disc1 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	disc1
Entrez Gene ID	407621
Full Name	disrupted in schizophrenia 1
General protein information	Preferred Names disrupted in schizophrenia 1 Names disrupted in schizophrenia 1 protein
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001142263.1	NP_001135735.1	disrupted in schizophrenia 1 protein

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Maternal and embryonic exposure to the water soluble fraction of crude oil or lead induces behavioral abnormalities in zebrafish (Danio rerio), and the mechanisms involved.
Wang Y, Shen C, Wang C, Zhou Y, Gao D, Zuo Z
Chemosphere1917-16(2018 Jan)

Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function.
Eachus H, Bright C, Cunliffe VT, Placzek M, Wood JD, Watt PJ
Human molecular genetics26(11)1992-2005(2017 06)

Maternal exposure to the water soluble fraction of crude oil, lead and their mixture induces autism-like behavioral deficits in zebrafish (Danio rerio) larvae.
Wang Y, Zhong H, Wang C, Gao D, Zhou Y, Zuo Z
Ecotoxicology and environmental safety134P123-30(2016 Dec)

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A Disc1 peptide binds to GSK3beta, and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin-mediated Wnt signaling and inhibiting GSK3beta activity.
Title: Disc1 regulates both ?-catenin-mediated and noncanonical Wnt signaling during vertebrate embryogenesis.

Disc1 functions in the transcriptional repression of foxd3 and sox10, thus mediating cranial neural crest cell migration and differentiation.
Title: Disc1 regulates foxd3 and sox10 expression, affecting neural crest migration and differentiation.

Disc1 and nrg1 function in controlling development of oligodendrocytes and neurones from olig2-expressing precursor cells.
Title: Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain.

The following disc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the disc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa30903	NM_001142263.1 Latest version!	Danio rerio DISC1 scaffold protein (disc1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

disc1 ( NM_001142263.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001135735.1 Danio rerio DISC1 scaffold protein (disc1), mRNA.

Price & Availability↑

CloneID	ODa30903
Clone ID Related Accession (Same CDS sequence)	NM_001142263.1
Accession Version	NM_001142263.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2985bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-23
Organism	Danio rerio(zebrafish)
Product	disrupted in schizophrenia 1 protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EU273350.1. On Nov 26, 2008 this sequence version replaced XM_679428.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU273350.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGATGTTCG CAGGAATGGT CAGGGTGGAA AACACCTCAA AAACGCTCAA AACTGACATA 
GACTCTCCAT GTCACCGGTG TGCTGTGAGG ACAGGTGGTG TGAATCCTTC GGGAAACCAC 
CGCAGGAGGA GCTTCAGACG GCCCGGATAC ATGCGGTCTG AGCCGATTAA CCAGCTGGAC 
GTTGCAGAAA CATCATGTGA TTCTGAACAT CACAGAAGTC CTATTTCCAA GTCGCCTGCT 
GTGGAGAACA CTCAAAAGAG TGCTTCAGAA TTACTTGGCG AGAAATGGCT GACAGAGGGT 
TTCGAGAGAG ACAACTCATC AAAGTCTTCA AATAAACACC ATTTGCATGA TGAGGAGGAC 
AATTTACCAG TGCAATCACG TGATGTTTTC AATTCCAGTT TCAGTTTCAT TCAACAGTCG 
CTAGACACTA GCGATTTATT AGATGTAAAC ACATGCTATT CACCCAGAAC TGAACACAAA 
CAATCTGAAT CAGCGTCAGG GCACCAGCTG AAGTCTAAAA CTTCAAATTC AGGCTTTCTT 
AAACCTCCAT CTGATTTAAT GAATCACTTG AGCCAATCAG AAACCAGCAT TGTTCAAATG 
AACCAATTAG AAACCAGAAC TGTCCCGGTA AGCCAATCAA AATCAAGCTT TTTAAAACCT 
CTGTCTGCTT TAATGAATCA CTTAAGCCAA TCGGAAACCA CCAGTGTTCC AATCAACCAA 
TCAGAAACCA GCAGTGCCCC AAAAAGCCAA TCAAACTCAG GATTTTTAAA ACCTCTGTCT 
GATTTAATGA AACACTTGAC CCCACCAGAA TCCAGCATTG TTTTAATGAA CCAATCAGAA 
ACCATAACTA TTCCAATGAA CCAAACAAAA AACAGCACCA TCCCAGTGAG CCAATCAAAT 
GCAGACTTTT TAAATCCTCC ATCTGCTTTA ATGAATCACT TGAACCAATC AGAAACTGTG 
CTTATTCCAA TGAACCAATC AGAAACCAGC TCTATCCCAG TAAGCCAATC AAACTCAGGG 
TTTTTAAAAC CTTCATCTAA TTTAATAAAT CACTTAAGCC AATCAGAATC AGTCACTGTT 
CCAATGAACC AATCAGAAAC AAGCACGGTC TCATTAAGCC AATCAGAACC TGATTTTTTT 
TCTTTGAGAC ATTTGCCTTG TTCGATTGGT CAGTCGGCGC AGCAGAAAGG TCTGCTATTG 
GACCGAGAGC TGTGGTTGGT GGATCTGGAC TTGCAGACCT CGTCCTCCAT TATGTCTAAG 
TATACAAAAG AAAACATCCA GGATTCGGAT TCTGGCTCTC TGGACGCTGA AATCACGTCT 
TCACACTCCA TTGACTCTTC AGACTCGACT TCGTCTGGAT ATGAAAGCAC CACACCGTCC 
TCAGATCAGA GTCAGGATGG TTTAATGAAG AAGTATGAGG ATTTTCTGCA AGACTGTCTG 
CAAAACAATC GCACAAACAC CAAGATCGAG TCCATAATGA TGAAGCTTCA GAGATTACAG 
CACAAAGCCA TTCTGGATGA TGATTATGAC ACAGCTGAGC GTTTTGGTAA GAAACTGGAG 
GAACTGAGAA GAGAAAGAGC GACACTTAAG CCTGGACTTC CATCCAGACA CCCTGAAGTC 
ACTGGATATC TGGAGCGGCT CAGAACAGCA GTGAACAGCG CCATCCACAG GACAGACTCA 
GACTGCAGCA CTGGTGACCC GAGTGAAGAT CAGAGGTCCT GCATCTCTCA GAGTCGAGCT 
CAAACACGAG AGACGCTGTT AGAGGAGAAA CAGAGGATTC AGAAGGAGAT GTGTGATGTT 
CAGCGGCGGC TGCGGGATCT GCAGGAGCGC AGCAGGGCTC TGGAGCTTCA GCTGGAGCTG 
CAGGAGATGC AGGGACCCGT CCTCAGGGCC GCAGACTCTC CTCATCTGCA TCTGACGGCT 
CGAGCGCTGG AGGATCTGCT CACGTCTGAA CATCGCCAGC GCATCAGCGT TTCTCCACCA 
GCACACATCC GCAGGCTTGA AGAGCAGGAG CGAGTGCTGA GTTTGTCCAT CAGAGAAGCA 
GAGACTAAAG TGTTGTTGAA TCAGAGGTTG TGCTTCAGTC TGAGGCAGAA GGTCAGCGAG 
AGCGAAACGC AGCTGCTGGC GCTTCATGAA GCCAAACTCA CAGCCGTATC AGGAAATGAT 
TTCAGCAGTG CTAAAGAGCT TAAGGCGGAG ATCAGGAGTG TGTACAGAGA GAGGGATCGT 
CTGGAGCTCC TGCATAGAAA GCTGCAGACT CTGAGCACAG GAAGTGGACT CGACCTGAGC 
CGCATGAAGG AGAAACACAA GCACATCAAG CTGGAGCTGC AGAACGGAGA AGCTCAGTAT 
GAGCGCAGTT TGAAGGAAAA CACTGTGAAG TACATTGAGC TTCTGGAGGA CAAACTTCAC 
AGCTGTGGAA GTGCAGCGCT GGAACATGTT TTGGAGGCTG ATTTGGAGGC CTGTCATCTC 
CTCCTGAAAG GCCTGGATCA GAGAAACCTC AGCCTCTCCC AGACGGAGGA TCTTCCCTCA 
GGATCCGCAT CTGCTTCAGA TGTCCTGCAG TTCACTAAAG ATGAAGAGGA CTGCGCCATG 
TTGACTGCTT TAGGGGGACG CTGGTGTCCC GAAGCTGATC TACAGCACTC TCAGTTCACA 
AAGAAATTGG AGGAGTTTCT CTTCTGTTTG GAGGACGAGG CTCCAGAGAA TCTGTGTGGA 
GAAACAACAG AGCTGACGGA GCGCTGTGAA CTCATCAGTT ACCGACTGCA TTACCTGGAA 
GAGCAGCTTC AGACAGCCAT AGACAACAAT GACAAGGAGC TCACTCTCTC TCTGGAGAGG 
GAGGTCCTGG AGCTGAAGTC TGCTCTTCAG GCGATGCTGT CTCAGCTGAA GGAGGAAGAT 
GAGGATGAAG AAGACGAAGA GAAATACTGT GATGTAGAAG AAGAACAGGT TGAAGATGAA 
GACCTGGAGG AGGAGCACTA CTTCAGTGAC AGCTGGGAAA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001135735.1
CDS	83..3067
Translation	MMFAGMVRVENTSKTLKTDIDSPCHRCAVRTGGVNPSGNHRRRSFRRPGYMRSEPINQLDVAETSCDSEHHRSPISKSPAVENTQKSASELLGEKWLTEGFERDNSSKSSNKHHLHDEEDNLPVQSRDVFNSSFSFIQQSLDTSDLLDVNTCYSPRTEHKQSESASGHQLKSKTSNSGFLKPPSDLMNHLSQSETSIVQMNQLETRTVPVSQSKSSFLKPLSALMNHLSQSETTSVPINQSETSSAPKSQSNSGFLKPLSDLMKHLTPPESSIVLMNQSETITIPMNQTKNSTIPVSQSNADFLNPPSALMNHLNQSETVLIPMNQSETSSIPVSQSNSGFLKPSSNLINHLSQSESVTVPMNQSETSTVSLSQSEPDFFSLRHLPCSIGQSAQQKGLLLDRELWLVDLDLQTSSSIMSKYTKENIQDSDSGSLDAEITSSHSIDSSDSTSSGYESTTPSSDQSQDGLMKKYEDFLQDCLQNNRTNTKIESIMMKLQRLQHKAILDDDYDTAERFGKKLEELRRERATLKPGLPSRHPEVTGYLERLRTAVNSAIHRTDSDCSTGDPSEDQRSCISQSRAQTRETLLEEKQRIQKEMCDVQRRLRDLQERSRALELQLELQEMQGPVLRAADSPHLHLTARALEDLLTSEHRQRISVSPPAHIRRLEEQERVLSLSIREAETKVLLNQRLCFSLRQKVSESETQLLALHEAKLTAVSGNDFSSAKELKAEIRSVYRERDRLELLHRKLQTLSTGSGLDLSRMKEKHKHIKLELQNGEAQYERSLKENTVKYIELLEDKLHSCGSAALEHVLEADLEACHLLLKGLDQRNLSLSQTEDLPSGSASASDVLQFTKDEEDCAMLTALGGRWCPEADLQHSQFTKKLEEFLFCLEDEAPENLCGETTELTERCELISYRLHYLEEQLQTAIDNNDKELTLSLEREVLELKSALQAMLSQLKEEDEDEEDEEKYCDVEEEQVEDEDLEEEHYFSDSWEI

Target ORF information:

RefSeq Version	NM_001142263.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio DISC1 scaffold protein (disc1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142263.1

ORF Insert Sequence:

ATGATGTTCG CAGGAATGGT CAGGGTGGAA AACACCTCAA AAACGCTCAA AACTGACATA 
GACTCTCCAT GTCACCGGTG TGCTGTGAGG ACAGGTGGTG TGAATCCTTC GGGAAACCAC 
CGCAGGAGGA GCTTCAGACG GCCCGGATAC ATGCGGTCTG AGCCGATTAA CCAGCTGGAC 
GTTGCAGAAA CATCATGTGA TTCTGAACAT CACAGAAGTC CTATTTCCAA GTCGCCTGCT 
GTGGAGAACA CTCAAAAGAG TGCTTCAGAA TTACTTGGCG AGAAATGGCT GACAGAGGGT 
TTCGAGAGAG ACAACTCATC AAAGTCTTCA AATAAACACC ATTTGCATGA TGAGGAGGAC 
AATTTACCAG TGCAATCACG TGATGTTTTC AATTCCAGTT TCAGTTTCAT TCAACAGTCG 
CTAGACACTA GCGATTTATT AGATGTAAAC ACATGCTATT CACCCAGAAC TGAACACAAA 
CAATCTGAAT CAGCGTCAGG GCACCAGCTG AAGTCTAAAA CTTCAAATTC AGGCTTTCTT 
AAACCTCCAT CTGATTTAAT GAATCACTTG AGCCAATCAG AAACCAGCAT TGTTCAAATG 
AACCAATTAG AAACCAGAAC TGTCCCGGTA AGCCAATCAA AATCAAGCTT TTTAAAACCT 
CTGTCTGCTT TAATGAATCA CTTAAGCCAA TCGGAAACCA CCAGTGTTCC AATCAACCAA 
TCAGAAACCA GCAGTGCCCC AAAAAGCCAA TCAAACTCAG GATTTTTAAA ACCTCTGTCT 
GATTTAATGA AACACTTGAC CCCACCAGAA TCCAGCATTG TTTTAATGAA CCAATCAGAA 
ACCATAACTA TTCCAATGAA CCAAACAAAA AACAGCACCA TCCCAGTGAG CCAATCAAAT 
GCAGACTTTT TAAATCCTCC ATCTGCTTTA ATGAATCACT TGAACCAATC AGAAACTGTG 
CTTATTCCAA TGAACCAATC AGAAACCAGC TCTATCCCAG TAAGCCAATC AAACTCAGGG 
TTTTTAAAAC CTTCATCTAA TTTAATAAAT CACTTAAGCC AATCAGAATC AGTCACTGTT 
CCAATGAACC AATCAGAAAC AAGCACGGTC TCATTAAGCC AATCAGAACC TGATTTTTTT 
TCTTTGAGAC ATTTGCCTTG TTCGATTGGT CAGTCGGCGC AGCAGAAAGG TCTGCTATTG 
GACCGAGAGC TGTGGTTGGT GGATCTGGAC TTGCAGACCT CGTCCTCCAT TATGTCTAAG 
TATACAAAAG AAAACATCCA GGATTCGGAT TCTGGCTCTC TGGACGCTGA AATCACGTCT 
TCACACTCCA TTGACTCTTC AGACTCGACT TCGTCTGGAT ATGAAAGCAC CACACCGTCC 
TCAGATCAGA GTCAGGATGG TTTAATGAAG AAGTATGAGG ATTTTCTGCA AGACTGTCTG 
CAAAACAATC GCACAAACAC CAAGATCGAG TCCATAATGA TGAAGCTTCA GAGATTACAG 
CACAAAGCCA TTCTGGATGA TGATTATGAC ACAGCTGAGC GTTTTGGTAA GAAACTGGAG 
GAACTGAGAA GAGAAAGAGC GACACTTAAG CCTGGACTTC CATCCAGACA CCCTGAAGTC 
ACTGGATATC TGGAGCGGCT CAGAACAGCA GTGAACAGCG CCATCCACAG GACAGACTCA 
GACTGCAGCA CTGGTGACCC GAGTGAAGAT CAGAGGTCCT GCATCTCTCA GAGTCGAGCT 
CAAACACGAG AGACGCTGTT AGAGGAGAAA CAGAGGATTC AGAAGGAGAT GTGTGATGTT 
CAGCGGCGGC TGCGGGATCT GCAGGAGCGC AGCAGGGCTC TGGAGCTTCA GCTGGAGCTG 
CAGGAGATGC AGGGACCCGT CCTCAGGGCC GCAGACTCTC CTCATCTGCA TCTGACGGCT 
CGAGCGCTGG AGGATCTGCT CACGTCTGAA CATCGCCAGC GCATCAGCGT TTCTCCACCA 
GCACACATCC GCAGGCTTGA AGAGCAGGAG CGAGTGCTGA GTTTGTCCAT CAGAGAAGCA 
GAGACTAAAG TGTTGTTGAA TCAGAGGTTG TGCTTCAGTC TGAGGCAGAA GGTCAGCGAG 
AGCGAAACGC AGCTGCTGGC GCTTCATGAA GCCAAACTCA CAGCCGTATC AGGAAATGAT 
TTCAGCAGTG CTAAAGAGCT TAAGGCGGAG ATCAGGAGTG TGTACAGAGA GAGGGATCGT 
CTGGAGCTCC TGCATAGAAA GCTGCAGACT CTGAGCACAG GAAGTGGACT CGACCTGAGC 
CGCATGAAGG AGAAACACAA GCACATCAAG CTGGAGCTGC AGAACGGAGA AGCTCAGTAT 
GAGCGCAGTT TGAAGGAAAA CACTGTGAAG TACATTGAGC TTCTGGAGGA CAAACTTCAC 
AGCTGTGGAA GTGCAGCGCT GGAACATGTT TTGGAGGCTG ATTTGGAGGC CTGTCATCTC 
CTCCTGAAAG GCCTGGATCA GAGAAACCTC AGCCTCTCCC AGACGGAGGA TCTTCCCTCA 
GGATCCGCAT CTGCTTCAGA TGTCCTGCAG TTCACTAAAG ATGAAGAGGA CTGCGCCATG 
TTGACTGCTT TAGGGGGACG CTGGTGTCCC GAAGCTGATC TACAGCACTC TCAGTTCACA 
AAGAAATTGG AGGAGTTTCT CTTCTGTTTG GAGGACGAGG CTCCAGAGAA TCTGTGTGGA 
GAAACAACAG AGCTGACGGA GCGCTGTGAA CTCATCAGTT ACCGACTGCA TTACCTGGAA 
GAGCAGCTTC AGACAGCCAT AGACAACAAT GACAAGGAGC TCACTCTCTC TCTGGAGAGG 
GAGGTCCTGG AGCTGAAGTC TGCTCTTCAG GCGATGCTGT CTCAGCTGAA GGAGGAAGAT 
GAGGATGAAG AAGACGAAGA GAAATACTGT GATGTAGAAG AAGAACAGGT TGAAGATGAA 
GACCTGGAGG AGGAGCACTA CTTCAGTGAC AGCTGGGAAA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Maternal and embryonic exposure to the water soluble fraction of crude oil or lead induces behavioral abnormalities in zebrafish (Danio rerio), and the mechanisms involved.
Chemosphere1917-16(2018 Jan)
Wang Y,Shen C,Wang C,Zhou Y,Gao D,Zuo Z

Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function.
Human molecular genetics26(11)1992-2005(2017 06)
Eachus H,Bright C,Cunliffe VT,Placzek M,Wood JD,Watt PJ

Maternal exposure to the water soluble fraction of crude oil, lead and their mixture induces autism-like behavioral deficits in zebrafish (Danio rerio) larvae.
Ecotoxicology and environmental safety134P123-30(2016 Dec)
Wang Y,Zhong H,Wang C,Gao D,Zhou Y,Zuo Z

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

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disc1 cDNA ORF clone, Danio rerio(zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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