CLU cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLU
Entrez Gene ID	442971
Full Name	clusterin
Synonyms	GP80
General protein information	Preferred Names clusterin Names clusterin clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J) glycoprotein 80
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)
Summary	This gene encodes a protein that is similar to the human clusterin protein, a secreted chaperone that can also be found in the cell cytosol under certain stress conditions. The human protein has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. [provided by RefSeq, May 2011].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003370.1	NP_001003370.1	clusterin precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CLU	XP_519677.2
Homo sapiens (human)	CLU	NP_001822.3
Canis lupus familiaris (dog)	CLU	NP_001003370.1
Bos taurus (cattle)	CLU	NP_776327.1
Danio rerio (zebrafish)	clu	NP_957096.1
Xenopus tropicalis (tropical clawed frog)	clu	NP_001004936.1
	CLU	XP_001109522.2
Mus musculus (house mouse)	Clu	NP_038520.2
Rattus norvegicus (Norway rat)	Clu	NP_444180.2
Gallus gallus (chicken)	CLU	NP_990231.1

Gene Ontology
Bibliography

Related articles in PubMed

The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog.
Shafie IN, McLaughlin M, Burchmore R, Lim MA, Montague P, Johnston PE, Penderis J, Anderson TJ
Cell stress & chaperones19(3)311-20(2014 May)

Clusterin facilitates in vivo clearance of extracellular misfolded proteins.
Wyatt AR, Yerbury JJ, Berghofer P, Greguric I, Katsifis A, Dobson CM, Wilson MR
Cellular and molecular life sciences : CMLS68(23)3919-31(2011 Dec)

Clusterin induces CXCR4 expression and migration of cardiac progenitor cells.
Li Y, Qu J, Shelat H, Gao S, Wassler M, Geng YJ
Experimental cell research316(20)3435-42(2010 Dec)

Chapter 6: The chaperone action of Clusterin and its putative role in quality control of extracellular protein folding.
Wyatt A, Yerbury J, Poon S, Dabbs R, Wilson M
Advances in cancer research10489-114(2009)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Clusterin may potentially serve as a marker for chronic spinal cord disease in the dog.
Title: The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog.

The chaperone clusterin mediates systemic clearance of extracellular misfolded proteins
Title: Clusterin facilitates in vivo clearance of extracellular misfolded proteins.

Clusterin expression may increase cardiac progenitor cell migration via increasing CXCR4 expression and SDF-1/chemokine receptor signaling in a PI3/Akt-dependent manner.
Title: Clusterin induces CXCR4 expression and migration of cardiac progenitor cells.

The chaperone action of clusterin is important in quality control of extracellular protein folding
Title: Chapter 6: The chaperone action of Clusterin and its putative role in quality control of extracellular protein folding.

The extracellular chaperone clusterin appears in the cytosol during endoplasmic reticulum stress
Title: Stress-induced retrotranslocation of clusterin/ApoJ into the cytosol.

The following CLU gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLU cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe00373	NM_001003370.1 Latest version!	Canis lupus familiaris clusterin (CLU), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLU ( NM_001003370.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001003370.1 Canis lupus familiaris clusterin (CLU), mRNA.

Price & Availability↑

CloneID	OCe00373
Clone ID Related Accession (Same CDS sequence)	NM_001003370.1
Accession Version	NM_001003370.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1338bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Canis lupus familiaris(dog)
Product	clusterin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M55251.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M55251.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END##

ATGATGAAGA CTCTCCTGCT GCTGGTGGGG CTGCTGCTGA CCTGGGACAA TGGACGGGTT 
CTGGGAGACC AGGCTGTCTC AGACACCGAG CTCCAGGAAA TGTCCACCGA AGGTAGTAAG 
TACATTAATA AGGAAATAAA AAATGCTCTC AAGGGGGTGA AACAGATAAA GACCCTAATA 
GAACAGACAA ACGAAGAGCG CAAATCACTG CTCAGCAACC TGGAGGAAGC CAAGAAGAAG 
AAAGAGGATG CACTAAATGA TACCAAGGAT TCTGAAACGA AGCTGAAGGC GTCCCAGGGG 
GTGTGCAATG ACACCATGAT GGCCCTCTGG GAGGAGTGCA AGCCCTGCCT GAAACAGACC 
TGCATGAAGT TCTACGCACG TGTCTGCAGA AGTGGCTCGG GGCTAGTTGG CCACCAGCTC 
GAGGAGTTCC TGAACCAGAG TTCTCCCTTC TACTTCTGGA TGAATGGCGA TCGTATCGAC 
TCCCTGCTGG AGAACGACCG GCAGCAGACC CACGCCCTGG ACGTCATGCA GGACAGCTTC 
AACCGGGCAT CCAGCATCAT GGATGAGCTT TTCCAGGACA GATTCTTCAC CCGGGAGCCC 
CAGGATACTT ACCACTACTC ACCCTTCAGC TTATTCCAGA GGAGGCCTTT CTTCAATCCC 
AAATTTCGCA TCGCCCGGAA CATAATACCT TTCCCTAGAT TCCAGCCCTT AAACTTCCAT 
GACATGTTTC AGCCCTTCTT TGACATGATA CACCAGGCTC AACAGGCCAT GGATGTTAAC 
CTGCATAGAA TTCCTTACCA CTTCCCAATT GAATTCCCAG AAGAAGATAA CCGCACCGTG 
TGCAAGGAGA TCCGTCACAA CTCCACAGGT TGCCTGAAAA TGAAGGACCA GTGTGAAAAG 
TGCCAGGAGA TCTTGTCAGT GGATTGTTCT TCCAACAACC CTGCGCAGGT CCAGCTGCGA 
CAGGAACTTA GTAATTCCCT CCAGATTGCG GAGAAGTTCA CCAAGCTCTA CGACGAGCTG 
CTGCAGTCCT ACCAGGAGAA GATGTTCAAC ACGTCCTCCC TGCTGAAGCA GCTGAACGAG 
CAGTTTAGCT GGGTGTCCCA ACTGGCTAAC CTCACTCAAA GTGAAGACCC ATTCTATCTC 
CAGGTCACGA CGGTGGGTTC TCAGACTTCT GACTCCAATG TTCCCGTGGG CTTCACTAAG 
GTGGTTGTGA AGCTCTTTGA TTCTGACCCC ATCACGGTGA TGATCCCAGA AGCAGTCTCC 
AGGAACAATC CTAAATTTAT GGAGACTGTG GCAGAGAAGG CTCTTCAGGA GTATCGCCAA 
AAGCACCGAG AGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003370.1
CDS	54..1391
Translation	MMKTLLLLVGLLLTWDNGRVLGDQAVSDTELQEMSTEGSKYINKEIKNALKGVKQIKTLIEQTNEERKSLLSNLEEAKKKKEDALNDTKDSETKLKASQGVCNDTMMALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHALDVMQDSFNRASSIMDELFQDRFFTREPQDTYHYSPFSLFQRRPFFNPKFRIARNIIPFPRFQPLNFHDMFQPFFDMIHQAQQAMDVNLHRIPYHFPIEFPEEDNRTVCKEIRHNSTGCLKMKDQCEKCQEILSVDCSSNNPAQVQLRQELSNSLQIAEKFTKLYDELLQSYQEKMFNTSSLLKQLNEQFSWVSQLANLTQSEDPFYLQVTTVGSQTSDSNVPVGFTKVVVKLFDSDPITVMIPEAVSRNNPKFMETVAEKALQEYRQKHREE

Target ORF information:

RefSeq Version	NM_001003370.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris clusterin (CLU), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003370.1

ORF Insert Sequence:

ATGATGAAGA CTCTCCTGCT GCTGGTGGGG CTGCTGCTGA CCTGGGACAA TGGACGGGTT 
CTGGGAGACC AGGCTGTCTC AGACACCGAG CTCCAGGAAA TGTCCACCGA AGGTAGTAAG 
TACATTAATA AGGAAATAAA AAATGCTCTC AAGGGGGTGA AACAGATAAA GACCCTAATA 
GAACAGACAA ACGAAGAGCG CAAATCACTG CTCAGCAACC TGGAGGAAGC CAAGAAGAAG 
AAAGAGGATG CACTAAATGA TACCAAGGAT TCTGAAACGA AGCTGAAGGC GTCCCAGGGG 
GTGTGCAATG ACACCATGAT GGCCCTCTGG GAGGAGTGCA AGCCCTGCCT GAAACAGACC 
TGCATGAAGT TCTACGCACG TGTCTGCAGA AGTGGCTCGG GGCTAGTTGG CCACCAGCTC 
GAGGAGTTCC TGAACCAGAG TTCTCCCTTC TACTTCTGGA TGAATGGCGA TCGTATCGAC 
TCCCTGCTGG AGAACGACCG GCAGCAGACC CACGCCCTGG ACGTCATGCA GGACAGCTTC 
AACCGGGCAT CCAGCATCAT GGATGAGCTT TTCCAGGACA GATTCTTCAC CCGGGAGCCC 
CAGGATACTT ACCACTACTC ACCCTTCAGC TTATTCCAGA GGAGGCCTTT CTTCAATCCC 
AAATTTCGCA TCGCCCGGAA CATAATACCT TTCCCTAGAT TCCAGCCCTT AAACTTCCAT 
GACATGTTTC AGCCCTTCTT TGACATGATA CACCAGGCTC AACAGGCCAT GGATGTTAAC 
CTGCATAGAA TTCCTTACCA CTTCCCAATT GAATTCCCAG AAGAAGATAA CCGCACCGTG 
TGCAAGGAGA TCCGTCACAA CTCCACAGGT TGCCTGAAAA TGAAGGACCA GTGTGAAAAG 
TGCCAGGAGA TCTTGTCAGT GGATTGTTCT TCCAACAACC CTGCGCAGGT CCAGCTGCGA 
CAGGAACTTA GTAATTCCCT CCAGATTGCG GAGAAGTTCA CCAAGCTCTA CGACGAGCTG 
CTGCAGTCCT ACCAGGAGAA GATGTTCAAC ACGTCCTCCC TGCTGAAGCA GCTGAACGAG 
CAGTTTAGCT GGGTGTCCCA ACTGGCTAAC CTCACTCAAA GTGAAGACCC ATTCTATCTC 
CAGGTCACGA CGGTGGGTTC TCAGACTTCT GACTCCAATG TTCCCGTGGG CTTCACTAAG 
GTGGTTGTGA AGCTCTTTGA TTCTGACCCC ATCACGGTGA TGATCCCAGA AGCAGTCTCC 
AGGAACAATC CTAAATTTAT GGAGACTGTG GCAGAGAAGG CTCTTCAGGA GTATCGCCAA 
AAGCACCGAG AGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog.
Cell stress & chaperones19(3)311-20(2014 May)
Shafie IN,McLaughlin M,Burchmore R,Lim MA,Montague P,Johnston PE,Penderis J,Anderson TJ

Clusterin facilitates in vivo clearance of extracellular misfolded proteins.
Cellular and molecular life sciences : CMLS68(23)3919-31(2011 Dec)
Wyatt AR,Yerbury JJ,Berghofer P,Greguric I,Katsifis A,Dobson CM,Wilson MR

Clusterin induces CXCR4 expression and migration of cardiac progenitor cells.
Experimental cell research316(20)3435-42(2010 Dec)
Li Y,Qu J,Shelat H,Gao S,Wassler M,Geng YJ

Chapter 6: The chaperone action of Clusterin and its putative role in quality control of extracellular protein folding.
Advances in cancer research10489-114(2009)
Wyatt A,Yerbury J,Poon S,Dabbs R,Wilson M

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CLU cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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