Gene Symbol | JHD2 |
Entrez Gene ID | 853583 |
Full Name | histone demethylase |
Synonyms | KDM5 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » JHD2 cDNA ORF clone
Gene Symbol | JHD2 |
Entrez Gene ID | 853583 |
Full Name | histone demethylase |
Synonyms | KDM5 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001181777.1 | NP_012653.1 | histone demethylase |
Kluyveromyces lactis | KLLA0D10758g | XP_453541.1 |
Saccharomyces cerevisiae (baker's yeast) | JHD2 | NP_012653.1 |
Eremothecium gossypii | AGOS_ABR167C | NP_983115.1 |
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.
Galibert F, Alexandraki D, Baur A, Boles E, Chalwatzis N, Chuat JC, Coster F, Cziepluch C, De Haan M, Domdey H, Durand P, Entian KD, Gatius M, Goffeau A, Grivell LA, Hennemann A, Herbert CJ, Heumann K, Hilger F, Hollenberg CP, Huang ME, Jacq C, Jauniaux JC, Katsoulou C, Karpfinger-Hartl L
The EMBO journal15(9)2031-49(1996 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
H2B Lys-123 ubiquitination blocks Jhd2 from accessing its binding site on chromatin, and thereby, we have uncovered a second mechanism by which H2B ubiquitination contributes to the trans-histone regulation of H3K4 methylation.
Title: Interaction of the Jhd2 Histone H3 Lys-4 Demethylase with Chromatin Is Controlled by Histone H2A Surfaces and Restricted by H2B Ubiquitination.
Jhd2, an evolutionarily conserved JARID1 family H3 Lys4 demethylase, effects all states of methylated histone H3K4 within the NTS regions of rDNA, and its activity is required for the regulation of rDNA silencing in a Sir2-independent manner.
Title: Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic rDNA condensation.
the JmjN domain of Jhd2 is important for its protein stability, and the plant homeodomain (PHD) finger mediates its chromatin association independent of H3K4 methylation
Title: The JmjN domain of Jhd2 is important for its protein stability, and the plant homeodomain (PHD) finger mediates its chromatin association independent of H3K4 methylation.
the protein level of the yeast histone H3 Lys 4 (H3 K4) demethylase Jhd2/Kdm5 is modulated through polyubiquitination by the E3 ubiquitin ligase Not4 and turnover by the proteasome
Title: Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression.
Ectopic overexpression of mouse Jarid1B, a Yjr119Cp homolog, greatly diminished H3-(lysine) K4me3 and H3-K4me2 in HeLa cells, suggesting these proteins function as K4 demethylases in vivo.
Title: Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins.
The following JHD2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the JHD2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi02812 | |
Clone ID Related Accession (Same CDS sequence) | NM_001181777.1 | |
Accession Version | NM_001181777.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2187bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | histone demethylase | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001142). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGGAGGAAA TTCCTGCCCT GTATCCAACG GAACAAGAAT TCAAAAATCC GATCGATTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_012653.1 |
CDS | 1..2187 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001181777.1 |
1 | ATGGAGGAAA TTCCTGCCCT GTATCCAACG GAACAAGAAT TCAAAAATCC GATCGATTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Life with 6000 genes. |
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. |