Mmp1a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mmp1a
Entrez Gene ID	83995
Full Name	matrix metallopeptidase 1a (interstitial collagenase)
Synonyms	MMP-1a,Mcol-A,Mcola
General protein information	Preferred Names matrix metallopeptidase 1a (interstitial collagenase) Names interstitial collagenase A collagenase-like A matrix metalloproteinase 1a (interstitial collagenase)
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 A1
Summary	This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades collagens. Mice lacking the encoded protein exhibit decreased susceptibility to chemical carcinogen-induced lung tumor development and angiogenesis. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_032006.3	NP_114395.1	interstitial collagenase A preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MMP1	XP_508722.2
	MMP1	XP_001098302.1
Gallus gallus (chicken)	MMP1	XP_417176.1
Homo sapiens (human)	MMP1	NP_002412.1
Bos taurus (cattle)	MMP1	NP_776537.1
Mus musculus (house mouse)	Mmp1a	NP_114395.1
Bos taurus (cattle)	LOC100848085	XP_003586977.1
Rattus norvegicus (Norway rat)	Mmp1	NP_001128002.1
Canis lupus familiaris (dog)	LOC489428	XP_546546.3

Gene Ontology
Bibliography

Related articles in PubMed

Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription.
Takeda S, Sasagawa S, Oyama T, Searleman AC, Westergard TD, Cheng EH, Hsieh JJ
The Journal of clinical investigation125(3)1203-14(2015 Mar)

Matrix metalloproteinases and genetic mouse models in cancer research: a mini-review.
Wieczorek E, Jablonska E, Wasowicz W, Reszka E
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(1)163-75(2015 Jan)

Mouse matrix metalloprotease-1a (Mmp1a) gives new insight into MMP function.
Foley CJ, Kuliopulos A
Journal of cellular physiology229(12)1875-80(2014 Dec)

Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis.
Foley CJ, Fanjul-Fern?ndez M, Bohm A, Nguyen N, Agarwal A, Austin K, Koukos G, Covic L, L?pez-Ot?n C, Kuliopulos A
Oncogene33(17)2264-72(2014 Apr)

HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma.
Takeda S, Liu H, Sasagawa S, Dong Y, Trainor PA, Cheng EH, Hsieh JJ
The Journal of clinical investigation123(7)3154-65(2013 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The difficulty to effectively maintain Mmp1a in the zymogen form may account for the tight control of Mmp1a expression and reduced expression in normal tissue as compared to inflammatory states or cancer.
Title: Mouse matrix metalloprotease-1a (Mmp1a) gives new insight into MMP function.

Stromal Mmp1a drives in vivo tumorigenesis.
Title: Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis.

Matrix metalloproteinase Mmp-1a is not required for growth and fertility in mice and has a role in lung cancer progression by modulating inflammatory responses
Title: Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses.

The following Mmp1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mmp1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08666	NM_032006.3 Latest version!	Mus musculus matrix metallopeptidase 1a (interstitial collagenase) (Mmp1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$272.30 $389.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mmp1a ( NM_032006.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_114395.1 Mus musculus matrix metallopeptidase 1a (interstitial collagenase) (Mmp1a), mRNA.

Price & Availability↑

CloneID	OMu08666
Clone ID Related Accession (Same CDS sequence)	NM_032006.3
Accession Version	NM_032006.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1395bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	interstitial collagenase A preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK049552.1 and BQ558168.1. On Mar 20, 2007 this sequence version replaced NM_032006.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC117756.2, AK049552.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134 [ECO:0000348] ##Evidence-Data-END##

ATGCCTAGCC TTCCTTTGCT GTTGCTTCTC TGGGCTGCTA GCTCATACAG TTTCCCTGTG 
TTTCACAACG GAGACCGGCA AAATGTGGAG ACAGTCTGGA AATACCTGGA AAACTACTAC 
AACTTGGGCA AAAACATGCA AGCTAAAAAC GTGAATGGCA AGGAGATGAT GGCTGAAAAG 
CTGAGGCAAA TGCAGCAGTT ATTTGGGCTG AAAGTGACTG GAAATTCAGA TCCTGAAACC 
CTGAGAGCTA TGAAGAAGCC CAGGTGTGGG GTGCCTGATG TGGCCCCATA TGCCATTACT 
CACAACAATC CTCGTTGGAC CAAAACACAT CTGACATACA GCATTTTAAA CTACACACCA 
TATTTGCCAA AAGCAGTTGT GGAAGATGCC ATCGCGAGAG CCTTTAGAGT CTGGAGTGAT 
GTGACACCAC TTACGTTCCA AAGAGTCTTT GAGGAGGAAG GCGATATTGT GCTCTCCTTC 
CACAGAGGAG ACCATGGTGA CAACAACCCA TTTGATGGAC CTAACTATAA GCTTGCTCAC 
ACTTTCCAGC CAGGCCCAGG TTTGGGGGGT GATGTTCATT ATGACCTTGA TGAGACGTGG 
ACCAACAGCA GTGAAAATTT CAACTTGTTC TATGTTACGG CTCATGAACT GGGTCACTCC 
CTTGGGCTCA CTCATTCTAG TGATATAGGA GCACTAATGT TCCCCAGTTA CACGTGGTAC 
ACTGAAGACT TTGTGCTAAA CCAGGATGAT ATTAATCGCA TCCAGGACTT ATATGGACCT 
TCCCCAAATC CCATCCAGCC AACAGGTGCA ACAACACCAC ATCCATGTAA TGGTGATCTA 
ACCTTTGATG CTATAACTAC ATTTAGGGGA GAGGTGTTTT TCTTCAAAGG CAGGTTCTAC 
ATTCGGGTAA ATAGATTCAT GCCAGAACCT GAGCTCAATT TAATAGGTAT TCTCTGGCCA 
AATCTTCCAG TTAAACTTGA CGCTGCTTAT GAAGCTAGTA TGATAGATCA AGTCCGCTAT 
TTCAAAGGCA GCAAAGTATG GGCTGTTCAA GAGCAGAGTG TACTGAGAGG ATTCCCCAGA 
GACATCCACA GTTTCTTTGG CTTCCCTAGC AATGTGACAC ACATTGATGC TGCTGTTTGT 
GAGGAAGAGA CTGGAAAAAC ATACTTCTTT GTTGACCACA TGTACTGGAG GTATGATGAA 
AATACACAGT CTATGGATCC AGGTTATCCC AGATTAACAG CAGAAGACTT CCCTGGAATT 
GATGATAAAG TTGATGATGT TTTCCAAAAA GGAGAAAATT TCTATTTCTT TCACCAATCA 
GTTCAACACA GATTTAACCT CCAAATAAGA AGAGTTGATG ATTCCCGTGA TTCTAGTACA 
TGGTTCAACT GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114395.1
CDS	57..1451
Translation	MPSLPLLLLLWAASSYSFPVFHNGDRQNVETVWKYLENYYNLGKNMQAKNVNGKEMMAEKLRQMQQLFGLKVTGNSDPETLRAMKKPRCGVPDVAPYAITHNNPRWTKTHLTYSILNYTPYLPKAVVEDAIARAFRVWSDVTPLTFQRVFEEEGDIVLSFHRGDHGDNNPFDGPNYKLAHTFQPGPGLGGDVHYDLDETWTNSSENFNLFYVTAHELGHSLGLTHSSDIGALMFPSYTWYTEDFVLNQDDINRIQDLYGPSPNPIQPTGATTPHPCNGDLTFDAITTFRGEVFFFKGRFYIRVNRFMPEPELNLIGILWPNLPVKLDAAYEASMIDQVRYFKGSKVWAVQEQSVLRGFPRDIHSFFGFPSNVTHIDAAVCEEETGKTYFFVDHMYWRYDENTQSMDPGYPRLTAEDFPGIDDKVDDVFQKGENFYFFHQSVQHRFNLQIRRVDDSRDSSTWFNC

Target ORF information:

RefSeq Version	NM_032006.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus matrix metallopeptidase 1a (interstitial collagenase) (Mmp1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032006.3

ORF Insert Sequence:

ATGCCTAGCC TTCCTTTGCT GTTGCTTCTC TGGGCTGCTA GCTCATACAG TTTCCCTGTG 
TTTCACAACG GAGACCGGCA AAATGTGGAG ACAGTCTGGA AATACCTGGA AAACTACTAC 
AACTTGGGCA AAAACATGCA AGCTAAAAAC GTGAATGGCA AGGAGATGAT GGCTGAAAAG 
CTGAGGCAAA TGCAGCAGTT ATTTGGGCTG AAAGTGACTG GAAATTCAGA TCCTGAAACC 
CTGAGAGCTA TGAAGAAGCC CAGGTGTGGG GTGCCTGATG TGGCCCCATA TGCCATTACT 
CACAACAATC CTCGTTGGAC CAAAACACAT CTGACATACA GCATTTTAAA CTACACACCA 
TATTTGCCAA AAGCAGTTGT GGAAGATGCC ATCGCGAGAG CCTTTAGAGT CTGGAGTGAT 
GTGACACCAC TTACGTTCCA AAGAGTCTTT GAGGAGGAAG GCGATATTGT GCTCTCCTTC 
CACAGAGGAG ACCATGGTGA CAACAACCCA TTTGATGGAC CTAACTATAA GCTTGCTCAC 
ACTTTCCAGC CAGGCCCAGG TTTGGGGGGT GATGTTCATT ATGACCTTGA TGAGACGTGG 
ACCAACAGCA GTGAAAATTT CAACTTGTTC TATGTTACGG CTCATGAACT GGGTCACTCC 
CTTGGGCTCA CTCATTCTAG TGATATAGGA GCACTAATGT TCCCCAGTTA CACGTGGTAC 
ACTGAAGACT TTGTGCTAAA CCAGGATGAT ATTAATCGCA TCCAGGACTT ATATGGACCT 
TCCCCAAATC CCATCCAGCC AACAGGTGCA ACAACACCAC ATCCATGTAA TGGTGATCTA 
ACCTTTGATG CTATAACTAC ATTTAGGGGA GAGGTGTTTT TCTTCAAAGG CAGGTTCTAC 
ATTCGGGTAA ATAGATTCAT GCCAGAACCT GAGCTCAATT TAATAGGTAT TCTCTGGCCA 
AATCTTCCAG TTAAACTTGA CGCTGCTTAT GAAGCTAGTA TGATAGATCA AGTCCGCTAT 
TTCAAAGGCA GCAAAGTATG GGCTGTTCAA GAGCAGAGTG TACTGAGAGG ATTCCCCAGA 
GACATCCACA GTTTCTTTGG CTTCCCTAGC AATGTGACAC ACATTGATGC TGCTGTTTGT 
GAGGAAGAGA CTGGAAAAAC ATACTTCTTT GTTGACCACA TGTACTGGAG GTATGATGAA 
AATACACAGT CTATGGATCC AGGTTATCCC AGATTAACAG CAGAAGACTT CCCTGGAATT 
GATGATAAAG TTGATGATGT TTTCCAAAAA GGAGAAAATT TCTATTTCTT TCACCAATCA 
GTTCAACACA GATTTAACCT CCAAATAAGA AGAGTTGATG ATTCCCGTGA TTCTAGTACA 
TGGTTCAACT GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription.
The Journal of clinical investigation125(3)1203-14(2015 Mar)
Takeda S,Sasagawa S,Oyama T,Searleman AC,Westergard TD,Cheng EH,Hsieh JJ

Matrix metalloproteinases and genetic mouse models in cancer research: a mini-review.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(1)163-75(2015 Jan)
Wieczorek E,Jablonska E,Wasowicz W,Reszka E

Mouse matrix metalloprotease-1a (Mmp1a) gives new insight into MMP function.
Journal of cellular physiology229(12)1875-80(2014 Dec)
Foley CJ,Kuliopulos A

Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis.
Oncogene33(17)2264-72(2014 Apr)
Foley CJ,Fanjul-Fern?ndez M,Bohm A,Nguyen N,Agarwal A,Austin K,Koukos G,Covic L,L?pez-Ot?n C,Kuliopulos A

HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma.
The Journal of clinical investigation123(7)3154-65(2013 Jul)
Takeda S,Liu H,Sasagawa S,Dong Y,Trainor PA,Cheng EH,Hsieh JJ

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Mmp1a cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報