PCSK7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PCSK7
Entrez Gene ID	9159
Full Name	proprotein convertase subtilisin/kexin type 7
Synonyms	LPC,PC7,PC8,SPC7
General protein information	Preferred Names proprotein convertase subtilisin/kexin type 7 Names proprotein convertase subtilisin/kexin type 7 lymphoma proprotein convertase prohormone convertase 7 prohormone convertase PC7 proprotein convertase 7 proprotein convertase 8 proprotein convertase PC7 proprotein convertase subtilisin/kexin type 7 precursor variant 2 subtilisin/kexin-like protease PC7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q23.3
Summary	This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014].
Disorder MIM:	604872

mRNA and Protein(s)

mRNA	Protein	Name
XM_017018546.1	XP_016874035.1	proprotein convertase subtilisin/kexin type 7 isoform X1
XM_024448764.1	XP_024304532.1	proprotein convertase subtilisin/kexin type 7 isoform X1
NM_004716.4	NP_004707.2	proprotein convertase subtilisin/kexin type 7 preproprotein
XM_006718940.3	XP_006719003.1	proprotein convertase subtilisin/kexin type 7 isoform X1
NM_004716.3	NP_004707.2	proprotein convertase subtilisin/kexin type 7 preproprotein
XM_024448765.1	XP_024304533.1	proprotein convertase subtilisin/kexin type 7 isoform X2
XM_006718940.4	XP_006719003.1	proprotein convertase subtilisin/kexin type 7 isoform X2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PCSK7	XP_508776.2
Bos taurus (cattle)	PCSK7	NP_001179907.1
Danio rerio (zebrafish)	pcsk7	NP_001076494.1
Gallus gallus (chicken)	PCSK7	NP_001025528.1
	PCSK7	XP_001093007.1
Canis lupus familiaris (dog)	PCSK7	XP_850224.1
Xenopus tropicalis (tropical clawed frog)	pcsk7	XP_002932953.2
Homo sapiens (human)	PCSK7	NP_004707.2
Mus musculus (house mouse)	Pcsk7	NP_001268863.1
Rattus norvegicus (Norway rat)	Pcsk7	NP_062119.1

Gene Ontology
Bibliography

Related articles in PubMed

Proprotein convertase 7 rs236918 associated with liver fibrosis in Italian patients with HFE-related hemochromatosis.
Pelucchi S, Galimberti S, Greni F, Rametta R, Mariani R, Pelloni I, Girelli D, Busti F, Ravasi G, Valsecchi MG, Valenti L, Piperno A
Journal of gastroenterology and hepatology31(7)1342-8(2016 Jul)

Genome-wide association study of serum lipids confirms previously reported associations as well as new associations of common SNPs within PCSK7 gene with triglyceride.
Kurano M, Tsukamoto K, Kamitsuji S, Kamatani N, Hara M, Ishikawa T, Kim BJ, Moon S, Jin Kim Y, Teramoto T
Journal of human genetics61(5)427-33(2016 May)

Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cells.
Fu J, Zhang J, Gong Y, Testa CL, Klein-Szanto AJ
Molecular carcinogenesis54(9)698-706(2015 Sep)

PCSK7 genotype modifies effect of a weight-loss diet on 2-year changes of insulin resistance: the POUNDS LOST trial.
Huang T, Huang J, Qi Q, Li Y, Bray GA, Rood J, Sacks FM, Qi L
Diabetes care38(3)439-44(2015 Mar)

Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis.
Stickel F, Buch S, Zoller H, Hultcrantz R, Gallati S, ?sterreicher C, Finkenstedt A, Stadlmayr A, Aigner E, Sahinbegovic E, Sarrazin C, Schafmayer C, Braun F, Erhart W, Nothnagel M, Lerch MM, Mayerle J, V?lzke H, Schaller A, Kratzer W, Boehm BO, Sipos B, D'Amato M, Torkvist L, Stal P, Arlt A, Franke A, Becker T, Krawczak M, Zwerina J, Berg T, Hinrichsen H, Krones E, Dejaco C, Strasser M, Datz C, Hampe J
Human molecular genetics23(14)3883-90(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PCSK7 rs236918 C allele is a risk factor for cirrhosis development in Italian patients with HFE-Hemochromatosis.
Title: Proprotein convertase 7 rs236918 associated with liver fibrosis in Italian patients with HFE-related hemochromatosis.

Our present data suggest that PCSK7 as well as PCSK9 may be associated with lipids, especially triglyceride, and may serve as a candidate for a new drug target to treat lipid abnormality syndromes.
Title: Genome-wide association study of serum lipids confirms previously reported associations as well as new associations of common SNPs within PCSK7 gene with triglyceride.

Furin and PC7 siRNAs induced HIF-1alpha protein by increasing its translation, resulting in upregulation of VEGF-A.
Title: Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cells.

The data suggest that PCSK7 genotypes may interact with dietary CHO intake on changes in insulin sensitivity in the white Americans.
Title: PCSK7 genotype modifies effect of a weight-loss diet on 2-year changes of insulin resistance: the POUNDS LOST trial.

Results demonstrate that PCSK7 variation is a strong host risk factor of liver cirrhosis in hereditary hemochromatosis patients homozygous for HFE C282Y.
Title: Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis.

The following PCSK7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PCSK7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11691	NM_004716.4 Latest version!	Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
OHu45922	XM_006718940.4 Latest version!	Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), transcript variant X8, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OHu45922	XM_017018546.1 Latest version!	Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), transcript variant X8, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OHu45922	XM_024448765.1 Latest version!	Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), transcript variant X9, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OHu103656	XM_024448764.1 Latest version!	Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
View Old Accession Versions >>
OHu11691	NM_004716.3	Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
OHu45922	XM_006718940.3	Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), transcript variant X7, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PCSK7 ( NM_004716.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004707.2 Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), mRNA.

Price & Availability↑

CloneID	OHu11691
Clone ID Related Accession (Same CDS sequence)	NM_004716.4 , NM_004716.3
Accession Version	NM_004716.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2358bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	proprotein convertase subtilisin/kexin type 7 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC010696.1, EL950661.1 and AP000892.4. On May 17, 2019 this sequence version replaced NM_004716.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC010696.1, SRR1660807.211522.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000320934.8/ ENSP00000325917.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCGAAGG GGAGGCAGAA AGTGCCACAC TTGGATGCCC CCCTGGGCCT GCCCACCTGC 
CTCTGGCTGG AATTAGCCGG GCTCTTCTTA CTGGTTCCCT GGGTCATGGG CCTGGCAGGG 
ACAGGTGGGC CTGATGGCCA GGGCACAGGG GGGCCGAGCT GGGCTGTGCA CCTGGAAAGC 
CTGGAAGGTG ACGGGGAGGA AGAGACTCTG GAGCAGCAGG CGGATGCCTT GGCCCAGGCA 
GCAGGGCTGG TGAATGCTGG ACGCATCGGA GAGCTTCAGG GGCACTACCT CTTTGTCCAG 
CCTGCTGGGC ACAGGCCGGC CCTGGAGGTG GAGGCCATCC GGCAGCAGGT GGAGGCTGTG 
TTGGCTGGGC ATGAAGCTGT GCGCTGGCAC TCAGAGCAGA GGCTGCTAAG GCGGGCCAAG 
CGCAGCGTCC ACTTCAACGA CCCCAAGTAC CCGCAGCAAT GGCACCTGAA TAACCGACGG 
AGCCCGGGCA GGGACATCAA CGTGACGGGT GTGTGGGAAC GCAATGTGAC TGGGCGAGGG 
GTGACGGTGG TGGTAGTGGA TGACGGAGTG GAACACACCA TCCAGGACAT TGCACCCAAC 
TATAGCCCTG AGGGTAGCTA TGACCTCAAC TCTAATGACC CTGACCCCAT GCCCCACCCG 
GATGTGGAGA ATGGCAACCA CCATGGCACG CGATGTGCAG GAGAGATCGC GGCTGTGCCC 
AACAACAGCT TCTGTGCCGT GGGCGTGGCC TACGGGAGCC GCATCGCAGG TATCCGGGTA 
CTGGATGGAC CTCTCACAGA CAGCATGGAG GCAGTGGCGT TCAACAAGCA CTATCAGATC 
AATGACATCT ACAGCTGCAG CTGGGGACCA GATGACGATG GGAAGACAGT GGATGGCCCC 
CATCAGCTTG GAAAGGCTGC CTTACAACAT GGGGTGATTG CTGGTCGCCA GGGCTTTGGG 
AGCATCTTTG TGGTAGCCAG TGGCAACGGA GGCCAACACA ACGACAACTG CAACTACGAT 
GGCTACGCCA ACTCCATCTA CACCGTCACC ATAGGAGCTG TGGATGAGGA GGGACGCATG 
CCTTTCTATG CAGAAGAATG TGCCTCCATG CTGGCAGTCA CCTTCAGTGG TGGGGACAAG 
ATGCTTCGGA GCATTGTGAC CACTGACTGG GACCTTCAGA AGGGCACTGG CTGCACTGAG 
GGCCACACAG GGACCTCAGC TGCAGCGCCT CTGGCAGCTG GCATGATAGC CTTAATGCTG 
CAGGTGCGGC CCTGCCTCAC GTGGCGTGAC GTCCAGCACA TCATTGTCTT CACAGCCACC 
CGGTATGAGG ATCGCCGTGC AGAGTGGGTC ACCAACGAGG CAGGCTTCAG CCATAGCCAC 
CAGCACGGTT TCGGCCTCCT CAACGCCTGG AGGCTCGTGA ATGCAGCCAA GATCTGGACA 
TCTGTCCCTT ACTTAGCATC CTACGTCAGT CCCGTGTTAA AAGAAAACAA GGCGATTCCG 
CAGTCCCCCC GTTCCCTGGA GGTCCTGTGG AATGTCAGCA GGATGGACCT GGAGATGTCA 
GGGCTGAAGA CCCTGGAGCA TGTGGCAGTG ACAGTCTCCA TCACTCACCC ACGGCGCGGC 
AGCTTGGAGC TGAAGCTGTT CTGCCCCAGT GGCATGATGT CCCTCATCGG CGCCCCCCGC 
AGCATGGACT CGGATCCCAA CGGCTTCAAT GACTGGACCT TCTCCACTGT GCGATGCTGG 
GGGGAGAGAG CCCGAGGGAC CTACAGGCTT GTCATCAGGG ATGTCGGGGA TGAGTCATTC 
CAGGTCGGCA TCCTCCGGCA ATGGCAGCTG ACCCTATATG GCTCTGTGTG GAGTGCAGTA 
GACATCAGGG ACAGACAAAG GCTGTTAGAG AGTGCCATGA GTGGAAAATA CCTGCACGAT 
GACTTCGCCC TGCCCTGCCC ACCGGGGCTG AAAATTCCTG AGGAAGATGG TTACACCATC 
ACCCCCAACA CCCTCAAGAC CCTGGTGCTG GTAGGCTGTT TCACCGTCTT CTGGACTGTT 
TACTACATGC TGGAAGTATA TTTGAGCCAG AGGAATGTGG CTTCCAATCA AGTTTGTAGG 
AGTGGACCCT GCCACTGGCC CCATCGGAGC CGGAAAGCCA AGGAGGAAGG GACAGAGCTA 
GAATCAGTGC CACTTTGCAG CAGCAAGGAT CCAGACGAAG TGGAAACAGA GAGCAGGGGC 
CCTCCCACCA CCTCTGACCT CCTTGCCCCA GACCTGCTGG AGCAAGGGGA CTGGAGCCTG 
TCCCAGAACA AGAGCGCCCT GGACTGCCCT CATCAGCACC TAGACGTACC GCACGGGAAG 
GAGGAGCAGA TCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004707.2
CDS	180..2537
Translation	MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAVLAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC

Target ORF information:

RefSeq Version	NM_004716.4
Organism	Homo sapiens(human)
Definition	Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004716.4

ORF Insert Sequence:

ATGCCGAAGG GGAGGCAGAA AGTGCCACAC TTGGATGCCC CCCTGGGCCT GCCCACCTGC 
CTCTGGCTGG AATTAGCCGG GCTCTTCTTA CTGGTTCCCT GGGTCATGGG CCTGGCAGGG 
ACAGGTGGGC CTGATGGCCA GGGCACAGGG GGGCCGAGCT GGGCTGTGCA CCTGGAAAGC 
CTGGAAGGTG ACGGGGAGGA AGAGACTCTG GAGCAGCAGG CGGATGCCTT GGCCCAGGCA 
GCAGGGCTGG TGAATGCTGG ACGCATCGGA GAGCTTCAGG GGCACTACCT CTTTGTCCAG 
CCTGCTGGGC ACAGGCCGGC CCTGGAGGTG GAGGCCATCC GGCAGCAGGT GGAGGCTGTG 
TTGGCTGGGC ATGAAGCTGT GCGCTGGCAC TCAGAGCAGA GGCTGCTAAG GCGGGCCAAG 
CGCAGCGTCC ACTTCAACGA CCCCAAGTAC CCGCAGCAAT GGCACCTGAA TAACCGACGG 
AGCCCGGGCA GGGACATCAA CGTGACGGGT GTGTGGGAAC GCAATGTGAC TGGGCGAGGG 
GTGACGGTGG TGGTAGTGGA TGACGGAGTG GAACACACCA TCCAGGACAT TGCACCCAAC 
TATAGCCCTG AGGGTAGCTA TGACCTCAAC TCTAATGACC CTGACCCCAT GCCCCACCCG 
GATGTGGAGA ATGGCAACCA CCATGGCACG CGATGTGCAG GAGAGATCGC GGCTGTGCCC 
AACAACAGCT TCTGTGCCGT GGGCGTGGCC TACGGGAGCC GCATCGCAGG TATCCGGGTA 
CTGGATGGAC CTCTCACAGA CAGCATGGAG GCAGTGGCGT TCAACAAGCA CTATCAGATC 
AATGACATCT ACAGCTGCAG CTGGGGACCA GATGACGATG GGAAGACAGT GGATGGCCCC 
CATCAGCTTG GAAAGGCTGC CTTACAACAT GGGGTGATTG CTGGTCGCCA GGGCTTTGGG 
AGCATCTTTG TGGTAGCCAG TGGCAACGGA GGCCAACACA ACGACAACTG CAACTACGAT 
GGCTACGCCA ACTCCATCTA CACCGTCACC ATAGGAGCTG TGGATGAGGA GGGACGCATG 
CCTTTCTATG CAGAAGAATG TGCCTCCATG CTGGCAGTCA CCTTCAGTGG TGGGGACAAG 
ATGCTTCGGA GCATTGTGAC CACTGACTGG GACCTTCAGA AGGGCACTGG CTGCACTGAG 
GGCCACACAG GGACCTCAGC TGCAGCGCCT CTGGCAGCTG GCATGATAGC CTTAATGCTG 
CAGGTGCGGC CCTGCCTCAC GTGGCGTGAC GTCCAGCACA TCATTGTCTT CACAGCCACC 
CGGTATGAGG ATCGCCGTGC AGAGTGGGTC ACCAACGAGG CAGGCTTCAG CCATAGCCAC 
CAGCACGGTT TCGGCCTCCT CAACGCCTGG AGGCTCGTGA ATGCAGCCAA GATCTGGACA 
TCTGTCCCTT ACTTAGCATC CTACGTCAGT CCCGTGTTAA AAGAAAACAA GGCGATTCCG 
CAGTCCCCCC GTTCCCTGGA GGTCCTGTGG AATGTCAGCA GGATGGACCT GGAGATGTCA 
GGGCTGAAGA CCCTGGAGCA TGTGGCAGTG ACAGTCTCCA TCACTCACCC ACGGCGCGGC 
AGCTTGGAGC TGAAGCTGTT CTGCCCCAGT GGCATGATGT CCCTCATCGG CGCCCCCCGC 
AGCATGGACT CGGATCCCAA CGGCTTCAAT GACTGGACCT TCTCCACTGT GCGATGCTGG 
GGGGAGAGAG CCCGAGGGAC CTACAGGCTT GTCATCAGGG ATGTCGGGGA TGAGTCATTC 
CAGGTCGGCA TCCTCCGGCA ATGGCAGCTG ACCCTATATG GCTCTGTGTG GAGTGCAGTA 
GACATCAGGG ACAGACAAAG GCTGTTAGAG AGTGCCATGA GTGGAAAATA CCTGCACGAT 
GACTTCGCCC TGCCCTGCCC ACCGGGGCTG AAAATTCCTG AGGAAGATGG TTACACCATC 
ACCCCCAACA CCCTCAAGAC CCTGGTGCTG GTAGGCTGTT TCACCGTCTT CTGGACTGTT 
TACTACATGC TGGAAGTATA TTTGAGCCAG AGGAATGTGG CTTCCAATCA AGTTTGTAGG 
AGTGGACCCT GCCACTGGCC CCATCGGAGC CGGAAAGCCA AGGAGGAAGG GACAGAGCTA 
GAATCAGTGC CACTTTGCAG CAGCAAGGAT CCAGACGAAG TGGAAACAGA GAGCAGGGGC 
CCTCCCACCA CCTCTGACCT CCTTGCCCCA GACCTGCTGG AGCAAGGGGA CTGGAGCCTG 
TCCCAGAACA AGAGCGCCCT GGACTGCCCT CATCAGCACC TAGACGTACC GCACGGGAAG 
GAGGAGCAGA TCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCSK7 ( NM_004716.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004707.2 Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), mRNA.

Price & Availability↑

CloneID	OHu11691
Clone ID Related Accession (Same CDS sequence)	NM_004716.4 , NM_004716.3
Accession Version	NM_004716.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2358bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	proprotein convertase subtilisin/kexin type 7 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP000892.4, DA126121.1, BC010696.1 and EL950661.1. On Feb 4, 2014 this sequence version replaced NM_004716.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.35757.1, BC010696.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGAAGG GGAGGCAGAA AGTGCCACAC TTGGATGCCC CCCTGGGCCT GCCCACCTGC 
CTCTGGCTGG AATTAGCCGG GCTCTTCTTA CTGGTTCCCT GGGTCATGGG CCTGGCAGGG 
ACAGGTGGGC CTGATGGCCA GGGCACAGGG GGGCCGAGCT GGGCTGTGCA CCTGGAAAGC 
CTGGAAGGTG ACGGGGAGGA AGAGACTCTG GAGCAGCAGG CGGATGCCTT GGCCCAGGCA 
GCAGGGCTGG TGAATGCTGG ACGCATCGGA GAGCTTCAGG GGCACTACCT CTTTGTCCAG 
CCTGCTGGGC ACAGGCCGGC CCTGGAGGTG GAGGCCATCC GGCAGCAGGT GGAGGCTGTG 
TTGGCTGGGC ATGAAGCTGT GCGCTGGCAC TCAGAGCAGA GGCTGCTAAG GCGGGCCAAG 
CGCAGCGTCC ACTTCAACGA CCCCAAGTAC CCGCAGCAAT GGCACCTGAA TAACCGACGG 
AGCCCGGGCA GGGACATCAA CGTGACGGGT GTGTGGGAAC GCAATGTGAC TGGGCGAGGG 
GTGACGGTGG TGGTAGTGGA TGACGGAGTG GAACACACCA TCCAGGACAT TGCACCCAAC 
TATAGCCCTG AGGGTAGCTA TGACCTCAAC TCTAATGACC CTGACCCCAT GCCCCACCCG 
GATGTGGAGA ATGGCAACCA CCATGGCACG CGATGTGCAG GAGAGATCGC GGCTGTGCCC 
AACAACAGCT TCTGTGCCGT GGGCGTGGCC TACGGGAGCC GCATCGCAGG TATCCGGGTA 
CTGGATGGAC CTCTCACAGA CAGCATGGAG GCAGTGGCGT TCAACAAGCA CTATCAGATC 
AATGACATCT ACAGCTGCAG CTGGGGACCA GATGACGATG GGAAGACAGT GGATGGCCCC 
CATCAGCTTG GAAAGGCTGC CTTACAACAT GGGGTGATTG CTGGTCGCCA GGGCTTTGGG 
AGCATCTTTG TGGTAGCCAG TGGCAACGGA GGCCAACACA ACGACAACTG CAACTACGAT 
GGCTACGCCA ACTCCATCTA CACCGTCACC ATAGGAGCTG TGGATGAGGA GGGACGCATG 
CCTTTCTATG CAGAAGAATG TGCCTCCATG CTGGCAGTCA CCTTCAGTGG TGGGGACAAG 
ATGCTTCGGA GCATTGTGAC CACTGACTGG GACCTTCAGA AGGGCACTGG CTGCACTGAG 
GGCCACACAG GGACCTCAGC TGCAGCGCCT CTGGCAGCTG GCATGATAGC CTTAATGCTG 
CAGGTGCGGC CCTGCCTCAC GTGGCGTGAC GTCCAGCACA TCATTGTCTT CACAGCCACC 
CGGTATGAGG ATCGCCGTGC AGAGTGGGTC ACCAACGAGG CAGGCTTCAG CCATAGCCAC 
CAGCACGGTT TCGGCCTCCT CAACGCCTGG AGGCTCGTGA ATGCAGCCAA GATCTGGACA 
TCTGTCCCTT ACTTAGCATC CTACGTCAGT CCCGTGTTAA AAGAAAACAA GGCGATTCCG 
CAGTCCCCCC GTTCCCTGGA GGTCCTGTGG AATGTCAGCA GGATGGACCT GGAGATGTCA 
GGGCTGAAGA CCCTGGAGCA TGTGGCAGTG ACAGTCTCCA TCACTCACCC ACGGCGCGGC 
AGCTTGGAGC TGAAGCTGTT CTGCCCCAGT GGCATGATGT CCCTCATCGG CGCCCCCCGC 
AGCATGGACT CGGATCCCAA CGGCTTCAAT GACTGGACCT TCTCCACTGT GCGATGCTGG 
GGGGAGAGAG CCCGAGGGAC CTACAGGCTT GTCATCAGGG ATGTCGGGGA TGAGTCATTC 
CAGGTCGGCA TCCTCCGGCA ATGGCAGCTG ACCCTATATG GCTCTGTGTG GAGTGCAGTA 
GACATCAGGG ACAGACAAAG GCTGTTAGAG AGTGCCATGA GTGGAAAATA CCTGCACGAT 
GACTTCGCCC TGCCCTGCCC ACCGGGGCTG AAAATTCCTG AGGAAGATGG TTACACCATC 
ACCCCCAACA CCCTCAAGAC CCTGGTGCTG GTAGGCTGTT TCACCGTCTT CTGGACTGTT 
TACTACATGC TGGAAGTATA TTTGAGCCAG AGGAATGTGG CTTCCAATCA AGTTTGTAGG 
AGTGGACCCT GCCACTGGCC CCATCGGAGC CGGAAAGCCA AGGAGGAAGG GACAGAGCTA 
GAATCAGTGC CACTTTGCAG CAGCAAGGAT CCAGACGAAG TGGAAACAGA GAGCAGGGGC 
CCTCCCACCA CCTCTGACCT CCTTGCCCCA GACCTGCTGG AGCAAGGGGA CTGGAGCCTG 
TCCCAGAACA AGAGCGCCCT GGACTGCCCT CATCAGCACC TAGACGTACC GCACGGGAAG 
GAGGAGCAGA TCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004707.2
CDS	632..2989
Translation	MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAVLAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC

Target ORF information:

RefSeq Version	NM_004716.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004716.3

ORF Insert Sequence:

ATGCCGAAGG GGAGGCAGAA AGTGCCACAC TTGGATGCCC CCCTGGGCCT GCCCACCTGC 
CTCTGGCTGG AATTAGCCGG GCTCTTCTTA CTGGTTCCCT GGGTCATGGG CCTGGCAGGG 
ACAGGTGGGC CTGATGGCCA GGGCACAGGG GGGCCGAGCT GGGCTGTGCA CCTGGAAAGC 
CTGGAAGGTG ACGGGGAGGA AGAGACTCTG GAGCAGCAGG CGGATGCCTT GGCCCAGGCA 
GCAGGGCTGG TGAATGCTGG ACGCATCGGA GAGCTTCAGG GGCACTACCT CTTTGTCCAG 
CCTGCTGGGC ACAGGCCGGC CCTGGAGGTG GAGGCCATCC GGCAGCAGGT GGAGGCTGTG 
TTGGCTGGGC ATGAAGCTGT GCGCTGGCAC TCAGAGCAGA GGCTGCTAAG GCGGGCCAAG 
CGCAGCGTCC ACTTCAACGA CCCCAAGTAC CCGCAGCAAT GGCACCTGAA TAACCGACGG 
AGCCCGGGCA GGGACATCAA CGTGACGGGT GTGTGGGAAC GCAATGTGAC TGGGCGAGGG 
GTGACGGTGG TGGTAGTGGA TGACGGAGTG GAACACACCA TCCAGGACAT TGCACCCAAC 
TATAGCCCTG AGGGTAGCTA TGACCTCAAC TCTAATGACC CTGACCCCAT GCCCCACCCG 
GATGTGGAGA ATGGCAACCA CCATGGCACG CGATGTGCAG GAGAGATCGC GGCTGTGCCC 
AACAACAGCT TCTGTGCCGT GGGCGTGGCC TACGGGAGCC GCATCGCAGG TATCCGGGTA 
CTGGATGGAC CTCTCACAGA CAGCATGGAG GCAGTGGCGT TCAACAAGCA CTATCAGATC 
AATGACATCT ACAGCTGCAG CTGGGGACCA GATGACGATG GGAAGACAGT GGATGGCCCC 
CATCAGCTTG GAAAGGCTGC CTTACAACAT GGGGTGATTG CTGGTCGCCA GGGCTTTGGG 
AGCATCTTTG TGGTAGCCAG TGGCAACGGA GGCCAACACA ACGACAACTG CAACTACGAT 
GGCTACGCCA ACTCCATCTA CACCGTCACC ATAGGAGCTG TGGATGAGGA GGGACGCATG 
CCTTTCTATG CAGAAGAATG TGCCTCCATG CTGGCAGTCA CCTTCAGTGG TGGGGACAAG 
ATGCTTCGGA GCATTGTGAC CACTGACTGG GACCTTCAGA AGGGCACTGG CTGCACTGAG 
GGCCACACAG GGACCTCAGC TGCAGCGCCT CTGGCAGCTG GCATGATAGC CTTAATGCTG 
CAGGTGCGGC CCTGCCTCAC GTGGCGTGAC GTCCAGCACA TCATTGTCTT CACAGCCACC 
CGGTATGAGG ATCGCCGTGC AGAGTGGGTC ACCAACGAGG CAGGCTTCAG CCATAGCCAC 
CAGCACGGTT TCGGCCTCCT CAACGCCTGG AGGCTCGTGA ATGCAGCCAA GATCTGGACA 
TCTGTCCCTT ACTTAGCATC CTACGTCAGT CCCGTGTTAA AAGAAAACAA GGCGATTCCG 
CAGTCCCCCC GTTCCCTGGA GGTCCTGTGG AATGTCAGCA GGATGGACCT GGAGATGTCA 
GGGCTGAAGA CCCTGGAGCA TGTGGCAGTG ACAGTCTCCA TCACTCACCC ACGGCGCGGC 
AGCTTGGAGC TGAAGCTGTT CTGCCCCAGT GGCATGATGT CCCTCATCGG CGCCCCCCGC 
AGCATGGACT CGGATCCCAA CGGCTTCAAT GACTGGACCT TCTCCACTGT GCGATGCTGG 
GGGGAGAGAG CCCGAGGGAC CTACAGGCTT GTCATCAGGG ATGTCGGGGA TGAGTCATTC 
CAGGTCGGCA TCCTCCGGCA ATGGCAGCTG ACCCTATATG GCTCTGTGTG GAGTGCAGTA 
GACATCAGGG ACAGACAAAG GCTGTTAGAG AGTGCCATGA GTGGAAAATA CCTGCACGAT 
GACTTCGCCC TGCCCTGCCC ACCGGGGCTG AAAATTCCTG AGGAAGATGG TTACACCATC 
ACCCCCAACA CCCTCAAGAC CCTGGTGCTG GTAGGCTGTT TCACCGTCTT CTGGACTGTT 
TACTACATGC TGGAAGTATA TTTGAGCCAG AGGAATGTGG CTTCCAATCA AGTTTGTAGG 
AGTGGACCCT GCCACTGGCC CCATCGGAGC CGGAAAGCCA AGGAGGAAGG GACAGAGCTA 
GAATCAGTGC CACTTTGCAG CAGCAAGGAT CCAGACGAAG TGGAAACAGA GAGCAGGGGC 
CCTCCCACCA CCTCTGACCT CCTTGCCCCA GACCTGCTGG AGCAAGGGGA CTGGAGCCTG 
TCCCAGAACA AGAGCGCCCT GGACTGCCCT CATCAGCACC TAGACGTACC GCACGGGAAG 
GAGGAGCAGA TCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCSK7 ( XM_017018546.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016874035.1 Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), transcript variant X8, mRNA.

Price & Availability↑

CloneID	OHu45922
Clone ID Related Accession (Same CDS sequence)	XM_017018546.1 , XM_006718940.3 , XM_024448765.1 , XM_006718940.4
Accession Version	XM_017018546.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1281bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	proprotein convertase subtilisin/kexin type 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTTTCT ATGCAGAAGA ATGTGCCTCC ATGCTGGCAG TCACCTTCAG TGGTGGGGAC 
AAGATGCTTC GGAGCATTGT GACCACTGAC TGGGACCTTC AGAAGGGCAC TGGCTGCACT 
GAGGGCCACA CAGGGACCTC AGCTGCAGCG CCTCTGGCAG CTGGCATGAT AGCCTTAATG 
CTGCAGGTGC GGCCCTGCCT CACGTGGCGT GACGTCCAGC ACATCATTGT CTTCACAGCC 
ACCCGGTATG AGGATCGCCG TGCAGAGTGG GTCACCAACG AGGCAGGCTT CAGCCATAGC 
CACCAGCACG GTTTCGGCCT CCTCAACGCC TGGAGGCTCG TGAATGCAGC CAAGATCTGG 
ACATCTGTCC CTTACTTAGC ATCCTACGTC AGTCCCGTGT TAAAAGAAAA CAAGGCGATT 
CCGCAGTCCC CCCGTTCCCT GGAGGTCCTG TGGAATGTCA GCAGGATGGA CCTGGAGATG 
TCAGGGCTGA AGACCCTGGA GCATGTGGCA GTGACAGTCT CCATCACTCA CCCACGGCGC 
GGCAGCTTGG AGCTGAAGCT GTTCTGCCCC AGTGGCATGA TGTCCCTCAT CGGCGCCCCC 
CGCAGCATGG ACTCGGATCC CAACGGCTTC AATGACTGGA CCTTCTCCAC TGTGCGATGC 
TGGGGGGAGA GAGCCCGAGG GACCTACAGG CTTGTCATCA GGGATGTCGG GGATGAGTCA 
TTCCAGGTCG GCATCCTCCG GCAATGGCAG CTGACCCTAT ATGGCTCTGT GTGGAGTGCA 
GTAGACATCA GGGACAGACA AAGGCTGTTA GAGAGTGCCA TGAGTGGAAA ATACCTGCAC 
GATGACTTCG CCCTGCCCTG CCCACCGGGG CTGAAAATTC CTGAGGAAGA TGGTTACACC 
ATCACCCCCA ACACCCTCAA GACCCTGGTG CTGGTAGGCT GTTTCACCGT CTTCTGGACT 
GTTTACTACA TGCTGGAAGT ATATTTGAGC CAGAGGAATG TGGCTTCCAA TCAAGTTTGT 
AGGAGTGGAC CCTGCCACTG GCCCCATCGG AGCCGGAAAG CCAAGGAGGA AGGGACAGAG 
CTAGAATCAG TGCCACTTTG CAGCAGCAAG GATCCAGACG AAGTGGAAAC AGAGAGCAGG 
GGCCCTCCCA CCACCTCTGA CCTCCTTGCC CCAGACCTGC TGGAGCAAGG GGACTGGAGC 
CTGTCCCAGA ACAAGAGCGC CCTGGACTGC CCTCATCAGC ACCTAGACGT ACCGCACGGG 
AAGGAGGAGC AGATCTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016874035.1
CDS	237..1517
Translation	MPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC

Target ORF information:

RefSeq Version	XM_017018546.1
Organism	Homo sapiens(human)
Definition	Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), transcript variant X8, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017018546.1

ORF Insert Sequence:

ATGCCTTTCT ATGCAGAAGA ATGTGCCTCC ATGCTGGCAG TCACCTTCAG TGGTGGGGAC 
AAGATGCTTC GGAGCATTGT GACCACTGAC TGGGACCTTC AGAAGGGCAC TGGCTGCACT 
GAGGGCCACA CAGGGACCTC AGCTGCAGCG CCTCTGGCAG CTGGCATGAT AGCCTTAATG 
CTGCAGGTGC GGCCCTGCCT CACGTGGCGT GACGTCCAGC ACATCATTGT CTTCACAGCC 
ACCCGGTATG AGGATCGCCG TGCAGAGTGG GTCACCAACG AGGCAGGCTT CAGCCATAGC 
CACCAGCACG GTTTCGGCCT CCTCAACGCC TGGAGGCTCG TGAATGCAGC CAAGATCTGG 
ACATCTGTCC CTTACTTAGC ATCCTACGTC AGTCCCGTGT TAAAAGAAAA CAAGGCGATT 
CCGCAGTCCC CCCGTTCCCT GGAGGTCCTG TGGAATGTCA GCAGGATGGA CCTGGAGATG 
TCAGGGCTGA AGACCCTGGA GCATGTGGCA GTGACAGTCT CCATCACTCA CCCACGGCGC 
GGCAGCTTGG AGCTGAAGCT GTTCTGCCCC AGTGGCATGA TGTCCCTCAT CGGCGCCCCC 
CGCAGCATGG ACTCGGATCC CAACGGCTTC AATGACTGGA CCTTCTCCAC TGTGCGATGC 
TGGGGGGAGA GAGCCCGAGG GACCTACAGG CTTGTCATCA GGGATGTCGG GGATGAGTCA 
TTCCAGGTCG GCATCCTCCG GCAATGGCAG CTGACCCTAT ATGGCTCTGT GTGGAGTGCA 
GTAGACATCA GGGACAGACA AAGGCTGTTA GAGAGTGCCA TGAGTGGAAA ATACCTGCAC 
GATGACTTCG CCCTGCCCTG CCCACCGGGG CTGAAAATTC CTGAGGAAGA TGGTTACACC 
ATCACCCCCA ACACCCTCAA GACCCTGGTG CTGGTAGGCT GTTTCACCGT CTTCTGGACT 
GTTTACTACA TGCTGGAAGT ATATTTGAGC CAGAGGAATG TGGCTTCCAA TCAAGTTTGT 
AGGAGTGGAC CCTGCCACTG GCCCCATCGG AGCCGGAAAG CCAAGGAGGA AGGGACAGAG 
CTAGAATCAG TGCCACTTTG CAGCAGCAAG GATCCAGACG AAGTGGAAAC AGAGAGCAGG 
GGCCCTCCCA CCACCTCTGA CCTCCTTGCC CCAGACCTGC TGGAGCAAGG GGACTGGAGC 
CTGTCCCAGA ACAAGAGCGC CCTGGACTGC CCTCATCAGC ACCTAGACGT ACCGCACGGG 
AAGGAGGAGC AGATCTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCSK7 ( XM_006718940.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006719003.1 Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), transcript variant X7, mRNA.

Price & Availability↑

CloneID	OHu45922
Clone ID Related Accession (Same CDS sequence)	XM_017018546.1 , XM_006718940.3 , XM_024448765.1 , XM_006718940.4
Accession Version	XM_006718940.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1281bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	proprotein convertase subtilisin/kexin type 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006718940.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTTTCT ATGCAGAAGA ATGTGCCTCC ATGCTGGCAG TCACCTTCAG TGGTGGGGAC 
AAGATGCTTC GGAGCATTGT GACCACTGAC TGGGACCTTC AGAAGGGCAC TGGCTGCACT 
GAGGGCCACA CAGGGACCTC AGCTGCAGCG CCTCTGGCAG CTGGCATGAT AGCCTTAATG 
CTGCAGGTGC GGCCCTGCCT CACGTGGCGT GACGTCCAGC ACATCATTGT CTTCACAGCC 
ACCCGGTATG AGGATCGCCG TGCAGAGTGG GTCACCAACG AGGCAGGCTT CAGCCATAGC 
CACCAGCACG GTTTCGGCCT CCTCAACGCC TGGAGGCTCG TGAATGCAGC CAAGATCTGG 
ACATCTGTCC CTTACTTAGC ATCCTACGTC AGTCCCGTGT TAAAAGAAAA CAAGGCGATT 
CCGCAGTCCC CCCGTTCCCT GGAGGTCCTG TGGAATGTCA GCAGGATGGA CCTGGAGATG 
TCAGGGCTGA AGACCCTGGA GCATGTGGCA GTGACAGTCT CCATCACTCA CCCACGGCGC 
GGCAGCTTGG AGCTGAAGCT GTTCTGCCCC AGTGGCATGA TGTCCCTCAT CGGCGCCCCC 
CGCAGCATGG ACTCGGATCC CAACGGCTTC AATGACTGGA CCTTCTCCAC TGTGCGATGC 
TGGGGGGAGA GAGCCCGAGG GACCTACAGG CTTGTCATCA GGGATGTCGG GGATGAGTCA 
TTCCAGGTCG GCATCCTCCG GCAATGGCAG CTGACCCTAT ATGGCTCTGT GTGGAGTGCA 
GTAGACATCA GGGACAGACA AAGGCTGTTA GAGAGTGCCA TGAGTGGAAA ATACCTGCAC 
GATGACTTCG CCCTGCCCTG CCCACCGGGG CTGAAAATTC CTGAGGAAGA TGGTTACACC 
ATCACCCCCA ACACCCTCAA GACCCTGGTG CTGGTAGGCT GTTTCACCGT CTTCTGGACT 
GTTTACTACA TGCTGGAAGT ATATTTGAGC CAGAGGAATG TGGCTTCCAA TCAAGTTTGT 
AGGAGTGGAC CCTGCCACTG GCCCCATCGG AGCCGGAAAG CCAAGGAGGA AGGGACAGAG 
CTAGAATCAG TGCCACTTTG CAGCAGCAAG GATCCAGACG AAGTGGAAAC AGAGAGCAGG 
GGCCCTCCCA CCACCTCTGA CCTCCTTGCC CCAGACCTGC TGGAGCAAGG GGACTGGAGC 
CTGTCCCAGA ACAAGAGCGC CCTGGACTGC CCTCATCAGC ACCTAGACGT ACCGCACGGG 
AAGGAGGAGC AGATCTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006719003.1
CDS	468..1748
Translation	MPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC

Target ORF information:

RefSeq Version	XM_006718940.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), transcript variant X7, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006718940.3

ORF Insert Sequence:

ATGCCTTTCT ATGCAGAAGA ATGTGCCTCC ATGCTGGCAG TCACCTTCAG TGGTGGGGAC 
AAGATGCTTC GGAGCATTGT GACCACTGAC TGGGACCTTC AGAAGGGCAC TGGCTGCACT 
GAGGGCCACA CAGGGACCTC AGCTGCAGCG CCTCTGGCAG CTGGCATGAT AGCCTTAATG 
CTGCAGGTGC GGCCCTGCCT CACGTGGCGT GACGTCCAGC ACATCATTGT CTTCACAGCC 
ACCCGGTATG AGGATCGCCG TGCAGAGTGG GTCACCAACG AGGCAGGCTT CAGCCATAGC 
CACCAGCACG GTTTCGGCCT CCTCAACGCC TGGAGGCTCG TGAATGCAGC CAAGATCTGG 
ACATCTGTCC CTTACTTAGC ATCCTACGTC AGTCCCGTGT TAAAAGAAAA CAAGGCGATT 
CCGCAGTCCC CCCGTTCCCT GGAGGTCCTG TGGAATGTCA GCAGGATGGA CCTGGAGATG 
TCAGGGCTGA AGACCCTGGA GCATGTGGCA GTGACAGTCT CCATCACTCA CCCACGGCGC 
GGCAGCTTGG AGCTGAAGCT GTTCTGCCCC AGTGGCATGA TGTCCCTCAT CGGCGCCCCC 
CGCAGCATGG ACTCGGATCC CAACGGCTTC AATGACTGGA CCTTCTCCAC TGTGCGATGC 
TGGGGGGAGA GAGCCCGAGG GACCTACAGG CTTGTCATCA GGGATGTCGG GGATGAGTCA 
TTCCAGGTCG GCATCCTCCG GCAATGGCAG CTGACCCTAT ATGGCTCTGT GTGGAGTGCA 
GTAGACATCA GGGACAGACA AAGGCTGTTA GAGAGTGCCA TGAGTGGAAA ATACCTGCAC 
GATGACTTCG CCCTGCCCTG CCCACCGGGG CTGAAAATTC CTGAGGAAGA TGGTTACACC 
ATCACCCCCA ACACCCTCAA GACCCTGGTG CTGGTAGGCT GTTTCACCGT CTTCTGGACT 
GTTTACTACA TGCTGGAAGT ATATTTGAGC CAGAGGAATG TGGCTTCCAA TCAAGTTTGT 
AGGAGTGGAC CCTGCCACTG GCCCCATCGG AGCCGGAAAG CCAAGGAGGA AGGGACAGAG 
CTAGAATCAG TGCCACTTTG CAGCAGCAAG GATCCAGACG AAGTGGAAAC AGAGAGCAGG 
GGCCCTCCCA CCACCTCTGA CCTCCTTGCC CCAGACCTGC TGGAGCAAGG GGACTGGAGC 
CTGTCCCAGA ACAAGAGCGC CCTGGACTGC CCTCATCAGC ACCTAGACGT ACCGCACGGG 
AAGGAGGAGC AGATCTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCSK7 ( XM_024448765.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024304533.1 Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), transcript variant X9, mRNA.

Price & Availability↑

CloneID	OHu45922
Clone ID Related Accession (Same CDS sequence)	XM_017018546.1 , XM_006718940.3 , XM_024448765.1 , XM_006718940.4
Accession Version	XM_024448765.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1281bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	proprotein convertase subtilisin/kexin type 7 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTTTCT ATGCAGAAGA ATGTGCCTCC ATGCTGGCAG TCACCTTCAG TGGTGGGGAC 
AAGATGCTTC GGAGCATTGT GACCACTGAC TGGGACCTTC AGAAGGGCAC TGGCTGCACT 
GAGGGCCACA CAGGGACCTC AGCTGCAGCG CCTCTGGCAG CTGGCATGAT AGCCTTAATG 
CTGCAGGTGC GGCCCTGCCT CACGTGGCGT GACGTCCAGC ACATCATTGT CTTCACAGCC 
ACCCGGTATG AGGATCGCCG TGCAGAGTGG GTCACCAACG AGGCAGGCTT CAGCCATAGC 
CACCAGCACG GTTTCGGCCT CCTCAACGCC TGGAGGCTCG TGAATGCAGC CAAGATCTGG 
ACATCTGTCC CTTACTTAGC ATCCTACGTC AGTCCCGTGT TAAAAGAAAA CAAGGCGATT 
CCGCAGTCCC CCCGTTCCCT GGAGGTCCTG TGGAATGTCA GCAGGATGGA CCTGGAGATG 
TCAGGGCTGA AGACCCTGGA GCATGTGGCA GTGACAGTCT CCATCACTCA CCCACGGCGC 
GGCAGCTTGG AGCTGAAGCT GTTCTGCCCC AGTGGCATGA TGTCCCTCAT CGGCGCCCCC 
CGCAGCATGG ACTCGGATCC CAACGGCTTC AATGACTGGA CCTTCTCCAC TGTGCGATGC 
TGGGGGGAGA GAGCCCGAGG GACCTACAGG CTTGTCATCA GGGATGTCGG GGATGAGTCA 
TTCCAGGTCG GCATCCTCCG GCAATGGCAG CTGACCCTAT ATGGCTCTGT GTGGAGTGCA 
GTAGACATCA GGGACAGACA AAGGCTGTTA GAGAGTGCCA TGAGTGGAAA ATACCTGCAC 
GATGACTTCG CCCTGCCCTG CCCACCGGGG CTGAAAATTC CTGAGGAAGA TGGTTACACC 
ATCACCCCCA ACACCCTCAA GACCCTGGTG CTGGTAGGCT GTTTCACCGT CTTCTGGACT 
GTTTACTACA TGCTGGAAGT ATATTTGAGC CAGAGGAATG TGGCTTCCAA TCAAGTTTGT 
AGGAGTGGAC CCTGCCACTG GCCCCATCGG AGCCGGAAAG CCAAGGAGGA AGGGACAGAG 
CTAGAATCAG TGCCACTTTG CAGCAGCAAG GATCCAGACG AAGTGGAAAC AGAGAGCAGG 
GGCCCTCCCA CCACCTCTGA CCTCCTTGCC CCAGACCTGC TGGAGCAAGG GGACTGGAGC 
CTGTCCCAGA ACAAGAGCGC CCTGGACTGC CCTCATCAGC ACCTAGACGT ACCGCACGGG 
AAGGAGGAGC AGATCTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024304533.1
CDS	1966..3246
Translation	MPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC

Target ORF information:

RefSeq Version	XM_024448765.1
Organism	Homo sapiens(human)
Definition	Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), transcript variant X9, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024448765.1

ORF Insert Sequence:

ATGCCTTTCT ATGCAGAAGA ATGTGCCTCC ATGCTGGCAG TCACCTTCAG TGGTGGGGAC 
AAGATGCTTC GGAGCATTGT GACCACTGAC TGGGACCTTC AGAAGGGCAC TGGCTGCACT 
GAGGGCCACA CAGGGACCTC AGCTGCAGCG CCTCTGGCAG CTGGCATGAT AGCCTTAATG 
CTGCAGGTGC GGCCCTGCCT CACGTGGCGT GACGTCCAGC ACATCATTGT CTTCACAGCC 
ACCCGGTATG AGGATCGCCG TGCAGAGTGG GTCACCAACG AGGCAGGCTT CAGCCATAGC 
CACCAGCACG GTTTCGGCCT CCTCAACGCC TGGAGGCTCG TGAATGCAGC CAAGATCTGG 
ACATCTGTCC CTTACTTAGC ATCCTACGTC AGTCCCGTGT TAAAAGAAAA CAAGGCGATT 
CCGCAGTCCC CCCGTTCCCT GGAGGTCCTG TGGAATGTCA GCAGGATGGA CCTGGAGATG 
TCAGGGCTGA AGACCCTGGA GCATGTGGCA GTGACAGTCT CCATCACTCA CCCACGGCGC 
GGCAGCTTGG AGCTGAAGCT GTTCTGCCCC AGTGGCATGA TGTCCCTCAT CGGCGCCCCC 
CGCAGCATGG ACTCGGATCC CAACGGCTTC AATGACTGGA CCTTCTCCAC TGTGCGATGC 
TGGGGGGAGA GAGCCCGAGG GACCTACAGG CTTGTCATCA GGGATGTCGG GGATGAGTCA 
TTCCAGGTCG GCATCCTCCG GCAATGGCAG CTGACCCTAT ATGGCTCTGT GTGGAGTGCA 
GTAGACATCA GGGACAGACA AAGGCTGTTA GAGAGTGCCA TGAGTGGAAA ATACCTGCAC 
GATGACTTCG CCCTGCCCTG CCCACCGGGG CTGAAAATTC CTGAGGAAGA TGGTTACACC 
ATCACCCCCA ACACCCTCAA GACCCTGGTG CTGGTAGGCT GTTTCACCGT CTTCTGGACT 
GTTTACTACA TGCTGGAAGT ATATTTGAGC CAGAGGAATG TGGCTTCCAA TCAAGTTTGT 
AGGAGTGGAC CCTGCCACTG GCCCCATCGG AGCCGGAAAG CCAAGGAGGA AGGGACAGAG 
CTAGAATCAG TGCCACTTTG CAGCAGCAAG GATCCAGACG AAGTGGAAAC AGAGAGCAGG 
GGCCCTCCCA CCACCTCTGA CCTCCTTGCC CCAGACCTGC TGGAGCAAGG GGACTGGAGC 
CTGTCCCAGA ACAAGAGCGC CCTGGACTGC CCTCATCAGC ACCTAGACGT ACCGCACGGG 
AAGGAGGAGC AGATCTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCSK7 ( XM_006718940.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_006719003.1 Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), transcript variant X8, mRNA.

Price & Availability↑

CloneID	OHu45922
Clone ID Related Accession (Same CDS sequence)	XM_017018546.1 , XM_006718940.3 , XM_024448765.1 , XM_006718940.4
Accession Version	XM_006718940.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1281bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	proprotein convertase subtilisin/kexin type 7 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006718940.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTTTCT ATGCAGAAGA ATGTGCCTCC ATGCTGGCAG TCACCTTCAG TGGTGGGGAC 
AAGATGCTTC GGAGCATTGT GACCACTGAC TGGGACCTTC AGAAGGGCAC TGGCTGCACT 
GAGGGCCACA CAGGGACCTC AGCTGCAGCG CCTCTGGCAG CTGGCATGAT AGCCTTAATG 
CTGCAGGTGC GGCCCTGCCT CACGTGGCGT GACGTCCAGC ACATCATTGT CTTCACAGCC 
ACCCGGTATG AGGATCGCCG TGCAGAGTGG GTCACCAACG AGGCAGGCTT CAGCCATAGC 
CACCAGCACG GTTTCGGCCT CCTCAACGCC TGGAGGCTCG TGAATGCAGC CAAGATCTGG 
ACATCTGTCC CTTACTTAGC ATCCTACGTC AGTCCCGTGT TAAAAGAAAA CAAGGCGATT 
CCGCAGTCCC CCCGTTCCCT GGAGGTCCTG TGGAATGTCA GCAGGATGGA CCTGGAGATG 
TCAGGGCTGA AGACCCTGGA GCATGTGGCA GTGACAGTCT CCATCACTCA CCCACGGCGC 
GGCAGCTTGG AGCTGAAGCT GTTCTGCCCC AGTGGCATGA TGTCCCTCAT CGGCGCCCCC 
CGCAGCATGG ACTCGGATCC CAACGGCTTC AATGACTGGA CCTTCTCCAC TGTGCGATGC 
TGGGGGGAGA GAGCCCGAGG GACCTACAGG CTTGTCATCA GGGATGTCGG GGATGAGTCA 
TTCCAGGTCG GCATCCTCCG GCAATGGCAG CTGACCCTAT ATGGCTCTGT GTGGAGTGCA 
GTAGACATCA GGGACAGACA AAGGCTGTTA GAGAGTGCCA TGAGTGGAAA ATACCTGCAC 
GATGACTTCG CCCTGCCCTG CCCACCGGGG CTGAAAATTC CTGAGGAAGA TGGTTACACC 
ATCACCCCCA ACACCCTCAA GACCCTGGTG CTGGTAGGCT GTTTCACCGT CTTCTGGACT 
GTTTACTACA TGCTGGAAGT ATATTTGAGC CAGAGGAATG TGGCTTCCAA TCAAGTTTGT 
AGGAGTGGAC CCTGCCACTG GCCCCATCGG AGCCGGAAAG CCAAGGAGGA AGGGACAGAG 
CTAGAATCAG TGCCACTTTG CAGCAGCAAG GATCCAGACG AAGTGGAAAC AGAGAGCAGG 
GGCCCTCCCA CCACCTCTGA CCTCCTTGCC CCAGACCTGC TGGAGCAAGG GGACTGGAGC 
CTGTCCCAGA ACAAGAGCGC CCTGGACTGC CCTCATCAGC ACCTAGACGT ACCGCACGGG 
AAGGAGGAGC AGATCTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006719003.1
CDS	1926..3206
Translation	MPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC

Target ORF information:

RefSeq Version	XM_006718940.4
Organism	Homo sapiens(human)
Definition	Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), transcript variant X8, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006718940.4

ORF Insert Sequence:

ATGCCTTTCT ATGCAGAAGA ATGTGCCTCC ATGCTGGCAG TCACCTTCAG TGGTGGGGAC 
AAGATGCTTC GGAGCATTGT GACCACTGAC TGGGACCTTC AGAAGGGCAC TGGCTGCACT 
GAGGGCCACA CAGGGACCTC AGCTGCAGCG CCTCTGGCAG CTGGCATGAT AGCCTTAATG 
CTGCAGGTGC GGCCCTGCCT CACGTGGCGT GACGTCCAGC ACATCATTGT CTTCACAGCC 
ACCCGGTATG AGGATCGCCG TGCAGAGTGG GTCACCAACG AGGCAGGCTT CAGCCATAGC 
CACCAGCACG GTTTCGGCCT CCTCAACGCC TGGAGGCTCG TGAATGCAGC CAAGATCTGG 
ACATCTGTCC CTTACTTAGC ATCCTACGTC AGTCCCGTGT TAAAAGAAAA CAAGGCGATT 
CCGCAGTCCC CCCGTTCCCT GGAGGTCCTG TGGAATGTCA GCAGGATGGA CCTGGAGATG 
TCAGGGCTGA AGACCCTGGA GCATGTGGCA GTGACAGTCT CCATCACTCA CCCACGGCGC 
GGCAGCTTGG AGCTGAAGCT GTTCTGCCCC AGTGGCATGA TGTCCCTCAT CGGCGCCCCC 
CGCAGCATGG ACTCGGATCC CAACGGCTTC AATGACTGGA CCTTCTCCAC TGTGCGATGC 
TGGGGGGAGA GAGCCCGAGG GACCTACAGG CTTGTCATCA GGGATGTCGG GGATGAGTCA 
TTCCAGGTCG GCATCCTCCG GCAATGGCAG CTGACCCTAT ATGGCTCTGT GTGGAGTGCA 
GTAGACATCA GGGACAGACA AAGGCTGTTA GAGAGTGCCA TGAGTGGAAA ATACCTGCAC 
GATGACTTCG CCCTGCCCTG CCCACCGGGG CTGAAAATTC CTGAGGAAGA TGGTTACACC 
ATCACCCCCA ACACCCTCAA GACCCTGGTG CTGGTAGGCT GTTTCACCGT CTTCTGGACT 
GTTTACTACA TGCTGGAAGT ATATTTGAGC CAGAGGAATG TGGCTTCCAA TCAAGTTTGT 
AGGAGTGGAC CCTGCCACTG GCCCCATCGG AGCCGGAAAG CCAAGGAGGA AGGGACAGAG 
CTAGAATCAG TGCCACTTTG CAGCAGCAAG GATCCAGACG AAGTGGAAAC AGAGAGCAGG 
GGCCCTCCCA CCACCTCTGA CCTCCTTGCC CCAGACCTGC TGGAGCAAGG GGACTGGAGC 
CTGTCCCAGA ACAAGAGCGC CCTGGACTGC CCTCATCAGC ACCTAGACGT ACCGCACGGG 
AAGGAGGAGC AGATCTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCSK7 ( XM_024448764.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024304532.1 Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu103656
Clone ID Related Accession (Same CDS sequence)	XM_024448764.1
Accession Version	XM_024448764.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2118bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	proprotein convertase subtilisin/kexin type 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGAAGG GGAGGCAGAA AGTGCCACAC TTGGATGCCC CCCTGGGCCT GCCCACCTGC 
CTCTGGCTGG AATTAGCCGG GCTCTTCTTA CTGGTTCCCT GGGTCATGGG CCTGGCAGGG 
ACAGGTGGGC CTGATGGCCA GGGCACAGGG GGGCCGAGCT GGGCTGTGCA CCTGGAAAGC 
CTGGAAGGTG ACGGGGAGGA AGAGACTCTG GAGCAGCAGG CGGATGCCTT GGCCCAGGCA 
GCAGGGCTGG TGAATGCTGG ACGCATCGGA GAGCTTCAGG GGCACTACCT CTTTGTCCAG 
CCTGCTGGGC ACAGGCCGGC CCTGGAGGTG GAGGCCATCC GGCAGCAGGT GGAGGCTGTG 
TTGGCTGGGC ATGAAGCTGT GCGCTGGCAC TCAGAGCAGA GGCTGCTAAG GCGGGCCAAG 
CGCAGCGTCC ACTTCAACGA CCCCAAGTAC CCGCAGCAAT GGCACCTGAA TAACCGACGG 
AGCCCGGGCA GGGACATCAA CGTGACGGGT GTGTGGGAAC GCAATGTGAC TGGGCGAGGG 
GTGACGGTGG TGGTAGTGGA TGACGGAGTG GAACACACCA TCCAGGACAT TGCACCCAAC 
TATAGCCCTG AGGGTAGCTA TGACCTCAAC TCTAATGACC CTGACCCCAT GCCCCACCCG 
GATGTGGAGA ATGGCAACCA CCATGGCACG CGATGTGCAG GAGAGATCGC GGCTGTGCCC 
AACAACAGCT TCTGTGCCGT GGGCGTGGCC TACGGGAGCC GCATCGCAGG TATCCGGGTA 
CTGGATGGAC CTCTCACAGA CAGCATGGAG GCAGTGGCGT TCAACAAGCA CTATCAGATC 
AATGACATCT ACAGCTGCAG CTGGGGACCA GATGACGATG GGAAGACAGT GGATGGCCCC 
CATCAGCTTG GAAAGGCTGC CTTACAACAT GGGGTGATTG CTGGTCGCCA GGGCTTTGGG 
AGCATCTTTG TGGTAGCCAG TGGCAACGGA GGCCAACACA ACGACAACTG CAACTACGAT 
GGCTACGCCA ACTCCATCTA CACCGTCACC ATAGGAGCTG TGGATGAGGA GGGACGCATG 
CCTTTCTATG CAGAAGAATG TGCCTCCATG CTGGCAGTCA CCTTCAGTGG TGGGGACAAG 
ATGCTTCGGA GCATTGTGAC CACTGACTGG GACCTTCAGA AGGGCACTGG CTGCACTGAG 
GGCCACACAG GGACCTCAGC TGCAGCGCCT CTGGCAGCTG GCATGATAGC CTTAATGCTG 
CAGGTGCGGC CCTGCCTCAC GTGGCGTGAC GTCCAGCACA TCATTGTCTT CACAGCCACC 
CGGTATGAGG ATCGCCGTGC AGAGTGGGTC ACCAACGAGG CAGGCTTCAG CCATAGCCAC 
CAGCACGGTT TCGGCCTCCT CAACGCCTGG AGGCTCGTGA ATGCAGCCAA GATCTGGACA 
TCTGTCCCTT ACTTAGCATC CTACGTCAGT CCCGTGTTAA AAGAAAACAA GGCGATTCCG 
CAGTCCCCCC GTTCCCTGGA GGTCCTGTGG AATGTCAGCA GGATGGACCT GGAGATGTCA 
GGGCTGAAGA CCCTGGAGCA TGTGGCAGTG ACAGTCTCCA TCACTCACCC ACGGCGCGGC 
AGCTTGGAGC TGAAGCTGTT CTGCCCCAGT GGCATGATGT CCCTCATCGG CGCCCCCCGC 
AGCATGGACT CGGATCCCAA CGGCTTCAAT GACTGGACCT TCTCCACTGT GCGATGCTGG 
GGGGAGAGAG CCCGAGGGAC CTACAGGCTT GTCATCAGGG ATGTCGGGGA TGAGTCATTC 
CAGGTCGGCA TCCTCCGGCA ATGGCAGCTG ACCCTATATG GCTCTGTGTG GAGTGCAGTA 
GACATCAGGG ACAGACAAAG GCTGTTAGAG AGTGCCATGA GTGGAAAATA CCTGCACGAT 
GACTTCGCCC TGCCCTGCCC ACCGGGGCTG AAAATTCCTG AGGAAGATGG TTACACCATC 
ACCCCCAACA CCCTCAAGGG TGCTGTGCCT TCTCTCCAGT GTTTGTCTGA AGAGACTTCC 
AAAAGAGGTA CCAAAGGAAG CCGAACCCAT CCCCTGGCCT CAGAGGGGTC AGAGGTTGGG 
AGGGACACGC TGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024304532.1
CDS	201..2318
Translation	MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAVLAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKGAVPSLQCLSEETSKRGTKGSRTHPLASEGSEVGRDTLV

Target ORF information:

RefSeq Version	XM_024448764.1
Organism	Homo sapiens(human)
Definition	Homo sapiens proprotein convertase subtilisin/kexin type 7 (PCSK7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024448764.1

ORF Insert Sequence:

ATGCCGAAGG GGAGGCAGAA AGTGCCACAC TTGGATGCCC CCCTGGGCCT GCCCACCTGC 
CTCTGGCTGG AATTAGCCGG GCTCTTCTTA CTGGTTCCCT GGGTCATGGG CCTGGCAGGG 
ACAGGTGGGC CTGATGGCCA GGGCACAGGG GGGCCGAGCT GGGCTGTGCA CCTGGAAAGC 
CTGGAAGGTG ACGGGGAGGA AGAGACTCTG GAGCAGCAGG CGGATGCCTT GGCCCAGGCA 
GCAGGGCTGG TGAATGCTGG ACGCATCGGA GAGCTTCAGG GGCACTACCT CTTTGTCCAG 
CCTGCTGGGC ACAGGCCGGC CCTGGAGGTG GAGGCCATCC GGCAGCAGGT GGAGGCTGTG 
TTGGCTGGGC ATGAAGCTGT GCGCTGGCAC TCAGAGCAGA GGCTGCTAAG GCGGGCCAAG 
CGCAGCGTCC ACTTCAACGA CCCCAAGTAC CCGCAGCAAT GGCACCTGAA TAACCGACGG 
AGCCCGGGCA GGGACATCAA CGTGACGGGT GTGTGGGAAC GCAATGTGAC TGGGCGAGGG 
GTGACGGTGG TGGTAGTGGA TGACGGAGTG GAACACACCA TCCAGGACAT TGCACCCAAC 
TATAGCCCTG AGGGTAGCTA TGACCTCAAC TCTAATGACC CTGACCCCAT GCCCCACCCG 
GATGTGGAGA ATGGCAACCA CCATGGCACG CGATGTGCAG GAGAGATCGC GGCTGTGCCC 
AACAACAGCT TCTGTGCCGT GGGCGTGGCC TACGGGAGCC GCATCGCAGG TATCCGGGTA 
CTGGATGGAC CTCTCACAGA CAGCATGGAG GCAGTGGCGT TCAACAAGCA CTATCAGATC 
AATGACATCT ACAGCTGCAG CTGGGGACCA GATGACGATG GGAAGACAGT GGATGGCCCC 
CATCAGCTTG GAAAGGCTGC CTTACAACAT GGGGTGATTG CTGGTCGCCA GGGCTTTGGG 
AGCATCTTTG TGGTAGCCAG TGGCAACGGA GGCCAACACA ACGACAACTG CAACTACGAT 
GGCTACGCCA ACTCCATCTA CACCGTCACC ATAGGAGCTG TGGATGAGGA GGGACGCATG 
CCTTTCTATG CAGAAGAATG TGCCTCCATG CTGGCAGTCA CCTTCAGTGG TGGGGACAAG 
ATGCTTCGGA GCATTGTGAC CACTGACTGG GACCTTCAGA AGGGCACTGG CTGCACTGAG 
GGCCACACAG GGACCTCAGC TGCAGCGCCT CTGGCAGCTG GCATGATAGC CTTAATGCTG 
CAGGTGCGGC CCTGCCTCAC GTGGCGTGAC GTCCAGCACA TCATTGTCTT CACAGCCACC 
CGGTATGAGG ATCGCCGTGC AGAGTGGGTC ACCAACGAGG CAGGCTTCAG CCATAGCCAC 
CAGCACGGTT TCGGCCTCCT CAACGCCTGG AGGCTCGTGA ATGCAGCCAA GATCTGGACA 
TCTGTCCCTT ACTTAGCATC CTACGTCAGT CCCGTGTTAA AAGAAAACAA GGCGATTCCG 
CAGTCCCCCC GTTCCCTGGA GGTCCTGTGG AATGTCAGCA GGATGGACCT GGAGATGTCA 
GGGCTGAAGA CCCTGGAGCA TGTGGCAGTG ACAGTCTCCA TCACTCACCC ACGGCGCGGC 
AGCTTGGAGC TGAAGCTGTT CTGCCCCAGT GGCATGATGT CCCTCATCGG CGCCCCCCGC 
AGCATGGACT CGGATCCCAA CGGCTTCAAT GACTGGACCT TCTCCACTGT GCGATGCTGG 
GGGGAGAGAG CCCGAGGGAC CTACAGGCTT GTCATCAGGG ATGTCGGGGA TGAGTCATTC 
CAGGTCGGCA TCCTCCGGCA ATGGCAGCTG ACCCTATATG GCTCTGTGTG GAGTGCAGTA 
GACATCAGGG ACAGACAAAG GCTGTTAGAG AGTGCCATGA GTGGAAAATA CCTGCACGAT 
GACTTCGCCC TGCCCTGCCC ACCGGGGCTG AAAATTCCTG AGGAAGATGG TTACACCATC 
ACCCCCAACA CCCTCAAGGG TGCTGTGCCT TCTCTCCAGT GTTTGTCTGA AGAGACTTCC 
AAAAGAGGTA CCAAAGGAAG CCGAACCCAT CCCCTGGCCT CAGAGGGGTC AGAGGTTGGG 
AGGGACACGC TGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proprotein convertase 7 rs236918 associated with liver fibrosis in Italian patients with HFE-related hemochromatosis.
Journal of gastroenterology and hepatology31(7)1342-8(2016 Jul)
Pelucchi S,Galimberti S,Greni F,Rametta R,Mariani R,Pelloni I,Girelli D,Busti F,Ravasi G,Valsecchi MG,Valenti L,Piperno A

Genome-wide association study of serum lipids confirms previously reported associations as well as new associations of common SNPs within PCSK7 gene with triglyceride.
Journal of human genetics61(5)427-33(2016 May)
Kurano M,Tsukamoto K,Kamitsuji S,Kamatani N,Hara M,Ishikawa T,Kim BJ,Moon S,Jin Kim Y,Teramoto T

Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cells.
Molecular carcinogenesis54(9)698-706(2015 Sep)
Fu J,Zhang J,Gong Y,Testa CL,Klein-Szanto AJ

PCSK7 genotype modifies effect of a weight-loss diet on 2-year changes of insulin resistance: the POUNDS LOST trial.
Diabetes care38(3)439-44(2015 Mar)
Huang T,Huang J,Qi Q,Li Y,Bray GA,Rood J,Sacks FM,Qi L

Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis.
Human molecular genetics23(14)3883-90(2014 Jul)
Stickel F,Buch S,Zoller H,Hultcrantz R,Gallati S,?sterreicher C,Finkenstedt A,Stadlmayr A,Aigner E,Sahinbegovic E,Sarrazin C,Schafmayer C,Braun F,Erhart W,Nothnagel M,Lerch MM,Mayerle J,V?lzke H,Schaller A,Kratzer W,Boehm BO,Sipos B,D'Amato M,Torkvist L,Stal P,Arlt A,Franke A,Becker T,Krawczak M,Zwerina J,Berg T,Hinrichsen H,Krones E,Dejaco C,Strasser M,Datz C,Hampe J

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

PCSK7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報