clustering Ca(V)1.3a channels at the presynapse and stabilizing contacts with afferent neurons--and suggest that Ribeye plays an organizing role in synaptogenesis.
Title: Ribeye is required for presynaptic Ca(V)1.3a channel localization and afferent innervation of sensory hair cells.

Ctbp2l is also expressed in hair cells of the inner ear and the lateral line.
Title: Vesicular glutamate transporter 3 is required for synaptic transmission in zebrafish hair cells.

We show that zebrafish have two ribeye genes, ribeye a and ribeye b; ribeye b is absent in the pineal gland and is detected only in photoreceptors of the retina.
Title: Two ribeye genes in teleosts: the role of Ribeye in ribbon formation and bipolar cell development.

The following ctbp2l gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ctbp2l cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa01180	NM_001015064.1 Latest version!	Danio rerio C-terminal binding protein 2, like (ctbp2l), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$510.30 $729.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ctbp2l ( NM_001015064.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001015064.1 Danio rerio C-terminal binding protein 2, like (ctbp2l), mRNA.

Price & Availability↑

CloneID	ODa01180
Clone ID Related Accession (Same CDS sequence)	NM_001015064.1
Accession Version	NM_001015064.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2583bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-10
Organism	Danio rerio(zebrafish)
Product	C-terminal-binding protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY878351.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY878351.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGATGGCAG TGCGAGGCAC GGTTCCTCCT CCGGATTATT ACCCGTTTGA CATCGCCCTC 
TCGGCCCAGC CACCAGAAGA CCTGCAGGGC TTTTATAAGG CAAACCAGCA CATGCTGAGC 
AGATCCGGCT CGCATTACGG CCTCTCCAGG ACTGCATGGG ATCAGACTCG AGCGGCTACT 
CCCGGTCCTC CTCCACCTCC TCCACCGCCC CCTCCACCCC CTCCTCCACC CCCGCCCTCG 
GCTCACGAGA TCAGCCGCAT GTACAGGGAT TCCCTCTCCA TCAAGATGAT CCCAGACACT 
CAGCGCATTC GCAGTAGAGC CGCTTCTCCA GCCTGCTTCG GCGTTGAATC TGGCTATCCC 
GGTCACTCCA TTCCCGCAGA CCTGAACGGA TATTCCCTGG AGTCCTGTCA GCCGGCCTCC 
ACCTGCATCG TGGTGGATCC CACAGCCTCA GGTATGGACG GGAATATTCC CCGGGGAACT 
CTTTCCTATG GTTCTGTGGT GACTCAAAGG ATGCCGTATG ACCCTGCGTA TGATCCAGGA 
TCTGCTATGG TGCATGCATC ACCTGCTCCG CTGAACACAG GTATGCCAGC GCACCATCCA 
TCAGCGGGAG TCGACCCTAA GAGAAACGTG GATCCAAGTT TTCTTGCACT CCTTCGCTCT 
GAGGGTCTGT CAGAAAGCAC CATTACTCTA CTCCTACAGC AAGGGTTTGA TTCCACATCG 
ATGCTTGCCA TGATGGAAGA TCATGACGTC CGTTCTGTGG CTCCCAATTT GGGTCAAGCA 
CGAGTGTTAT CCCGAATTGT GCTGAATTGC AAGACTGGAG CGACTGTAAT GCGCGGTCGA 
TCCAATAGCT TCAGCCACCG TAATGATCTC TACATGCAGC CGCAGAGTCT GGGTATGGAC 
GCACAGCTCA TGCAGCAGCC TCCGAATGCT TTGCAGTCTG TTTCTCCGAG GATGGGAGAG 
TTTTTGGGTC GTAGACCCAG CAGTGCACCA TCGCAGCATC TACTGGAAAC CACTACATAT 
CCTGCAAGTC GTCCGATTGG AGGTCTCCCG GTTAGTCCGG GCGGTTACAC CAATGCTTTG 
CCTCAATCGC GACCGTTATC CATGTATAAT GCTCACACCG GTCTGGCCAT GTCTGCTCTG 
CCGGCTCAGC AACAGCCTCC GATGACTCCA GGAGCGGCTC CGAAGACGTT TTCCGGCACG 
TACACGCCGA TGGAGCTGAT GAAGCGTCCT CCCAACCTGC CTCCGCTGTC TCCGGCTCAC 
AGTCCGCATC TGAGCCCTCA GTTGATGCGC AAAGGAGCAG CGGTGGAAAA TGCCGTCATT 
CCAGCATCCT CCGCCGTCCA GACGCAGAAT ATTAATGCCA ATAACAAGCA GACCCGCAGA 
ACCGGACCTC CAGTCATCGT GTCCACCATG GCTTCACCGG AGACAAGTAT CCGCCCTCAG 
CTGGTGAACG GGCCTCTTCA TCCTCGTCCT CTGGTGGCTC TGCTGGACGG TCGGGACTGT 
ACGGTGGAGA TGCCCATCCT TAAAGATCTG GCAACCGTTG CCTTCTGTGA CGCCCAGTCC 
ACACAGGAGA TCCATGAGAA GGTGCTGAAC GAGGCTGTCG GTGCTCTGAT GTATCACACC 
ATCACACTCA CCCGAGAAGA TCTGGAGAAG TTTAAAGCTC TGAGAATCGT CATCCGCATC 
GGCAGCGGAT ACGACAACAT CGACATTAAA GCAGCCGGAG AGATGGGTAT TGCGGTGTGT 
AATATCCCGT CAGCAGCAGT GGAGGAGACG GCGGACTCGA CTCTGTGTCA CGTGTTGAAT 
CTGTACCGCA GGAACACGTG GTTATACCGG GCTCTGCGCG AGGGCACGCG TGTGCAGAGT 
GTGGAGCAGA TCCGAGAGGT GGCGTCCGGA GCCGCACGCA TCCGCGGAGA AACACTCGGA 
CTCATCGGCC TCGGTCGGTC AGGTCAGGCC GTCGCCGTCC GGGCCAAAGT GTTCGGCTTC 
AACGTGATCT TCTACGACCC GTACCTGCAG GACGGTCTGG AGCGCTCGCT GGGCGTGCAG 
CGCGTTTACA CACTGCAGGA CCTGCTGTAC CAGAGCGACT GTGTGTCTCT GCACTGCAAC 
CTGAACGAAC ACAACCATCA CCTCATCAGC GACTTCACCA TCAAACAGAT GCGACAGGGA 
GCGTTTCTCG TGAACACAGC TCGCGGTGGT CTGGTGGATG AGAAAGCTCT GGCTCAGGCT 
CTGAAAGAGG GCAGGATACG CGGCGCTGCC CTGGACGTTC ATGAGTCTGA ACCCTTCAGT 
TTCACTCAGG GTCCTCTGAA GGACGCGCCC AATCTGATCT GCACCCCTCA CACAGCCTGG 
TACAGTGAGC AGGCCTCACT AGAGATGAGA GAGGCAGCAG CCACTGAGAT CCGCAGAGCC 
ATCACCGGTC GTATTCCAGA CAGTCTCAGA AACTGCGTCA ACAAAGAGTT TTTTGTGACT 
ACGGCGCCGT GGGGGGTGAT GGAGCAGCAG GTTCATCCGG AGCTCAACGG CGGAGCCTAC 
AGAGTCGCCC AGCCGCTCCC AGCCGTCTCT CCCGGCGGCC TGCAAGACAA AATGTATACC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001015064.1
CDS	1..2583
Translation	MMAVRGTVPPPDYYPFDIALSAQPPEDLQGFYKANQHMLSRSGSHYGLSRTAWDQTRAATPGPPPPPPPPPPPPPPPPPSAHEISRMYRDSLSIKMIPDTQRIRSRAASPACFGVESGYPGHSIPADLNGYSLESCQPASTCIVVDPTASGMDGNIPRGTLSYGSVVTQRMPYDPAYDPGSAMVHASPAPLNTGMPAHHPSAGVDPKRNVDPSFLALLRSEGLSESTITLLLQQGFDSTSMLAMMEDHDVRSVAPNLGQARVLSRIVLNCKTGATVMRGRSNSFSHRNDLYMQPQSLGMDAQLMQQPPNALQSVSPRMGEFLGRRPSSAPSQHLLETTTYPASRPIGGLPVSPGGYTNALPQSRPLSMYNAHTGLAMSALPAQQQPPMTPGAAPKTFSGTYTPMELMKRPPNLPPLSPAHSPHLSPQLMRKGAAVENAVIPASSAVQTQNINANNKQTRRTGPPVIVSTMASPETSIRPQLVNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIVIRIGSGYDNIDIKAAGEMGIAVCNIPSAAVEETADSTLCHVLNLYRRNTWLYRALREGTRVQSVEQIREVASGAARIRGETLGLIGLGRSGQAVAVRAKVFGFNVIFYDPYLQDGLERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLISDFTIKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFTQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPDSLRNCVNKEFFVTTAPWGVMEQQVHPELNGGAYRVAQPLPAVSPGGLQDKMYT

Target ORF information:

RefSeq Version	NM_001015064.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio C-terminal binding protein 2, like (ctbp2l), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001015064.1

ORF Insert Sequence:

ATGATGGCAG TGCGAGGCAC GGTTCCTCCT CCGGATTATT ACCCGTTTGA CATCGCCCTC 
TCGGCCCAGC CACCAGAAGA CCTGCAGGGC TTTTATAAGG CAAACCAGCA CATGCTGAGC 
AGATCCGGCT CGCATTACGG CCTCTCCAGG ACTGCATGGG ATCAGACTCG AGCGGCTACT 
CCCGGTCCTC CTCCACCTCC TCCACCGCCC CCTCCACCCC CTCCTCCACC CCCGCCCTCG 
GCTCACGAGA TCAGCCGCAT GTACAGGGAT TCCCTCTCCA TCAAGATGAT CCCAGACACT 
CAGCGCATTC GCAGTAGAGC CGCTTCTCCA GCCTGCTTCG GCGTTGAATC TGGCTATCCC 
GGTCACTCCA TTCCCGCAGA CCTGAACGGA TATTCCCTGG AGTCCTGTCA GCCGGCCTCC 
ACCTGCATCG TGGTGGATCC CACAGCCTCA GGTATGGACG GGAATATTCC CCGGGGAACT 
CTTTCCTATG GTTCTGTGGT GACTCAAAGG ATGCCGTATG ACCCTGCGTA TGATCCAGGA 
TCTGCTATGG TGCATGCATC ACCTGCTCCG CTGAACACAG GTATGCCAGC GCACCATCCA 
TCAGCGGGAG TCGACCCTAA GAGAAACGTG GATCCAAGTT TTCTTGCACT CCTTCGCTCT 
GAGGGTCTGT CAGAAAGCAC CATTACTCTA CTCCTACAGC AAGGGTTTGA TTCCACATCG 
ATGCTTGCCA TGATGGAAGA TCATGACGTC CGTTCTGTGG CTCCCAATTT GGGTCAAGCA 
CGAGTGTTAT CCCGAATTGT GCTGAATTGC AAGACTGGAG CGACTGTAAT GCGCGGTCGA 
TCCAATAGCT TCAGCCACCG TAATGATCTC TACATGCAGC CGCAGAGTCT GGGTATGGAC 
GCACAGCTCA TGCAGCAGCC TCCGAATGCT TTGCAGTCTG TTTCTCCGAG GATGGGAGAG 
TTTTTGGGTC GTAGACCCAG CAGTGCACCA TCGCAGCATC TACTGGAAAC CACTACATAT 
CCTGCAAGTC GTCCGATTGG AGGTCTCCCG GTTAGTCCGG GCGGTTACAC CAATGCTTTG 
CCTCAATCGC GACCGTTATC CATGTATAAT GCTCACACCG GTCTGGCCAT GTCTGCTCTG 
CCGGCTCAGC AACAGCCTCC GATGACTCCA GGAGCGGCTC CGAAGACGTT TTCCGGCACG 
TACACGCCGA TGGAGCTGAT GAAGCGTCCT CCCAACCTGC CTCCGCTGTC TCCGGCTCAC 
AGTCCGCATC TGAGCCCTCA GTTGATGCGC AAAGGAGCAG CGGTGGAAAA TGCCGTCATT 
CCAGCATCCT CCGCCGTCCA GACGCAGAAT ATTAATGCCA ATAACAAGCA GACCCGCAGA 
ACCGGACCTC CAGTCATCGT GTCCACCATG GCTTCACCGG AGACAAGTAT CCGCCCTCAG 
CTGGTGAACG GGCCTCTTCA TCCTCGTCCT CTGGTGGCTC TGCTGGACGG TCGGGACTGT 
ACGGTGGAGA TGCCCATCCT TAAAGATCTG GCAACCGTTG CCTTCTGTGA CGCCCAGTCC 
ACACAGGAGA TCCATGAGAA GGTGCTGAAC GAGGCTGTCG GTGCTCTGAT GTATCACACC 
ATCACACTCA CCCGAGAAGA TCTGGAGAAG TTTAAAGCTC TGAGAATCGT CATCCGCATC 
GGCAGCGGAT ACGACAACAT CGACATTAAA GCAGCCGGAG AGATGGGTAT TGCGGTGTGT 
AATATCCCGT CAGCAGCAGT GGAGGAGACG GCGGACTCGA CTCTGTGTCA CGTGTTGAAT 
CTGTACCGCA GGAACACGTG GTTATACCGG GCTCTGCGCG AGGGCACGCG TGTGCAGAGT 
GTGGAGCAGA TCCGAGAGGT GGCGTCCGGA GCCGCACGCA TCCGCGGAGA AACACTCGGA 
CTCATCGGCC TCGGTCGGTC AGGTCAGGCC GTCGCCGTCC GGGCCAAAGT GTTCGGCTTC 
AACGTGATCT TCTACGACCC GTACCTGCAG GACGGTCTGG AGCGCTCGCT GGGCGTGCAG 
CGCGTTTACA CACTGCAGGA CCTGCTGTAC CAGAGCGACT GTGTGTCTCT GCACTGCAAC 
CTGAACGAAC ACAACCATCA CCTCATCAGC GACTTCACCA TCAAACAGAT GCGACAGGGA 
GCGTTTCTCG TGAACACAGC TCGCGGTGGT CTGGTGGATG AGAAAGCTCT GGCTCAGGCT 
CTGAAAGAGG GCAGGATACG CGGCGCTGCC CTGGACGTTC ATGAGTCTGA ACCCTTCAGT 
TTCACTCAGG GTCCTCTGAA GGACGCGCCC AATCTGATCT GCACCCCTCA CACAGCCTGG 
TACAGTGAGC AGGCCTCACT AGAGATGAGA GAGGCAGCAG CCACTGAGAT CCGCAGAGCC 
ATCACCGGTC GTATTCCAGA CAGTCTCAGA AACTGCGTCA ACAAAGAGTT TTTTGTGACT 
ACGGCGCCGT GGGGGGTGAT GGAGCAGCAG GTTCATCCGG AGCTCAACGG CGGAGCCTAC 
AGAGTCGCCC AGCCGCTCCC AGCCGTCTCT CCCGGCGGCC TGCAAGACAA AATGTATACC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ribeye protein is intrinsically dynamic but is stabilized in the context of the ribbon synapse.
The Journal of physiology(2017 Oct)
Chen Z,Chou SW,McDermott BM Jr

In Vivo Ribbon Mobility and Turnover of Ribeye at Zebrafish Hair Cell Synapses.
Scientific reports7(1)7467(2017 Aug)
Graydon CW,Manor U,Kindt KS

Enlargement of Ribbons in Zebrafish Hair Cells Increases Calcium Currents But Disrupts Afferent Spontaneous Activity and Timing of Stimulus Onset.
The Journal of neuroscience : the official journal of the Society for Neuroscience37(26)6299-6313(2017 Jun)
Sheets L,He XJ,Olt J,Schreck M,Petralia RS,Wang YX,Zhang Q,Beirl A,Nicolson T,Marcotti W,Trapani JG,Kindt KS

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ctbp2l cDNA ORF clone, Danio rerio(zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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