Gene Symbol | trx1 |
Entrez Gene ID | 2542084 |
Full Name | cytosolic thioredoxin Trx1 |
Gene Type | protein-coding |
Organism | Schizosaccharomyces pombe(fission yeast) |
ORF » Species Summary » Schizosaccharomyces pombe » trx1 cDNA ORF clone
Gene Symbol | trx1 |
Entrez Gene ID | 2542084 |
Full Name | cytosolic thioredoxin Trx1 |
Gene Type | protein-coding |
Organism | Schizosaccharomyces pombe(fission yeast) |
mRNA | Protein | Name |
---|---|---|
NM_001019281.2 | NP_593852.1 | cytosolic thioredoxin Trx1 |
Canis lupus familiaris (dog) | LOC474798 | XP_532029.2 |
Gallus gallus (chicken) | TXN | NP_990784.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100170420 | NP_001123670.1 |
Drosophila melanogaster (fruit fly) | Trx-2 | NP_523526.1 |
Saccharomyces cerevisiae (baker's yeast) | TRX3 | NP_010006.1 |
Oryza sativa (rice) | Os07g0190800 | NP_001059090.1 |
Bos taurus (cattle) | TXN | NP_776393.1 |
Kluyveromyces lactis | KLLA0F10351g | XP_455551.1 |
Neurospora crassa | NCU06556 | XP_962263.2 |
Homo sapiens (human) | TXN | NP_003320.2 |
Pan troglodytes (chimpanzee) | TXN | XP_003339222.1 |
TXN | XP_001083928.1 | |
Danio rerio (zebrafish) | zgc:56493 | NP_956317.1 |
Anopheles gambiae (African malaria mosquito) | TRX1 | XP_318603.3 |
Schizosaccharomyces pombe (fission yeast) | trx1 | NP_593852.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_04236 | XP_003719578.1 |
Arabidopsis thaliana (thale cress) | TRX2 | NP_198811.1 |
Oryza sativa (rice) | Os03g0800700 | NP_001051587.1 |
Mus musculus (house mouse) | Txn1 | NP_035790.1 |
Rattus norvegicus (Norway rat) | Txn1 | NP_446252.1 |
Danio rerio (zebrafish) | txn | NP_001002461.1 |
The genome sequence of Schizosaccharomyces pombe.
Wood V, Gwilliam R, Rajandream MA, Lyne M, Lyne R, Stewart A, Sgouros J, Peat N, Hayles J, Baker S, Basham D, Bowman S, Brooks K, Brown D, Brown S, Chillingworth T, Churcher C, Collins M, Connor R, Cronin A, Davis P, Feltwell T, Fraser A, Gentles S, Goble A, Hamlin N, Harris D, Hidalgo J, Hodgson G, Holroyd S, Hornsby T, Howarth S, Huckle EJ, Hunt S, Jagels K, James K, Jones L, Jones M, Leather S, McDonald S, McLean J, Mooney P, Moule S, Mungall K, Murphy L, Niblett D, Odell C, Oliver K, O'Neil S, Pearson D, Quail MA, Rabbinowitsch E, Rutherford K, Rutter S, Saunders D, Seeger K, Sharp S, Skelton J, Simmonds M, Squares R, Squares S, Stevens K, Taylor K, Taylor RG, Tivey A, Walsh S, Warren T, Whitehead S, Woodward J, Volckaert G, Aert R, Robben J, Grymonprez B, Weltjens I, Vanstreels E, Rieger M, Sch?fer M, M?ller-Auer S, Gabel C, Fuchs M, D?sterh?ft A, Fritzc C, Holzer E, Moestl D, Hilbert H, Borzym K, Langer I, Beck A, Lehrach H, Reinhardt R, Pohl TM, Eger P, Zimmermann W, Wedler H, Wambutt R, Purnelle B, Goffeau A, Cadieu E, Dr?ano S, Gloux S, Lelaure V, Mottier S, Galibert F, Aves SJ, Xiang Z, Hunt C, Moore K, Hurst SM, Lucas M, Rochet M, Gaillardin C, Tallada VA, Garzon A, Thode G, Daga RR, Cruzado L, Jimenez J, S?nchez M, del Rey F, Benito J, Dom?nguez A, Revuelta JL, Moreno S, Armstrong J, Forsburg SL, Cerutti L, Lowe T, McCombie WR, Paulsen I, Potashkin J, Shpakovski GV, Ussery D, Barrell BG, Nurse P, Cerrutti L
Nature415(6874)871-80(2002 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
We propose that in a mutant strain compromised in reducing equivalents, the absence of an abundant and competitive substrate such as the peroxiredoxin Tpx1 has been selected as a lethality suppressor to favor RNR function at the expense of the non-essential peroxide scavenging function, to allow DNA synthesis and cell growth.
Title: Lack of a peroxiredoxin suppresses the lethality of cells devoid of electron donors by channelling electrons to oxidized ribonucleotide reductase.
our data establish that redox-coupling between Trx1 and the thioredoxin peroxidase activity of Tpx1 is central for initiation of appropriate responses to different levels of hydrogen peroxide in S. pombe
Title: Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival.
Trxl plays a major role in protecting S. pombe against various stressful conditions and enables proper sulfur metabolism.
Title: The role and regulation of Trxl, a cytosolic thioredoxin in Schizosaccharomyces pombe.
These results indicate that glutathione reductase is essential in the aerobic growth of S. pombe due to its role in maintaining oxidation-labile Fe-S enzymes and iron homeostasis through mitochondrial thioredoxin Trx2.
Title: Glutathione reductase and a mitochondrial thioredoxin play overlapping roles in maintaining iron-sulfur enzymes in fission yeast.
The following trx1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the trx1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSc102742 | |
Clone ID Related Accession (Same CDS sequence) | NM_001019281.2 | |
Accession Version | NM_001019281.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-04-02 | |
Organism | Schizosaccharomyces pombe(fission yeast) | |
Product | cytosolic thioredoxin Trx1 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. This record is derived from an annotated genomic sequence (NC_003424). On Dec 10, 2012 this sequence version replaced NM_001019281.1. |
1 | ATGGTGAAAC AAGTCTCCGA CTCTTCTGAA TTTAAATCTA TTGTTTGCCA AGACAAGCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_593852.1 |
CDS | 142..453 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGGTGAAAC AAGTCTCCGA CTCTTCTGAA TTTAAATCTA TTGTTTGCCA AGACAAGCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The genome sequence of Schizosaccharomyces pombe. |