hda-1 cDNA ORF clone, Caenorhabditis elegans

Gene
Clones
gRNAs

Summary

Gene Symbol	hda-1
Entrez Gene ID	179959
Full Name	Histone deacetylase 1
Gene Type	protein-coding
Organism	Caenorhabditis elegans

mRNA and Protein(s)

mRNA	Protein	Name
NM_074198.7	NP_506599.1	Histone deacetylase 1
NM_074198.8	NP_506599.1	Histone deacetylase 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HDAC2	XP_518700.2
Oryza sativa (rice)	Os08g0344100	NP_001061596.1
Bos taurus (cattle)	HDAC2	NP_001068614.1
Arabidopsis thaliana (thale cress)	HDA6	NP_201116.1
Xenopus tropicalis (tropical clawed frog)	hdac2	NP_001005432.1
Canis lupus familiaris (dog)	HDAC2	XP_532270.4
Mus musculus (house mouse)	Hdac2	NP_032255.2
Danio rerio (zebrafish)	hdac1	NP_775343.1
Homo sapiens (human)	HDAC2	NP_001518.3
Rattus norvegicus (Norway rat)	Hdac2	NP_445899.1
Gallus gallus (chicken)	HDAC2	NP_990162.1
Caenorhabditis elegans (roundworm)	hda-1	NP_506599.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome sequence of the nematode C. elegans: a platform for investigating biology.

Science (New York, N.Y.)282(5396)2012-8(1998 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We further show that G1 arrest is necessary for the histone deacetylase HDA-1, a key regulator of differentiation, to promote pro-invasive gene expression and invadopodia formation.
Title: Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression.

hda-1 target genes revealed that fos-1 acts downstream of hda-1 in vulval cells, whereas egl-43 and nhr-67 mediate hda-1 function in the gonadal anchor cell.
Title: Caenorhabditis elegans histone deacetylase hda-1 is required for morphogenesis of the vulva and LIN-12/Notch-mediated specification of uterine cell fates.

HDAC behaves as a co-repressor modulating FOS-1-mediated transcriptional regulation
Title: The Caenorhabditis elegans JNK signaling pathway activates expression of stress response genes by derepressing the Fos/HDAC repressor complex.

Theses studies define a new role for HDA-1 in nervous system development, and provide the first evidence for HDAC function in regulating neuronal axon guidance.
Title: The C. elegans histone deacetylase HDA-1 is required for cell migration and axon pathfinding.

The following hda-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the hda-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OCa345783	NM_074198.8 Latest version!	Caenorhabditis elegans Histone deacetylase 1 (hda-1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OCa345783	NM_074198.7	Caenorhabditis elegans Histone deacetylase 1 (hda-1), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$258.30 $369.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

hda-1 ( NM_074198.7 ) cDNA ORF clone, Caenorhabditis elegans -> NP_506599.1 Caenorhabditis elegans Histone deacetylase 1 (hda-1), partial mRNA.

Price & Availability↑

CloneID	OCa345783
Clone ID Related Accession (Same CDS sequence)	NM_074198.7 , NM_074198.8
Accession Version	NM_074198.7	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1386bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-08
Organism	Caenorhabditis elegans
Product	Histone deacetylase 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). On Jun 26, 2012 this sequence version replaced NM_074198.6. COMPLETENESS: incomplete on both ends.

ATGAACTCAA ACGGCCCGTT GATGGAGCAC GGTAAGCGCC GTGTCGCCTA CTACTATGAC 
TCCAACATTG GAAATTACTA TTATGGTCAA GGGCACGTCA TGAAGCCACA TCGTATCAGA 
ATGACCCATC ATCTCGTTCT CAACTATGGT CTGTACCGGA ATTTAGAGAT TTTCCGCCCA 
TTCCCTGCAT CATTCGAAGA CATGACTCGT TTTCACAGCG ACGAGTACAT GACGTTTTTG 
AAGAGTGCGA ATCCAGATAA TCTGAAATCC TTCAACAAAC AAATGCTTAA GTTCAATGTT 
GGAGAAGATT GTCCTCTCTT TGATGGTCTT TATGAGTTCT GCCAACTCAG TTCGGGAGGT 
TCTCTGGCTG CTGCCACTAA ATTGAACAAG CAGAAGGTGG ACATTGCTAT CAATTGGATG 
GGAGGCCTCC ATCACGCCAA GAAAAGCGAG GCGTCCGGAT TCTGTTACAC CAATGACATC 
GTTCTCGGTA TTCTCGAGCT TCTCAAGTAC CACAAGCGAG TACTTTACGT CGATATTGAT 
GTTCATCACG GAGATGGAGT AGAGGAGGCG TTCTATACGA CTGATCGAGT AATGACAGTG 
TCATTCCATA AATATGGAGA TTTCTTCCCA GGAACCGGAG ACCTGAAAGA TATAGGAGCT 
GGAAAAGGAA AGCTCTATTC AGTCAATGTT CCACTTCGCG ATGGAATCAC CGACGTCTCT 
TACCAGAGTA TTTTTAAACC AATCATGACA AAGGTTATGG AGAGATTTGA TCCCTGTGCT 
GTTGTTCTTC AATGTGGAGC TGATTCTCTC AACGGAGATA GACTTGGACC ATTCAATCTG 
ACCTTGAAAG GCCACGGAGA ATGTGCTCGT TTCTTCCGAA GCTACAACGT TCCACTTATG 
ATGGTCGGTG GAGGTGGATA CACTCCAAGA AATGTGGCAC GTTGTTGGAC GTACGAAACC 
TCGATTGCCG TCGATAAGGA AGTTCCAAAT GAGTTGCCAT ACAATGACTA CTTCGAATAC 
TTTGGACCAA ACTACCGACT TCACATCGAG TCGTCGAATG CAGCAAATGA AAATAGCTCC 
GATATGCTGG CTAAATTGCA AACTGACGTC ATCGCCAATC TCGAGCAGCT CACTTTTGTT 
CCAAGTGTTC AAATGAGACC GATCCCAGAA GACGCCCTCT CTGCATTGAA TGATGACTCA 
TTGATCGCCG ACCAAGCTAA TCCCGACAAA CGACTACCAC CACAAATTAC CGATGGAATG 
ATTCAAGACG ATGGAGACTT CTACGATGGT GAGCGTGAGG GAGATGATCG AAGAAACGAG 
AGCGATGCGA AGAGAGCAGC TCAGTTTGAG TCGGAAGGTG GTGAAAAGCG TCAGAAGACA 
GAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_506599.1
CDS	1..1386
Translation	MNSNGPLMEHGKRRVAYYYDSNIGNYYYGQGHVMKPHRIRMTHHLVLNYGLYRNLEIFRPFPASFEDMTRFHSDEYMTFLKSANPDNLKSFNKQMLKFNVGEDCPLFDGLYEFCQLSSGGSLAAATKLNKQKVDIAINWMGGLHHAKKSEASGFCYTNDIVLGILELLKYHKRVLYVDIDVHHGDGVEEAFYTTDRVMTVSFHKYGDFFPGTGDLKDIGAGKGKLYSVNVPLRDGITDVSYQSIFKPIMTKVMERFDPCAVVLQCGADSLNGDRLGPFNLTLKGHGECARFFRSYNVPLMMVGGGGYTPRNVARCWTYETSIAVDKEVPNELPYNDYFEYFGPNYRLHIESSNAANENSSDMLAKLQTDVIANLEQLTFVPSVQMRPIPEDALSALNDDSLIADQANPDKRLPPQITDGMIQDDGDFYDGEREGDDRRNESDAKRAAQFESEGGEKRQKTE

Target ORF information:

RefSeq Version	NM_074198.7
Organism	Caenorhabditis elegans
Definition	Caenorhabditis elegans Histone deacetylase 1 (hda-1), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_074198.7

ORF Insert Sequence:

ATGAACTCAA ACGGCCCGTT GATGGAGCAC GGTAAGCGCC GTGTCGCCTA CTACTATGAC 
TCCAACATTG GAAATTACTA TTATGGTCAA GGGCACGTCA TGAAGCCACA TCGTATCAGA 
ATGACCCATC ATCTCGTTCT CAACTATGGT CTGTACCGGA ATTTAGAGAT TTTCCGCCCA 
TTCCCTGCAT CATTCGAAGA CATGACTCGT TTTCACAGCG ACGAGTACAT GACGTTTTTG 
AAGAGTGCGA ATCCAGATAA TCTGAAATCC TTCAACAAAC AAATGCTTAA GTTCAATGTT 
GGAGAAGATT GTCCTCTCTT TGATGGTCTT TATGAGTTCT GCCAACTCAG TTCGGGAGGT 
TCTCTGGCTG CTGCCACTAA ATTGAACAAG CAGAAGGTGG ACATTGCTAT CAATTGGATG 
GGAGGCCTCC ATCACGCCAA GAAAAGCGAG GCGTCCGGAT TCTGTTACAC CAATGACATC 
GTTCTCGGTA TTCTCGAGCT TCTCAAGTAC CACAAGCGAG TACTTTACGT CGATATTGAT 
GTTCATCACG GAGATGGAGT AGAGGAGGCG TTCTATACGA CTGATCGAGT AATGACAGTG 
TCATTCCATA AATATGGAGA TTTCTTCCCA GGAACCGGAG ACCTGAAAGA TATAGGAGCT 
GGAAAAGGAA AGCTCTATTC AGTCAATGTT CCACTTCGCG ATGGAATCAC CGACGTCTCT 
TACCAGAGTA TTTTTAAACC AATCATGACA AAGGTTATGG AGAGATTTGA TCCCTGTGCT 
GTTGTTCTTC AATGTGGAGC TGATTCTCTC AACGGAGATA GACTTGGACC ATTCAATCTG 
ACCTTGAAAG GCCACGGAGA ATGTGCTCGT TTCTTCCGAA GCTACAACGT TCCACTTATG 
ATGGTCGGTG GAGGTGGATA CACTCCAAGA AATGTGGCAC GTTGTTGGAC GTACGAAACC 
TCGATTGCCG TCGATAAGGA AGTTCCAAAT GAGTTGCCAT ACAATGACTA CTTCGAATAC 
TTTGGACCAA ACTACCGACT TCACATCGAG TCGTCGAATG CAGCAAATGA AAATAGCTCC 
GATATGCTGG CTAAATTGCA AACTGACGTC ATCGCCAATC TCGAGCAGCT CACTTTTGTT 
CCAAGTGTTC AAATGAGACC GATCCCAGAA GACGCCCTCT CTGCATTGAA TGATGACTCA 
TTGATCGCCG ACCAAGCTAA TCCCGACAAA CGACTACCAC CACAAATTAC CGATGGAATG 
ATTCAAGACG ATGGAGACTT CTACGATGGT GAGCGTGAGG GAGATGATCG AAGAAACGAG 
AGCGATGCGA AGAGAGCAGC TCAGTTTGAG TCGGAAGGTG GTGAAAAGCG TCAGAAGACA 
GAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

hda-1 ( NM_074198.8 ) cDNA ORF clone, Caenorhabditis elegans -> NP_506599.1 Caenorhabditis elegans Histone deacetylase 1 (hda-1), mRNA.

Price & Availability↑

CloneID	OCa345783
Clone ID Related Accession (Same CDS sequence)	NM_074198.7 , NM_074198.8
Accession Version	NM_074198.8 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1386bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Caenorhabditis elegans
Product	Histone deacetylase 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). On Sep 4, 2019 this sequence version replaced NM_074198.7.

ATGAACTCAA ACGGCCCGTT GATGGAGCAC GGTAAGCGCC GTGTCGCCTA CTACTATGAC 
TCCAACATTG GAAATTACTA TTATGGTCAA GGGCACGTCA TGAAGCCACA TCGTATCAGA 
ATGACCCATC ATCTCGTTCT CAACTATGGT CTGTACCGGA ATTTAGAGAT TTTCCGCCCA 
TTCCCTGCAT CATTCGAAGA CATGACTCGT TTTCACAGCG ACGAGTACAT GACGTTTTTG 
AAGAGTGCGA ATCCAGATAA TCTGAAATCC TTCAACAAAC AAATGCTTAA GTTCAATGTT 
GGAGAAGATT GTCCTCTCTT TGATGGTCTT TATGAGTTCT GCCAACTCAG TTCGGGAGGT 
TCTCTGGCTG CTGCCACTAA ATTGAACAAG CAGAAGGTGG ACATTGCTAT CAATTGGATG 
GGAGGCCTCC ATCACGCCAA GAAAAGCGAG GCGTCCGGAT TCTGTTACAC CAATGACATC 
GTTCTCGGTA TTCTCGAGCT TCTCAAGTAC CACAAGCGAG TACTTTACGT CGATATTGAT 
GTTCATCACG GAGATGGAGT AGAGGAGGCG TTCTATACGA CTGATCGAGT AATGACAGTG 
TCATTCCATA AATATGGAGA TTTCTTCCCA GGAACCGGAG ACCTGAAAGA TATAGGAGCT 
GGAAAAGGAA AGCTCTATTC AGTCAATGTT CCACTTCGCG ATGGAATCAC CGACGTCTCT 
TACCAGAGTA TTTTTAAACC AATCATGACA AAGGTTATGG AGAGATTTGA TCCCTGTGCT 
GTTGTTCTTC AATGTGGAGC TGATTCTCTC AACGGAGATA GACTTGGACC ATTCAATCTG 
ACCTTGAAAG GCCACGGAGA ATGTGCTCGT TTCTTCCGAA GCTACAACGT TCCACTTATG 
ATGGTCGGTG GAGGTGGATA CACTCCAAGA AATGTGGCAC GTTGTTGGAC GTACGAAACC 
TCGATTGCCG TCGATAAGGA AGTTCCAAAT GAGTTGCCAT ACAATGACTA CTTCGAATAC 
TTTGGACCAA ACTACCGACT TCACATCGAG TCGTCGAATG CAGCAAATGA AAATAGCTCC 
GATATGCTGG CTAAATTGCA AACTGACGTC ATCGCCAATC TCGAGCAGCT CACTTTTGTT 
CCAAGTGTTC AAATGAGACC GATCCCAGAA GACGCCCTCT CTGCATTGAA TGATGACTCA 
TTGATCGCCG ACCAAGCTAA TCCCGACAAA CGACTACCAC CACAAATTAC CGATGGAATG 
ATTCAAGACG ATGGAGACTT CTACGATGGT GAGCGTGAGG GAGATGATCG AAGAAACGAG 
AGCGATGCGA AGAGAGCAGC TCAGTTTGAG TCGGAAGGTG GTGAAAAGCG TCAGAAGACA 
GAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_506599.1
CDS	20..1405
Translation	MNSNGPLMEHGKRRVAYYYDSNIGNYYYGQGHVMKPHRIRMTHHLVLNYGLYRNLEIFRPFPASFEDMTRFHSDEYMTFLKSANPDNLKSFNKQMLKFNVGEDCPLFDGLYEFCQLSSGGSLAAATKLNKQKVDIAINWMGGLHHAKKSEASGFCYTNDIVLGILELLKYHKRVLYVDIDVHHGDGVEEAFYTTDRVMTVSFHKYGDFFPGTGDLKDIGAGKGKLYSVNVPLRDGITDVSYQSIFKPIMTKVMERFDPCAVVLQCGADSLNGDRLGPFNLTLKGHGECARFFRSYNVPLMMVGGGGYTPRNVARCWTYETSIAVDKEVPNELPYNDYFEYFGPNYRLHIESSNAANENSSDMLAKLQTDVIANLEQLTFVPSVQMRPIPEDALSALNDDSLIADQANPDKRLPPQITDGMIQDDGDFYDGEREGDDRRNESDAKRAAQFESEGGEKRQKTE

Target ORF information:

RefSeq Version	NM_074198.8
Organism	Caenorhabditis elegans
Definition	Caenorhabditis elegans Histone deacetylase 1 (hda-1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_074198.8

ORF Insert Sequence:

ATGAACTCAA ACGGCCCGTT GATGGAGCAC GGTAAGCGCC GTGTCGCCTA CTACTATGAC 
TCCAACATTG GAAATTACTA TTATGGTCAA GGGCACGTCA TGAAGCCACA TCGTATCAGA 
ATGACCCATC ATCTCGTTCT CAACTATGGT CTGTACCGGA ATTTAGAGAT TTTCCGCCCA 
TTCCCTGCAT CATTCGAAGA CATGACTCGT TTTCACAGCG ACGAGTACAT GACGTTTTTG 
AAGAGTGCGA ATCCAGATAA TCTGAAATCC TTCAACAAAC AAATGCTTAA GTTCAATGTT 
GGAGAAGATT GTCCTCTCTT TGATGGTCTT TATGAGTTCT GCCAACTCAG TTCGGGAGGT 
TCTCTGGCTG CTGCCACTAA ATTGAACAAG CAGAAGGTGG ACATTGCTAT CAATTGGATG 
GGAGGCCTCC ATCACGCCAA GAAAAGCGAG GCGTCCGGAT TCTGTTACAC CAATGACATC 
GTTCTCGGTA TTCTCGAGCT TCTCAAGTAC CACAAGCGAG TACTTTACGT CGATATTGAT 
GTTCATCACG GAGATGGAGT AGAGGAGGCG TTCTATACGA CTGATCGAGT AATGACAGTG 
TCATTCCATA AATATGGAGA TTTCTTCCCA GGAACCGGAG ACCTGAAAGA TATAGGAGCT 
GGAAAAGGAA AGCTCTATTC AGTCAATGTT CCACTTCGCG ATGGAATCAC CGACGTCTCT 
TACCAGAGTA TTTTTAAACC AATCATGACA AAGGTTATGG AGAGATTTGA TCCCTGTGCT 
GTTGTTCTTC AATGTGGAGC TGATTCTCTC AACGGAGATA GACTTGGACC ATTCAATCTG 
ACCTTGAAAG GCCACGGAGA ATGTGCTCGT TTCTTCCGAA GCTACAACGT TCCACTTATG 
ATGGTCGGTG GAGGTGGATA CACTCCAAGA AATGTGGCAC GTTGTTGGAC GTACGAAACC 
TCGATTGCCG TCGATAAGGA AGTTCCAAAT GAGTTGCCAT ACAATGACTA CTTCGAATAC 
TTTGGACCAA ACTACCGACT TCACATCGAG TCGTCGAATG CAGCAAATGA AAATAGCTCC 
GATATGCTGG CTAAATTGCA AACTGACGTC ATCGCCAATC TCGAGCAGCT CACTTTTGTT 
CCAAGTGTTC AAATGAGACC GATCCCAGAA GACGCCCTCT CTGCATTGAA TGATGACTCA 
TTGATCGCCG ACCAAGCTAA TCCCGACAAA CGACTACCAC CACAAATTAC CGATGGAATG 
ATTCAAGACG ATGGAGACTT CTACGATGGT GAGCGTGAGG GAGATGATCG AAGAAACGAG 
AGCGATGCGA AGAGAGCAGC TCAGTTTGAG TCGGAAGGTG GTGAAAAGCG TCAGAAGACA 
GAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)

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hda-1 cDNA ORF clone, Caenorhabditis elegans

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

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