Gene Symbol | HBS1 |
Entrez Gene ID | 853959 |
Full Name | ribosome dissociation factor GTPase HBS1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » HBS1 cDNA ORF clone
Gene Symbol | HBS1 |
Entrez Gene ID | 853959 |
Full Name | ribosome dissociation factor GTPase HBS1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001179874.3 | NP_013010.3 | ribosome dissociation factor GTPase HBS1 |
Homo sapiens (human) | HBS1L | NP_006611.1 |
Drosophila melanogaster (fruit fly) | HBS1 | NP_652729.2 |
Caenorhabditis elegans (roundworm) | K07A12.4 | NP_001021556.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002603 | XP_312333.3 |
Magnaporthe oryzae (rice blast fungus) | MGG_02504 | XP_003709309.1 |
Rattus norvegicus (Norway rat) | Hbs1l | NP_001011934.1 |
Danio rerio (zebrafish) | hbs1l | NP_955970.1 |
Kluyveromyces lactis | KLLA0A07799g | XP_451347.2 |
Neurospora crassa | NCU03981 | XP_956566.2 |
Pan troglodytes (chimpanzee) | HBS1L | XP_001170393.1 |
Canis lupus familiaris (dog) | HBS1L | XP_533416.2 |
Mus musculus (house mouse) | Hbs1l | NP_062676.2 |
Saccharomyces cerevisiae (baker's yeast) | HBS1 | NP_013010.3 |
Xenopus tropicalis (tropical clawed frog) | hbs1l | NP_001123821.1 |
HBS1L | XP_002803933.1 | |
Bos taurus (cattle) | HBS1L | NP_001039963.1 |
Gallus gallus (chicken) | HBS1L | XP_004935787.1 |
Eremothecium gossypii | AGOS_ADR221C | NP_984317.2 |
Schizosaccharomyces pombe (fission yeast) | SPBC25B2.01 | XP_001713137.1 |
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Complete DNA sequence of yeast chromosome XI.
Dujon B, Alexandraki D, Andr? B, Ansorge W, Baladron V, Ballesta JP, Banrevi A, Bolle PA, Bolotin-Fukuhara M, Bossier P, Bou G, Boyer J, Bultrago MJ, Cheret G, Colleaux L, Dalgnan-Fornler B, del Rey F, Dlon C, Domdey H, D?sterhoft A, D?sterhus S, Entlan KD, Erfle H, Esteban PF, Feldmann H, Fernandes L, Robo GM, Fritz C, Fukuhara H, Gabel C, Gaillon L, Carcia-Cantalejo JM, Garcia-Ramirez JJ, Gent NE, Ghazvini M, Goffeau A, Gonzal?z A, Grothues D, Guerreiro P, Hegemann J, Hewitt N, Hilger F, Hollenberg CP, Horaitis O, Indge KJ, Jacquier A, James CM, Jauniaux C, Jimenez A, Keuchel H, Kirchrath L, Kleine K, K?tter P, Legrain P, Liebl S, Louis EJ, Maia e Silva A, Marck C, Monnier AL, M?stl D, M?ller S, Obermaier B, Oliver SG, Pallier C, Pascolo S, Pfeiffer F, Philippsen P, Planta RJ, Pohl FM, Pohl TM, P?hlmann R, Portetelle D, Purnelle B, Puzos V, Ramezani Rad M, Rasmussen SW, Remacha M, Revuelta JL, Richard GF, Rieger M, Rodrigues-Pousada C, Rose M, Rupp T, Santos MA, Schwager C, Sensen C, Skala J, Soares H, Sor F, Stegemann J, Tettelin H, Thierry A, Tzermia M, Urrestarazu LA, van Dyck L, Van Vliet-Reedijk JC, Valens M, Vandenbo M, Vilela C, Vissers S, von Wettstein D, Voss H, Wiemann S, Xu G, Zimmermann J, Haasemann M, Becker I, Mewes HW
Nature369(6479)371-8(1994 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Roles of dom34:hbs1 in nonstop protein clearance from translocators for normal organelle protein influx.
Title: Roles of dom34:hbs1 in nonstop protein clearance from translocators for normal organelle protein influx.
Dom34:Hbs1 facilitates the decay of nonstop mRNAs from the 3' end by exosomes and is required for the complete degradation of nonstop mRNA decay intermediates.
Title: Dom34:hbs1 plays a general role in quality-control systems by dissociation of a stalled ribosome at the 3' end of aberrant mRNA.
The close structural similarity of Dom34 and Hbs1 to eukaryotic release factors (eRFs) enabled the authors to propose a model for the ribosome-bound eRF1-eRF3 complex.
Title: Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosome.
findings show that Dom34:Hbs1 (two interacting factors genetically implicated in no-go decay) interacts with the ribosome to promote subunit dissociation and peptidyl-tRNA drop-off
Title: Dom34:Hbs1 promotes subunit dissociation and peptidyl-tRNA drop-off to initiate no-go decay.
Dom34 has a role in an mRNA decay pathway called No-Go decay and the interaction of Dom34 with Hbs1 results in an increase in the affinity constant of Hbs1 for GTP but not GDP
Title: Structure of yeast Dom34: a protein related to translation termination factor Erf1 and involved in No-Go decay.
The following HBS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HBS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi03136 | |
Clone ID Related Accession (Same CDS sequence) | NM_001179874.3 | |
Accession Version | NM_001179874.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1836bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | ribosome dissociation factor GTPase HBS1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001143). On Jul 30, 2012 this sequence version replaced NM_001179874.2. ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGGCTTACA GTGACTACAG CGATGGAGCA GACGACATGC CGGACTTTCA CGACGAAGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_013010.3 |
CDS | 1..1836 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGGCTTACA GTGACTACAG CGATGGAGCA GACGACATGC CGGACTTTCA CGACGAAGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Life with 6000 genes. |
Complete DNA sequence of yeast chromosome XI. |