COX6A1 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	COX6A1
Entrez Gene ID	282199
Full Name	cytochrome c oxidase subunit VIa polypeptide 1
Synonyms	VIA L
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001077831.2	NP_001071299.1	cytochrome c oxidase subunit 6A1, mitochondrial precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LOC101902002	XP_005206806.1
Danio rerio (zebrafish)	cox6a2	NP_001004680.1
Bos taurus (cattle)	COX6A1	NP_001071299.1
Xenopus tropicalis (tropical clawed frog)	cox6a2	NP_001004884.1

Gene Ontology
Bibliography

Related articles in PubMed

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Glutamic acid 242 is a valve in the proton pump of cytochrome c oxidase.
Kaila VR, Verkhovsky MI, Hummer G, Wikstr?m M
Proceedings of the National Academy of Sciences of the United States of America105(17)6255-9(2008 Apr)

Peroxidase activity of mitochondrial cytochrome c oxidase.
Vygodina TV, Konstantinov AA
Biochemistry. Biokhimiia72(10)1056-64(2007 Oct)

An IR study of protonation changes associated with heme-heme electron transfer in bovine cytochrome c oxidase.
Iwaki M, Rich PR
Journal of the American Chemical Society129(10)2923-9(2007 Mar)

The inhibitory binding site(s) of Zn2+ in cytochrome c oxidase.
Francia F, Giachini L, Boscherini F, Venturoli G, Capitanio G, Martino PL, Papa S
FEBS letters581(4)611-6(2007 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The conserved glutamic acid 242 near the active site of CcO undergoes a protonation state-dependent conformational change, which provides a valve in the pumping mechanism.
Title: Glutamic acid 242 is a valve in the proton pump of cytochrome c oxidase.

analysis of the peroxidase activity of mitochondrial cytochrome c oxidase peroxidase activity
Title: Peroxidase activity of mitochondrial cytochrome c oxidase.

perturbation of an arginine guanidinium, probably Arg-438, lowers the energy of the transient charge-uncompensated electron-transfer intermediate by changing the charge distribution in response to heme-heme electron transfer
Title: An IR study of protonation changes associated with heme-heme electron transfer in bovine cytochrome c oxidase.

Extended x-ray absorption spectroscopy analysis of Zn binding site(s) in bovine-heart cytochrome c oxidase and characterization of the inhibitory effect of internal zinc on respiratory activity and proton pumping reconstituted oxidase are presented.
Title: The inhibitory binding site(s) of Zn2+ in cytochrome c oxidase.

The P(M)-->F transition of the catalytic cycle of cytochrome c oxidase from bovine heart was investigated using single-electron photoreduction and monitoring the subsequent events using spectroscopic and electometric techniques.
Title: Single-electron photoreduction of the P(M) intermediate of cytochrome c oxidase.

The following COX6A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX6A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa00606	NM_001077831.2 Latest version!	Bos taurus cytochrome c oxidase subunit VIa polypeptide 1 (COX6A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COX6A1 ( NM_001077831.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001071299.1 Bos taurus cytochrome c oxidase subunit VIa polypeptide 1 (COX6A1), mRNA.

Price & Availability↑

CloneID	OBa00606
Clone ID Related Accession (Same CDS sequence)	NM_001077831.2
Accession Version	NM_001077831.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Bos taurus(cattle)
Product	cytochrome c oxidase subunit 6A1, mitochondrial precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC114182.1. On Aug 31, 2012 this sequence version replaced NM_001077831.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC114182.1, DV837713.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGCGGCGG CAGCTGGATC TCGGGTTTTT GGGTTGCTGG GTCGTTCCCG GCTGCAGCTG 
AGTCGGTGTA TGTCCAGTGG CGCCCATGGC GAGGAGGGCT CAGCTCGCAT GTGGAAGGCC 
CTCACCTACT TCGTGGCGCT CCCTGGGGTG GGAGTGAGCA TGCTGAATGT CTTCCTGAAG 
TCGCACCACG GAGAGGAGGA GAGACCCGAG TTCGTGGCCT ATCCCCATCT CCGCATCAGG 
TCCAAGCCCT TTCCCTGGGG AGATGGTAAC CATACCCTAT TCCATAACCC TCATGTGAAC 
CCGCTTCCAA CCGGCTATGA AGACGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001071299.1
CDS	18..347
Translation	MAAAAGSRVFGLLGRSRLQLSRCMSSGAHGEEGSARMWKALTYFVALPGVGVSMLNVFLKSHHGEEERPEFVAYPHLRIRSKPFPWGDGNHTLFHNPHVNPLPTGYEDE

Target ORF information:

RefSeq Version	NM_001077831.2
Organism	Bos taurus(cattle)
Definition	Bos taurus cytochrome c oxidase subunit VIa polypeptide 1 (COX6A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001077831.2

ORF Insert Sequence:

ATGGCGGCGG CAGCTGGATC TCGGGTTTTT GGGTTGCTGG GTCGTTCCCG GCTGCAGCTG 
AGTCGGTGTA TGTCCAGTGG CGCCCATGGC GAGGAGGGCT CAGCTCGCAT GTGGAAGGCC 
CTCACCTACT TCGTGGCGCT CCCTGGGGTG GGAGTGAGCA TGCTGAATGT CTTCCTGAAG 
TCGCACCACG GAGAGGAGGA GAGACCCGAG TTCGTGGCCT ATCCCCATCT CCGCATCAGG 
TCCAAGCCCT TTCCCTGGGG AGATGGTAAC CATACCCTAT TCCATAACCC TCATGTGAAC 
CCGCTTCCAA CCGGCTATGA AGACGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Glutamic acid 242 is a valve in the proton pump of cytochrome c oxidase.
Proceedings of the National Academy of Sciences of the United States of America105(17)6255-9(2008 Apr)
Kaila VR,Verkhovsky MI,Hummer G,Wikstr?m M

Peroxidase activity of mitochondrial cytochrome c oxidase.
Biochemistry. Biokhimiia72(10)1056-64(2007 Oct)
Vygodina TV,Konstantinov AA

An IR study of protonation changes associated with heme-heme electron transfer in bovine cytochrome c oxidase.
Journal of the American Chemical Society129(10)2923-9(2007 Mar)
Iwaki M,Rich PR

The inhibitory binding site(s) of Zn2+ in cytochrome c oxidase.
FEBS letters581(4)611-6(2007 Feb)
Francia F,Giachini L,Boscherini F,Venturoli G,Capitanio G,Martino PL,Papa S

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COX6A1 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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