Tgm2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tgm2
Entrez Gene ID	56083
Full Name	transglutaminase 2
Synonyms	TgaseII
General protein information	Preferred Names transglutaminase 2 Names protein-glutamine gamma-glutamyltransferase 2 glutamine gamma-glutamyltransferase 2 tissue-type transglutaminase transglutaminase 2, C polypeptide
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q42
Summary	catalyzes acyl transferase reaction of gamma-carboxamide groups of glutamine residues (donor peptide) with epsilon-amino groups of lysine residues (acceptor peptide) [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019386.2	NP_062259.2	protein-glutamine gamma-glutamyltransferase 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TGM2	XP_001144553.2
Canis lupus familiaris (dog)	TGM2	XP_542991.4
Gallus gallus (chicken)	TGM2	NP_990779.1
Danio rerio (zebrafish)	tgm2b	NP_997821.2
Homo sapiens (human)	TGM2	NP_004604.2
Bos taurus (cattle)	TGM2	NP_803473.1
Rattus norvegicus (Norway rat)	Tgm2	NP_062259.2
Xenopus tropicalis (tropical clawed frog)	tgm2	NP_001123852.1
Mus musculus (house mouse)	Tgm2	NP_033399.1

Gene Ontology
Bibliography

Related articles in PubMed

Depletion of transglutaminase 2 in neurons alters expression of extracellular matrix and signal transduction genes and compromises cell viability.
Yunes-Medina L, Paciorkowski A, Nuzbrokh Y, Johnson GVW
Molecular and cellular neurosciences8672-80(2018 Jan)

Tissue transglutaminase in astrocytes is enhanced by inflammatory mediators and is involved in the formation of fibronectin fibril-like structures.
Espitia Pinz?n N, Brev? JJP, Bol JGJM, Drukarch B, Baron W, van Dam AM
Journal of neuroinflammation14(1)260(2017 Dec)

?
Vyas FS, Nelson CP, Freeman F, Boocock DJ, Hargreaves AJ, Dickenson JM
European journal of pharmacology813105-121(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

An increase in TG2 activity contributes to age-associated increase in diastolic stiffness, thereby facilitating age-associated diastolic dysfunction.
Title: Role of tissue transglutaminase in age-associated ventricular stiffness.

our findings suggest that cystamine induced vasodilatation in rat mesenteric small arteries by inhibition of receptor-coupled TG2, leading to opening of Kv channels and reduction of intracellular calcium as well as activation of a pathway sensitive to inhibitors of the mitochondrial complexes I and III
Title: Involvement of transglutaminase 2 and voltage-gated potassium channels in cystamine vasodilatation in rat mesenteric small arteries.

Expression, activity, and functionality of TG1 and TG2 are decreased in the aorta, but not in the vena cava, from hypertensive rats.
Title: Transglutaminase activity is decreased in large arteries from hypertensive rats compared with normotensive controls.

a pleiotropic enzyme transglutaminase type 2 targets the allosteric coupling domain of IP3R type 1 (IP3R1) and negatively regulates IP3R1-mediated calcium signaling and autophagy by locking the subunit configurations.
Title: Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors.

Chronic allograft nephropathy was associated with upregulation of renal TG2 pathway.
Title: Upregulation of transglutaminase and ? (?-glutamyl)-lysine in the Fisher-Lewis rat model of chronic allograft nephropathy.

The following Tgm2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tgm2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13801	NM_019386.2 Latest version!	Rattus norvegicus transglutaminase 2 (Tgm2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$405.30 $579.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tgm2 ( NM_019386.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062259.2 Rattus norvegicus transglutaminase 2 (Tgm2), mRNA.

Price & Availability↑

CloneID	ORa13801
Clone ID Related Accession (Same CDS sequence)	NM_019386.2
Accession Version	NM_019386.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2061bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Rattus norvegicus(Norway rat)
Product	protein-glutamine gamma-glutamyltransferase 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC062062.1. On Feb 9, 2004 this sequence version replaced NM_019386.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC062062.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCCGAGG AGCTGAACCT GGAGAGGTGC GATTTGGAGA TACAGGCCAA TGGCCGTGAT 
CACCACACGG CCGACCTGTG CCAAGAGAAA CTGGTGCTGC GGCGAGGCCA GCGCTTCCGG 
CTGACACTGT ACTTCGAGGG CCGTGGCTAT GAGGCCAGCG TGGACAGACT TACATTTGGT 
GCCGTGACCG GCCCAGATCC CAGTGAAGAG GCAGGGACCA AGGCCCGCTT CTCACTGTCT 
GACGATGTGG AGGAGGGATC CTGGTCAGCC TCTGTGCTGG ACCAACAGGA CAATGTCCTC 
TCGCTGCAGC TCTGCACCCC AGCCAATGCT CCTGTTGGCC AGTACCGCCT CAGCCTGGAG 
ACTTCTACTG GCTACCAAGG CTCCAGCTTC ATGCTGGGTC ACTTCATCCT GCTCTTCAAT 
GCCTGGTGCC CAGCGGATGA CGTGTACCTA GATTCAGAGG CGGAGCGCCG GGAATACGTC 
CTCACACAGC AGGGCTTCAT CTACCAGGGC TCTGTCAAGT TCATCAAGAG TGTGCCTTGG 
AACTTTGGGC AGTTTGAGGA TGGGATCCTG GATGCCTGCC TGATGCTTTT GGATGTGAAC 
CCCAAGTTCC TGAAGGACCG TAGCCGGGAC TGCTCACGAC GCAGCAGTCC CATCTATGTG 
GGCCGCGTGG TGAGCGGCAT GGTCAACTGC AATGATGACC AGGGTGTGCT TCTGGGTCGC 
TGGGACAACA ATTATGGGGA CGGTATCAGT CCCATGGCCT GGATTGGCAG CGTGGACATT 
CTGCGGCGCT GGAAGGAACA CGGCTGTCAG CAAGTGAAGT ATGGCCAGTG CTGGGTGTTT 
GCGGCGGTAG CCTGCACAGT GCTGCGGTGC CTTGGCATCC CTACCAGAGT GGTGACCAAC 
TACAACTCCG CCCACGACCA GAACAGCAAC CTGCTCATCG AGTACTTCCG AAACGAGTAC 
GGGGAGCTGG AGAGCAACAA GAGCGAGATG ATCTGGAATT TCCACTGCTG GGTGGAGTCC 
TGGATGACCA GGCCAGACCT ACAGCCAGGC TATGAGGGGT GGCAGGCCAT TGACCCCACA 
CCGCAGGAGA AGAGCGAAGG AACATACTGT TGTGGCCCAG TCTCAGTGCG GGCCATCAAG 
GAGGGTGACC TGAGCACCAA GTATGATGCG TCCTTCGTGT TTGCCGAGGT CAACGCTGAT 
GTGGTGGACT GGATCCGGCA GTCAGATGGG TCTGTGCTCA AATCCATCAA CAATTCCCTG 
GTCGTGGGGC AGAAGATCAG CACTAAGAGC GTGGGCCGTG ATGACCGGGA GGACATCACC 
TATACCTACA AGTACCCAGA GGGGTCCCCA GAGGAGAGGG AAGTCTTCAC CAGAGCCAAC 
CACCTGAACA AACTGGCAGA GAAAGAGGAG ACAGGGGTGG CCATGCGGAT CCGAGTGGGG 
GATGGTATGA GCTTGGGCAA TGACTTTGAC GTGTTTGCCC ACATCGGCAA CGACACCTCG 
GAGAGCCGTG AGTGCCGCCT CCTGCTCTGT GCCCGCACTG TCAGCTACAA CGGCGTGCTG 
GGGCCCGAGT GTGGCACTGA GGACATCAAC CTGACCCTGG ATCCCTACTC TGAGAACAGC 
ATCCCCCTTC GCATCCTCTA CGAGAAGTAC AGCGGTTGCC TGACCGAGTC AAACCTCATC 
AAGGTGCGGG GTCTCCTCGT CGAGCCAGCC GCTAACAGCT ACCTGCTGGC TGAGAGAGAT 
CTCTACCTGG AGAATCCTGA AATCAAGATC CGGATCCTGG GGGAGCCCAA GCAGAACCGC 
AAACTGGTGG CTGAGGTGTC CCTGAAGAAC CCACTTTCTG ATTCCCTGTA TGACTGTGTC 
TTCACTGTGG AGGGGGCTGG CCTGACCAAG GAACAGAAGT CTGTGGAGGT CTCAGACCCT 
GTGCCAGCAG GAGATGCGGT CAAGGTGCGG GTTGACCTGT TCCCGACTGA TATTGGCCTC 
CACAAGTTGG TGGTGAACTT CCAGTGTGAC AAGCTGAAGT CGGTCAAGGG TTACCGGAAT 
ATCATCATCG GCCCGGCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062259.2
CDS	57..2117
Translation	MAEELNLERCDLEIQANGRDHHTADLCQEKLVLRRGQRFRLTLYFEGRGYEASVDRLTFGAVTGPDPSEEAGTKARFSLSDDVEEGSWSASVLDQQDNVLSLQLCTPANAPVGQYRLSLETSTGYQGSSFMLGHFILLFNAWCPADDVYLDSEAERREYVLTQQGFIYQGSVKFIKSVPWNFGQFEDGILDACLMLLDVNPKFLKDRSRDCSRRSSPIYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGISPMAWIGSVDILRRWKEHGCQQVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEYGELESNKSEMIWNFHCWVESWMTRPDLQPGYEGWQAIDPTPQEKSEGTYCCGPVSVRAIKEGDLSTKYDASFVFAEVNADVVDWIRQSDGSVLKSINNSLVVGQKISTKSVGRDDREDITYTYKYPEGSPEEREVFTRANHLNKLAEKEETGVAMRIRVGDGMSLGNDFDVFAHIGNDTSESRECRLLLCARTVSYNGVLGPECGTEDINLTLDPYSENSIPLRILYEKYSGCLTESNLIKVRGLLVEPAANSYLLAERDLYLENPEIKIRILGEPKQNRKLVAEVSLKNPLSDSLYDCVFTVEGAGLTKEQKSVEVSDPVPAGDAVKVRVDLFPTDIGLHKLVVNFQCDKLKSVKGYRNIIIGPA

Target ORF information:

RefSeq Version	NM_019386.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transglutaminase 2 (Tgm2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019386.2

ORF Insert Sequence:

ATGGCCGAGG AGCTGAACCT GGAGAGGTGC GATTTGGAGA TACAGGCCAA TGGCCGTGAT 
CACCACACGG CCGACCTGTG CCAAGAGAAA CTGGTGCTGC GGCGAGGCCA GCGCTTCCGG 
CTGACACTGT ACTTCGAGGG CCGTGGCTAT GAGGCCAGCG TGGACAGACT TACATTTGGT 
GCCGTGACCG GCCCAGATCC CAGTGAAGAG GCAGGGACCA AGGCCCGCTT CTCACTGTCT 
GACGATGTGG AGGAGGGATC CTGGTCAGCC TCTGTGCTGG ACCAACAGGA CAATGTCCTC 
TCGCTGCAGC TCTGCACCCC AGCCAATGCT CCTGTTGGCC AGTACCGCCT CAGCCTGGAG 
ACTTCTACTG GCTACCAAGG CTCCAGCTTC ATGCTGGGTC ACTTCATCCT GCTCTTCAAT 
GCCTGGTGCC CAGCGGATGA CGTGTACCTA GATTCAGAGG CGGAGCGCCG GGAATACGTC 
CTCACACAGC AGGGCTTCAT CTACCAGGGC TCTGTCAAGT TCATCAAGAG TGTGCCTTGG 
AACTTTGGGC AGTTTGAGGA TGGGATCCTG GATGCCTGCC TGATGCTTTT GGATGTGAAC 
CCCAAGTTCC TGAAGGACCG TAGCCGGGAC TGCTCACGAC GCAGCAGTCC CATCTATGTG 
GGCCGCGTGG TGAGCGGCAT GGTCAACTGC AATGATGACC AGGGTGTGCT TCTGGGTCGC 
TGGGACAACA ATTATGGGGA CGGTATCAGT CCCATGGCCT GGATTGGCAG CGTGGACATT 
CTGCGGCGCT GGAAGGAACA CGGCTGTCAG CAAGTGAAGT ATGGCCAGTG CTGGGTGTTT 
GCGGCGGTAG CCTGCACAGT GCTGCGGTGC CTTGGCATCC CTACCAGAGT GGTGACCAAC 
TACAACTCCG CCCACGACCA GAACAGCAAC CTGCTCATCG AGTACTTCCG AAACGAGTAC 
GGGGAGCTGG AGAGCAACAA GAGCGAGATG ATCTGGAATT TCCACTGCTG GGTGGAGTCC 
TGGATGACCA GGCCAGACCT ACAGCCAGGC TATGAGGGGT GGCAGGCCAT TGACCCCACA 
CCGCAGGAGA AGAGCGAAGG AACATACTGT TGTGGCCCAG TCTCAGTGCG GGCCATCAAG 
GAGGGTGACC TGAGCACCAA GTATGATGCG TCCTTCGTGT TTGCCGAGGT CAACGCTGAT 
GTGGTGGACT GGATCCGGCA GTCAGATGGG TCTGTGCTCA AATCCATCAA CAATTCCCTG 
GTCGTGGGGC AGAAGATCAG CACTAAGAGC GTGGGCCGTG ATGACCGGGA GGACATCACC 
TATACCTACA AGTACCCAGA GGGGTCCCCA GAGGAGAGGG AAGTCTTCAC CAGAGCCAAC 
CACCTGAACA AACTGGCAGA GAAAGAGGAG ACAGGGGTGG CCATGCGGAT CCGAGTGGGG 
GATGGTATGA GCTTGGGCAA TGACTTTGAC GTGTTTGCCC ACATCGGCAA CGACACCTCG 
GAGAGCCGTG AGTGCCGCCT CCTGCTCTGT GCCCGCACTG TCAGCTACAA CGGCGTGCTG 
GGGCCCGAGT GTGGCACTGA GGACATCAAC CTGACCCTGG ATCCCTACTC TGAGAACAGC 
ATCCCCCTTC GCATCCTCTA CGAGAAGTAC AGCGGTTGCC TGACCGAGTC AAACCTCATC 
AAGGTGCGGG GTCTCCTCGT CGAGCCAGCC GCTAACAGCT ACCTGCTGGC TGAGAGAGAT 
CTCTACCTGG AGAATCCTGA AATCAAGATC CGGATCCTGG GGGAGCCCAA GCAGAACCGC 
AAACTGGTGG CTGAGGTGTC CCTGAAGAAC CCACTTTCTG ATTCCCTGTA TGACTGTGTC 
TTCACTGTGG AGGGGGCTGG CCTGACCAAG GAACAGAAGT CTGTGGAGGT CTCAGACCCT 
GTGCCAGCAG GAGATGCGGT CAAGGTGCGG GTTGACCTGT TCCCGACTGA TATTGGCCTC 
CACAAGTTGG TGGTGAACTT CCAGTGTGAC AAGCTGAAGT CGGTCAAGGG TTACCGGAAT 
ATCATCATCG GCCCGGCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Depletion of transglutaminase 2 in neurons alters expression of extracellular matrix and signal transduction genes and compromises cell viability.
Molecular and cellular neurosciences8672-80(2018 Jan)
Yunes-Medina L,Paciorkowski A,Nuzbrokh Y,Johnson GVW

Tissue transglutaminase in astrocytes is enhanced by inflammatory mediators and is involved in the formation of fibronectin fibril-like structures.
Journal of neuroinflammation14(1)260(2017 Dec)
Espitia Pinz?n N,Brev? JJP,Bol JGJM,Drukarch B,Baron W,van Dam AM

?
European journal of pharmacology813105-121(2017 Oct)
Vyas FS,Nelson CP,Freeman F,Boocock DJ,Hargreaves AJ,Dickenson JM

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Tgm2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

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