TGM2 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	TGM2
Entrez Gene ID	281528
Full Name	transglutaminase 2
General protein information	Preferred Names transglutaminase 2 Names protein-glutamine gamma-glutamyltransferase 2 TG(C) TGC TGase C TGase-2 tissue transglutaminase transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) transglutaminase C
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_177507.2	NP_803473.1	protein-glutamine gamma-glutamyltransferase 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TGM2	XP_001144553.2
Canis lupus familiaris (dog)	TGM2	XP_542991.4
Gallus gallus (chicken)	TGM2	NP_990779.1
Danio rerio (zebrafish)	tgm2b	NP_997821.2
Homo sapiens (human)	TGM2	NP_004604.2
Bos taurus (cattle)	TGM2	NP_803473.1
Rattus norvegicus (Norway rat)	Tgm2	NP_062259.2
Xenopus tropicalis (tropical clawed frog)	tgm2	NP_001123852.1
Mus musculus (house mouse)	Tgm2	NP_033399.1

Gene Ontology
Bibliography

Related articles in PubMed

Tissue transglutaminase promotes serotonin-induced AKT signaling and mitogenesis in pulmonary vascular smooth muscle cells.
Penumatsa K, Abualkhair S, Wei L, Warburton R, Preston I, Hill NS, Watts SW, Fanburg BL, Toksoz D
Cellular signalling26(12)2818-25(2014 Dec)

Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation.
Penumatsa KC, Toksoz D, Warburton RR, Hilmer AJ, Liu T, Khosla C, Comhair SA, Fanburg BL
American journal of physiology. Lung cellular and molecular physiology307(7)L576-85(2014 Oct)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification.
Johnson KA, Terkeltaub RA
The Journal of biological chemistry280(15)15004-12(2005 Apr)

Retinol-induced morphological changes of cultured bovine endothelial cells are accompanied by a marked increase in transglutaminase.
Nara K, Nakanishi K, Hagiwara H, Wakita K, Kojima S, Hirose S
The Journal of biological chemistry264(32)19308-12(1989 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TG2 contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.
Title: Tissue transglutaminase promotes serotonin-induced AKT signaling and mitogenesis in pulmonary vascular smooth muscle cells.

An important role for TG2, mediated by intracellular calcium fluxes and HIF1A, in hypoxia-induced pulmonary artery smooth muscle cells proliferation.
Title: Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation.

externalized GTP-bound TG2 serves as a molecular switch for differentiation of chondrocytes to a hypertrophic, calcifying phenotype in a manner that does not require either TG2 transamidation activity or fibronectin binding
Title: External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification.

The following TGM2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TGM2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa41835	NM_177507.2 Latest version!	Bos taurus transglutaminase 2 (TGM2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TGM2 ( NM_177507.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_803473.1 Bos taurus transglutaminase 2 (TGM2), mRNA.

Price & Availability↑

CloneID	OBa41835
Clone ID Related Accession (Same CDS sequence)	NM_177507.2
Accession Version	NM_177507.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2064bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Bos taurus(cattle)
Product	protein-glutamine gamma-glutamyltransferase 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X60686.1. On or before Mar 29, 2005 this sequence version replaced XM_614855.1, NM_177507.1. ##Evidence-Data-START## Transcript exon combination :: X60686.1, BC103290.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN03145412, SAMN03145413 [ECO:0000350] ##Evidence-Data-END##

ATGGCCGAGG AGCTGGTCCT GGAGAGATGT GACCTGGAGC TGGAGGCCAA TGGCCGTGAC 
CACCACACAG CTGACCTGTG CAGGGAAAGG CTGGTAGTGC GGCGGGGCCA GCCCTTCTGG 
CTGACTCTGC ACTTTGAGGG CCGGAACTAT GAGGCCAGCG TGGACAGCCT CACCTTTTGT 
GCTGTGACTG GCCCAGACCC CAGTGAGGAG GCCGGGACCA AGGCCCTCTT CAGGCTGTCC 
GATGCTACGG AGGAGGGGGC CTGGGCAGCG GTGGCAGCGG ACCAGCGAGA CAGCACCCTC 
TCGCTGCACC TCAGCACCCC GGCCAATGCC CCCGTTGGCC ATTACCGCCT CAGCTTGGAG 
GCCTCCACTG GCTACCAGGG CTCCAGTTTC ATGCTGGGTC AGTTCACCCT GCTCTTCAAC 
AGCTGGTGTC CAGCGGATGC TGTGTACCTG GACTCAGATG AGGAGCGGCA AGAATACGTC 
CTTACCCAGC AAGGCTTCAT CTACCAGGGC TCAGCCAAGT TCATCAAGAA CATACCTTGG 
AATTTTGGGC AGTTTGAAGA AGGGATCCTA GACATCTGCC TGATGCTCCT GGATGTCAAC 
CCCAAGTTCC TGAGGAATGC CGGCCGAGAC TGCTCCCGCC GCAGTAGTCC GGTCTATGTG 
GGCCGGGTGG TGAGCGGCAT GGTCAACTGC AACGATGACC AGGGCGTGCT GCTGGGGCGC 
TGGGACAACA ACTACGCAGA CGGCATCAGC CCCATGTCCT GGATCGGCAG CGTGGACATC 
CTGCGGCGCT GGAAGAGAGA TGGCTGCCAG CGCGTCAAGT ACGGCCAGTG CTGGGTGTTC 
GCGGCTGTGG CCTGCACCGT GCTGCGGTGC CTTGGCATCC CTACCCGAGT CGTGACCAAC 
TATAACTCAG CCCATGACCA GAACAGCAAC CTGCTCATCG AGTACTTCCG CAATGAGTTC 
GGGGAGATCC AGAGTGACAA GAGCGAGATG ATCTGGAACT TCCACTGCTG GGTGGAGTCG 
TGGATGACCA GGCCAGACCT GCAGCCGGGG TACGAGGGGT GGCAGGCCCT CGACCCCACG 
CCCCAGGAGA AGAGCGAAGG GACTTACTGC TGTGGCCCGG TTCCCGTTCG TGCCATCAAG 
GAGGGTGACC TGAGCACCAA ATACGACGCC CCTTTCGTCT TTGCCGAAGT CAACGCTGAC 
GTGGTGGACT GGATCCGGCA GGACGATGGG TCTCTGCACA AATCCATCAA CCACTCCCTG 
GTGGTGGGGC TGAAGATCAG CACAAAGTGT GTGGGCAGAG ATGATCGGGA GGACATCACC 
CACAGCTACA AGTACCCGGA GGGGTCCCCA GAGGAAAGGG AAGCCTTCAC AAGAGCCAAC 
CATCTGAACA AACTGGTTAA CAAAGAGGAG ACAGGGGTGG CCATGCGGAT CCGTGTGGGC 
GAGGGCATGA ACAGAGGCTG CGACTTCGAC GTCTTTGCCC ACATCACCAA CAGCACCCCT 
GAGGAGCACA CTGGCCGCCT CCTGCTCTGT GCCCGCACTG TCAGCTACAA TGGGATCCTG 
GGACCTGAGT GCGGCACCAA GGATCTGCTC AGCCTTTCCC TGGAGCCCTA CTCTGAGAAG 
AGCATTCCCC TTCGAATCCT CTACGAAAAG TACTGTGATT GCCTGACCGA ATCGAACCTT 
ATCAAGGTGC GGGGCCTCCT TATTGAGCCA GCTGCCAATA GCTACCTGCT GGCCGAGAGG 
GACATCTACC TGGAGAACCC AGAAATCAAG ATCCGGATCC TGGGAGAGCC CAAGCAGAAC 
CGCAAGCTGG TGGCTGAGAT ATCTCTGCAG AACCCGCTCA CTGTGGCGCT GTCGGGCTGC 
ACCTTCACTG TGGAGGGAGC AGGCCTGATT GAGGAGCAGA AGACTGTGGA CGTCCCAGAC 
CCCGTGGAAG CAGGGGAGGA AGTCAAGGTG AGGGTGGACC TGCTGCCTCT GTACGTGGGC 
CGCCACAAGC TGGTGGTGAA CTTCGAGAGC GACAGGCTGA AGGCCGTGAA GGGCTTTAGG 
AACGTCATCG TTGGCCCCTC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_803473.1
CDS	47..2110
Translation	MAEELVLERCDLELEANGRDHHTADLCRERLVVRRGQPFWLTLHFEGRNYEASVDSLTFCAVTGPDPSEEAGTKALFRLSDATEEGAWAAVAADQRDSTLSLHLSTPANAPVGHYRLSLEASTGYQGSSFMLGQFTLLFNSWCPADAVYLDSDEERQEYVLTQQGFIYQGSAKFIKNIPWNFGQFEEGILDICLMLLDVNPKFLRNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYADGISPMSWIGSVDILRRWKRDGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGEIQSDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIRQDDGSLHKSINHSLVVGLKISTKCVGRDDREDITHSYKYPEGSPEEREAFTRANHLNKLVNKEETGVAMRIRVGEGMNRGCDFDVFAHITNSTPEEHTGRLLLCARTVSYNGILGPECGTKDLLSLSLEPYSEKSIPLRILYEKYCDCLTESNLIKVRGLLIEPAANSYLLAERDIYLENPEIKIRILGEPKQNRKLVAEISLQNPLTVALSGCTFTVEGAGLIEEQKTVDVPDPVEAGEEVKVRVDLLPLYVGRHKLVVNFESDRLKAVKGFRNVIVGPS

Target ORF information:

RefSeq Version	NM_177507.2
Organism	Bos taurus(cattle)
Definition	Bos taurus transglutaminase 2 (TGM2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177507.2

ORF Insert Sequence:

ATGGCCGAGG AGCTGGTCCT GGAGAGATGT GACCTGGAGC TGGAGGCCAA TGGCCGTGAC 
CACCACACAG CTGACCTGTG CAGGGAAAGG CTGGTAGTGC GGCGGGGCCA GCCCTTCTGG 
CTGACTCTGC ACTTTGAGGG CCGGAACTAT GAGGCCAGCG TGGACAGCCT CACCTTTTGT 
GCTGTGACTG GCCCAGACCC CAGTGAGGAG GCCGGGACCA AGGCCCTCTT CAGGCTGTCC 
GATGCTACGG AGGAGGGGGC CTGGGCAGCG GTGGCAGCGG ACCAGCGAGA CAGCACCCTC 
TCGCTGCACC TCAGCACCCC GGCCAATGCC CCCGTTGGCC ATTACCGCCT CAGCTTGGAG 
GCCTCCACTG GCTACCAGGG CTCCAGTTTC ATGCTGGGTC AGTTCACCCT GCTCTTCAAC 
AGCTGGTGTC CAGCGGATGC TGTGTACCTG GACTCAGATG AGGAGCGGCA AGAATACGTC 
CTTACCCAGC AAGGCTTCAT CTACCAGGGC TCAGCCAAGT TCATCAAGAA CATACCTTGG 
AATTTTGGGC AGTTTGAAGA AGGGATCCTA GACATCTGCC TGATGCTCCT GGATGTCAAC 
CCCAAGTTCC TGAGGAATGC CGGCCGAGAC TGCTCCCGCC GCAGTAGTCC GGTCTATGTG 
GGCCGGGTGG TGAGCGGCAT GGTCAACTGC AACGATGACC AGGGCGTGCT GCTGGGGCGC 
TGGGACAACA ACTACGCAGA CGGCATCAGC CCCATGTCCT GGATCGGCAG CGTGGACATC 
CTGCGGCGCT GGAAGAGAGA TGGCTGCCAG CGCGTCAAGT ACGGCCAGTG CTGGGTGTTC 
GCGGCTGTGG CCTGCACCGT GCTGCGGTGC CTTGGCATCC CTACCCGAGT CGTGACCAAC 
TATAACTCAG CCCATGACCA GAACAGCAAC CTGCTCATCG AGTACTTCCG CAATGAGTTC 
GGGGAGATCC AGAGTGACAA GAGCGAGATG ATCTGGAACT TCCACTGCTG GGTGGAGTCG 
TGGATGACCA GGCCAGACCT GCAGCCGGGG TACGAGGGGT GGCAGGCCCT CGACCCCACG 
CCCCAGGAGA AGAGCGAAGG GACTTACTGC TGTGGCCCGG TTCCCGTTCG TGCCATCAAG 
GAGGGTGACC TGAGCACCAA ATACGACGCC CCTTTCGTCT TTGCCGAAGT CAACGCTGAC 
GTGGTGGACT GGATCCGGCA GGACGATGGG TCTCTGCACA AATCCATCAA CCACTCCCTG 
GTGGTGGGGC TGAAGATCAG CACAAAGTGT GTGGGCAGAG ATGATCGGGA GGACATCACC 
CACAGCTACA AGTACCCGGA GGGGTCCCCA GAGGAAAGGG AAGCCTTCAC AAGAGCCAAC 
CATCTGAACA AACTGGTTAA CAAAGAGGAG ACAGGGGTGG CCATGCGGAT CCGTGTGGGC 
GAGGGCATGA ACAGAGGCTG CGACTTCGAC GTCTTTGCCC ACATCACCAA CAGCACCCCT 
GAGGAGCACA CTGGCCGCCT CCTGCTCTGT GCCCGCACTG TCAGCTACAA TGGGATCCTG 
GGACCTGAGT GCGGCACCAA GGATCTGCTC AGCCTTTCCC TGGAGCCCTA CTCTGAGAAG 
AGCATTCCCC TTCGAATCCT CTACGAAAAG TACTGTGATT GCCTGACCGA ATCGAACCTT 
ATCAAGGTGC GGGGCCTCCT TATTGAGCCA GCTGCCAATA GCTACCTGCT GGCCGAGAGG 
GACATCTACC TGGAGAACCC AGAAATCAAG ATCCGGATCC TGGGAGAGCC CAAGCAGAAC 
CGCAAGCTGG TGGCTGAGAT ATCTCTGCAG AACCCGCTCA CTGTGGCGCT GTCGGGCTGC 
ACCTTCACTG TGGAGGGAGC AGGCCTGATT GAGGAGCAGA AGACTGTGGA CGTCCCAGAC 
CCCGTGGAAG CAGGGGAGGA AGTCAAGGTG AGGGTGGACC TGCTGCCTCT GTACGTGGGC 
CGCCACAAGC TGGTGGTGAA CTTCGAGAGC GACAGGCTGA AGGCCGTGAA GGGCTTTAGG 
AACGTCATCG TTGGCCCCTC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tissue transglutaminase promotes serotonin-induced AKT signaling and mitogenesis in pulmonary vascular smooth muscle cells.
Cellular signalling26(12)2818-25(2014 Dec)
Penumatsa K,Abualkhair S,Wei L,Warburton R,Preston I,Hill NS,Watts SW,Fanburg BL,Toksoz D

Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation.
American journal of physiology. Lung cellular and molecular physiology307(7)L576-85(2014 Oct)
Penumatsa KC,Toksoz D,Warburton RR,Hilmer AJ,Liu T,Khosla C,Comhair SA,Fanburg BL

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification.
The Journal of biological chemistry280(15)15004-12(2005 Apr)
Johnson KA,Terkeltaub RA

Retinol-induced morphological changes of cultured bovine endothelial cells are accompanied by a marked increase in transglutaminase.
The Journal of biological chemistry264(32)19308-12(1989 Nov)
Nara K,Nakanishi K,Hagiwara H,Wakita K,Kojima S,Hirose S

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TGM2 cDNA ORF clone, Bos taurus(cattle)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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