Gpx3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gpx3
Entrez Gene ID	14778
Full Name	glutathione peroxidase 3
Synonyms	AA960521,EGPx,GPx,GSHPx-3,GSHPx-P
General protein information	Preferred Names glutathione peroxidase 3 Names glutathione peroxidase 3 GPx-3 GPx-P extracellular GPx plasma GPx plasma glutathione peroxidase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 B1.3
Summary	The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted and is highly expressed in mouse kidney, which appears to be the major source of the enzyme in plasma. It has a role in mouse organogenesis, and dysregulation of this isozyme has been associated with obesity-related metabolic complications, platelet-dependent thrombosis, colitis-associated carcinoma, and thermosensitive phenotype. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_008161.4	NP_032187.2	glutathione peroxidase 3 isoform 1 precursor
NM_008161.3	NP_032187.2	glutathione peroxidase 3 precursor
NM_001329860.1	NP_001316789.1	glutathione peroxidase 3 isoform 2 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	GPX3	NP_001157926.1
Gallus gallus (chicken)	GPX3	NP_001156704.1
	GPX3	NP_001152772.1
Mus musculus (house mouse)	Gpx3	NP_032187.2
Homo sapiens (human)	GPX3	NP_002075.2
Rattus norvegicus (Norway rat)	Gpx3	NP_071970.2
Danio rerio (zebrafish)	gpx3	NP_001131027.1
Xenopus tropicalis (tropical clawed frog)	gpx3	NP_988961.2
Pan troglodytes (chimpanzee)	GPX3	NP_001108629.1
Bos taurus (cattle)	GPX3	NP_776502.1

Gene Ontology
Bibliography

Related articles in PubMed

Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function.
Pang P, Abbott M, Abdi M, Fucci QA, Chauhan N, Mistri M, Proctor B, Chin M, Wang B, Yin W, Lu TS, Halim A, Lim K, Handy DE, Loscalzo J, Siedlecki AM
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association(2017 Dec)

Glutathione peroxidase 3 is a protective factor against acetaminophen?induced hepatotoxicity in vivo and in vitro.
Kanno SI, Tomizawa A, Yomogida S, Hara A
International journal of molecular medicine40(3)748-754(2017 Sep)

GPX3 promoter methylation predicts platinum sensitivity in colorectal cancer.
Pelosof L, Yerram S, Armstrong T, Chu N, Danilova L, Yanagisawa B, Hidalgo M, Azad N, Herman JG
Epigenetics12(7)540-550(2017 07)

Expression of extracellular glutathione peroxidase in human and mouse gastrointestinal tract.
Tham DM, Whitin JC, Kim KK, Zhu SX, Cohen HJ
The American journal of physiology275(6 Pt 1)G1463-71(1998 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GPX3 promoter methylation predicts colorectal carcinoma sensitivity to platinum.
Title: GPX3 promoter methylation predicts platinum sensitivity in colorectal cancer.

GPX3 may play a major role in reducing hydrogen peroxide during decidualization.
Title: Differential expression and anti-oxidant function of glutathione peroxidase 3 in mouse uterus during decidualization.

Sepp1(UF) and small selenium-containing proteins are filtered by the glomerulus and taken up by PCT cells via megalin-mediated endocytosis, preventing loss of selenium in the urine and providing selenium for the synthesis of glutathione peroxidase-3
Title: Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1.

Results indicate that selenoprotein P (Sepp1) is important for this transport in selenium-replete mice but that glutathione peroxidase-3 (Gpx3) is not.
Title: Selenoprotein P is the major selenium transport protein in mouse milk.

Data indicate that uptake of Sepp1 and Gpx3 by d-13 visceral yolk sac was independent of apoER2 and megalin.
Title: Maternal-fetal transfer of selenium in the mouse.

The following Gpx3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpx3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu13660	NM_008161.4 Latest version!	Mus musculus glutathione peroxidase 3 (Gpx3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu83473	NM_001329860.1 Latest version!	Mus musculus glutathione peroxidase 3 (Gpx3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu13660	NM_008161.3	Mus musculus glutathione peroxidase 3 (Gpx3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gpx3 ( NM_008161.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032187.2 Mus musculus glutathione peroxidase 3 (Gpx3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu13660
Clone ID Related Accession (Same CDS sequence)	NM_008161.4 , NM_008161.3
Accession Version	NM_008161.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 681bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Mus musculus(house mouse)
Product	glutathione peroxidase 3 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY061328.1, AK004942.1 and BG796554.1. On Aug 3, 2016 this sequence version replaced NM_008161.3. Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC037134.1, AK002219.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal protein contains selenocysteine :: PMID: 7929449 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGGA TCCTCCGGGC ATCCTGCCTT CTGTCCCTGC TCCTGGCCGG GTTTGTTCCG 
CCGGGCCGGG GACAAGAGAA GTCTAAGACA GACTGCCATG GCGGTATGAG TGGTACCATC 
TACGAGTATG GAGCCCTCAC CATCGATGGG GAGGAATACA TTCCTTTTAA GCAGTATGCA 
GGCAAATATA TCCTCTTTGT CAACGTAGCC AGCTACTGAG GTCTGACAGA CCAATACCTT 
GAACTGAATG CACTACAAGA AGAACTTGGG CCATTTGGCT TGGTCATTCT GGGCTTCCCT 
TCCAACCAAT TTGGCAAACA GGAGCCAGGC GAGAACTCGG AGATACTCCC CAGTCTCAAG 
TATGTTCGAC CAGGTGGGGG CTTTGTGCCT AATTTCCAGC TCTTTGAGAA AGGAGATGTG 
AACGGGGAGA AAGAGCAGAA ATTCTACACT TTCCTGAAGA ACTCCTGCCC TCCCACTGCA 
GAACTCCTGG GCTCACCTGG CCGCCTCTTT TGGGAACCCA TGAAGATCCA TGACATCCGC 
TGGAACTTTG AGAAGTTCCT GGTGGGGCCA GATGGCATAC CGGTTATGCG CTGGTACCAC 
CGGACCACAG TCAGCAACGT CAAGATGGAC ATCCTGTCTT ACATGAGGCG GCAGGCAGCC 
CTGAGCGCCA GGGGGAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032187.2
CDS	113..793
Translation	MARILRASCLLSLLLAGFVPPGRGQEKSKTDCHGGMSGTIYEYGALTIDGEEYIPFKQYAGKYILFVNVASY*GLTDQYLELNALQEELGPFGLVILGFPSNQFGKQEPGENSEILPSLKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTAELLGSPGRLFWEPMKIHDIRWNFEKFLVGPDGIPVMRWYHRTTVSNVKMDILSYMRRQAALSARGK

Target ORF information:

RefSeq Version	NM_008161.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutathione peroxidase 3 (Gpx3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008161.4

ORF Insert Sequence:

ATGGCCCGGA TCCTCCGGGC ATCCTGCCTT CTGTCCCTGC TCCTGGCCGG GTTTGTTCCG 
CCGGGCCGGG GACAAGAGAA GTCTAAGACA GACTGCCATG GCGGTATGAG TGGTACCATC 
TACGAGTATG GAGCCCTCAC CATCGATGGG GAGGAATACA TTCCTTTTAA GCAGTATGCA 
GGCAAATATA TCCTCTTTGT CAACGTAGCC AGCTACTGAG GTCTGACAGA CCAATACCTT 
GAACTGAATG CACTACAAGA AGAACTTGGG CCATTTGGCT TGGTCATTCT GGGCTTCCCT 
TCCAACCAAT TTGGCAAACA GGAGCCAGGC GAGAACTCGG AGATACTCCC CAGTCTCAAG 
TATGTTCGAC CAGGTGGGGG CTTTGTGCCT AATTTCCAGC TCTTTGAGAA AGGAGATGTG 
AACGGGGAGA AAGAGCAGAA ATTCTACACT TTCCTGAAGA ACTCCTGCCC TCCCACTGCA 
GAACTCCTGG GCTCACCTGG CCGCCTCTTT TGGGAACCCA TGAAGATCCA TGACATCCGC 
TGGAACTTTG AGAAGTTCCT GGTGGGGCCA GATGGCATAC CGGTTATGCG CTGGTACCAC 
CGGACCACAG TCAGCAACGT CAAGATGGAC ATCCTGTCTT ACATGAGGCG GCAGGCAGCC 
CTGAGCGCCA GGGGGAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gpx3 ( NM_008161.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032187.2 Mus musculus glutathione peroxidase 3 (Gpx3), mRNA.

Price & Availability↑

CloneID	OMu13660
Clone ID Related Accession (Same CDS sequence)	NM_008161.4 , NM_008161.3
Accession Version	NM_008161.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 681bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-07-09
Organism	Mus musculus(House mouse)
Product	glutathione peroxidase 3 precursor
Comment

ATGGCCCGGA TCCTCCGGGC ATCCTGCCTT CTGTCCCTGC TCCTGGCCGG GTTTGTTCCG 
CCGGGCCGGG GACAAGAGAA GTCTAAGACA GACTGCCATG GCGGTATGAG TGGTACCATC 
TACGAGTATG GAGCCCTCAC CATCGATGGG GAGGAATACA TTCCTTTTAA GCAGTATGCA 
GGCAAATATA TCCTCTTTGT CAACGTAGCC AGCTACTGAG GTCTGACAGA CCAATACCTT 
GAACTGAATG CACTACAAGA AGAACTTGGG CCATTTGGCT TGGTCATTCT GGGCTTCCCT 
TCCAACCAAT TTGGCAAACA GGAGCCAGGC GAGAACTCGG AGATACTCCC CAGTCTCAAG 
TATGTTCGAC CAGGTGGGGG CTTTGTGCCT AATTTCCAGC TCTTTGAGAA AGGAGATGTG 
AACGGGGAGA AAGAGCAGAA ATTCTACACT TTCCTGAAGA ACTCCTGCCC TCCCACTGCA 
GAACTCCTGG GCTCACCTGG CCGCCTCTTT TGGGAACCCA TGAAGATCCA TGACATCCGC 
TGGAACTTTG AGAAGTTCCT GGTGGGGCCA GATGGCATAC CGGTTATGCG CTGGTACCAC 
CGGACCACAG TCAGCAACGT CAAGATGGAC ATCCTGTCTT ACATGAGGCG GCAGGCAGCC 
CTGAGCGCCA GGGGGAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032187.2
Translation	MARILRASCLLSLLLAGFVPPGRGQEKSKTDCHGGMSGTIYEYGALTIDGEEYIPFKQYAGKYILFVNVASY*GLTDQYLELNALQEELGPFGLVILGFPSNQFGKQEPGENSEILPSLKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTAELLGSPGRLFWEPMKIHDIRWNFEKFLVGPDGIPVMRWYHRTTVSNVKMDILSYMRRQAALSARGK

Target ORF information:

RefSeq Version	NM_008161.3
Organism	Mus musculus(House mouse)
Definition	Mus musculus glutathione peroxidase 3 (Gpx3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008161.3

ORF Insert Sequence:

ATGGCCCGGA TCCTCCGGGC ATCCTGCCTT CTGTCCCTGC TCCTGGCCGG GTTTGTTCCG 
CCGGGCCGGG GACAAGAGAA GTCTAAGACA GACTGCCATG GCGGTATGAG TGGTACCATC 
TACGAGTATG GAGCCCTCAC CATCGATGGG GAGGAATACA TTCCTTTTAA GCAGTATGCA 
GGCAAATATA TCCTCTTTGT CAACGTAGCC AGCTACTGAG GTCTGACAGA CCAATACCTT 
GAACTGAATG CACTACAAGA AGAACTTGGG CCATTTGGCT TGGTCATTCT GGGCTTCCCT 
TCCAACCAAT TTGGCAAACA GGAGCCAGGC GAGAACTCGG AGATACTCCC CAGTCTCAAG 
TATGTTCGAC CAGGTGGGGG CTTTGTGCCT AATTTCCAGC TCTTTGAGAA AGGAGATGTG 
AACGGGGAGA AAGAGCAGAA ATTCTACACT TTCCTGAAGA ACTCCTGCCC TCCCACTGCA 
GAACTCCTGG GCTCACCTGG CCGCCTCTTT TGGGAACCCA TGAAGATCCA TGACATCCGC 
TGGAACTTTG AGAAGTTCCT GGTGGGGCCA GATGGCATAC CGGTTATGCG CTGGTACCAC 
CGGACCACAG TCAGCAACGT CAAGATGGAC ATCCTGTCTT ACATGAGGCG GCAGGCAGCC 
CTGAGCGCCA GGGGGAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gpx3 ( NM_001329860.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001316789.1 Mus musculus glutathione peroxidase 3 (Gpx3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu83473
Clone ID Related Accession (Same CDS sequence)	NM_001329860.1
Accession Version	NM_001329860.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 777bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Mus musculus(house mouse)
Product	glutathione peroxidase 3 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY061328.1, AK004942.1, AW319411.1 and BG796554.1. Transcript Variant: This variant (2) has an additional in-frame coding exon compared to variant 1. The resulting isoform (2) is longer, containing a 32 aa protein segment not found in isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AW319411.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal protein contains selenocysteine :: PMID: 7929449 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGGA TCCTCCGGGC ATCCTGCCTT CTGTCCCTGC TCCTGGCCGG GTTTGTTCCG 
CCGGGCCGGG GACAAGAGAA GTCTAAGACA GACTGCCATG GCGGTATGAG TGGTACCATC 
TACGAGTATG GAGCCCTCAC CATCGATGGG GAGGAATACA TTCCTTTTAA GCAGTATGCA 
GGCAAATATA TCCTCTTTGT CAACGTAGCC AGCTACTGAG GTCTGACAGA CCAATACCTT 
GGGTTTCTGG GTAGCCCTGG CTGTCCTCAG ACTTGCTCTG TGGACCAAGA TGGCCTCAAA 
CTCAGGTCTG CTTGCCTCCT AAATGCTGAG ATCAAAGAAC TGAATGCACT ACAAGAAGAA 
CTTGGGCCAT TTGGCTTGGT CATTCTGGGC TTCCCTTCCA ACCAATTTGG CAAACAGGAG 
CCAGGCGAGA ACTCGGAGAT ACTCCCCAGT CTCAAGTATG TTCGACCAGG TGGGGGCTTT 
GTGCCTAATT TCCAGCTCTT TGAGAAAGGA GATGTGAACG GGGAGAAAGA GCAGAAATTC 
TACACTTTCC TGAAGAACTC CTGCCCTCCC ACTGCAGAAC TCCTGGGCTC ACCTGGCCGC 
CTCTTTTGGG AACCCATGAA GATCCATGAC ATCCGCTGGA ACTTTGAGAA GTTCCTGGTG 
GGGCCAGATG GCATACCGGT TATGCGCTGG TACCACCGGA CCACAGTCAG CAACGTCAAG 
ATGGACATCC TGTCTTACAT GAGGCGGCAG GCAGCCCTGA GCGCCAGGGG GAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001316789.1
CDS	113..889
Translation	MARILRASCLLSLLLAGFVPPGRGQEKSKTDCHGGMSGTIYEYGALTIDGEEYIPFKQYAGKYILFVNVASY*GLTDQYLGFLGSPGCPQTCSVDQDGLKLRSACLLNAEIKELNALQEELGPFGLVILGFPSNQFGKQEPGENSEILPSLKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTAELLGSPGRLFWEPMKIHDIRWNFEKFLVGPDGIPVMRWYHRTTVSNVKMDILSYMRRQAALSARGK

Target ORF information:

RefSeq Version	NM_001329860.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutathione peroxidase 3 (Gpx3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001329860.1

ORF Insert Sequence:

ATGGCCCGGA TCCTCCGGGC ATCCTGCCTT CTGTCCCTGC TCCTGGCCGG GTTTGTTCCG 
CCGGGCCGGG GACAAGAGAA GTCTAAGACA GACTGCCATG GCGGTATGAG TGGTACCATC 
TACGAGTATG GAGCCCTCAC CATCGATGGG GAGGAATACA TTCCTTTTAA GCAGTATGCA 
GGCAAATATA TCCTCTTTGT CAACGTAGCC AGCTACTGAG GTCTGACAGA CCAATACCTT 
GGGTTTCTGG GTAGCCCTGG CTGTCCTCAG ACTTGCTCTG TGGACCAAGA TGGCCTCAAA 
CTCAGGTCTG CTTGCCTCCT AAATGCTGAG ATCAAAGAAC TGAATGCACT ACAAGAAGAA 
CTTGGGCCAT TTGGCTTGGT CATTCTGGGC TTCCCTTCCA ACCAATTTGG CAAACAGGAG 
CCAGGCGAGA ACTCGGAGAT ACTCCCCAGT CTCAAGTATG TTCGACCAGG TGGGGGCTTT 
GTGCCTAATT TCCAGCTCTT TGAGAAAGGA GATGTGAACG GGGAGAAAGA GCAGAAATTC 
TACACTTTCC TGAAGAACTC CTGCCCTCCC ACTGCAGAAC TCCTGGGCTC ACCTGGCCGC 
CTCTTTTGGG AACCCATGAA GATCCATGAC ATCCGCTGGA ACTTTGAGAA GTTCCTGGTG 
GGGCCAGATG GCATACCGGT TATGCGCTGG TACCACCGGA CCACAGTCAG CAACGTCAAG 
ATGGACATCC TGTCTTACAT GAGGCGGCAG GCAGCCCTGA GCGCCAGGGG GAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association(2017 Dec)
Pang P,Abbott M,Abdi M,Fucci QA,Chauhan N,Mistri M,Proctor B,Chin M,Wang B,Yin W,Lu TS,Halim A,Lim K,Handy DE,Loscalzo J,Siedlecki AM

Glutathione peroxidase 3 is a protective factor against acetaminophen?induced hepatotoxicity in vivo and in vitro.
International journal of molecular medicine40(3)748-754(2017 Sep)
Kanno SI,Tomizawa A,Yomogida S,Hara A

GPX3 promoter methylation predicts platinum sensitivity in colorectal cancer.
Epigenetics12(7)540-550(2017 07)
Pelosof L,Yerram S,Armstrong T,Chu N,Danilova L,Yanagisawa B,Hidalgo M,Azad N,Herman JG

Expression of extracellular glutathione peroxidase in human and mouse gastrointestinal tract.
The American journal of physiology275(6 Pt 1)G1463-71(1998 Dec)
Tham DM,Whitin JC,Kim KK,Zhu SX,Cohen HJ

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Gpx3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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