pcsk7 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	pcsk7
Entrez Gene ID	100009656
Full Name	proprotein convertase subtilisin/kexin type 7
Synonyms	wu:fj05c03,zgc:158336
General protein information	Preferred Names proprotein convertase subtilisin/kexin type 7 Names proprotein convertase subtilisin/kexin type 7 fj05c03
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
XM_021481321.1	XP_021336996.1	proprotein convertase subtilisin/kexin type 7 isoform X1
NM_001320428.1	NP_001307357.1	proprotein convertase subtilisin/kexin type 7 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PCSK7	XP_508776.2
Bos taurus (cattle)	PCSK7	NP_001179907.1
Danio rerio (zebrafish)	pcsk7	NP_001076494.1
Gallus gallus (chicken)	PCSK7	NP_001025528.1
	PCSK7	XP_001093007.1
Canis lupus familiaris (dog)	PCSK7	XP_850224.1
Xenopus tropicalis (tropical clawed frog)	pcsk7	XP_002932953.2
Homo sapiens (human)	PCSK7	NP_004707.2
Mus musculus (house mouse)	Pcsk7	NP_001268863.1
Rattus norvegicus (Norway rat)	Pcsk7	NP_062119.1

Gene Ontology
Bibliography

Related articles in PubMed

Regulation of the proprotein convertases expression and activity during regenerative angiogenesis: Role of hypoxia-inducible factor (HIF).
Ma J, Evrard S, Badiola I, Siegfried G, Khatib AM
European journal of cell biology96(5)457-468(2017 Aug)

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum.
Ojanen MJ, Turpeinen H, Cordova ZM, Hammar?n MM, Harjula SK, Parikka M, R?met M, Pesu M
Infection and immunity83(4)1431-42(2015 Apr)

Proprotein convertase subtilisin/kexin type 7 (PCSK7) is essential for the zebrafish development and bioavailability of transforming growth factor ?1a (TGF?1a).
Turpeinen H, Oksanen A, Kivinen V, Kukkurainen S, Uusim?ki A, R?met M, Parikka M, Hyt?nen VP, Nykter M, Pesu M
The Journal of biological chemistry288(51)36610-23(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PCSK7 is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.
Title: Proprotein convertase subtilisin/kexin type 7 (PCSK7) is essential for the zebrafish development and bioavailability of transforming growth factor ?1a (TGF?1a).

The following pcsk7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the pcsk7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa53300	NM_001320428.1 Latest version!	Danio rerio proprotein convertase subtilisin/kexin type 7 (pcsk7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$426.30 $609.00
ODa53300	XM_021481321.1 Latest version!	Danio rerio proprotein convertase subtilisin/kexin type 7 (pcsk7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$426.30 $609.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

pcsk7 ( NM_001320428.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001307357.1 Danio rerio proprotein convertase subtilisin/kexin type 7 (pcsk7), mRNA.

Price & Availability↑

CloneID	ODa53300
Clone ID Related Accession (Same CDS sequence)	XM_021481321.1 , NM_001320428.1
Accession Version	NM_001320428.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2130bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-23
Organism	Danio rerio(zebrafish)
Product	proprotein convertase subtilisin/kexin type 7 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EL648947.1, BC133084.1, CU469509.8 and CA477349.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC133084.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168446, SAMEA2168447 [ECO:0000348] ##Evidence-Data-END##

ATGGCGTCCT GCTCCTCCCG GGTGTGTTTG GGACTGTACC CGCTGCTCCT GCTGTTCTCC 
TCCTCCTCCT CCTCATGTGC TCCGGGGCGC TCCTGGGCGG TGCAACTTCA GCCGGACTCC 
CTGAGCTCTG CCGGGTCTCC GGATCTGCTG GCCCAGGCGG TGGCACAGGA TGTGGGTCTG 
CGGAGCCACG GGCAGATCGG GCAGCTGGAG GGGCACTACC TGCTGTGCCA GGACCCAGCG 
CAGGGCGAGG ACTGGCGCTG GATGGAGGCT GCTCTGGACA GGCACCCTCA CGTGGCCTGG 
CACTCGCAGG AAAATGTGCT GCGGCGCTCC AAGAGGAGTG TGCACTTCAA TGACCCTAAA 
TTTCCCAGTC AGTGGCACCT GCACAATGAC ATGAAGCGAG GGATGGACAT CAATGTGACG 
GGCGTGTGGG AGAGGAACAT CACCGGCGCG GGCGTCACTG TGGTGGTGGT GGACGACGGC 
ATTCAGCACA ACCTGGCAGA CATCCAGCCT AACTATAGTC CTGAAGGCAG CTATGACCTG 
AACTCTAATG ACCCAGACCC CATGCCTCAC CCAGACGGTC CCAGTGATAA TCATCACGGC 
ACGCGCTGCG CTGGAGAGAT CGCCGCCGTC TCCAACAACA GCTTCTGTGC GGTGGGCGTG 
GCATACGGCA GCAGGGTGGC CGGCATCAGA GTGTTGGACG GGCCGCTCAC AGACAGTATG 
GAGGCCATCG CTTTCAACAA GCATTACCAG GTCAATGACA TCTACAGCTG CAGTTGGGGT 
CCAGATGATG ACGGCCGGAC GGTTGACGGA CCGCATCCAT TAGGCAAGGC GGCGCTGCAG 
CACGGTGTGA TCGCGGGCCG CAAGGGTTTC GGCAGCATCT TCATTGTGGC CAGTGGCAAT 
GGAGGACAGA ATCAGGACAA CTGCAACTAC GACGGCTACG CTAACTCCAT CTACACCGTC 
ACCATCGGAG CAGTGGACGA GAGCGGCAGG AAACCAACCT ATGCGGAGGA GTGTGCGTCC 
ATGCTGGCCG TCACCTTCAG CAGCGGGAAC ACACCGCTGC GCAGCATAGT GACGTCAGAC 
TGGTCTCTGC AGAGCGGCAC CGGCTGTACT AGTGGGCACA CGGGCACCTC CGCCGCTGCT 
CCTCTGGCTG CAGGGATGGT GGCGCTGATG CTGCAGGTGC GGCCCTGTCT GAGCTGGCGA 
GATGTGCAGC ACATCATCAC CTACACCGCC ACACAGCATG ACCTTCAGGC GGACTGGGTC 
ACTAATGGAG CTGGTTTCCA TCACAGCCAC AAGTACGGCT TCGGCCTCCT GAACGCCTGG 
AGACTCGTCA ATGCTGCAAA GGTTTGGGAG TCTGTCCCCT TCCTGGTGTC CTACCAGAGT 
CCAGTTCTGA GGGTCAATGA GGTCATCACG ACCTCCACAA ACCTCACACA AACCTGGAAC 
GTGTCTGAGT CTGACCTGCA GCGCTCCGGT ATGCAGACTC TGGAGCATGT GTCCGTGACT 
CTCAGCATTC AGCATCCCAG AAGAGGAAAC CTGCAGATCC TGCTGCTCTG CCCCAGCGGC 
ATCAGCTCCC TGATTGGAGC ACGCAGGGCA CTGGACGTAG ATTCTGCAGG CCTGACGGAC 
TGGACGTTCT CCACCGTGCG CTGCTGGGGA GAGCAAGCCG AGGGCCAGTA CAGCCTGCTG 
ATCATGGACG ACGCGCCTCT GTCCTCAGGT ATTCTGAAGA GCTGGAAACT GACGCTGTAC 
GGCTCGTCTC TGTCCCATCA GCAGGTCACA GACAGACAGA GAGTTGTTGA GGAGGCCATG 
AGTGGACATT ACCTGAGCAG CAGCTTCTCT CTGCCGTGTC CACCGGGTAT AGATGTGCCT 
GCGGAGATCG TCAACCCCTT CACCTCCAGC AGCCTCAAGT CTCTGCTGCT GCTGGGTTGT 
TTCACGCTCT TCTGGTCGCT CTACTACACT CTGGAGGTGG TGCTCACACA CTGGGACTGG 
CGCGGTGGGT GTGTCCGCGG GCGGGACGGC GACGCCGGAT ACTCCAGACT GTCCCGGGAC 
GAGGCTCAGA CGGACCCTCA GCAGGTGGAG GTCCTGCTGG AGACACACAG CCAGGACAAA 
GTGCTGCTCA TAGCGGACAC ACACACGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307357.1
CDS	169..2298
Translation	MASCSSRVCLGLYPLLLLFSSSSSSCAPGRSWAVQLQPDSLSSAGSPDLLAQAVAQDVGLRSHGQIGQLEGHYLLCQDPAQGEDWRWMEAALDRHPHVAWHSQENVLRRSKRSVHFNDPKFPSQWHLHNDMKRGMDINVTGVWERNITGAGVTVVVVDDGIQHNLADIQPNYSPEGSYDLNSNDPDPMPHPDGPSDNHHGTRCAGEIAAVSNNSFCAVGVAYGSRVAGIRVLDGPLTDSMEAIAFNKHYQVNDIYSCSWGPDDDGRTVDGPHPLGKAALQHGVIAGRKGFGSIFIVASGNGGQNQDNCNYDGYANSIYTVTIGAVDESGRKPTYAEECASMLAVTFSSGNTPLRSIVTSDWSLQSGTGCTSGHTGTSAAAPLAAGMVALMLQVRPCLSWRDVQHIITYTATQHDLQADWVTNGAGFHHSHKYGFGLLNAWRLVNAAKVWESVPFLVSYQSPVLRVNEVITTSTNLTQTWNVSESDLQRSGMQTLEHVSVTLSIQHPRRGNLQILLLCPSGISSLIGARRALDVDSAGLTDWTFSTVRCWGEQAEGQYSLLIMDDAPLSSGILKSWKLTLYGSSLSHQQVTDRQRVVEEAMSGHYLSSSFSLPCPPGIDVPAEIVNPFTSSSLKSLLLLGCFTLFWSLYYTLEVVLTHWDWRGGCVRGRDGDAGYSRLSRDEAQTDPQQVEVLLETHSQDKVLLIADTHT

Target ORF information:

RefSeq Version	NM_001320428.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio proprotein convertase subtilisin/kexin type 7 (pcsk7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320428.1

ORF Insert Sequence:

ATGGCGTCCT GCTCCTCCCG GGTGTGTTTG GGACTGTACC CGCTGCTCCT GCTGTTCTCC 
TCCTCCTCCT CCTCATGTGC TCCGGGGCGC TCCTGGGCGG TGCAACTTCA GCCGGACTCC 
CTGAGCTCTG CCGGGTCTCC GGATCTGCTG GCCCAGGCGG TGGCACAGGA TGTGGGTCTG 
CGGAGCCACG GGCAGATCGG GCAGCTGGAG GGGCACTACC TGCTGTGCCA GGACCCAGCG 
CAGGGCGAGG ACTGGCGCTG GATGGAGGCT GCTCTGGACA GGCACCCTCA CGTGGCCTGG 
CACTCGCAGG AAAATGTGCT GCGGCGCTCC AAGAGGAGTG TGCACTTCAA TGACCCTAAA 
TTTCCCAGTC AGTGGCACCT GCACAATGAC ATGAAGCGAG GGATGGACAT CAATGTGACG 
GGCGTGTGGG AGAGGAACAT CACCGGCGCG GGCGTCACTG TGGTGGTGGT GGACGACGGC 
ATTCAGCACA ACCTGGCAGA CATCCAGCCT AACTATAGTC CTGAAGGCAG CTATGACCTG 
AACTCTAATG ACCCAGACCC CATGCCTCAC CCAGACGGTC CCAGTGATAA TCATCACGGC 
ACGCGCTGCG CTGGAGAGAT CGCCGCCGTC TCCAACAACA GCTTCTGTGC GGTGGGCGTG 
GCATACGGCA GCAGGGTGGC CGGCATCAGA GTGTTGGACG GGCCGCTCAC AGACAGTATG 
GAGGCCATCG CTTTCAACAA GCATTACCAG GTCAATGACA TCTACAGCTG CAGTTGGGGT 
CCAGATGATG ACGGCCGGAC GGTTGACGGA CCGCATCCAT TAGGCAAGGC GGCGCTGCAG 
CACGGTGTGA TCGCGGGCCG CAAGGGTTTC GGCAGCATCT TCATTGTGGC CAGTGGCAAT 
GGAGGACAGA ATCAGGACAA CTGCAACTAC GACGGCTACG CTAACTCCAT CTACACCGTC 
ACCATCGGAG CAGTGGACGA GAGCGGCAGG AAACCAACCT ATGCGGAGGA GTGTGCGTCC 
ATGCTGGCCG TCACCTTCAG CAGCGGGAAC ACACCGCTGC GCAGCATAGT GACGTCAGAC 
TGGTCTCTGC AGAGCGGCAC CGGCTGTACT AGTGGGCACA CGGGCACCTC CGCCGCTGCT 
CCTCTGGCTG CAGGGATGGT GGCGCTGATG CTGCAGGTGC GGCCCTGTCT GAGCTGGCGA 
GATGTGCAGC ACATCATCAC CTACACCGCC ACACAGCATG ACCTTCAGGC GGACTGGGTC 
ACTAATGGAG CTGGTTTCCA TCACAGCCAC AAGTACGGCT TCGGCCTCCT GAACGCCTGG 
AGACTCGTCA ATGCTGCAAA GGTTTGGGAG TCTGTCCCCT TCCTGGTGTC CTACCAGAGT 
CCAGTTCTGA GGGTCAATGA GGTCATCACG ACCTCCACAA ACCTCACACA AACCTGGAAC 
GTGTCTGAGT CTGACCTGCA GCGCTCCGGT ATGCAGACTC TGGAGCATGT GTCCGTGACT 
CTCAGCATTC AGCATCCCAG AAGAGGAAAC CTGCAGATCC TGCTGCTCTG CCCCAGCGGC 
ATCAGCTCCC TGATTGGAGC ACGCAGGGCA CTGGACGTAG ATTCTGCAGG CCTGACGGAC 
TGGACGTTCT CCACCGTGCG CTGCTGGGGA GAGCAAGCCG AGGGCCAGTA CAGCCTGCTG 
ATCATGGACG ACGCGCCTCT GTCCTCAGGT ATTCTGAAGA GCTGGAAACT GACGCTGTAC 
GGCTCGTCTC TGTCCCATCA GCAGGTCACA GACAGACAGA GAGTTGTTGA GGAGGCCATG 
AGTGGACATT ACCTGAGCAG CAGCTTCTCT CTGCCGTGTC CACCGGGTAT AGATGTGCCT 
GCGGAGATCG TCAACCCCTT CACCTCCAGC AGCCTCAAGT CTCTGCTGCT GCTGGGTTGT 
TTCACGCTCT TCTGGTCGCT CTACTACACT CTGGAGGTGG TGCTCACACA CTGGGACTGG 
CGCGGTGGGT GTGTCCGCGG GCGGGACGGC GACGCCGGAT ACTCCAGACT GTCCCGGGAC 
GAGGCTCAGA CGGACCCTCA GCAGGTGGAG GTCCTGCTGG AGACACACAG CCAGGACAAA 
GTGCTGCTCA TAGCGGACAC ACACACGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

pcsk7 ( XM_021481321.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> XP_021336996.1 Danio rerio proprotein convertase subtilisin/kexin type 7 (pcsk7), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ODa53300
Clone ID Related Accession (Same CDS sequence)	XM_021481321.1 , NM_001320428.1
Accession Version	XM_021481321.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2130bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-06-14
Organism	Danio rerio(zebrafish)
Product	proprotein convertase subtilisin/kexin type 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007126.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGTCCT GCTCCTCCCG GGTGTGTTTG GGACTGTACC CGCTGCTCCT GCTGTTCTCC 
TCCTCCTCCT CCTCATGTGC TCCGGGGCGC TCCTGGGCGG TGCAACTTCA GCCGGACTCC 
CTGAGCTCTG CCGGGTCTCC GGATCTGCTG GCCCAGGCGG TGGCACAGGA TGTGGGTCTG 
CGGAGCCACG GGCAGATCGG GCAGCTGGAG GGGCACTACC TGCTGTGCCA GGACCCAGCG 
CAGGGCGAGG ACTGGCGCTG GATGGAGGCT GCTCTGGACA GGCACCCTCA CGTGGCCTGG 
CACTCGCAGG AAAATGTGCT GCGGCGCTCC AAGAGGAGTG TGCACTTCAA TGACCCTAAA 
TTTCCCAGTC AGTGGCACCT GCACAATGAC ATGAAGCGAG GGATGGACAT CAATGTGACG 
GGCGTGTGGG AGAGGAACAT CACCGGCGCG GGCGTCACTG TGGTGGTGGT GGACGACGGC 
ATTCAGCACA ACCTGGCAGA CATCCAGCCT AACTATAGTC CTGAAGGCAG CTATGACCTG 
AACTCTAATG ACCCAGACCC CATGCCTCAC CCAGACGGTC CCAGTGATAA TCATCACGGC 
ACGCGCTGCG CTGGAGAGAT CGCCGCCGTC TCCAACAACA GCTTCTGTGC GGTGGGCGTG 
GCATACGGCA GCAGGGTGGC CGGCATCAGA GTGTTGGACG GGCCGCTCAC AGACAGTATG 
GAGGCCATCG CTTTCAACAA GCATTACCAG GTCAATGACA TCTACAGCTG CAGTTGGGGT 
CCAGATGATG ACGGCCGGAC GGTTGACGGA CCGCATCCAT TAGGCAAGGC GGCGCTGCAG 
CACGGTGTGA TCGCGGGCCG CAAGGGTTTC GGCAGCATCT TCATTGTGGC CAGTGGCAAT 
GGAGGACAGA ATCAGGACAA CTGCAACTAC GACGGCTACG CTAACTCCAT CTACACCGTC 
ACCATCGGAG CAGTGGACGA GAGCGGCAGG AAACCAACCT ATGCGGAGGA GTGTGCGTCC 
ATGCTGGCCG TCACCTTCAG CAGCGGGAAC ACACCGCTGC GCAGCATAGT GACGTCAGAC 
TGGTCTCTGC AGAGCGGCAC CGGCTGTACT AGTGGGCACA CGGGCACCTC CGCCGCTGCT 
CCTCTGGCTG CAGGGATGGT GGCGCTGATG CTGCAGGTGC GGCCCTGTCT GAGCTGGCGA 
GATGTGCAGC ACATCATCAC CTACACCGCC ACACAGCATG ACCTTCAGGC GGACTGGGTC 
ACTAATGGAG CTGGTTTCCA TCACAGCCAC AAGTACGGCT TCGGCCTCCT GAACGCCTGG 
AGACTCGTCA ATGCTGCAAA GGTTTGGGAG TCTGTCCCCT TCCTGGTGTC CTACCAGAGT 
CCAGTTCTGA GGGTCAATGA GGTCATCACG ACCTCCACAA ACCTCACACA AACCTGGAAC 
GTGTCTGAGT CTGACCTGCA GCGCTCCGGT ATGCAGACTC TGGAGCATGT GTCCGTGACT 
CTCAGCATTC AGCATCCCAG AAGAGGAAAC CTGCAGATCC TGCTGCTCTG CCCCAGCGGC 
ATCAGCTCCC TGATTGGAGC ACGCAGGGCA CTGGACGTAG ATTCTGCAGG CCTGACGGAC 
TGGACGTTCT CCACCGTGCG CTGCTGGGGA GAGCAAGCCG AGGGCCAGTA CAGCCTGCTG 
ATCATGGACG ACGCGCCTCT GTCCTCAGGT ATTCTGAAGA GCTGGAAACT GACGCTGTAC 
GGCTCGTCTC TGTCCCATCA GCAGGTCACA GACAGACAGA GAGTTGTTGA GGAGGCCATG 
AGTGGACATT ACCTGAGCAG CAGCTTCTCT CTGCCGTGTC CACCGGGTAT AGATGTGCCT 
GCGGAGATCG TCAACCCCTT CACCTCCAGC AGCCTCAAGT CTCTGCTGCT GCTGGGTTGT 
TTCACGCTCT TCTGGTCGCT CTACTACACT CTGGAGGTGG TGCTCACACA CTGGGACTGG 
CGCGGTGGGT GTGTCCGCGG GCGGGACGGC GACGCCGGAT ACTCCAGACT GTCCCGGGAC 
GAGGCTCAGA CGGACCCTCA GCAGGTGGAG GTCCTGCTGG AGACACACAG CCAGGACAAA 
GTGCTGCTCA TAGCGGACAC ACACACGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_021336996.1
CDS	225..2354
Translation	MASCSSRVCLGLYPLLLLFSSSSSSCAPGRSWAVQLQPDSLSSAGSPDLLAQAVAQDVGLRSHGQIGQLEGHYLLCQDPAQGEDWRWMEAALDRHPHVAWHSQENVLRRSKRSVHFNDPKFPSQWHLHNDMKRGMDINVTGVWERNITGAGVTVVVVDDGIQHNLADIQPNYSPEGSYDLNSNDPDPMPHPDGPSDNHHGTRCAGEIAAVSNNSFCAVGVAYGSRVAGIRVLDGPLTDSMEAIAFNKHYQVNDIYSCSWGPDDDGRTVDGPHPLGKAALQHGVIAGRKGFGSIFIVASGNGGQNQDNCNYDGYANSIYTVTIGAVDESGRKPTYAEECASMLAVTFSSGNTPLRSIVTSDWSLQSGTGCTSGHTGTSAAAPLAAGMVALMLQVRPCLSWRDVQHIITYTATQHDLQADWVTNGAGFHHSHKYGFGLLNAWRLVNAAKVWESVPFLVSYQSPVLRVNEVITTSTNLTQTWNVSESDLQRSGMQTLEHVSVTLSIQHPRRGNLQILLLCPSGISSLIGARRALDVDSAGLTDWTFSTVRCWGEQAEGQYSLLIMDDAPLSSGILKSWKLTLYGSSLSHQQVTDRQRVVEEAMSGHYLSSSFSLPCPPGIDVPAEIVNPFTSSSLKSLLLLGCFTLFWSLYYTLEVVLTHWDWRGGCVRGRDGDAGYSRLSRDEAQTDPQQVEVLLETHSQDKVLLIADTHT

Target ORF information:

RefSeq Version	XM_021481321.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio proprotein convertase subtilisin/kexin type 7 (pcsk7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_021481321.1

ORF Insert Sequence:

ATGGCGTCCT GCTCCTCCCG GGTGTGTTTG GGACTGTACC CGCTGCTCCT GCTGTTCTCC 
TCCTCCTCCT CCTCATGTGC TCCGGGGCGC TCCTGGGCGG TGCAACTTCA GCCGGACTCC 
CTGAGCTCTG CCGGGTCTCC GGATCTGCTG GCCCAGGCGG TGGCACAGGA TGTGGGTCTG 
CGGAGCCACG GGCAGATCGG GCAGCTGGAG GGGCACTACC TGCTGTGCCA GGACCCAGCG 
CAGGGCGAGG ACTGGCGCTG GATGGAGGCT GCTCTGGACA GGCACCCTCA CGTGGCCTGG 
CACTCGCAGG AAAATGTGCT GCGGCGCTCC AAGAGGAGTG TGCACTTCAA TGACCCTAAA 
TTTCCCAGTC AGTGGCACCT GCACAATGAC ATGAAGCGAG GGATGGACAT CAATGTGACG 
GGCGTGTGGG AGAGGAACAT CACCGGCGCG GGCGTCACTG TGGTGGTGGT GGACGACGGC 
ATTCAGCACA ACCTGGCAGA CATCCAGCCT AACTATAGTC CTGAAGGCAG CTATGACCTG 
AACTCTAATG ACCCAGACCC CATGCCTCAC CCAGACGGTC CCAGTGATAA TCATCACGGC 
ACGCGCTGCG CTGGAGAGAT CGCCGCCGTC TCCAACAACA GCTTCTGTGC GGTGGGCGTG 
GCATACGGCA GCAGGGTGGC CGGCATCAGA GTGTTGGACG GGCCGCTCAC AGACAGTATG 
GAGGCCATCG CTTTCAACAA GCATTACCAG GTCAATGACA TCTACAGCTG CAGTTGGGGT 
CCAGATGATG ACGGCCGGAC GGTTGACGGA CCGCATCCAT TAGGCAAGGC GGCGCTGCAG 
CACGGTGTGA TCGCGGGCCG CAAGGGTTTC GGCAGCATCT TCATTGTGGC CAGTGGCAAT 
GGAGGACAGA ATCAGGACAA CTGCAACTAC GACGGCTACG CTAACTCCAT CTACACCGTC 
ACCATCGGAG CAGTGGACGA GAGCGGCAGG AAACCAACCT ATGCGGAGGA GTGTGCGTCC 
ATGCTGGCCG TCACCTTCAG CAGCGGGAAC ACACCGCTGC GCAGCATAGT GACGTCAGAC 
TGGTCTCTGC AGAGCGGCAC CGGCTGTACT AGTGGGCACA CGGGCACCTC CGCCGCTGCT 
CCTCTGGCTG CAGGGATGGT GGCGCTGATG CTGCAGGTGC GGCCCTGTCT GAGCTGGCGA 
GATGTGCAGC ACATCATCAC CTACACCGCC ACACAGCATG ACCTTCAGGC GGACTGGGTC 
ACTAATGGAG CTGGTTTCCA TCACAGCCAC AAGTACGGCT TCGGCCTCCT GAACGCCTGG 
AGACTCGTCA ATGCTGCAAA GGTTTGGGAG TCTGTCCCCT TCCTGGTGTC CTACCAGAGT 
CCAGTTCTGA GGGTCAATGA GGTCATCACG ACCTCCACAA ACCTCACACA AACCTGGAAC 
GTGTCTGAGT CTGACCTGCA GCGCTCCGGT ATGCAGACTC TGGAGCATGT GTCCGTGACT 
CTCAGCATTC AGCATCCCAG AAGAGGAAAC CTGCAGATCC TGCTGCTCTG CCCCAGCGGC 
ATCAGCTCCC TGATTGGAGC ACGCAGGGCA CTGGACGTAG ATTCTGCAGG CCTGACGGAC 
TGGACGTTCT CCACCGTGCG CTGCTGGGGA GAGCAAGCCG AGGGCCAGTA CAGCCTGCTG 
ATCATGGACG ACGCGCCTCT GTCCTCAGGT ATTCTGAAGA GCTGGAAACT GACGCTGTAC 
GGCTCGTCTC TGTCCCATCA GCAGGTCACA GACAGACAGA GAGTTGTTGA GGAGGCCATG 
AGTGGACATT ACCTGAGCAG CAGCTTCTCT CTGCCGTGTC CACCGGGTAT AGATGTGCCT 
GCGGAGATCG TCAACCCCTT CACCTCCAGC AGCCTCAAGT CTCTGCTGCT GCTGGGTTGT 
TTCACGCTCT TCTGGTCGCT CTACTACACT CTGGAGGTGG TGCTCACACA CTGGGACTGG 
CGCGGTGGGT GTGTCCGCGG GCGGGACGGC GACGCCGGAT ACTCCAGACT GTCCCGGGAC 
GAGGCTCAGA CGGACCCTCA GCAGGTGGAG GTCCTGCTGG AGACACACAG CCAGGACAAA 
GTGCTGCTCA TAGCGGACAC ACACACGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulation of the proprotein convertases expression and activity during regenerative angiogenesis: Role of hypoxia-inducible factor (HIF).
European journal of cell biology96(5)457-468(2017 Aug)
Ma J,Evrard S,Badiola I,Siegfried G,Khatib AM

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Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

RFX transcription factors are essential for hearing in mice.
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pcsk7 cDNA ORF clone, Danio rerio(zebrafish)

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