Gene Symbol | CDC34 |
Entrez Gene ID | 851624 |
Full Name | SCF E2 ubiquitin-protein ligase catalytic subunit CDC34 |
Synonyms | DNA6,UBC3 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » CDC34 cDNA ORF clone
Gene Symbol | CDC34 |
Entrez Gene ID | 851624 |
Full Name | SCF E2 ubiquitin-protein ligase catalytic subunit CDC34 |
Synonyms | DNA6,UBC3 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001180362.1 | NP_010339.1 | SCF E2 ubiquitin-protein ligase catalytic subunit CDC34 |
Bos taurus (cattle) | UBE2R2 | NP_001193039.1 |
Neurospora crassa | NCU01188 | XP_961554.1 |
Xenopus tropicalis (tropical clawed frog) | ube2r2 | NP_001072702.1 |
Canis lupus familiaris (dog) | UBE2R2 | XP_854606.3 |
Caenorhabditis elegans (roundworm) | ubc-3 | NP_490882.3 |
Saccharomyces cerevisiae (baker's yeast) | CDC34 | NP_010339.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_14266 | XP_003711064.1 |
Mus musculus (house mouse) | Ube2r2 | NP_080551.1 |
Gallus gallus (chicken) | LOC427134 | XP_424727.3 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP008680 | XP_314780.3 |
Pan troglodytes (chimpanzee) | UBE2R2 | XP_001155644.3 |
Danio rerio (zebrafish) | ube2r2 | NP_001002600.1 |
Kluyveromyces lactis | KLLA0D09196g | XP_453472.1 |
Eremothecium gossypii | AGOS_AGL203C | NP_986464.1 |
Homo sapiens (human) | UBE2R2 | NP_060281.2 |
LOC701507 | XP_001089803.2 | |
Rattus norvegicus (Norway rat) | LOC689226 | NP_001121045.1 |
Drosophila melanogaster (fruit fly) | CG7656 | NP_001261885.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Jacq C, Alt-M?rbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Bl?cker H, Blugeon C, Boskovic J, Brandt P, Br?ckner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P
Nature387(6632 Suppl)75-8(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Cdc34 showed a strong preference for Ub lysine 48 (K48), with lower activity towards lysine 11 (K11) and lysine 63 (K63).
Title: Molecular and structural insight into lysine selection on substrate and ubiquitin lysine 48 by the ubiquitin-conjugating enzyme Cdc34.
Cdc34 is particularly sensitive to oxidative inactivation, through sequestration of the catalytic cysteine in a disulfide complex with Uba1, by levels of oxidant that do not reduce global ubiquitinylation of proteins.
Title: Oxidative stress responses involve oxidation of a conserved ubiquitin pathway enzyme.
chromosome segregation in cdc6 mutant is caused by the deregulation of spindle dynamics induced via a regulatory network involving the ubiquitin-conjugating enzyme Cdc34, microtubule-associated proteins and the anaphase-promoting complex activator Cdh1.
Title: "Reductional anaphase" in replication-defective cells is caused by ubiquitin-conjugating enzyme Cdc34-mediated deregulation of the spindle.
Through analysis of the phenotype of a mutant missing a highly conserved sequence motif within the catalytic domain of Cdc34, we discovered previously unrecognized levels of regulation
Title: New insight into the role of the Cdc34 ubiquitin-conjugating enzyme in cell cycle regulation via Ace2 and Sic1.
Cdc34 phosphorylation by PKA and Sch9 provides a direct tether between G1 cell division events and cell growth
Title: Nutrient sensing kinases PKA and Sch9 phosphorylate the catalytic domain of the ubiquitin-conjugating enzyme Cdc34.
The following CDC34 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDC34 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi01143 | |
Clone ID Related Accession (Same CDS sequence) | NM_001180362.1 | |
Accession Version | NM_001180362.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | SCF E2 ubiquitin-protein ligase catalytic subunit CDC34 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001136). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGAGTAGTC GCAAAAGCAC CGCTTCTAGC TTACTGTTAC GGCAATATAG AGAACTTACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_010339.1 |
CDS | 1..888 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGAGTAGTC GCAAAAGCAC CGCTTCTAGC TTACTGTTAC GGCAATATAG AGAACTTACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. |
Life with 6000 genes. |