RQC2 cDNA ORF clone, Saccharomyces cerevisiae S288C

Gene
Clones
gRNAs

Summary

Gene Symbol	RQC2
Entrez Gene ID	856098
Full Name	Rqc2p
Synonyms	TAE2
Gene Type	protein-coding
Organism	Saccharomyces cerevisiae S288C

mRNA and Protein(s)

mRNA	Protein	Name
NM_001183823.1	NP_015316.1	Rqc2p

Pathways from BioSystems

Homologies

Magnaporthe oryzae (rice blast fungus)	MGG_02697	XP_003721068.1
Saccharomyces cerevisiae (baker's yeast)	TAE2	NP_015316.1
Eremothecium gossypii	AGOS_AGL017W	NP_986649.2
Neurospora crassa	NCU09191	XP_959135.1
Kluyveromyces lactis	KLLA0F27335g	XP_456296.1

Gene Ontology
Bibliography

Related articles in PubMed

The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
Bussey H, Storms RK, Ahmed A, Albermann K, Allen E, Ansorge W, Araujo R, Aparicio A, Barrell B, Badcock K, Benes V, Botstein D, Bowman S, Br?ckner M, Carpenter J, Cherry JM, Chung E, Churcher C, Coster F, Davis K, Davis RW, Dietrich FS, Delius H, DiPaolo T, Hani J
Nature387(6632 Suppl)103-5(1997 May)

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that Saccharomyces cerevisiae proteins Rqc1, Ltn1, and Cdc48 prevent the aggregation of aberrant proteins that can only appear after C-terminal alanine-threonine tail (CAT-tail) addition by Rqc2.
Title: Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits.

Rqc2 modifies stalled nascent polypeptide chains with a carboxy-terminal, Ala- and Thr-containing extension-the 'CAT tail'.
Title: The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation.

protein aggregation is dependent on a C-terminal alanine/threonine tail that is added to stalled polypeptides by the RQC component, Rqc2p
Title: Failure of RQC machinery causes protein aggregation and proteotoxic stress.

The following RQC2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RQC2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSi04955	NM_001183823.1 Latest version!	Saccharomyces cerevisiae S288C Rqc2p (RQC2), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$629.30 $899.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RQC2 ( NM_001183823.1 ) cDNA ORF clone, Saccharomyces cerevisiae S288C -> NP_015316.1 Saccharomyces cerevisiae S288C Rqc2p (RQC2), partial mRNA.

Price & Availability↑

CloneID	OSi04955
Clone ID Related Accession (Same CDS sequence)	NM_001183823.1
Accession Version	NM_001183823.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3117bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-31
Organism	Saccharomyces cerevisiae S288C
Product	Rqc2p
Comment	Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001148). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends.

ATGAAGCAAA GAATTAGTGC CCTAGATTTA CTGCTGTTGG CTAGAGAGCT GAAACAGGAT 
TTGGAAGGCT ACCGATTGAG TAATATATAT AACATTGCCG ATTCCTCAAA ACAATTTTTG 
CTGAAATTTA ATAAACCAGA TTCTAAACTC AATGTTGTTG TCGATTGTGG CTTAAGAATT 
TACTTAACTG AATTTAGTAG GCCAATACCT CCAACTCCTT CCGGCTTTGT TGTCAAACTA 
AGGAAGCATC TTAAAGCTAA ACGGTTAACA GCTTTAAAGC AAGTAGACCA GGATAGAATT 
CTTGTTCTAC AATTTGCTGA TGGCCACTTC TATTTAGTTT TGGAATTTTT CAGTGCAGGG 
AATGTCATTC TTCTAGATGA GAACAGAAGA ATTATGGCTT TGCAAAGAGT CGTTCTAGAG 
CATGAAAATA AGGTCGGACA AATTTATGAA ATGTTTGACG AATCACTTTT TACCACAAAT 
AACGAGTCTG CTGATGAATC CATAGAAAAA AACAGAAAGG CAGAATACAC CTCTGAACTA 
GTCAACGAGT GGATAAAAGC AGTTCAAGCC AAGTATGAAT CAGACATTAC TGTTATTAAG 
CAACTTAACA TTCAAGGGAA GGAGGGCGCT AAAAAAAAAA AAGTGAAAGT ACCTTCCATC 
CATAAACTGC TGCTTTCGAA AGTCCCTCAT TTGTCTTCAG ATTTATTATC AAAGAACCTT 
AAGGTATTCA ATATCGACCC TTCAGAGTCT TGTTTAAATC TTTTGGAGGA AACAGACTCA 
CTCGCCGAAT TGCTAAACAG TACTCAGTTA GAATATAATC AACTTTTAAC TACCACCGAT 
AGAAAGGGTT ACATTTTGGC CAAAAGAAAT GAAAATTATA TCTCTGAAAA AGATACTGCC 
GATTTGGAAT TTATTTATGA TACATTCCAT CCCTTTAAGC CATATATAAA TGGGGGAGAC 
ACTGACTCTT CTTGTATCAT TGAAGTTGAA GGTCCTTACA ATAGGACGCT AGACAAATTT 
TTCTCAACAA TAGAATCCTC TAAGTATGCT CTACGTATAC AAAATCAGGA ATCGCAAGCG 
CAAAAGAAAA TCGATGATGC TCGTGCCGAA AATGATAGAA AAATACAAGC TTTATTAGAC 
GTCCAAGAAC TAAATGAAAG GAAAGGCCAT CTCATAATTG AAAATGCACC CTTAATAGAG 
GAAGTTAAGC TTGCTGTTCA GGGTCTAATC GATCAACAAA TGGACTGGAA CACTATTGAG 
AAACTAATTA AAAGTGAACA AAAAAAAGGC AACAGAATTG CTCAGCTTTT GAACTTGCCT 
TTGAACTTGA AACAGAACAA AATTAGCGTC AAGCTTGATC TCTCTAGCAA GGAACTCAAC 
ACTTCTTCAG ACGAGGACAA TGAATCAGAA GGCAATACTA CTGATAGTTC TAGTGACTCA 
GACTCAGAAG ACATGGAGAG TTCGAAGGAG AGGAGTACAA AAAGTATGAA AAGAAAATCT 
AATGAAAAGA TAAACGTTAC AATTGACCTT GGTTTATCAG CTTATGCCAA TGCCACTGAA 
TATTTCAATA TCAAAAAAAC AAGTGCTCAA AAGCAGAAAA AAGTCGAAAA GAATGTCGGC 
AAGGCTATGA AGAATATTGA AGTCAAAATT GATCAACAAT TGAAAAAAAA GCTAAAAGAT 
TCTCACAGTG TCTTAAAAAA GATCCGCACT CCTTACTTTT TTGAAAAATA TAGTTGGTTT 
ATTTCAAGTG AAGGATTTTT GGTCATGATG GGTAAAAGTC CGGCTGAGAC AGATCAAATC 
TATTCAAAAT ATATTGAAGA TGATGATATT TATATGTCCA ATAGTTTTAA CTCTCATGTA 
TGGATCAAAA ATCCAGAAAA AACAGAAGTT CCACCGAACA CTTTGATGCA AGCGGGTATA 
CTATGCATGT CCTCAAGCGA GGCTTGGTCG AAGAAGATAT CTTCTTCTCC ATGGTGGTGC 
TTTGCAAAGA ATGTTAGTAA ATTCGATGGC TCTGATAACT CCATTCTGCC AGAAGGTGCC 
TTTCGGTTGA AAAATGAGAA TGATCAAAAC CATTTACCCC CTGCTCAACT TGTGATGGGT 
TTTGGATTTT TATGGAAAGT GAAAACCAGT GGAAATGAGG ATAATGGTGA TGATGACGAA 
GAAGAAGAAG AAGAAGAAGA GGAAGAAGAA GAAGAAGAAG AAGAAGAAGA AGAAGAAGAA 
GAAGAAGAAA AAGAAGAAGA AGAAAAAGAA GAAGAGCAAC AGCAAGATGA AGACGATAGT 
AACGAGGTCA ATGGGTTAGA GAAGGGTGGA GATTCAAACG ATAGCACGAA AAACAACAGT 
TTTGAACACG ATAATCTTGA AAAAGACATC GAAAAGCATT GCACCATATC ATCCGATACC 
GACTCTGATT CTGGAAATGC TAAAGCCAAA AATGACAATA GCAGTACGCA GCGTATCCTT 
GATGAACCAG GTGTTCCGAT ATCTTTAATC GAAAACATAA ACAGTAACGT CCGTGGTAAA 
AGAGGAAAAT TGAAGAAAAT TCAAAAGAAA TACGCCGACC AGGATGAAAC TGAACGTCTC 
TTGCGTTTGG AGGCCTTGGG TACTTTGAAG GGTATCGAAA AGCAGCAACA AAGGAAGAAA 
GAAGAAATAA TGAAGCGAGA AGTTAGAGAA GATAGAAAGA ATAAACGCGA GAAACAAAGA 
AGACTACAGG CTTTAAAATT CACCAAAAAA GAGAAAGCAA GAGTGAACTA TGATAAACAC 
AAGTCCGAAT TAAAACCATC TCTCGATAAG GGCGATGTGG TTGATGATAT TATACCAGTA 
TTTGCCCCCT GGCCTGCGCT TTTGAAATAT AAATACAAAG TCAAAATACA ACCGGGAAGT 
GCGAAGAAAA CTAAGACTTT AACTGAAATT TTACATTATT TCAAGAGTAG ACCACTAGAC 
GGTTCTTCAA CTGACAACGA AATGGATTGG CCCCAAGAAC ATGAAATGAT TAAAGGCTTG 
AAGGAACAGG ACTTGGTTCT TCTGCTCTGT GTCGACAAGT TAAAAGTAAC AATCGCTGGG 
CAGAAATCCA CCAAGAACGG TGGTAACTCT TCGAAGAAGG GCAAAAAAAA ACGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_015316.1
CDS	1..3117
Translation	MKQRISALDLLLLARELKQDLEGYRLSNIYNIADSSKQFLLKFNKPDSKLNVVVDCGLRIYLTEFSRPIPPTPSGFVVKLRKHLKAKRLTALKQVDQDRILVLQFADGHFYLVLEFFSAGNVILLDENRRIMALQRVVLEHENKVGQIYEMFDESLFTTNNESADESIEKNRKAEYTSELVNEWIKAVQAKYESDITVIKQLNIQGKEGAKKKKVKVPSIHKLLLSKVPHLSSDLLSKNLKVFNIDPSESCLNLLEETDSLAELLNSTQLEYNQLLTTTDRKGYILAKRNENYISEKDTADLEFIYDTFHPFKPYINGGDTDSSCIIEVEGPYNRTLDKFFSTIESSKYALRIQNQESQAQKKIDDARAENDRKIQALLDVQELNERKGHLIIENAPLIEEVKLAVQGLIDQQMDWNTIEKLIKSEQKKGNRIAQLLNLPLNLKQNKISVKLDLSSKELNTSSDEDNESEGNTTDSSSDSDSEDMESSKERSTKSMKRKSNEKINVTIDLGLSAYANATEYFNIKKTSAQKQKKVEKNVGKAMKNIEVKIDQQLKKKLKDSHSVLKKIRTPYFFEKYSWFISSEGFLVMMGKSPAETDQIYSKYIEDDDIYMSNSFNSHVWIKNPEKTEVPPNTLMQAGILCMSSSEAWSKKISSSPWWCFAKNVSKFDGSDNSILPEGAFRLKNENDQNHLPPAQLVMGFGFLWKVKTSGNEDNGDDDEEEEEEEEEEEEEEEEEEEEEEEEKEEEEKEEEQQQDEDDSNEVNGLEKGGDSNDSTKNNSFEHDNLEKDIEKHCTISSDTDSDSGNAKAKNDNSSTQRILDEPGVPISLIENINSNVRGKRGKLKKIQKKYADQDETERLLRLEALGTLKGIEKQQQRKKEEIMKREVREDRKNKREKQRRLQALKFTKKEKARVNYDKHKSELKPSLDKGDVVDDIIPVFAPWPALLKYKYKVKIQPGSAKKTKTLTEILHYFKSRPLDGSSTDNEMDWPQEHEMIKGLKEQDLVLLLCVDKLKVTIAGQKSTKNGGNSSKKGKKKR

Target ORF information:

RefSeq Version	NM_001183823.1
Organism	Saccharomyces cerevisiae S288C
Definition	Saccharomyces cerevisiae S288C Rqc2p (RQC2), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001183823.1

ORF Insert Sequence:

ATGAAGCAAA GAATTAGTGC CCTAGATTTA CTGCTGTTGG CTAGAGAGCT GAAACAGGAT 
TTGGAAGGCT ACCGATTGAG TAATATATAT AACATTGCCG ATTCCTCAAA ACAATTTTTG 
CTGAAATTTA ATAAACCAGA TTCTAAACTC AATGTTGTTG TCGATTGTGG CTTAAGAATT 
TACTTAACTG AATTTAGTAG GCCAATACCT CCAACTCCTT CCGGCTTTGT TGTCAAACTA 
AGGAAGCATC TTAAAGCTAA ACGGTTAACA GCTTTAAAGC AAGTAGACCA GGATAGAATT 
CTTGTTCTAC AATTTGCTGA TGGCCACTTC TATTTAGTTT TGGAATTTTT CAGTGCAGGG 
AATGTCATTC TTCTAGATGA GAACAGAAGA ATTATGGCTT TGCAAAGAGT CGTTCTAGAG 
CATGAAAATA AGGTCGGACA AATTTATGAA ATGTTTGACG AATCACTTTT TACCACAAAT 
AACGAGTCTG CTGATGAATC CATAGAAAAA AACAGAAAGG CAGAATACAC CTCTGAACTA 
GTCAACGAGT GGATAAAAGC AGTTCAAGCC AAGTATGAAT CAGACATTAC TGTTATTAAG 
CAACTTAACA TTCAAGGGAA GGAGGGCGCT AAAAAAAAAA AAGTGAAAGT ACCTTCCATC 
CATAAACTGC TGCTTTCGAA AGTCCCTCAT TTGTCTTCAG ATTTATTATC AAAGAACCTT 
AAGGTATTCA ATATCGACCC TTCAGAGTCT TGTTTAAATC TTTTGGAGGA AACAGACTCA 
CTCGCCGAAT TGCTAAACAG TACTCAGTTA GAATATAATC AACTTTTAAC TACCACCGAT 
AGAAAGGGTT ACATTTTGGC CAAAAGAAAT GAAAATTATA TCTCTGAAAA AGATACTGCC 
GATTTGGAAT TTATTTATGA TACATTCCAT CCCTTTAAGC CATATATAAA TGGGGGAGAC 
ACTGACTCTT CTTGTATCAT TGAAGTTGAA GGTCCTTACA ATAGGACGCT AGACAAATTT 
TTCTCAACAA TAGAATCCTC TAAGTATGCT CTACGTATAC AAAATCAGGA ATCGCAAGCG 
CAAAAGAAAA TCGATGATGC TCGTGCCGAA AATGATAGAA AAATACAAGC TTTATTAGAC 
GTCCAAGAAC TAAATGAAAG GAAAGGCCAT CTCATAATTG AAAATGCACC CTTAATAGAG 
GAAGTTAAGC TTGCTGTTCA GGGTCTAATC GATCAACAAA TGGACTGGAA CACTATTGAG 
AAACTAATTA AAAGTGAACA AAAAAAAGGC AACAGAATTG CTCAGCTTTT GAACTTGCCT 
TTGAACTTGA AACAGAACAA AATTAGCGTC AAGCTTGATC TCTCTAGCAA GGAACTCAAC 
ACTTCTTCAG ACGAGGACAA TGAATCAGAA GGCAATACTA CTGATAGTTC TAGTGACTCA 
GACTCAGAAG ACATGGAGAG TTCGAAGGAG AGGAGTACAA AAAGTATGAA AAGAAAATCT 
AATGAAAAGA TAAACGTTAC AATTGACCTT GGTTTATCAG CTTATGCCAA TGCCACTGAA 
TATTTCAATA TCAAAAAAAC AAGTGCTCAA AAGCAGAAAA AAGTCGAAAA GAATGTCGGC 
AAGGCTATGA AGAATATTGA AGTCAAAATT GATCAACAAT TGAAAAAAAA GCTAAAAGAT 
TCTCACAGTG TCTTAAAAAA GATCCGCACT CCTTACTTTT TTGAAAAATA TAGTTGGTTT 
ATTTCAAGTG AAGGATTTTT GGTCATGATG GGTAAAAGTC CGGCTGAGAC AGATCAAATC 
TATTCAAAAT ATATTGAAGA TGATGATATT TATATGTCCA ATAGTTTTAA CTCTCATGTA 
TGGATCAAAA ATCCAGAAAA AACAGAAGTT CCACCGAACA CTTTGATGCA AGCGGGTATA 
CTATGCATGT CCTCAAGCGA GGCTTGGTCG AAGAAGATAT CTTCTTCTCC ATGGTGGTGC 
TTTGCAAAGA ATGTTAGTAA ATTCGATGGC TCTGATAACT CCATTCTGCC AGAAGGTGCC 
TTTCGGTTGA AAAATGAGAA TGATCAAAAC CATTTACCCC CTGCTCAACT TGTGATGGGT 
TTTGGATTTT TATGGAAAGT GAAAACCAGT GGAAATGAGG ATAATGGTGA TGATGACGAA 
GAAGAAGAAG AAGAAGAAGA GGAAGAAGAA GAAGAAGAAG AAGAAGAAGA AGAAGAAGAA 
GAAGAAGAAA AAGAAGAAGA AGAAAAAGAA GAAGAGCAAC AGCAAGATGA AGACGATAGT 
AACGAGGTCA ATGGGTTAGA GAAGGGTGGA GATTCAAACG ATAGCACGAA AAACAACAGT 
TTTGAACACG ATAATCTTGA AAAAGACATC GAAAAGCATT GCACCATATC ATCCGATACC 
GACTCTGATT CTGGAAATGC TAAAGCCAAA AATGACAATA GCAGTACGCA GCGTATCCTT 
GATGAACCAG GTGTTCCGAT ATCTTTAATC GAAAACATAA ACAGTAACGT CCGTGGTAAA 
AGAGGAAAAT TGAAGAAAAT TCAAAAGAAA TACGCCGACC AGGATGAAAC TGAACGTCTC 
TTGCGTTTGG AGGCCTTGGG TACTTTGAAG GGTATCGAAA AGCAGCAACA AAGGAAGAAA 
GAAGAAATAA TGAAGCGAGA AGTTAGAGAA GATAGAAAGA ATAAACGCGA GAAACAAAGA 
AGACTACAGG CTTTAAAATT CACCAAAAAA GAGAAAGCAA GAGTGAACTA TGATAAACAC 
AAGTCCGAAT TAAAACCATC TCTCGATAAG GGCGATGTGG TTGATGATAT TATACCAGTA 
TTTGCCCCCT GGCCTGCGCT TTTGAAATAT AAATACAAAG TCAAAATACA ACCGGGAAGT 
GCGAAGAAAA CTAAGACTTT AACTGAAATT TTACATTATT TCAAGAGTAG ACCACTAGAC 
GGTTCTTCAA CTGACAACGA AATGGATTGG CCCCAAGAAC ATGAAATGAT TAAAGGCTTG 
AAGGAACAGG ACTTGGTTCT TCTGCTCTGT GTCGACAAGT TAAAAGTAAC AATCGCTGGG 
CAGAAATCCA CCAAGAACGG TGGTAACTCT TCGAAGAAGG GCAAAAAAAA ACGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
Nature387(6632 Suppl)103-5(1997 May)
Bussey H,Storms RK,Ahmed A,Albermann K,Allen E,Ansorge W,Araujo R,Aparicio A,Barrell B,Badcock K,Benes V,Botstein D,Bowman S,Br?ckner M,Carpenter J,Cherry JM,Chung E,Churcher C,Coster F,Davis K,Davis RW,Dietrich FS,Delius H,DiPaolo T,Hani J

Life with 6000 genes.
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Goffeau A,Barrell BG,Bussey H,Davis RW,Dujon B,Feldmann H,Galibert F,Hoheisel JD,Jacq C,Johnston M,Louis EJ,Mewes HW,Murakami Y,Philippsen P,Tettelin H,Oliver SG

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RQC2 cDNA ORF clone, Saccharomyces cerevisiae S288C

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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