The following CUBN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CUBN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OCe00367 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001003148.1 | |
| Accession Version | NM_001003148.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 10863bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-24 | |
| Organism | Canis lupus familiaris(dog) | |
| Product | cubilin precursor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF137068.1. ##Evidence-Data-START## Transcript exon combination :: AF137068.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00013638, SAMN00991611 [ECO:0000350] ##Evidence-Data-END## | |
1 | ATGTCCTCAC CTTTTCTTTG GAGTTTGATT ATTTTGTTGA CATTTGCTGA ATCAAATGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001003148.1 |
| CDS | 74..10936 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001003148.1 |
1 | ATGTCCTCAC CTTTTCTTTG GAGTTTGATT ATTTTGTTGA CATTTGCTGA ATCAAATGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
An exon 53 frameshift mutation in CUBN abrogates cubam function and causes Imerslund-Gr?sbeck syndrome in dogs. |
Contribution of cubilin and amnionless to processing and membrane targeting of cubilin-amnionless complex. |
Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivo. |
Genetic evidence of an accessory activity required specifically for cubilin brush-border expression and intrinsic factor-cobalamin absorption. |
Immunocytochemical localization of the intrinsic factor-cobalamin receptor in dog-ileum: distribution of intracellular receptor during cell maturation. |
