GPX3 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene
Clones
gRNAs

Summary

Gene Symbol	GPX3
Entrez Gene ID	713057
Full Name	glutathione peroxidase 3
Gene Type	protein-coding
Organism	Macaca mulatta(Rhesus monkey)
Summary	The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Jul 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001159300.2	NP_001152772.1	glutathione peroxidase 3 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	GPX3	NP_001157926.1
Gallus gallus (chicken)	GPX3	NP_001156704.1
	GPX3	NP_001152772.1
Mus musculus (house mouse)	Gpx3	NP_032187.2
Homo sapiens (human)	GPX3	NP_002075.2
Rattus norvegicus (Norway rat)	Gpx3	NP_071970.2
Danio rerio (zebrafish)	gpx3	NP_001131027.1
Xenopus tropicalis (tropical clawed frog)	gpx3	NP_988961.2
Pan troglodytes (chimpanzee)	GPX3	NP_001108629.1
Bos taurus (cattle)	GPX3	NP_776502.1

Gene Ontology
Bibliography

Related articles in PubMed

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S, Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Mar?ais G, Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA, Norgren RB Jr
Biology direct9(1)20(2014 Oct)

Analysis of the Macaca mulatta transcriptome and the sequence divergence between Macaca and human.
Magness CL, Fellin PC, Thomas MJ, Korth MJ, Agy MB, Proll SC, Fitzgibbon M, Scherer CA, Miner DG, Katze MG, Iadonato SP
Genome biology6(7)R60(2005)

Characterization of mammalian selenoproteomes.
Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guig? R, Gladyshev VN
Science (New York, N.Y.)300(5624)1439-43(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GPX3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPX3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMb03072	NM_001159300.2 Latest version!	Macaca mulatta glutathione peroxidase 3 (GPX3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GPX3 ( NM_001159300.2 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> NP_001152772.1 Macaca mulatta glutathione peroxidase 3 (GPX3), mRNA.

Price & Availability↑

CloneID	OMb03072
Clone ID Related Accession (Same CDS sequence)	NM_001159300.2
Accession Version	NM_001159300.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 681bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-11
Organism	Macaca mulatta(Rhesus monkey)
Product	glutathione peroxidase 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from QNVO02000388.1, JV046823.1, JV712955.1, CK231700.1 and JV649197.1. On Jul 29, 2016 this sequence version replaced NM_001159300.1. ##Evidence-Data-START## Transcript exon combination :: SRR5038768.384607.1, SRR3476739.512873.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4688316, SAMEA4688317 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGGC TGCTGCAGGC GTCCTGCCTG CTCTCCCTGC TCCTGGCCGG CTTCCTCCCG 
CAGAGCCGGG GACAAGATAA GTCGAAGATG GACTGCCATG GTGGCGTGAG CGGCACCATT 
TACGAGTATG GAGCCCTCAC CATTGATGGG GAGGAGTACA TCCCCTTCAA GCAGTACATT 
GGCAAATACG TCCTCTTTGT CAACGTGGCC AGCTACTGAG GCCTGACGGG CCAATACATT 
GAACTGAATG CACTACAAGA AGAGCTTGCA CCATTTGGTC TGGTCCTTCT CGGCTTTCCC 
TGCAACCAAT TTGGAAAACA GGAACCAGGC GAGAACTCAG AGATCCTTCC CAGCCTCAAG 
TATGTCCGAC CAGGTGGAGG CTTTGTCCCT AATTTCCAGC TCTTTGAGAA AGGGGATGTG 
AATGGAGAGA AAGAGCAGAA ATTCTACACT TTCCTAAAGA ACTCCTGTCC TCCCACCTCG 
GAGCTCCTGG GTACATCTGA CCGCCTCTTC TGGGAACCCA TGAAGGTCCA CGACATCCGC 
TGGAACTTTG AGAAGTTCCT GGTGGGGCCA GATGGTATAC CTGTCATGCG CTGGCACCAC 
CGGACCACGA TCAGCAATGT CAAGATGGAC ATCCTATCCT ACATGAGGCG GCAGGCAGCC 
CTGGGGGTCA AGAGGAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001152772.1
CDS	243..923
Translation	MARLLQASCLLSLLLAGFLPQSRGQDKSKMDCHGGVSGTIYEYGALTIDGEEYIPFKQYIGKYVLFVNVASY*GLTGQYIELNALQEELAPFGLVLLGFPCNQFGKQEPGENSEILPSLKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDIRWNFEKFLVGPDGIPVMRWHHRTTISNVKMDILSYMRRQAALGVKRK

Target ORF information:

RefSeq Version	NM_001159300.2
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta glutathione peroxidase 3 (GPX3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001159300.2

ORF Insert Sequence:

ATGGCCCGGC TGCTGCAGGC GTCCTGCCTG CTCTCCCTGC TCCTGGCCGG CTTCCTCCCG 
CAGAGCCGGG GACAAGATAA GTCGAAGATG GACTGCCATG GTGGCGTGAG CGGCACCATT 
TACGAGTATG GAGCCCTCAC CATTGATGGG GAGGAGTACA TCCCCTTCAA GCAGTACATT 
GGCAAATACG TCCTCTTTGT CAACGTGGCC AGCTACTGAG GCCTGACGGG CCAATACATT 
GAACTGAATG CACTACAAGA AGAGCTTGCA CCATTTGGTC TGGTCCTTCT CGGCTTTCCC 
TGCAACCAAT TTGGAAAACA GGAACCAGGC GAGAACTCAG AGATCCTTCC CAGCCTCAAG 
TATGTCCGAC CAGGTGGAGG CTTTGTCCCT AATTTCCAGC TCTTTGAGAA AGGGGATGTG 
AATGGAGAGA AAGAGCAGAA ATTCTACACT TTCCTAAAGA ACTCCTGTCC TCCCACCTCG 
GAGCTCCTGG GTACATCTGA CCGCCTCTTC TGGGAACCCA TGAAGGTCCA CGACATCCGC 
TGGAACTTTG AGAAGTTCCT GGTGGGGCCA GATGGTATAC CTGTCATGCG CTGGCACCAC 
CGGACCACGA TCAGCAATGT CAAGATGGAC ATCCTATCCT ACATGAGGCG GCAGGCAGCC 
CTGGGGGTCA AGAGGAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Biology direct9(1)20(2014 Oct)
Zimin AV,Cornish AS,Maudhoo MD,Gibbs RM,Zhang X,Pandey S,Meehan DT,Wipfler K,Bosinger SE,Johnson ZP,Tharp GK,Mar?ais G,Roberts M,Ferguson B,Fox HS,Treangen T,Salzberg SL,Yorke JA,Norgren RB Jr

Analysis of the Macaca mulatta transcriptome and the sequence divergence between Macaca and human.
Genome biology6(7)R60(2005)
Magness CL,Fellin PC,Thomas MJ,Korth MJ,Agy MB,Proll SC,Fitzgibbon M,Scherer CA,Miner DG,Katze MG,Iadonato SP

Characterization of mammalian selenoproteomes.
Science (New York, N.Y.)300(5624)1439-43(2003 May)
Kryukov GV,Castellano S,Novoselov SV,Lobanov AV,Zehtab O,Guig? R,Gladyshev VN

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GPX3 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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