FES1 cDNA ORF clone, Saccharomyces cerevisiae S288C

Gene
Clones
gRNAs

Summary

Gene Symbol	FES1
Entrez Gene ID	852397
Full Name	Fes1p
Gene Type	protein-coding
Organism	Saccharomyces cerevisiae S288C

mRNA and Protein(s)

mRNA	Protein	Name
NM_001178449.3	NP_009659.3	Fes1p

Pathways from BioSystems

Homologies

Saccharomyces cerevisiae (baker's yeast)	FES1	NP_009659.3
Neurospora crassa	NCU04172	XP_960730.1
Kluyveromyces lactis	KLLA0E11375g	XP_454462.1
Magnaporthe oryzae (rice blast fungus)	MGG_03983	XP_003719870.1
Eremothecium gossypii	AGOS_ADL319W	NP_983777.1

Gene Ontology
Bibliography

Related articles in PubMed

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

Complete DNA sequence of yeast chromosome II.
Feldmann H, Aigle M, Aljinovic G, Andr? B, Baclet MC, Barthe C, Baur A, B?cam AM, Biteau N, Boles E, Brandt T, Brendel M, Br?ckner M, Bussereau F, Christiansen C, Contreras R, Crouzet M, Cziepluch C, D?molis N, Delaveau T, Doignon F, Domdey H, D?sterhus S, Dubois E, Dujon B, El Bakkoury M, Entian KD, Feurmann M, Fiers W, Fobo GM, Fritz C, Gassenhuber H, Glandsdorff N, Goffeau A, Grivell LA, de Haan M, Hein C, Herbert CJ, Hollenberg CP, Holmstr?m K, Jacq C, Jacquet M, Jauniaux JC, Jonniaux JL, Kalles?e T, Kiesau P, Kirchrath L, K?tter P, Korol S, Liebl S, Logghe M, Lohan AJ, Louis EJ, Li ZY, Maat MJ, Mallet L, Mannhaupt G, Messenguy F, Miosga T, Molemans F, M?ller S, Nasr F, Obermaier B, Perea J, Pi?rard A, Piravandi E, Pohl FM, Pohl TM, Potier S, Proft M, Purnelle B, Ramezani Rad M, Rieger M, Rose M, Schaaff-Gerstenschl?ger I, Scherens B, Schwarzlose C, Skala J, Slonimski PP, Smits PH, Souciet JL, Steensma HY, Stucka R, Urrestarazu A, van der Aart QJ, van Dyck L, Vassarotti A, Vetter I, Vierendeels F, Vissers S, Wagner G, de Wergifosse P, Wolfe KH, Zagulski M, Zimmermann FK, Mewes HW, Kleine K
The EMBO journal13(24)5795-809(1994 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cytosolic splice isoform of Fes1 is required for the degradation of misfolded proteins in yeast.The FES1 transcript undergoes unique 3' alternative splicing that results in two equally active isoforms with alternative C-termini.
Title: Cytosolic splice isoform of Hsp70 nucleotide exchange factor Fes1 is required for the degradation of misfolded proteins in yeast.

cytosolic Hsp70 interacts with up to three types of nucleotide exchange factors (NEFs) homologous to human counterparts: Sse1/Sse2 (Heat shock protein 110 (Hsp110)), Fes1 (HspBP1), and Snl1 (Bag-1).
Title: Hierarchical functional specificity of cytosolic heat shock protein 70 (Hsp70) nucleotide exchange factors in yeast.

Fes1, an Hsp70 nucleotide exchange factor of hitherto unclear physiological function, is a cytosolic triaging factor that promotes proteasomal degradation of misfolded proteins
Title: Hsp70 nucleotide exchange factor Fes1 is essential for ubiquitin-dependent degradation of misfolded cytosolic proteins.

crystal structure and mechanism for Hsp70 nucleotide exchange
Title: Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange.

The following FES1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FES1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSi01808	NM_001178449.3 Latest version!	Saccharomyces cerevisiae S288C Fes1p (FES1), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FES1 ( NM_001178449.3 ) cDNA ORF clone, Saccharomyces cerevisiae S288C -> NP_009659.3 Saccharomyces cerevisiae S288C Fes1p (FES1), partial mRNA.

Price & Availability↑

CloneID	OSi01808
Clone ID Related Accession (Same CDS sequence)	NM_001178449.3
Accession Version	NM_001178449.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-31
Organism	Saccharomyces cerevisiae S288C
Product	Fes1p
Comment	Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001134). On Jul 30, 2012 this sequence version replaced NM_001178449.2. ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends.

ATGGAAAAGC TATTACAGTG GTCTATTGCG AATTCTCAAG GGGACAAAGA AGCTATGGCT 
AGGGCCGGCC AACCTGATCC TAAATTGCTA CAGCAGTTAT TCGGTGGTGG TGGTCCTGAC 
GATCCAACCT TAATGAAAGA ATCCATGGCT GTTATTATGA ATCCGGAGGT TGACTTAGAA 
ACAAAACTCG TTGCATTTGA CAACTTTGAA ATGTTGATTG AGAACTTAGA TAATGCTAAT 
AATATCGAAA ATTTAAAACT GTGGGAGCCA TTGTTGGATG TTCTTGTTCA GACGAAGGAT 
GAAGAACTAC GTGCTGCTGC TTTATCCATT ATTGGAACGG CTGTGCAAAA CAACTTGGAT 
TCGCAAAATA ATTTCATGAA ATACGACAAT GGTCTGCGAA GCCTTATCGA AATAGCTAGT 
GACAAGACAA AGCCACTCGA CGTGAGAACA AAAGCTTTTT ACGCACTATC TAATCTAATA 
AGAAACCACA AAGATATCTC AGAAAAGTTT TTCAAATTAA ATGGGCTCGA CTGCATAGCA 
CCTGTATTAA GTGATAACAC CGCCAAACCA AAACTGAAAA TGAGAGCCAT TGCCTTATTG 
ACCGCATATT TGTCATCTGT TAAGATTGAT GAAAATATAA TCAGTGTGCT GAGAAAGGAT 
GGAGTAATTG AAAGTACGAT TGAGTGCTTG TCTGACGAGA GTAACTTGAA CATCATAGAT 
AGAGTTCTGT CTTTTCTCTC TCACCTGATA TCTTCCGGAA TAAAATTTAA TGAACAGGAA 
TTGCACAAAT TGAACGAAGG TTACAAACAT ATCGAGCCTC TAAAGGACAG ACTTAATGAA 
GACGATTATT TAGCCGTAAA GTATGTATTA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009659.3
CDS	1..873
Translation	MEKLLQWSIANSQGDKEAMARAGQPDPKLLQQLFGGGGPDDPTLMKESMAVIMNPEVDLETKLVAFDNFEMLIENLDNANNIENLKLWEPLLDVLVQTKDEELRAAALSIIGTAVQNNLDSQNNFMKYDNGLRSLIEIASDKTKPLDVRTKAFYALSNLIRNHKDISEKFFKLNGLDCIAPVLSDNTAKPKLKMRAIALLTAYLSSVKIDENIISVLRKDGVIESTIECLSDESNLNIIDRVLSFLSHLISSGIKFNEQELHKLNEGYKHIEPLKDRLNEDDYLAVKYVL

Target ORF information:

RefSeq Version	NM_001178449.3
Organism	Saccharomyces cerevisiae S288C
Definition	Saccharomyces cerevisiae S288C Fes1p (FES1), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001178449.3

ORF Insert Sequence:

ATGGAAAAGC TATTACAGTG GTCTATTGCG AATTCTCAAG GGGACAAAGA AGCTATGGCT 
AGGGCCGGCC AACCTGATCC TAAATTGCTA CAGCAGTTAT TCGGTGGTGG TGGTCCTGAC 
GATCCAACCT TAATGAAAGA ATCCATGGCT GTTATTATGA ATCCGGAGGT TGACTTAGAA 
ACAAAACTCG TTGCATTTGA CAACTTTGAA ATGTTGATTG AGAACTTAGA TAATGCTAAT 
AATATCGAAA ATTTAAAACT GTGGGAGCCA TTGTTGGATG TTCTTGTTCA GACGAAGGAT 
GAAGAACTAC GTGCTGCTGC TTTATCCATT ATTGGAACGG CTGTGCAAAA CAACTTGGAT 
TCGCAAAATA ATTTCATGAA ATACGACAAT GGTCTGCGAA GCCTTATCGA AATAGCTAGT 
GACAAGACAA AGCCACTCGA CGTGAGAACA AAAGCTTTTT ACGCACTATC TAATCTAATA 
AGAAACCACA AAGATATCTC AGAAAAGTTT TTCAAATTAA ATGGGCTCGA CTGCATAGCA 
CCTGTATTAA GTGATAACAC CGCCAAACCA AAACTGAAAA TGAGAGCCAT TGCCTTATTG 
ACCGCATATT TGTCATCTGT TAAGATTGAT GAAAATATAA TCAGTGTGCT GAGAAAGGAT 
GGAGTAATTG AAAGTACGAT TGAGTGCTTG TCTGACGAGA GTAACTTGAA CATCATAGAT 
AGAGTTCTGT CTTTTCTCTC TCACCTGATA TCTTCCGGAA TAAAATTTAA TGAACAGGAA 
TTGCACAAAT TGAACGAAGG TTACAAACAT ATCGAGCCTC TAAAGGACAG ACTTAATGAA 
GACGATTATT TAGCCGTAAA GTATGTATTA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Life with 6000 genes.
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Goffeau A,Barrell BG,Bussey H,Davis RW,Dujon B,Feldmann H,Galibert F,Hoheisel JD,Jacq C,Johnston M,Louis EJ,Mewes HW,Murakami Y,Philippsen P,Tettelin H,Oliver SG

Complete DNA sequence of yeast chromosome II.
The EMBO journal13(24)5795-809(1994 Dec)
Feldmann H,Aigle M,Aljinovic G,Andr? B,Baclet MC,Barthe C,Baur A,B?cam AM,Biteau N,Boles E,Brandt T,Brendel M,Br?ckner M,Bussereau F,Christiansen C,Contreras R,Crouzet M,Cziepluch C,D?molis N,Delaveau T,Doignon F,Domdey H,D?sterhus S,Dubois E,Dujon B,El Bakkoury M,Entian KD,Feurmann M,Fiers W,Fobo GM,Fritz C,Gassenhuber H,Glandsdorff N,Goffeau A,Grivell LA,de Haan M,Hein C,Herbert CJ,Hollenberg CP,Holmstr?m K,Jacq C,Jacquet M,Jauniaux JC,Jonniaux JL,Kalles?e T,Kiesau P,Kirchrath L,K?tter P,Korol S,Liebl S,Logghe M,Lohan AJ,Louis EJ,Li ZY,Maat MJ,Mallet L,Mannhaupt G,Messenguy F,Miosga T,Molemans F,M?ller S,Nasr F,Obermaier B,Perea J,Pi?rard A,Piravandi E,Pohl FM,Pohl TM,Potier S,Proft M,Purnelle B,Ramezani Rad M,Rieger M,Rose M,Schaaff-Gerstenschl?ger I,Scherens B,Schwarzlose C,Skala J,Slonimski PP,Smits PH,Souciet JL,Steensma HY,Stucka R,Urrestarazu A,van der Aart QJ,van Dyck L,Vassarotti A,Vetter I,Vierendeels F,Vissers S,Wagner G,de Wergifosse P,Wolfe KH,Zagulski M,Zimmermann FK,Mewes HW,Kleine K

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FES1 cDNA ORF clone, Saccharomyces cerevisiae S288C

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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