MMP1 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	MMP1
Entrez Gene ID	281308
Full Name	matrix metallopeptidase 1 (interstitial collagenase)
Synonyms	MMP-1
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174112.1	NP_776537.1	interstitial collagenase precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MMP1	XP_508722.2
	MMP1	XP_001098302.1
Gallus gallus (chicken)	MMP1	XP_417176.1
Homo sapiens (human)	MMP1	NP_002412.1
Bos taurus (cattle)	MMP1	NP_776537.1
Mus musculus (house mouse)	Mmp1a	NP_114395.1
Bos taurus (cattle)	LOC100848085	XP_003586977.1
Rattus norvegicus (Norway rat)	Mmp1	NP_001128002.1
Canis lupus familiaris (dog)	LOC489428	XP_546546.3

Gene Ontology
Bibliography

Related articles in PubMed

Virus-Mediated Metalloproteinase 1 Induction Revealed by Transcriptome Profiling of Bovine Herpesvirus 4-Infected Bovine Endometrial Stromal Cells.
Tebaldi G, Jacca S, Montanini B, Capra E, Rosamilia A, Sala A, Stella A, Castiglioni B, Ottonello S, Donofrio G
Biology of reproduction95(1)12(2016 07)

Expression of MMP-1, -2, and -8 in longissimus dorsi muscle and their relationship with meat quality traits in cattle.
Qi YX, Zhang XH, Wang YQ, Pang YZ, Zhang ZB, Zhang TL, Zhang ZX
Genetics and molecular research : GMR15(1)15017593(2016 Mar)

Expression of matrix metalloproteinases in bovine luteal cells induced by prostaglandin F2?, interferon ? and tumor necrosis factor ?.
Abe H, Sakumoto R, Okuda K
The Journal of reproduction and development61(4)277-86(2015)

Study on matrix metalloproteinase 1 and 2 gene expression and NO in dairy cows with ovarian cysts.
Mutlag AM, Wang X, Yang Z, Meng J, Wang X, Zhang J, Qin Z, Wang G, Li J
Animal reproduction science1521-7(2015 Jan)

Cytoskeletal tension modulates MMP-1 gene expression from tenocytes on micropillar substrates.
Maeda E, Sugimoto M, Ohashi T
Journal of biomechanics46(5)991-7(2013 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

BoHV-4 infection affects various pathways related to cell proliferation and cell surface integrity, at least three of which were centered on upregulation of matrix metalloproteinase 1 (MMP1). MMP1 transcription was upregulated by the BoHV-4 transactivator IE2/RTA, leading to abnormally high metalloproteinase tissue levels, potentially leading to defective endometrium healing and unresolved inflammation.
Title: Virus-Mediated Metalloproteinase 1 Induction Revealed by Transcriptome Profiling of Bovine Herpesvirus 4-Infected Bovine Endometrial Stromal Cells.

The expression patterns of MMP1, MMP2, and MMP8 were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1, MMP2, and MMP8 expression levels with meat quality traits were analyzed in cattle. The expression of MMP1, MMP2, and MMP8 were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues.
Title: Expression of MMP-1, -2, and -8 in longissimus dorsi muscle and their relationship with meat quality traits in cattle.

Data suggest that luteolytic factors (such as interferon gamma, tumor necrosis factor alpha, and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.
Title: Expression of matrix metalloproteinases in bovine luteal cells induced by prostaglandin F2?, interferon ? and tumor necrosis factor ?.

The results showed that a decrease in MMP-1 and MMP-2 gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.
Title: Study on matrix metalloproteinase 1 and 2 gene expression and NO in dairy cows with ovarian cysts.

Cytoskeletal tension modulates MMP-1 gene expression from tenocytes on micropillar substrates.
Title: Cytoskeletal tension modulates MMP-1 gene expression from tenocytes on micropillar substrates.

The following MMP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MMP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa41752	NM_174112.1 Latest version!	Bos taurus matrix metallopeptidase 1 (interstitial collagenase) (MMP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MMP1 ( NM_174112.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776537.1 Bos taurus matrix metallopeptidase 1 (interstitial collagenase) (MMP1), mRNA.

Price & Availability↑

CloneID	OBa41752
Clone ID Related Accession (Same CDS sequence)	NM_174112.1
Accession Version	NM_174112.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1410bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Bos taurus(cattle)
Product	interstitial collagenase precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X58256.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X58256.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145438, SAMN03145468 [ECO:0000348] ##Evidence-Data-END##

ATGCCCAGAC TGCCTCTGCT GCTGCTGCTA CTCTGGGGCA CGGGGTCCCA CGGCTTCCCA 
GCAGCAACTT CAGAAACACA AGAACAAGAT GTGGAGACGG TGAAGAAATA CCTGGAAAAC 
TACTACAACC TGAACAGTAA TGGGAAGAAA GTTGAAAGGC AGAGAAACGG TGGCCTCATA 
ACTGAAAAGC TAAAGCAAAT GCAAAAATTC TTTGGGCTGA GAGTGACTGG GAAACCAGAT 
GCTGAAACCC TGAATGTGAT GAAGCAGCCC AGATGTGGGG TGCCCGACGT GGCTCCGTTT 
GTTCTTACTC CAGGGAAATC CTGTTGGGAG AACACAAACC TGACCTACAG GATTGAAAAT 
TACACCCCAG ACCTGTCAAG AGCAGATGTG GACCAAGCCA TTGAGAAAGC CTTTCAACTC 
TGGAGCAATG TCACACCCTT GACCTTCACC AAGGTCTCTG AGGGTCAAGC GGACATAATG 
ATATCCTTTG TCAGGGGAGA TCATCGTGAC AATTCTCCCT TTGATGGACC TGGTGGAAAC 
CTTGCTCATG CTTTTCAACC AGGTGCAGGT ATCGGAGGAG ACGCTCATTT TGATGATGAT 
GAATGGTGGA CCAGCAATTT CCAAGATTAT AACTTGTACC GGGTGGCAGC GCATGAATTT 
GGCCATTCCC TTGGACTTGC TCATTCTACT GACATTGGGG CTCTGATGTA CCCCAGTTAC 
ACCTTCAGTG GTGATGTTCA GCTTTCTCAG GACGACATTG ATGGGATCCA GGCCATCTAC 
GGACCTTCCC AAAATCCCAC TCAGCCAGTC GGCCCCCAAA CCCCAGAAGT GTGTGATAGC 
AAGCTAACTT TTGATGCCAT AACTACAATT CGGGGAGAAG TGATGTTCTT CAAAGACCGG 
TTCTACATGC GCACAAATCC CTTGTACCCA GAAGTGGAGC TCAATTTCAT CTCTGTTTTC 
TGGCCACAAC TCCCAAATGG ACTTCAAGCT GCTTATGAGG TTGCCGACAG GGATGAGGTC 
CGGTTTTTCA AAGGTAACAA GTACTGGGCC GTTAAGGGGC AGGATGTGCT CCGCGGATAC 
CCCAGGGACA TCTACAGATC CTTTGGCTTT CCGAGAACGG TGAAGAGCAT CGATGCCGCT 
GTTTCTGAGG AAGATACTGG GAAAACGTAT TTCTTTGTTG CCAACAAATG CTGGAGGTAT 
GATGAATATA AACAGTCCAT GGATGCAGGT TATCCCAAAA TGATAGCAGA AGACTTTCCC 
GGAATTGGCA ACAAAGTTGA TGCTGTTTTC CAGAAAGGTG GATTTTTCTA TTTCTTCCAT 
GGAAGAAGGC AATACAAATT TGATCCCCAA ACTAAGAGAA TTTTGACTCT TCTAAAAGCT 
AATAGCTGGT TCAACTGCAG AAAAAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776537.1
CDS	12..1421
Translation	MPRLPLLLLLLWGTGSHGFPAATSETQEQDVETVKKYLENYYNLNSNGKKVERQRNGGLITEKLKQMQKFFGLRVTGKPDAETLNVMKQPRCGVPDVAPFVLTPGKSCWENTNLTYRIENYTPDLSRADVDQAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGAGIGGDAHFDDDEWWTSNFQDYNLYRVAAHEFGHSLGLAHSTDIGALMYPSYTFSGDVQLSQDDIDGIQAIYGPSQNPTQPVGPQTPEVCDSKLTFDAITTIRGEVMFFKDRFYMRTNPLYPEVELNFISVFWPQLPNGLQAAYEVADRDEVRFFKGNKYWAVKGQDVLRGYPRDIYRSFGFPRTVKSIDAAVSEEDTGKTYFFVANKCWRYDEYKQSMDAGYPKMIAEDFPGIGNKVDAVFQKGGFFYFFHGRRQYKFDPQTKRILTLLKANSWFNCRKN

Target ORF information:

RefSeq Version	NM_174112.1
Organism	Bos taurus(cattle)
Definition	Bos taurus matrix metallopeptidase 1 (interstitial collagenase) (MMP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174112.1

ORF Insert Sequence:

ATGCCCAGAC TGCCTCTGCT GCTGCTGCTA CTCTGGGGCA CGGGGTCCCA CGGCTTCCCA 
GCAGCAACTT CAGAAACACA AGAACAAGAT GTGGAGACGG TGAAGAAATA CCTGGAAAAC 
TACTACAACC TGAACAGTAA TGGGAAGAAA GTTGAAAGGC AGAGAAACGG TGGCCTCATA 
ACTGAAAAGC TAAAGCAAAT GCAAAAATTC TTTGGGCTGA GAGTGACTGG GAAACCAGAT 
GCTGAAACCC TGAATGTGAT GAAGCAGCCC AGATGTGGGG TGCCCGACGT GGCTCCGTTT 
GTTCTTACTC CAGGGAAATC CTGTTGGGAG AACACAAACC TGACCTACAG GATTGAAAAT 
TACACCCCAG ACCTGTCAAG AGCAGATGTG GACCAAGCCA TTGAGAAAGC CTTTCAACTC 
TGGAGCAATG TCACACCCTT GACCTTCACC AAGGTCTCTG AGGGTCAAGC GGACATAATG 
ATATCCTTTG TCAGGGGAGA TCATCGTGAC AATTCTCCCT TTGATGGACC TGGTGGAAAC 
CTTGCTCATG CTTTTCAACC AGGTGCAGGT ATCGGAGGAG ACGCTCATTT TGATGATGAT 
GAATGGTGGA CCAGCAATTT CCAAGATTAT AACTTGTACC GGGTGGCAGC GCATGAATTT 
GGCCATTCCC TTGGACTTGC TCATTCTACT GACATTGGGG CTCTGATGTA CCCCAGTTAC 
ACCTTCAGTG GTGATGTTCA GCTTTCTCAG GACGACATTG ATGGGATCCA GGCCATCTAC 
GGACCTTCCC AAAATCCCAC TCAGCCAGTC GGCCCCCAAA CCCCAGAAGT GTGTGATAGC 
AAGCTAACTT TTGATGCCAT AACTACAATT CGGGGAGAAG TGATGTTCTT CAAAGACCGG 
TTCTACATGC GCACAAATCC CTTGTACCCA GAAGTGGAGC TCAATTTCAT CTCTGTTTTC 
TGGCCACAAC TCCCAAATGG ACTTCAAGCT GCTTATGAGG TTGCCGACAG GGATGAGGTC 
CGGTTTTTCA AAGGTAACAA GTACTGGGCC GTTAAGGGGC AGGATGTGCT CCGCGGATAC 
CCCAGGGACA TCTACAGATC CTTTGGCTTT CCGAGAACGG TGAAGAGCAT CGATGCCGCT 
GTTTCTGAGG AAGATACTGG GAAAACGTAT TTCTTTGTTG CCAACAAATG CTGGAGGTAT 
GATGAATATA AACAGTCCAT GGATGCAGGT TATCCCAAAA TGATAGCAGA AGACTTTCCC 
GGAATTGGCA ACAAAGTTGA TGCTGTTTTC CAGAAAGGTG GATTTTTCTA TTTCTTCCAT 
GGAAGAAGGC AATACAAATT TGATCCCCAA ACTAAGAGAA TTTTGACTCT TCTAAAAGCT 
AATAGCTGGT TCAACTGCAG AAAAAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Virus-Mediated Metalloproteinase 1 Induction Revealed by Transcriptome Profiling of Bovine Herpesvirus 4-Infected Bovine Endometrial Stromal Cells.
Biology of reproduction95(1)12(2016 07)
Tebaldi G,Jacca S,Montanini B,Capra E,Rosamilia A,Sala A,Stella A,Castiglioni B,Ottonello S,Donofrio G

Expression of MMP-1, -2, and -8 in longissimus dorsi muscle and their relationship with meat quality traits in cattle.
Genetics and molecular research : GMR15(1)15017593(2016 Mar)
Qi YX,Zhang XH,Wang YQ,Pang YZ,Zhang ZB,Zhang TL,Zhang ZX

Expression of matrix metalloproteinases in bovine luteal cells induced by prostaglandin F2?, interferon ? and tumor necrosis factor ?.
The Journal of reproduction and development61(4)277-86(2015)
Abe H,Sakumoto R,Okuda K

Study on matrix metalloproteinase 1 and 2 gene expression and NO in dairy cows with ovarian cysts.
Animal reproduction science1521-7(2015 Jan)
Mutlag AM,Wang X,Yang Z,Meng J,Wang X,Zhang J,Qin Z,Wang G,Li J

Cytoskeletal tension modulates MMP-1 gene expression from tenocytes on micropillar substrates.
Journal of biomechanics46(5)991-7(2013 Mar)
Maeda E,Sugimoto M,Ohashi T

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MMP1 cDNA ORF clone, Bos taurus(cattle)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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