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Homo sapiens (human)

Browse by Letter Index, Genomic Locus


Caspase activation via extrinsic apoptotic signalling pathway Activation of NOXA and translocation to mitochondria
Activation of PUMA and translocation to mitochondria Activation of BMF and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Regulation of activated PAK-2p34 by proteasome mediated degradation
Regulated Necrosis Signaling by Robo receptor
Inactivation of Cdc42 and Rac Role of Abl in Robo-Slit signaling
Recycling pathway of L1 Interaction between L1 and Ankyrins
Neurofascin interactions Regulation of gene expression in beta cells
Signaling by NODAL Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine Resolution of AP sites via the single-nucleotide replacement pathway
Translesion synthesis by POLK Termination of translesion DNA synthesis
ALKBH2 mediated reversal of alkylation damage Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Cellular response to heat stress Senescence-Associated Secretory Phenotype (SASP)
Chromatin organization TFAP2 (AP-2) family regulates transcription of cell cycle factors
VLDL interactions Reelin signalling pathway
Ub-specific processing proteases Metalloprotease DUBs
Ion influx/efflux at host-pathogen interface Neutrophil degranulation
Formation of the cornified envelope Downregulation of ERBB2 signaling
MET activates RAP1 and RAC1 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
tRNA processing DNA Double Strand Break Response
Processing of DNA double-strand break ends HDR through Homologous Recombination (HRR)
Presynaptic phase of homologous DNA pairing and strand exchange HDR through MMEJ (alt-NHEJ)
Nucleotide Excision Repair DNA Damage Recognition in GG-NER
Defective AVP causes neurohypophyseal diabetes insipidus (NDI) Diseases associated with surfactant metabolism
Interleukin-4 and 13 signaling RAB geranylgeranylation
ATF4 activates genes Transmission across Electrical Synapses
Electric Transmission Across Gap Junctions Norepinephrine Neurotransmitter Release Cycle
Neurotransmitter Clearance In The Synaptic Cleft Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Postsynaptic nicotinic acetylcholine receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
Activation of AMPA receptors Ionotropic activity of Kainate Receptors
GABA A (rho) receptor activation Potassium Channels
Ca2+ activated K+ channels Activation of G protein gated Potassium channels
ATP sensitive Potassium channels Organelle biogenesis and maintenance
Mitochondrial biogenesis Mitochondrial translation elongation
VxPx cargo-targeting to cilium BBSome-mediated cargo-targeting to cilium
Signaling by FGFR in disease Signaling by cytosolic FGFR1 fusion mutants
Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 PEST Domain Mutants in Cancer
Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Loss of Function of TGFBR2 in Cancer APC truncation mutants are not K63 polyubiquitinated
AMER1 mutants destabilize the destruction complex WNT ligand secretion is abrogated by the PORCN inhibitor LGK974
Disorders of transmembrane transporters Defective CFTR causes cystic fibrosis
Metabolic disorders of biological oxidation enzymes Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type
HIV Infection HIV Life Cycle
2-LTR circle formation Autointegration results in viral DNA circles
Late Phase of HIV Life Cycle HIV Transcription Initiation
Rev-mediated nuclear export of HIV RNA Membrane binding and targetting of GAG proteins
Budding and maturation of HIV virion Interactions of Rev with host cellular proteins
APOBEC3G mediated resistance to HIV-1 infection Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
Transport of Ribonucleoproteins into the Host Nucleus NEP/NS2 Interacts with the Cellular Export Machinery
Latent infection of Homo sapiens with Mycobacterium tuberculosis Toxicity of botulinum toxin type B (BoNT/B)
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