clu cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	clu
Entrez Gene ID	393775
Full Name	clusterin
Synonyms	zgc:73352
General protein information	Preferred Names clusterin Names clusterin clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)
Summary	This gene encodes a protein that is similar to the human clusterin protein, a secreted chaperone that can also be found in the cell cytosol under certain stress conditions. The human protein has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders.[provided by RefSeq, May 2011].

mRNA and Protein(s)

mRNA	Protein	Name
NM_200802.1	NP_957096.1	clusterin precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CLU	XP_519677.2
Homo sapiens (human)	CLU	NP_001822.3
Canis lupus familiaris (dog)	CLU	NP_001003370.1
Bos taurus (cattle)	CLU	NP_776327.1
Danio rerio (zebrafish)	clu	NP_957096.1
Xenopus tropicalis (tropical clawed frog)	clu	NP_001004936.1
	CLU	XP_001109522.2
Mus musculus (house mouse)	Clu	NP_038520.2
Rattus norvegicus (Norway rat)	Clu	NP_444180.2
Gallus gallus (chicken)	CLU	NP_990231.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration.
Cao J, Navis A, Cox BD, Dickson AL, Gemberling M, Karra R, Bagnat M, Poss KD
Development (Cambridge, England)143(2)232-43(2016 Jan)

Identification and Characterization of Androgen-Responsive Genes in Zebrafish Embryos.
Fetter E, Smetanov? S, Baldauf L, Lidzba A, Altenburger R, Sch?ttler A, Scholz S
Environmental science & technology49(19)11789-98(2015 Oct)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Zebrafish clusterin is expressed in the notochord and nervous system during development. Clusterin has also role in neuronal cell death and thus, more generally, in neurodegeneration.
Title: Induction of clusterin expression by neuronal cell death in Zebrafish.

Data show that inhibition or targeted knockdown of Notch signaling significantly increased clusterin mRNA expression in choroid plexus.
Title: The conserved clusterin gene is expressed in the developing choroid plexus under the regulation of notch but not IGF signaling in zebrafish.

The following clu gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the clu cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa36814	NM_200802.1 Latest version!	Danio rerio clusterin (clu), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

clu ( NM_200802.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_957096.1 Danio rerio clusterin (clu), mRNA.

Price & Availability↑

CloneID	ODa36814
Clone ID Related Accession (Same CDS sequence)	NM_200802.1
Accession Version	NM_200802.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1347bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-02
Organism	Danio rerio(zebrafish)
Product	clusterin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059667.1. ##Evidence-Data-START## Transcript exon combination :: GQ472932.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705 [ECO:0000348] ##Evidence-Data-END##

ATGAAGGTCT TGTGGTCTCT GCTGGGGCTG TTTCTCCTCT ACCTCTCCAC CGAATGTTTG 
CTGCCACCAT CCAAAGAGGA GCTTAACCAG ATGTCGCAAG TTGGTGAGAA ATACCTGGAC 
AGGCAGATTG AAAATGCCAT CAGTGGAGTG AAGGAGATGA AGACTGTGAT GGAGCGATCC 
GAAGAGGAGC ACAAGAGGAT GCTGTCGGAG ATGGAGAAAA CCCAAAAAGA GAAAGAGAAT 
GCCCTGAAGA CGGCTCAGGA GATGAAGGAG AAGCTCAGCG AGGAGCAGAG TGTGTGTAAT 
GAAACCATGG AGGCTTTGTG GGAAGAGTGT AAGCCCTGCT TGAGGAAGAC CTGTGTGAAG 
TTTTACTCAC GCACCTGCAG AAGCGGATCC GGCCTGGTGG GACGTCAGCT GGAGGAGATT 
TTGAACAGGA CTTCTCCCAT CTCCATCTTC ATAAACGGCC AGAGCATCGA GACCCTGCTG 
AGTGAGGATC AGCAGCAGAC CAGACACTTC CAGGACCTGG AGGAAAGTTA CACTGAGGTT 
TCAGATGGAG TGGAAAATAT GTTTACGGAC AGCATGAAGG TGTTTGACCA CATGCAGATG 
TTCCACCATC CCGGCTTCTT CCCCAGTAGA TTCCAGTTTC CCAGTATGTT TGGTGGGCAT 
GAGGGCTCCA CCCATGCTGG CCGCATCTAT AGGTCTCCAA TGCATGACTC CTTGTTTCAC 
AGCCTCCAAA GCTTGTTCAG GCCTATGGAG AGATCCATGA GCATGTTTGG AAAAAATGAA 
GAGAGGAACT TCACCTCAGA AGGTTGGAAA TTGAATGAGA AAGTTACTAC AGATGATAAG 
ATGACTTGCA AGGAAATCCG TCGCAATTCT TTCGGCTGCG TCAAACTGAA AGACGAGTGT 
GAAAAATGTC AACAGATCCA GCATATTGAC TGTTCTGGAA AGAGGCCCCT GGAAGGGCCC 
CTAAAGGAGG AGCTGGAGAG GGCTCTGGGC AAGGCAGAGG AATTCACCCA AGAGTTCAAC 
AACCTGTTAA ATATATTCCA GGAGCAGATG TTCAACACCT CAAGTCTGCT CGACCTGTTC 
AACAAGCAGT TTGGCTGGGT TTCCTCTCTC GCCAACCATA CCCAAAATGA AGACGGCTTC 
TTTCAGATAC AGGCAGTGAT GTCCAAAGGC TCAGATAATG CAGAGAATCC TGCTGACACC 
AGAGTGTCTG TCAAACTGTT TGACGGGCCA GATATGATCT ACACAGTGCC AGGAGATATT 
CCCTGGAGCG ACCCAAAATT CTCTGAAGTG GTGGCACAGG AAGCTTTGGA TCGCTACAAA 
CAGAACGCTG TAATCACAAA GCTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_957096.1
CDS	50..1396
Translation	MKVLWSLLGLFLLYLSTECLLPPSKEELNQMSQVGEKYLDRQIENAISGVKEMKTVMERSEEEHKRMLSEMEKTQKEKENALKTAQEMKEKLSEEQSVCNETMEALWEECKPCLRKTCVKFYSRTCRSGSGLVGRQLEEILNRTSPISIFINGQSIETLLSEDQQQTRHFQDLEESYTEVSDGVENMFTDSMKVFDHMQMFHHPGFFPSRFQFPSMFGGHEGSTHAGRIYRSPMHDSLFHSLQSLFRPMERSMSMFGKNEERNFTSEGWKLNEKVTTDDKMTCKEIRRNSFGCVKLKDECEKCQQIQHIDCSGKRPLEGPLKEELERALGKAEEFTQEFNNLLNIFQEQMFNTSSLLDLFNKQFGWVSSLANHTQNEDGFFQIQAVMSKGSDNAENPADTRVSVKLFDGPDMIYTVPGDIPWSDPKFSEVVAQEALDRYKQNAVITKL

Target ORF information:

RefSeq Version	NM_200802.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio clusterin (clu), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_200802.1

ORF Insert Sequence:

ATGAAGGTCT TGTGGTCTCT GCTGGGGCTG TTTCTCCTCT ACCTCTCCAC CGAATGTTTG 
CTGCCACCAT CCAAAGAGGA GCTTAACCAG ATGTCGCAAG TTGGTGAGAA ATACCTGGAC 
AGGCAGATTG AAAATGCCAT CAGTGGAGTG AAGGAGATGA AGACTGTGAT GGAGCGATCC 
GAAGAGGAGC ACAAGAGGAT GCTGTCGGAG ATGGAGAAAA CCCAAAAAGA GAAAGAGAAT 
GCCCTGAAGA CGGCTCAGGA GATGAAGGAG AAGCTCAGCG AGGAGCAGAG TGTGTGTAAT 
GAAACCATGG AGGCTTTGTG GGAAGAGTGT AAGCCCTGCT TGAGGAAGAC CTGTGTGAAG 
TTTTACTCAC GCACCTGCAG AAGCGGATCC GGCCTGGTGG GACGTCAGCT GGAGGAGATT 
TTGAACAGGA CTTCTCCCAT CTCCATCTTC ATAAACGGCC AGAGCATCGA GACCCTGCTG 
AGTGAGGATC AGCAGCAGAC CAGACACTTC CAGGACCTGG AGGAAAGTTA CACTGAGGTT 
TCAGATGGAG TGGAAAATAT GTTTACGGAC AGCATGAAGG TGTTTGACCA CATGCAGATG 
TTCCACCATC CCGGCTTCTT CCCCAGTAGA TTCCAGTTTC CCAGTATGTT TGGTGGGCAT 
GAGGGCTCCA CCCATGCTGG CCGCATCTAT AGGTCTCCAA TGCATGACTC CTTGTTTCAC 
AGCCTCCAAA GCTTGTTCAG GCCTATGGAG AGATCCATGA GCATGTTTGG AAAAAATGAA 
GAGAGGAACT TCACCTCAGA AGGTTGGAAA TTGAATGAGA AAGTTACTAC AGATGATAAG 
ATGACTTGCA AGGAAATCCG TCGCAATTCT TTCGGCTGCG TCAAACTGAA AGACGAGTGT 
GAAAAATGTC AACAGATCCA GCATATTGAC TGTTCTGGAA AGAGGCCCCT GGAAGGGCCC 
CTAAAGGAGG AGCTGGAGAG GGCTCTGGGC AAGGCAGAGG AATTCACCCA AGAGTTCAAC 
AACCTGTTAA ATATATTCCA GGAGCAGATG TTCAACACCT CAAGTCTGCT CGACCTGTTC 
AACAAGCAGT TTGGCTGGGT TTCCTCTCTC GCCAACCATA CCCAAAATGA AGACGGCTTC 
TTTCAGATAC AGGCAGTGAT GTCCAAAGGC TCAGATAATG CAGAGAATCC TGCTGACACC 
AGAGTGTCTG TCAAACTGTT TGACGGGCCA GATATGATCT ACACAGTGCC AGGAGATATT 
CCCTGGAGCG ACCCAAAATT CTCTGAAGTG GTGGCACAGG AAGCTTTGGA TCGCTACAAA 
CAGAACGCTG TAATCACAAA GCTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration.
Development (Cambridge, England)143(2)232-43(2016 Jan)
Cao J,Navis A,Cox BD,Dickson AL,Gemberling M,Karra R,Bagnat M,Poss KD

Identification and Characterization of Androgen-Responsive Genes in Zebrafish Embryos.
Environmental science & technology49(19)11789-98(2015 Oct)
Fetter E,Smetanov? S,Baldauf L,Lidzba A,Altenburger R,Sch?ttler A,Scholz S

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

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clu cDNA ORF clone, Danio rerio(zebrafish)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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