Gene Symbol | dlk-1 |
Entrez Gene ID | 173128 |
Full Name | Dual-Leucine zipper Kinase |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » dlk-1 cDNA ORF clone
Gene Symbol | dlk-1 |
Entrez Gene ID | 173128 |
Full Name | Dual-Leucine zipper Kinase |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_001026272.4 | NP_001021443.1 | Mitogen-activated protein kinase kinase kinase dlk-1 |
NM_001136297.3 | NP_001129769.1 | Mitogen-activated protein kinase kinase kinase dlk-1 |
NM_001026272.3 | NP_001021443.1 | Mitogen-activated protein kinase kinase kinase dlk-1 |
NM_001026274.3 | NP_001021445.1 | Mitogen-activated protein kinase kinase kinase dlk-1 |
NM_001026273.5 | NP_001021444.1 | Mitogen-activated protein kinase kinase kinase dlk-1 |
NM_001136297.2 | NP_001129769.1 | Mitogen-activated protein kinase kinase kinase dlk-1 |
NM_001265008.1 | NP_001251937.1 | Mitogen-activated protein kinase kinase kinase dlk-1 |
NM_001026273.6 | NP_001021444.1 | Mitogen-activated protein kinase kinase kinase dlk-1 |
NM_001265008.2 | NP_001251937.1 | Mitogen-activated protein kinase kinase kinase dlk-1 |
NM_001026274.4 | NP_001021445.1 | Mitogen-activated protein kinase kinase kinase dlk-1 |
Drosophila melanogaster (fruit fly) | wnd | NP_649137.3 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP006461 | XP_316502.4 |
Caenorhabditis elegans (roundworm) | dlk-1 | NP_001021445.1 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Mitochondrial localization to the axon after injury is regulated in part by dual-leucine zipper kinase 1 (DLK-1), a conserved regulator of axon regeneration.
Title: Mitochondria Localize to Injured Axons to Support Regeneration.
DLK-1, SEK-3 and PMK-3 have roles in C. elegans adaptation to disruption of the mitochondrial electron transport chain, and in extended lifespan
Title: DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans.
These findings explain how DLK specifically mediates nerve injury responses and reveal a novel cellular mechanism that ensures the specificity of neuronal kinase signaling.
Title: Palmitoylation controls DLK localization, interactions and activity to ensure effective axonal injury signaling.
Independent of myosin light chain activation, RHGF-1 acts via Rho-dependent kinase LET-502/ROCK and activates a conserved, retrograde DLK-1 MAPK pathway, triggering synaptic branch retraction and overgrowth of the PLM neurite in a dose-dependent manner.
Title: RHGF-1/PDZ-RhoGEF and retrograde DLK-1 signaling drive neuronal remodeling on microtubule disassembly.
Genetic, transgenic, and biochemical studies indicated that PPM-2 functions coordinately with the ubiquitin ligase activity of RPM-1 and the F-box protein FSN-1 to negatively regulate DLK-1
Title: RPM-1 uses both ubiquitin ligase and phosphatase-based mechanisms to regulate DLK-1 during neuronal development.
The following dlk-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the dlk-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa336186 | |
Clone ID Related Accession (Same CDS sequence) | NM_001265008.1 , NM_001265008.2 | |
Accession Version | NM_001265008.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Mitogen-activated protein kinase kinase kinase dlk-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). COMPLETENESS: incomplete on both ends. |
1 | ATGACGTCAT CATCTAGAGC CCGGAGCCCA ACTCCATATG ACAATGATTT TGAAAATGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001251937.1 |
CDS | 1..624 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001265008.1 |
1 | ATGACGTCAT CATCTAGAGC CCGGAGCCCA ACTCCATATG ACAATGATTT TGAAAATGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa336186 | |
Clone ID Related Accession (Same CDS sequence) | NM_001265008.1 , NM_001265008.2 | |
Accession Version | NM_001265008.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Mitogen-activated protein kinase kinase kinase dlk-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Sep 4, 2019 this sequence version replaced NM_001265008.1. COMPLETENESS: incomplete on the 5' end. |
1 | ATGACGTCAT CATCTAGAGC CCGGAGCCCA ACTCCATATG ACAATGATTT TGAAAATGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001251937.1 |
CDS | 1..624 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001265008.2 |
1 | ATGACGTCAT CATCTAGAGC CCGGAGCCCA ACTCCATATG ACAATGATTT TGAAAATGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa335547 | |
Clone ID Related Accession (Same CDS sequence) | NM_001026272.4 , NM_001026272.3 | |
Accession Version | NM_001026272.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2787bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Mitogen-activated protein kinase kinase kinase dlk-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Sep 4, 2019 this sequence version replaced NM_001026272.3. |
1 | ATGACATCTA CCACAATGGT AACCACTCTC GACTTGGTCA CACCAACATC AGAAGAACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001021443.1 |
CDS | 6..2792 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001026272.4 |
1 | ATGACATCTA CCACAATGGT AACCACTCTC GACTTGGTCA CACCAACATC AGAAGAACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa335547 | |
Clone ID Related Accession (Same CDS sequence) | NM_001026272.4 , NM_001026272.3 | |
Accession Version | NM_001026272.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2787bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Mitogen-activated protein kinase kinase kinase dlk-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Jun 26, 2012 this sequence version replaced NM_001026272.2. COMPLETENESS: incomplete on both ends. |
1 | ATGACATCTA CCACAATGGT AACCACTCTC GACTTGGTCA CACCAACATC AGAAGAACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001021443.1 |
CDS | 1..2787 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001026272.3 |
1 | ATGACATCTA CCACAATGGT AACCACTCTC GACTTGGTCA CACCAACATC AGAAGAACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa336261 | |
Clone ID Related Accession (Same CDS sequence) | NM_001026274.3 , NM_001026274.4 | |
Accession Version | NM_001026274.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1734bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Mitogen-activated protein kinase kinase kinase dlk-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Jun 26, 2012 this sequence version replaced NM_001026274.2. COMPLETENESS: incomplete on both ends. |
1 | ATGACATCTA CCACAATGGT AACCACTCTC GACTTGGTCA CACCAACATC AGAAGAACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001021445.1 |
CDS | 1..1734 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001026274.3 |
1 | ATGACATCTA CCACAATGGT AACCACTCTC GACTTGGTCA CACCAACATC AGAAGAACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa336261 | |
Clone ID Related Accession (Same CDS sequence) | NM_001026274.3 , NM_001026274.4 | |
Accession Version | NM_001026274.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1734bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Mitogen-activated protein kinase kinase kinase dlk-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Sep 4, 2019 this sequence version replaced NM_001026274.3. |
1 | ATGACATCTA CCACAATGGT AACCACTCTC GACTTGGTCA CACCAACATC AGAAGAACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001021445.1 |
CDS | 6..1739 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001026274.4 |
1 | ATGACATCTA CCACAATGGT AACCACTCTC GACTTGGTCA CACCAACATC AGAAGAACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa336262 | |
Clone ID Related Accession (Same CDS sequence) | NM_001026273.5 , NM_001026273.6 | |
Accession Version | NM_001026273.5 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2766bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Mitogen-activated protein kinase kinase kinase dlk-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Jun 26, 2012 this sequence version replaced NM_001026273.4. COMPLETENESS: incomplete on both ends. |
1 | ATGACATCTA CCACAATGGT AACCACTCTC GACTTGGTCA CACCAACATC AGAAGAACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001021444.1 |
CDS | 1..2766 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001026273.5 |
1 | ATGACATCTA CCACAATGGT AACCACTCTC GACTTGGTCA CACCAACATC AGAAGAACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa336262 | |
Clone ID Related Accession (Same CDS sequence) | NM_001026273.5 , NM_001026273.6 | |
Accession Version | NM_001026273.6 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2766bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Mitogen-activated protein kinase kinase kinase dlk-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Sep 4, 2019 this sequence version replaced NM_001026273.5. |
1 | ATGACATCTA CCACAATGGT AACCACTCTC GACTTGGTCA CACCAACATC AGAAGAACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001021444.1 |
CDS | 6..2771 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001026273.6 |
1 | ATGACATCTA CCACAATGGT AACCACTCTC GACTTGGTCA CACCAACATC AGAAGAACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa337221 | |
Clone ID Related Accession (Same CDS sequence) | NM_001136297.3 , NM_001136297.2 | |
Accession Version | NM_001136297.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2568bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Mitogen-activated protein kinase kinase kinase dlk-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Sep 4, 2019 this sequence version replaced NM_001136297.2. |
1 | ATGGTGGCTG CGACCGGGAA CGCGTCGAAA CCCAGCCTGA ACAGCTTCTA CGCAGATGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001129769.1 |
CDS | 2..2569 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001136297.3 |
1 | ATGGTGGCTG CGACCGGGAA CGCGTCGAAA CCCAGCCTGA ACAGCTTCTA CGCAGATGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa337221 | |
Clone ID Related Accession (Same CDS sequence) | NM_001136297.3 , NM_001136297.2 | |
Accession Version | NM_001136297.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2568bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Mitogen-activated protein kinase kinase kinase dlk-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Jun 26, 2012 this sequence version replaced NM_001136297.1. COMPLETENESS: incomplete on both ends. |
1 | ATGGTGGCTG CGACCGGGAA CGCGTCGAAA CCCAGCCTGA ACAGCTTCTA CGCAGATGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001129769.1 |
CDS | 1..2568 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001136297.2 |
1 | ATGGTGGCTG CGACCGGGAA CGCGTCGAAA CCCAGCCTGA ACAGCTTCTA CGCAGATGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |