Ntn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ntn1
Entrez Gene ID	114523
Full Name	netrin 1
Synonyms	netrin-1
General protein information	Preferred Names netrin 1 Names netrin-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q24
Summary	plays a role in axon guidance during development; may also be involved in cell-cell interactions in the adult nervous system [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006246568.3	XP_006246630.1	netrin-1 isoform X1
NM_053731.2	NP_446183.2	netrin-1 precursor
XM_006246567.3	XP_006246629.1	netrin-1 isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Ntn1	NP_446183.2
Homo sapiens (human)	NTN1	NP_004813.2
Canis lupus familiaris (dog)	NTN1	XP_850304.2
Mus musculus (house mouse)	Ntn1	NP_032770.2
Gallus gallus (chicken)	NTN1	NP_990750.1
Bos taurus (cattle)	NTN1	NP_001179495.1
Danio rerio (zebrafish)	ntn1a	NP_571104.1
Drosophila melanogaster (fruit fly)	NetB	NP_511155.1
Caenorhabditis elegans (roundworm)	unc-6	NP_509165.1
	NTN1	XP_001113322.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000228	XP_310904.5
Pan troglodytes (chimpanzee)	NTN1	XP_511846.3

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in the netrin-1 gene cause congenital mirror movements.
M?neret A, Franz EA, Trouillard O, Oliver TC, Zagar Y, Robertson SP, Welniarz Q, Gardner RJM, Gallea C, Srour M, Depienne C, Jasoni CL, Dubacq C, Riant F, Lamy JC, Morel MP, Gu?rois R, Andreani J, Fouquet C, Doulazmi M, Vidailhet M, Rouleau GA, Brice A, Ch?dotal A, Dusart I, Roze E, Markie D
The Journal of clinical investigation127(11)3923-3936(2017 Nov)

Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling.
Nagendran T, Larsen RS, Bigler RL, Frost SB, Philpot BD, Nudo RJ, Taylor AM
Nature communications8(1)625(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

netrin-1 modulates the spatiotemporal activation of RhoA in embryonic cortical neurons.
Title: Direct measurement of oscillatory RhoA activity in embryonic cortical neurons stimulated with the axon guidance cue netrin-1 using fluorescence resonance energy transfer.

netrin-1 might inhibit endothelial-to-mesenchymal transition by blocking the TGF-beta/Snail/alpha-SMA signaling pathway.
Title: Netrin-1 attenuates the progression of renal dysfunction by blocking endothelial-to-mesenchymal transition in the 5/6 nephrectomy rat model.

that Netrin-1 has the ability to augment the angiogenesis of bone marrow mesenchymal stem cells and improve the function of the ischaemic hind limb by increasing the level of vascular endothelial growth factor
Title: Netrin-1 promotes mesenchymal stem cell revascularization of limb ischaemia.

Netrin-1 reduced the Abeta1- 40-induced Abeta1-42 increase, increased sAbetaPPalpha, and reversed the Abeta-induced sAbetaPPalpha decrease in vitro
Title: Netrin-1 Interrupts Amyloid-? Amplification, Increases sA?PP? in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer's Disease.

Netrin-1 induces the migration of Schwann cells via p38 MAPK and PI3K-Akt signaling pathway mediated by the UNC5B receptor.
Title: Netrin-1 induces the migration of Schwann cells via p38 MAPK and PI3K-Akt signaling pathway mediated by the UNC5B receptor.

The following Ntn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ntn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa10453	NM_053731.2 Latest version!	Rattus norvegicus netrin 1 (Ntn1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
ORa10453	XM_006246568.3 Latest version!	Rattus norvegicus netrin 1 (Ntn1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
ORa10453	XM_006246567.3 Latest version!	Rattus norvegicus netrin 1 (Ntn1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ntn1 ( NM_053731.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446183.2 Rattus norvegicus netrin 1 (Ntn1), mRNA.

Price & Availability↑

CloneID	ORa10453
Clone ID Related Accession (Same CDS sequence)	XM_006246568.3 , NM_053731.2 , XM_006246567.3
Accession Version	NM_053731.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1815bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Rattus norvegicus(Norway rat)
Product	netrin-1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07029844.1 and AABR07029842.1. On Nov 2, 2012 this sequence version replaced NM_053731.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY028417.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906355 [ECO:0000348] ##Evidence-Data-END##

ATGATGCGCG CTGTGTGGGA GGCGCTGGCG GCGCTGGCGG CGGTGGCGTG CCTGGTGGGC 
GCGGTGCGCG GCGGGCCCGG GCTTAGCATG TTCGCCGGCC AGGCGGCGCA GCCTGATCCT 
TGCTCGGATG AGAACGGGCA CCCACGCCGC TGCATCCCGG ACTTTGTCAA CGCGGCTTTC 
GGCAAGGACG TGCGCGTGTC CAGCACCTGC GGCCGGCCCC CGGCGCGCTA CTGCGTGGTG 
AGCGAGCGTG GCGAGGAGCG GCTGCGCTCC TGTCACCTCT GCAACTCTTC CGATCCCAAG 
AAAGCGCATC CGCCCGCCTT CCTCACCGAC CTCAACAATC CGCACAACCT GACGTGCTGG 
CAGTCTGAGA ACTACCTGCA GTTCCCGCAC AACGTTACGC TCACTCTGTC GCTCGGCAAG 
AAGTTTGAGG TGACCTATGT GAGCCTGCAA TTCTGCTCGC CCCGGCCAGA GTCCATGGCC 
ATCTACAAGT CCATGGACTA CGGGCGCACG TGGGTGCCCT TCCAATTCTA TTCCACTCAG 
TGCCGCAAAA TGTACAACCG GCCGCACCGC GCGCCCATCA CTAAGCAGAA CGAGCAGGAG 
GCGGTGTGCA CCGACTCGCA CACCGACATG CGCCCGCTCT CCGGCGGGCT GATCGCTTTC 
AGCACGCTGG ACGGGCGGCC CTCGGCGCAC GACTTCGACA ACTCGCCGGT GCTGCAGGAC 
TGGGTCACCG CCACAGACAT CCGCGTGGCT TTCAGCCGCC TGCACACGTT TGGCGACGAG 
AACGAAGATG ACTCGGAGCT GGCTCGCGAC TCCTATTACT ATGCAGTATC TGACCTGCAG 
GTTGGCGGCC GCTGCAAGTG CAATGGCCAC GCGGCGCGTT GCGTGCGCGA CCGAGACGAC 
AGTCTGGTGT GTGACTGTAG GCACAACACG GCCGGCCCTG AATGCGACCG TTGCAAGCCC 
TTCCACTACG ATCGGCCCTG GCAGCGCGCC ACGGCTCGCG AGGCCAACGA GTGCGTGGCC 
TGCAACTGCA ACCTTCATGC TCGGCGCTGC AGATTCAACA TGGAGCTTTA CAAGCTATCA 
GGGCGCAAGA GCGGGGGTGT CTGTCTCAAC TGCCGCCACA ACACTGCCGG CCGCCACTGC 
CACTACTGCA AGGAGGGCTT CTACCGAGAC ATGGGCAAGC CTATCACCCA CCGGAAGGCT 
TGCAAAGCCT GTGATTGCCA CCCTGTGGGT GCTGCTGGTA AGACCTGCAA TCAAACCACC 
GGCCAGTGTC CCTGCAAGGA CGGCGTGACA GGCATCACCT GCAACCGCTG TGCCAAAGGC 
TACCAGCAGA GCCGCTCCCC CATCGCCCCT TGCATTAAGA TTCCTGTAGC GCCACCCACC 
ACTGCAGCCA GCAGCATGGA AGAACCTGAA GACTGTGACT CCTACTGCAA GGCTTCCAAA 
GGAAAACTGA AGATGAACAT GAAGAAATAC TGCAGGAAGG ACTATGCTGT CCAGATCCAC 
ATTCTGAAGG CGGACAAAGC AGGGGACTGG TGGAAGTTCA CAGTGAACAT CATCTCCGTG 
TACAAGCAGG GCACAAGTCG TATACGCCGT GGTGACCAGA GTTTGTGGAT CCGTTCGCGA 
GACATCGCTT GCAAGTGTCC CAAAATCAAG CCCCTCAAGA AGTACCTGCT GCTGGGCAAT 
GCTGAGGACT CGCCTGACCA GAGTGGCATC GTGGCAGACA AGAGCAGCCT GGTGATCCAG 
TGGCGGGACA CATGGGCACG ACGGCTGCGC AAGTTCCAGC AGCGGGAGAA GAAGGGCAAG 
TGCAAGAAGG CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446183.2
CDS	1..1815
Translation	MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRSCHLCNSSDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQCRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARDSYYYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGFYRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAPPTTAASSMEEPEDCDSYCKASKGKLKMNMKKYCRKDYAVQIHILKADKAGDWWKFTVNIISVYKQGTSRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLGNAEDSPDQSGIVADKSSLVIQWRDTWARRLRKFQQREKKGKCKKA

Target ORF information:

RefSeq Version	NM_053731.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus netrin 1 (Ntn1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053731.2

ORF Insert Sequence:

ATGATGCGCG CTGTGTGGGA GGCGCTGGCG GCGCTGGCGG CGGTGGCGTG CCTGGTGGGC 
GCGGTGCGCG GCGGGCCCGG GCTTAGCATG TTCGCCGGCC AGGCGGCGCA GCCTGATCCT 
TGCTCGGATG AGAACGGGCA CCCACGCCGC TGCATCCCGG ACTTTGTCAA CGCGGCTTTC 
GGCAAGGACG TGCGCGTGTC CAGCACCTGC GGCCGGCCCC CGGCGCGCTA CTGCGTGGTG 
AGCGAGCGTG GCGAGGAGCG GCTGCGCTCC TGTCACCTCT GCAACTCTTC CGATCCCAAG 
AAAGCGCATC CGCCCGCCTT CCTCACCGAC CTCAACAATC CGCACAACCT GACGTGCTGG 
CAGTCTGAGA ACTACCTGCA GTTCCCGCAC AACGTTACGC TCACTCTGTC GCTCGGCAAG 
AAGTTTGAGG TGACCTATGT GAGCCTGCAA TTCTGCTCGC CCCGGCCAGA GTCCATGGCC 
ATCTACAAGT CCATGGACTA CGGGCGCACG TGGGTGCCCT TCCAATTCTA TTCCACTCAG 
TGCCGCAAAA TGTACAACCG GCCGCACCGC GCGCCCATCA CTAAGCAGAA CGAGCAGGAG 
GCGGTGTGCA CCGACTCGCA CACCGACATG CGCCCGCTCT CCGGCGGGCT GATCGCTTTC 
AGCACGCTGG ACGGGCGGCC CTCGGCGCAC GACTTCGACA ACTCGCCGGT GCTGCAGGAC 
TGGGTCACCG CCACAGACAT CCGCGTGGCT TTCAGCCGCC TGCACACGTT TGGCGACGAG 
AACGAAGATG ACTCGGAGCT GGCTCGCGAC TCCTATTACT ATGCAGTATC TGACCTGCAG 
GTTGGCGGCC GCTGCAAGTG CAATGGCCAC GCGGCGCGTT GCGTGCGCGA CCGAGACGAC 
AGTCTGGTGT GTGACTGTAG GCACAACACG GCCGGCCCTG AATGCGACCG TTGCAAGCCC 
TTCCACTACG ATCGGCCCTG GCAGCGCGCC ACGGCTCGCG AGGCCAACGA GTGCGTGGCC 
TGCAACTGCA ACCTTCATGC TCGGCGCTGC AGATTCAACA TGGAGCTTTA CAAGCTATCA 
GGGCGCAAGA GCGGGGGTGT CTGTCTCAAC TGCCGCCACA ACACTGCCGG CCGCCACTGC 
CACTACTGCA AGGAGGGCTT CTACCGAGAC ATGGGCAAGC CTATCACCCA CCGGAAGGCT 
TGCAAAGCCT GTGATTGCCA CCCTGTGGGT GCTGCTGGTA AGACCTGCAA TCAAACCACC 
GGCCAGTGTC CCTGCAAGGA CGGCGTGACA GGCATCACCT GCAACCGCTG TGCCAAAGGC 
TACCAGCAGA GCCGCTCCCC CATCGCCCCT TGCATTAAGA TTCCTGTAGC GCCACCCACC 
ACTGCAGCCA GCAGCATGGA AGAACCTGAA GACTGTGACT CCTACTGCAA GGCTTCCAAA 
GGAAAACTGA AGATGAACAT GAAGAAATAC TGCAGGAAGG ACTATGCTGT CCAGATCCAC 
ATTCTGAAGG CGGACAAAGC AGGGGACTGG TGGAAGTTCA CAGTGAACAT CATCTCCGTG 
TACAAGCAGG GCACAAGTCG TATACGCCGT GGTGACCAGA GTTTGTGGAT CCGTTCGCGA 
GACATCGCTT GCAAGTGTCC CAAAATCAAG CCCCTCAAGA AGTACCTGCT GCTGGGCAAT 
GCTGAGGACT CGCCTGACCA GAGTGGCATC GTGGCAGACA AGAGCAGCCT GGTGATCCAG 
TGGCGGGACA CATGGGCACG ACGGCTGCGC AAGTTCCAGC AGCGGGAGAA GAAGGGCAAG 
TGCAAGAAGG CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ntn1 ( XM_006246568.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006246630.1 Rattus norvegicus netrin 1 (Ntn1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa10453
Clone ID Related Accession (Same CDS sequence)	XM_006246568.3 , NM_053731.2 , XM_006246567.3
Accession Version	XM_006246568.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1815bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	netrin-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006246568.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGCGCG CTGTGTGGGA GGCGCTGGCG GCGCTGGCGG CGGTGGCGTG CCTGGTGGGC 
GCGGTGCGCG GCGGGCCCGG GCTTAGCATG TTCGCCGGCC AGGCGGCGCA GCCTGATCCT 
TGCTCGGATG AGAACGGGCA CCCACGCCGC TGCATCCCGG ACTTTGTCAA CGCGGCTTTC 
GGCAAGGACG TGCGCGTGTC CAGCACCTGC GGCCGGCCCC CGGCGCGCTA CTGCGTGGTG 
AGCGAGCGTG GCGAGGAGCG GCTGCGCTCC TGTCACCTCT GCAACTCTTC CGATCCCAAG 
AAAGCGCATC CGCCCGCCTT CCTCACCGAC CTCAACAATC CGCACAACCT GACGTGCTGG 
CAGTCTGAGA ACTACCTGCA GTTCCCGCAC AACGTTACGC TCACTCTGTC GCTCGGCAAG 
AAGTTTGAGG TGACCTATGT GAGCCTGCAA TTCTGCTCGC CCCGGCCAGA GTCCATGGCC 
ATCTACAAGT CCATGGACTA CGGGCGCACG TGGGTGCCCT TCCAATTCTA TTCCACTCAG 
TGCCGCAAAA TGTACAACCG GCCGCACCGC GCGCCCATCA CTAAGCAGAA CGAGCAGGAG 
GCGGTGTGCA CCGACTCGCA CACCGACATG CGCCCGCTCT CCGGCGGGCT GATCGCTTTC 
AGCACGCTGG ACGGGCGGCC CTCGGCGCAC GACTTCGACA ACTCGCCGGT GCTGCAGGAC 
TGGGTCACCG CCACAGACAT CCGCGTGGCT TTCAGCCGCC TGCACACGTT TGGCGACGAG 
AACGAAGATG ACTCGGAGCT GGCTCGCGAC TCCTATTACT ATGCAGTATC TGACCTGCAG 
GTTGGCGGCC GCTGCAAGTG CAATGGCCAC GCGGCGCGTT GCGTGCGCGA CCGAGACGAC 
AGTCTGGTGT GTGACTGTAG GCACAACACG GCCGGCCCTG AATGCGACCG TTGCAAGCCC 
TTCCACTACG ATCGGCCCTG GCAGCGCGCC ACGGCTCGCG AGGCCAACGA GTGCGTGGCC 
TGCAACTGCA ACCTTCATGC TCGGCGCTGC AGATTCAACA TGGAGCTTTA CAAGCTATCA 
GGGCGCAAGA GCGGGGGTGT CTGTCTCAAC TGCCGCCACA ACACTGCCGG CCGCCACTGC 
CACTACTGCA AGGAGGGCTT CTACCGAGAC ATGGGCAAGC CTATCACCCA CCGGAAGGCT 
TGCAAAGCCT GTGATTGCCA CCCTGTGGGT GCTGCTGGTA AGACCTGCAA TCAAACCACC 
GGCCAGTGTC CCTGCAAGGA CGGCGTGACA GGCATCACCT GCAACCGCTG TGCCAAAGGC 
TACCAGCAGA GCCGCTCCCC CATCGCCCCT TGCATTAAGA TTCCTGTAGC GCCACCCACC 
ACTGCAGCCA GCAGCATGGA AGAACCTGAA GACTGTGACT CCTACTGCAA GGCTTCCAAA 
GGAAAACTGA AGATGAACAT GAAGAAATAC TGCAGGAAGG ACTATGCTGT CCAGATCCAC 
ATTCTGAAGG CGGACAAAGC AGGGGACTGG TGGAAGTTCA CAGTGAACAT CATCTCCGTG 
TACAAGCAGG GCACAAGTCG TATACGCCGT GGTGACCAGA GTTTGTGGAT CCGTTCGCGA 
GACATCGCTT GCAAGTGTCC CAAAATCAAG CCCCTCAAGA AGTACCTGCT GCTGGGCAAT 
GCTGAGGACT CGCCTGACCA GAGTGGCATC GTGGCAGACA AGAGCAGCCT GGTGATCCAG 
TGGCGGGACA CATGGGCACG ACGGCTGCGC AAGTTCCAGC AGCGGGAGAA GAAGGGCAAG 
TGCAAGAAGG CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006246630.1
CDS	220..2034
Translation	MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRSCHLCNSSDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQCRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARDSYYYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGFYRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAPPTTAASSMEEPEDCDSYCKASKGKLKMNMKKYCRKDYAVQIHILKADKAGDWWKFTVNIISVYKQGTSRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLGNAEDSPDQSGIVADKSSLVIQWRDTWARRLRKFQQREKKGKCKKA

Target ORF information:

RefSeq Version	XM_006246568.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus netrin 1 (Ntn1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006246568.3

ORF Insert Sequence:

ATGATGCGCG CTGTGTGGGA GGCGCTGGCG GCGCTGGCGG CGGTGGCGTG CCTGGTGGGC 
GCGGTGCGCG GCGGGCCCGG GCTTAGCATG TTCGCCGGCC AGGCGGCGCA GCCTGATCCT 
TGCTCGGATG AGAACGGGCA CCCACGCCGC TGCATCCCGG ACTTTGTCAA CGCGGCTTTC 
GGCAAGGACG TGCGCGTGTC CAGCACCTGC GGCCGGCCCC CGGCGCGCTA CTGCGTGGTG 
AGCGAGCGTG GCGAGGAGCG GCTGCGCTCC TGTCACCTCT GCAACTCTTC CGATCCCAAG 
AAAGCGCATC CGCCCGCCTT CCTCACCGAC CTCAACAATC CGCACAACCT GACGTGCTGG 
CAGTCTGAGA ACTACCTGCA GTTCCCGCAC AACGTTACGC TCACTCTGTC GCTCGGCAAG 
AAGTTTGAGG TGACCTATGT GAGCCTGCAA TTCTGCTCGC CCCGGCCAGA GTCCATGGCC 
ATCTACAAGT CCATGGACTA CGGGCGCACG TGGGTGCCCT TCCAATTCTA TTCCACTCAG 
TGCCGCAAAA TGTACAACCG GCCGCACCGC GCGCCCATCA CTAAGCAGAA CGAGCAGGAG 
GCGGTGTGCA CCGACTCGCA CACCGACATG CGCCCGCTCT CCGGCGGGCT GATCGCTTTC 
AGCACGCTGG ACGGGCGGCC CTCGGCGCAC GACTTCGACA ACTCGCCGGT GCTGCAGGAC 
TGGGTCACCG CCACAGACAT CCGCGTGGCT TTCAGCCGCC TGCACACGTT TGGCGACGAG 
AACGAAGATG ACTCGGAGCT GGCTCGCGAC TCCTATTACT ATGCAGTATC TGACCTGCAG 
GTTGGCGGCC GCTGCAAGTG CAATGGCCAC GCGGCGCGTT GCGTGCGCGA CCGAGACGAC 
AGTCTGGTGT GTGACTGTAG GCACAACACG GCCGGCCCTG AATGCGACCG TTGCAAGCCC 
TTCCACTACG ATCGGCCCTG GCAGCGCGCC ACGGCTCGCG AGGCCAACGA GTGCGTGGCC 
TGCAACTGCA ACCTTCATGC TCGGCGCTGC AGATTCAACA TGGAGCTTTA CAAGCTATCA 
GGGCGCAAGA GCGGGGGTGT CTGTCTCAAC TGCCGCCACA ACACTGCCGG CCGCCACTGC 
CACTACTGCA AGGAGGGCTT CTACCGAGAC ATGGGCAAGC CTATCACCCA CCGGAAGGCT 
TGCAAAGCCT GTGATTGCCA CCCTGTGGGT GCTGCTGGTA AGACCTGCAA TCAAACCACC 
GGCCAGTGTC CCTGCAAGGA CGGCGTGACA GGCATCACCT GCAACCGCTG TGCCAAAGGC 
TACCAGCAGA GCCGCTCCCC CATCGCCCCT TGCATTAAGA TTCCTGTAGC GCCACCCACC 
ACTGCAGCCA GCAGCATGGA AGAACCTGAA GACTGTGACT CCTACTGCAA GGCTTCCAAA 
GGAAAACTGA AGATGAACAT GAAGAAATAC TGCAGGAAGG ACTATGCTGT CCAGATCCAC 
ATTCTGAAGG CGGACAAAGC AGGGGACTGG TGGAAGTTCA CAGTGAACAT CATCTCCGTG 
TACAAGCAGG GCACAAGTCG TATACGCCGT GGTGACCAGA GTTTGTGGAT CCGTTCGCGA 
GACATCGCTT GCAAGTGTCC CAAAATCAAG CCCCTCAAGA AGTACCTGCT GCTGGGCAAT 
GCTGAGGACT CGCCTGACCA GAGTGGCATC GTGGCAGACA AGAGCAGCCT GGTGATCCAG 
TGGCGGGACA CATGGGCACG ACGGCTGCGC AAGTTCCAGC AGCGGGAGAA GAAGGGCAAG 
TGCAAGAAGG CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ntn1 ( XM_006246567.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006246629.1 Rattus norvegicus netrin 1 (Ntn1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa10453
Clone ID Related Accession (Same CDS sequence)	XM_006246568.3 , NM_053731.2 , XM_006246567.3
Accession Version	XM_006246567.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1815bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	netrin-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006246567.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGCGCG CTGTGTGGGA GGCGCTGGCG GCGCTGGCGG CGGTGGCGTG CCTGGTGGGC 
GCGGTGCGCG GCGGGCCCGG GCTTAGCATG TTCGCCGGCC AGGCGGCGCA GCCTGATCCT 
TGCTCGGATG AGAACGGGCA CCCACGCCGC TGCATCCCGG ACTTTGTCAA CGCGGCTTTC 
GGCAAGGACG TGCGCGTGTC CAGCACCTGC GGCCGGCCCC CGGCGCGCTA CTGCGTGGTG 
AGCGAGCGTG GCGAGGAGCG GCTGCGCTCC TGTCACCTCT GCAACTCTTC CGATCCCAAG 
AAAGCGCATC CGCCCGCCTT CCTCACCGAC CTCAACAATC CGCACAACCT GACGTGCTGG 
CAGTCTGAGA ACTACCTGCA GTTCCCGCAC AACGTTACGC TCACTCTGTC GCTCGGCAAG 
AAGTTTGAGG TGACCTATGT GAGCCTGCAA TTCTGCTCGC CCCGGCCAGA GTCCATGGCC 
ATCTACAAGT CCATGGACTA CGGGCGCACG TGGGTGCCCT TCCAATTCTA TTCCACTCAG 
TGCCGCAAAA TGTACAACCG GCCGCACCGC GCGCCCATCA CTAAGCAGAA CGAGCAGGAG 
GCGGTGTGCA CCGACTCGCA CACCGACATG CGCCCGCTCT CCGGCGGGCT GATCGCTTTC 
AGCACGCTGG ACGGGCGGCC CTCGGCGCAC GACTTCGACA ACTCGCCGGT GCTGCAGGAC 
TGGGTCACCG CCACAGACAT CCGCGTGGCT TTCAGCCGCC TGCACACGTT TGGCGACGAG 
AACGAAGATG ACTCGGAGCT GGCTCGCGAC TCCTATTACT ATGCAGTATC TGACCTGCAG 
GTTGGCGGCC GCTGCAAGTG CAATGGCCAC GCGGCGCGTT GCGTGCGCGA CCGAGACGAC 
AGTCTGGTGT GTGACTGTAG GCACAACACG GCCGGCCCTG AATGCGACCG TTGCAAGCCC 
TTCCACTACG ATCGGCCCTG GCAGCGCGCC ACGGCTCGCG AGGCCAACGA GTGCGTGGCC 
TGCAACTGCA ACCTTCATGC TCGGCGCTGC AGATTCAACA TGGAGCTTTA CAAGCTATCA 
GGGCGCAAGA GCGGGGGTGT CTGTCTCAAC TGCCGCCACA ACACTGCCGG CCGCCACTGC 
CACTACTGCA AGGAGGGCTT CTACCGAGAC ATGGGCAAGC CTATCACCCA CCGGAAGGCT 
TGCAAAGCCT GTGATTGCCA CCCTGTGGGT GCTGCTGGTA AGACCTGCAA TCAAACCACC 
GGCCAGTGTC CCTGCAAGGA CGGCGTGACA GGCATCACCT GCAACCGCTG TGCCAAAGGC 
TACCAGCAGA GCCGCTCCCC CATCGCCCCT TGCATTAAGA TTCCTGTAGC GCCACCCACC 
ACTGCAGCCA GCAGCATGGA AGAACCTGAA GACTGTGACT CCTACTGCAA GGCTTCCAAA 
GGAAAACTGA AGATGAACAT GAAGAAATAC TGCAGGAAGG ACTATGCTGT CCAGATCCAC 
ATTCTGAAGG CGGACAAAGC AGGGGACTGG TGGAAGTTCA CAGTGAACAT CATCTCCGTG 
TACAAGCAGG GCACAAGTCG TATACGCCGT GGTGACCAGA GTTTGTGGAT CCGTTCGCGA 
GACATCGCTT GCAAGTGTCC CAAAATCAAG CCCCTCAAGA AGTACCTGCT GCTGGGCAAT 
GCTGAGGACT CGCCTGACCA GAGTGGCATC GTGGCAGACA AGAGCAGCCT GGTGATCCAG 
TGGCGGGACA CATGGGCACG ACGGCTGCGC AAGTTCCAGC AGCGGGAGAA GAAGGGCAAG 
TGCAAGAAGG CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006246629.1
CDS	367..2181
Translation	MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRSCHLCNSSDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQCRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARDSYYYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGFYRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAPPTTAASSMEEPEDCDSYCKASKGKLKMNMKKYCRKDYAVQIHILKADKAGDWWKFTVNIISVYKQGTSRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLGNAEDSPDQSGIVADKSSLVIQWRDTWARRLRKFQQREKKGKCKKA

Target ORF information:

RefSeq Version	XM_006246567.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus netrin 1 (Ntn1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006246567.3

ORF Insert Sequence:

ATGATGCGCG CTGTGTGGGA GGCGCTGGCG GCGCTGGCGG CGGTGGCGTG CCTGGTGGGC 
GCGGTGCGCG GCGGGCCCGG GCTTAGCATG TTCGCCGGCC AGGCGGCGCA GCCTGATCCT 
TGCTCGGATG AGAACGGGCA CCCACGCCGC TGCATCCCGG ACTTTGTCAA CGCGGCTTTC 
GGCAAGGACG TGCGCGTGTC CAGCACCTGC GGCCGGCCCC CGGCGCGCTA CTGCGTGGTG 
AGCGAGCGTG GCGAGGAGCG GCTGCGCTCC TGTCACCTCT GCAACTCTTC CGATCCCAAG 
AAAGCGCATC CGCCCGCCTT CCTCACCGAC CTCAACAATC CGCACAACCT GACGTGCTGG 
CAGTCTGAGA ACTACCTGCA GTTCCCGCAC AACGTTACGC TCACTCTGTC GCTCGGCAAG 
AAGTTTGAGG TGACCTATGT GAGCCTGCAA TTCTGCTCGC CCCGGCCAGA GTCCATGGCC 
ATCTACAAGT CCATGGACTA CGGGCGCACG TGGGTGCCCT TCCAATTCTA TTCCACTCAG 
TGCCGCAAAA TGTACAACCG GCCGCACCGC GCGCCCATCA CTAAGCAGAA CGAGCAGGAG 
GCGGTGTGCA CCGACTCGCA CACCGACATG CGCCCGCTCT CCGGCGGGCT GATCGCTTTC 
AGCACGCTGG ACGGGCGGCC CTCGGCGCAC GACTTCGACA ACTCGCCGGT GCTGCAGGAC 
TGGGTCACCG CCACAGACAT CCGCGTGGCT TTCAGCCGCC TGCACACGTT TGGCGACGAG 
AACGAAGATG ACTCGGAGCT GGCTCGCGAC TCCTATTACT ATGCAGTATC TGACCTGCAG 
GTTGGCGGCC GCTGCAAGTG CAATGGCCAC GCGGCGCGTT GCGTGCGCGA CCGAGACGAC 
AGTCTGGTGT GTGACTGTAG GCACAACACG GCCGGCCCTG AATGCGACCG TTGCAAGCCC 
TTCCACTACG ATCGGCCCTG GCAGCGCGCC ACGGCTCGCG AGGCCAACGA GTGCGTGGCC 
TGCAACTGCA ACCTTCATGC TCGGCGCTGC AGATTCAACA TGGAGCTTTA CAAGCTATCA 
GGGCGCAAGA GCGGGGGTGT CTGTCTCAAC TGCCGCCACA ACACTGCCGG CCGCCACTGC 
CACTACTGCA AGGAGGGCTT CTACCGAGAC ATGGGCAAGC CTATCACCCA CCGGAAGGCT 
TGCAAAGCCT GTGATTGCCA CCCTGTGGGT GCTGCTGGTA AGACCTGCAA TCAAACCACC 
GGCCAGTGTC CCTGCAAGGA CGGCGTGACA GGCATCACCT GCAACCGCTG TGCCAAAGGC 
TACCAGCAGA GCCGCTCCCC CATCGCCCCT TGCATTAAGA TTCCTGTAGC GCCACCCACC 
ACTGCAGCCA GCAGCATGGA AGAACCTGAA GACTGTGACT CCTACTGCAA GGCTTCCAAA 
GGAAAACTGA AGATGAACAT GAAGAAATAC TGCAGGAAGG ACTATGCTGT CCAGATCCAC 
ATTCTGAAGG CGGACAAAGC AGGGGACTGG TGGAAGTTCA CAGTGAACAT CATCTCCGTG 
TACAAGCAGG GCACAAGTCG TATACGCCGT GGTGACCAGA GTTTGTGGAT CCGTTCGCGA 
GACATCGCTT GCAAGTGTCC CAAAATCAAG CCCCTCAAGA AGTACCTGCT GCTGGGCAAT 
GCTGAGGACT CGCCTGACCA GAGTGGCATC GTGGCAGACA AGAGCAGCCT GGTGATCCAG 
TGGCGGGACA CATGGGCACG ACGGCTGCGC AAGTTCCAGC AGCGGGAGAA GAAGGGCAAG 
TGCAAGAAGG CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in the netrin-1 gene cause congenital mirror movements.
The Journal of clinical investigation127(11)3923-3936(2017 Nov)
M?neret A,Franz EA,Trouillard O,Oliver TC,Zagar Y,Robertson SP,Welniarz Q,Gardner RJM,Gallea C,Srour M,Depienne C,Jasoni CL,Dubacq C,Riant F,Lamy JC,Morel MP,Gu?rois R,Andreani J,Fouquet C,Doulazmi M,Vidailhet M,Rouleau GA,Brice A,Ch?dotal A,Dusart I,Roze E,Markie D

Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling.
Nature communications8(1)625(2017 Sep)
Nagendran T,Larsen RS,Bigler RL,Frost SB,Philpot BD,Nudo RJ,Taylor AM

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Ntn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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