Gene Symbol | unc-60 |
Entrez Gene ID | 178640 |
Full Name | Actin-depolymerizing factor 1, isoforms a/b |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » unc-60 cDNA ORF clone
Gene Symbol | unc-60 |
Entrez Gene ID | 178640 |
Full Name | Actin-depolymerizing factor 1, isoforms a/b |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_071026.7 | NP_503427.2 | Actin-depolymerizing factor 2, isoform c |
NM_071024.5 | NP_503425.2 | Actin-depolymerizing factor 1, isoforms a/b |
NM_071026.8 | NP_503427.2 | Actin-depolymerizing factor 2, isoform c |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The invadopodial membrane is a specialized compartment whose recycling to form dynamic, functional invadopodia is dependent on localized F-actin disassembly by unc-60a.
Title: ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo.
results suggest that an optimal level of actin-filament-severing activity of ADF/cofilin is required for assembly of actin networks in the somatic gonad
Title: Essential role of ADF/cofilin for assembly of contractile actin networks in the C. elegans somatic gonad.
Data show that UNC-87 competes with ADF/cofilin (unc-60) for binding to actin filaments and inhibits ADF/cofilin-dependent filament severing and depolymerization in vitro.
Title: UNC-87, a calponin-related protein in C. elegans, antagonizes ADF/cofilin-mediated actin filament dynamics.
These results indicate that cofilin severs the actin filament by a mechanism of allosteric and cooperative destabilization.
Title: Actin filament severing by cofilin.
UNC-60A and UNC-60B play distinct roles in specific aspects of actin reorganization in vivo
Title: Specific requirement for two ADF/cofilin isoforms in distinct actin-dependent processes in Caenorhabditis elegans.
The following unc-60 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the unc-60 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa347279 | |
Clone ID Related Accession (Same CDS sequence) | NM_071024.5 | |
Accession Version | NM_071024.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 498bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Actin-depolymerizing factor 1, isoforms a/b | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). On Jun 26, 2012 this sequence version replaced NM_071024.4. COMPLETENESS: incomplete on both ends. |
1 | ATGAGTTCCG GTGTCATGGT CGACCCAGAT GTGCAGACAT CTTTCCAAAA GCTCTCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_503425.2 |
CDS | 1..498 |
Translation |
Target ORF information:
Target ORF information:
|
NM_071024.5 |
1 | ATGAGTTCCG GTGTCATGGT CGACCCAGAT GTGCAGACAT CTTTCCAAAA GCTCTCCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa347280 | |
Clone ID Related Accession (Same CDS sequence) | NM_071026.7 , NM_071026.8 | |
Accession Version | NM_071026.7 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Actin-depolymerizing factor 2, isoform c | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). On Jun 26, 2012 this sequence version replaced NM_071026.6. COMPLETENESS: incomplete on both ends. |
1 | ATGGCTTCCG GAGTCAAAGT TGATCCATCC TGCAAGAACG CCTACGATCT TCTCCACAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_503427.2 |
CDS | 1..459 |
Translation |
Target ORF information:
Target ORF information:
|
NM_071026.7 |
1 | ATGGCTTCCG GAGTCAAAGT TGATCCATCC TGCAAGAACG CCTACGATCT TCTCCACAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa347280 | |
Clone ID Related Accession (Same CDS sequence) | NM_071026.7 , NM_071026.8 | |
Accession Version | NM_071026.8 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Actin-depolymerizing factor 2, isoform c | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). On Sep 4, 2019 this sequence version replaced NM_071026.7. |
1 | ATGGCTTCCG GAGTCAAAGT TGATCCATCC TGCAAGAACG CCTACGATCT TCTCCACAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_503427.2 |
CDS | 54..512 |
Translation |
Target ORF information:
Target ORF information:
|
NM_071026.8 |
1 | ATGGCTTCCG GAGTCAAAGT TGATCCATCC TGCAAGAACG CCTACGATCT TCTCCACAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |