CSF2 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	CSF2
Entrez Gene ID	281095
Full Name	colony stimulating factor 2
Synonyms	CSF,GM-CSF,GMCSF
General protein information	Preferred Names colony stimulating factor 2 Names granulocyte-macrophage colony-stimulating factor colony stimulating factor 2 (granulocyte-macrophage) colony-stimulating factor
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174027.2	NP_776452.1	granulocyte-macrophage colony-stimulating factor precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CSF2	XP_527005.2
Bos taurus (cattle)	CSF2	NP_776452.1
Mus musculus (house mouse)	Csf2	NP_034099.2
Rattus norvegicus (Norway rat)	Csf2	NP_446304.1
Homo sapiens (human)	CSF2	NP_000749.2
Canis lupus familiaris (dog)	CSF2	NP_001003245.1
	CSF2	NP_001028121.1

Gene Ontology
Bibliography

Related articles in PubMed

Colony-stimulating factor 2 acts from days 5 to 7 of development to modify programming of the bovine conceptus at day 86 of gestation?.
Siqueira LG, Tribulo P, Chen Z, Denicol AC, Ortega MS, Negr?n-P?rez VM, Kannampuzha-Francis J, Pohler KG, Rivera RM, Hansen PJ
Biology of reproduction96(4)743-757(2017 Apr)

Suitable in vitro culture of Eimeria bovis meront II stages in bovine colonic epithelial cells and parasite-induced upregulation of CXCL10 and GM-CSF gene transcription.
Hermosilla C, Stamm I, Menge C, Taubert A
Parasitology research114(8)3125-36(2015 Aug)

Sexual dimorphism in developmental programming of the bovine preimplantation embryo caused by colony-stimulating factor 2.
Dobbs KB, Gagn? D, Fournier E, Dufort I, Robert C, Block J, Sirard MA, Bonilla L, Ealy AD, Loureiro B, Hansen PJ
Biology of reproduction91(3)80(2014 Sep)

Colony-stimulating factor 2 inhibits induction of apoptosis in the bovine preimplantation embryo.
Loureiro B, Oliveira LJ, Favoreto MG, Hansen PJ
American journal of reproductive immunology (New York, N.Y. : 1989)65(6)578-88(2011 Jun)

Consequences of conceptus exposure to colony-stimulating factor 2 on survival, elongation, interferon-? secretion, and gene expression.
Loureiro B, Block J, Favoreto MG, Carambula S, Pennington KA, Ealy AD, Hansen PJ
Reproduction (Cambridge, England)141(5)617-24(2011 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results demonstrated that bovine colonic cells seem capable to respond to E. bovis merozoite I infection by the upregulation of CXCL10 and GM-CSF gene transcription.
Title: Suitable in vitro culture of Eimeria bovis meront II stages in bovine colonic epithelial cells and parasite-induced upregulation of CXCL10 and GM-CSF gene transcription.

Data suggest exposure to maternal CSF2 from D5-D7 of development is fundamentally different for female/male blastocysts with respect to embryo elongation, characteristics of transcriptome/methylome, and endometrial interferon tau secretion at D15.
Title: Sexual dimorphism in developmental programming of the bovine preimplantation embryo caused by colony-stimulating factor 2.

inhibits induction of apoptosis in the bovine preimplantation embryo
Title: Colony-stimulating factor 2 inhibits induction of apoptosis in the bovine preimplantation embryo.

The increase in calving rate caused by CSF2 treatment involves, in part, more extensive development of extraembryonic membranes and capacity of the conceptus to secrete IFNT2 at day 15 of pregnancy.
Title: Consequences of conceptus exposure to colony-stimulating factor 2 on survival, elongation, interferon-? secretion, and gene expression.

CSF2 affect embryonic development and enhance embryo competence for posttransfer survival.
Title: Colony-stimulating factor 2 (CSF-2) improves development and posttransfer survival of bovine embryos produced in vitro.

The following CSF2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CSF2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa01244	NM_174027.2 Latest version!	Bos taurus colony stimulating factor 2 (CSF2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CSF2 ( NM_174027.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776452.1 Bos taurus colony stimulating factor 2 (CSF2), mRNA.

Price & Availability↑

CloneID	OBa01244
Clone ID Related Accession (Same CDS sequence)	NM_174027.2
Accession Version	NM_174027.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 432bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Bos taurus(cattle)
Product	granulocyte-macrophage colony-stimulating factor precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U22385.1. On Jun 3, 2003 this sequence version replaced NM_174027.1. ##Evidence-Data-START## Transcript exon combination :: U22385.1, FE003297.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145444, SAMN03145477 [ECO:0000348] ##Evidence-Data-END##

ATGTGGCTGC AGAACCTGCT TCTCCTGGGC ACTGTGGTCT GCAGCTTCTC CGCACCTACT 
CGCCCACCCA ACACTGCCAC CCGGCCCTGG CAGCATGTGG ATGCCATCAA GGAGGCCCTG 
AGCCTTCTGA ACCACAGCAG TGACACTGAT GCTGTGATGA ATGACACAGA AGTCGTCTCT 
GAAAAGTTTG ACTCCCAGGA ACCAACGTGC CTGCAGACTC GCCTGAAGCT GTACAAGAAC 
GGCCTGCAGG GCAGCCTCAC TAGTCTCATG GGCTCCTTGA CCATGATGGC CACCCACTAC 
GAGAAACACT GCCCACCCAC CCCGGAAACT TCCTGTGGAA CCCAGTTTAT CAGCTTCAAA 
AATTTCAAAG AGGACCTGAA GGAGTTCCTT TTTATCATTC CCTTTGACTG CTGGGAACCA 
GCCCAGAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776452.1
CDS	14..445
Translation	MWLQNLLLLGTVVCSFSAPTRPPNTATRPWQHVDAIKEALSLLNHSSDTDAVMNDTEVVSEKFDSQEPTCLQTRLKLYKNGLQGSLTSLMGSLTMMATHYEKHCPPTPETSCGTQFISFKNFKEDLKEFLFIIPFDCWEPAQK

Target ORF information:

RefSeq Version	NM_174027.2
Organism	Bos taurus(cattle)
Definition	Bos taurus colony stimulating factor 2 (CSF2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174027.2

ORF Insert Sequence:

ATGTGGCTGC AGAACCTGCT TCTCCTGGGC ACTGTGGTCT GCAGCTTCTC CGCACCTACT 
CGCCCACCCA ACACTGCCAC CCGGCCCTGG CAGCATGTGG ATGCCATCAA GGAGGCCCTG 
AGCCTTCTGA ACCACAGCAG TGACACTGAT GCTGTGATGA ATGACACAGA AGTCGTCTCT 
GAAAAGTTTG ACTCCCAGGA ACCAACGTGC CTGCAGACTC GCCTGAAGCT GTACAAGAAC 
GGCCTGCAGG GCAGCCTCAC TAGTCTCATG GGCTCCTTGA CCATGATGGC CACCCACTAC 
GAGAAACACT GCCCACCCAC CCCGGAAACT TCCTGTGGAA CCCAGTTTAT CAGCTTCAAA 
AATTTCAAAG AGGACCTGAA GGAGTTCCTT TTTATCATTC CCTTTGACTG CTGGGAACCA 
GCCCAGAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Colony-stimulating factor 2 acts from days 5 to 7 of development to modify programming of the bovine conceptus at day 86 of gestation?.
Biology of reproduction96(4)743-757(2017 Apr)
Siqueira LG,Tribulo P,Chen Z,Denicol AC,Ortega MS,Negr?n-P?rez VM,Kannampuzha-Francis J,Pohler KG,Rivera RM,Hansen PJ

Suitable in vitro culture of Eimeria bovis meront II stages in bovine colonic epithelial cells and parasite-induced upregulation of CXCL10 and GM-CSF gene transcription.
Parasitology research114(8)3125-36(2015 Aug)
Hermosilla C,Stamm I,Menge C,Taubert A

Sexual dimorphism in developmental programming of the bovine preimplantation embryo caused by colony-stimulating factor 2.
Biology of reproduction91(3)80(2014 Sep)
Dobbs KB,Gagn? D,Fournier E,Dufort I,Robert C,Block J,Sirard MA,Bonilla L,Ealy AD,Loureiro B,Hansen PJ

Colony-stimulating factor 2 inhibits induction of apoptosis in the bovine preimplantation embryo.
American journal of reproductive immunology (New York, N.Y. : 1989)65(6)578-88(2011 Jun)
Loureiro B,Oliveira LJ,Favoreto MG,Hansen PJ

Consequences of conceptus exposure to colony-stimulating factor 2 on survival, elongation, interferon-? secretion, and gene expression.
Reproduction (Cambridge, England)141(5)617-24(2011 May)
Loureiro B,Block J,Favoreto MG,Carambula S,Pennington KA,Ealy AD,Hansen PJ

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CSF2 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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