Gene Symbol | unc-6 |
Entrez Gene ID | 180961 |
Full Name | Netrin unc-6 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » unc-6 cDNA ORF clone
Gene Symbol | unc-6 |
Entrez Gene ID | 180961 |
Full Name | Netrin unc-6 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_076764.3 | NP_509165.1 | Netrin unc-6 |
NM_076764.5 | NP_509165.1 | Netrin unc-6 |
Rattus norvegicus (Norway rat) | Ntn1 | NP_446183.2 |
Homo sapiens (human) | NTN1 | NP_004813.2 |
Canis lupus familiaris (dog) | NTN1 | XP_850304.2 |
Mus musculus (house mouse) | Ntn1 | NP_032770.2 |
Gallus gallus (chicken) | NTN1 | NP_990750.1 |
Bos taurus (cattle) | NTN1 | NP_001179495.1 |
Danio rerio (zebrafish) | ntn1a | NP_571104.1 |
Drosophila melanogaster (fruit fly) | NetB | NP_511155.1 |
Caenorhabditis elegans (roundworm) | unc-6 | NP_509165.1 |
NTN1 | XP_001113322.2 | |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000228 | XP_310904.5 |
Pan troglodytes (chimpanzee) | NTN1 | XP_511846.3 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
the ENU-3 family proteins function in a pathway parallel to the UNC-6/Netrin pathway for motor neuron axon outgrowth, most likely in the Wnt pathway.
Title: The ENU-3 protein family members function in the Wnt pathway parallel to UNC-6/Netrin to promote motor neuron axon outgrowth in C. elegans.
rom these studies we conclude that FMO-1, FMO-4, FMO-5, and EHBP-1 represent new players downstream of UNC-6/Netrin receptors and Rac GTPases that inhibit growth cone filopodial protrusion in repulsive axon guidance
Title: Flavin monooxygenases regulate Caenorhabditis elegans axon guidance and growth cone protrusion with UNC-6/Netrin signaling and Rac GTPases.
We find that VANG-1 promotes Wnt signaling by facilitating Frizzled endocytosis and genetically acts in a common pathway with arr-1/beta-arrestin, whose mutation results in defective PLM branching and F-actin patterns similar to those in the Wnt, mig-1 or vang-1 mutants. On the other hand, the UNC-6/Netrin pathway intersects orthogonally with Wnt-PCP signaling to guide PLM branch growth along the dorsal-ventral axis.
Title: A Wnt-planar polarity pathway instructs neurite branching by restricting F-actin assembly through endosomal signaling.
LON-2/glypican acts as a modulator of UNC-40/DCC-mediated guidance to fine-tune axonal responses to UNC-6/netrin signals during migration.
Title: Glypican Is a Modulator of Netrin-Mediated Axon Guidance.
Ire-1/xbp-1 pathway of the unfolded protein response is crucial for establishing positional information of UNC-6/Netrin.
Title: IRE-1/XBP-1 pathway of the unfolded protein response is required for properly localizing neuronal UNC-6/Netrin for axon guidance in C.?elegans.
The following unc-6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the unc-6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa349594 | |
Clone ID Related Accession (Same CDS sequence) | NM_076764.3 , NM_076764.5 | |
Accession Version | NM_076764.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1839bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Netrin unc-6 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003284). On Jun 26, 2012 this sequence version replaced NM_076764.2. COMPLETENESS: incomplete on both ends. |
1 | ATGATCACAT CAGTATTGCG CTATGTGCTA GCGCTCTACT TTTGTATGGG CATAGCTCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_509165.1 |
CDS | 1..1839 |
Translation |
Target ORF information:
Target ORF information:
|
NM_076764.3 |
1 | ATGATCACAT CAGTATTGCG CTATGTGCTA GCGCTCTACT TTTGTATGGG CATAGCTCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa349594 | |
Clone ID Related Accession (Same CDS sequence) | NM_076764.3 , NM_076764.5 | |
Accession Version | NM_076764.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1839bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Netrin unc-6 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003284). On Oct 18, 2019 this sequence version replaced NM_076764.4. |
1 | ATGATCACAT CAGTATTGCG CTATGTGCTA GCGCTCTACT TTTGTATGGG CATAGCTCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_509165.1 |
CDS | 67..1905 |
Translation |
Target ORF information:
Target ORF information:
|
NM_076764.5 |
1 | ATGATCACAT CAGTATTGCG CTATGTGCTA GCGCTCTACT TTTGTATGGG CATAGCTCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |