wnt11b.L cDNA ORF clone, Xenopus laevis(African clawed frog)

Gene
Clones
gRNAs

Summary

Gene Symbol	wnt11b.L
Entrez Gene ID	399441
Full Name	wingless-type MMTV integration site family, member 11B L homeolog
Synonyms	WNT11,wnt-11,wnt11b,xwnt11
General protein information	Preferred Names wingless-type MMTV integration site family, member 11B L homeolog Names protein Wnt-11b Protein Wnt-11 XWnt-11 maternal protein
Gene Type	protein-coding
Organism	Xenopus laevis(African clawed frog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001090858.1	NP_001084327.1	protein Wnt-11b precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

The CapZ interacting protein Rcsd1 is required for cardiogenesis downstream of Wnt11a in Xenopus laevis.
Hempel A, K?hl SJ, Rothe M, Rao Tata P, Sirbu IO, Vainio SJ, K?hl M
Developmental biology424(1)28-39(2017 04)

Wnt proteins can direct planar cell polarity in vertebrate ectoderm.
Chu CW, Sokol SY
eLife5(2016 09)

Sulf1 has ligand-dependent effects on canonical and non-canonical Wnt signalling.
Fellgett SW, Maguire RJ, Pownall ME
Journal of cell science128(7)1408-21(2015 Apr)

Wnt11b is involved in cilia-mediated symmetry breakage during Xenopus left-right development.
Walentek P, Schneider I, Schweickert A, Blum M
PloS one8(9)e73646(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rcsd1 is required downstream of Wnt11 for ventricular trabeculation, terminal differentiation of cardiomyocytes and cardiac morphogenesis.
Title: The CapZ interacting protein Rcsd1 is required for cardiogenesis downstream of Wnt11a in Xenopus laevis.

In midgastrula embryos, Wnt5a, Wnt11, and Wnt11b, but not Wnt3a, acted across many cell diameters to orient Prickle3/Vangl2 complexes away from their sources regardless of their positions relative to the body axis.
Title: Wnt proteins can direct planar cell polarity in vertebrate ectoderm.

Sulf1 enhances the ability of Wnt11b to activate canonical and non-canonical Wnt signaling.
Title: Sulf1 has ligand-dependent effects on canonical and non-canonical Wnt signalling.

Wnt11b is involved in cilia-mediated symmetry breakage during Xenopus left-right development.
Title: Wnt11b is involved in cilia-mediated symmetry breakage during Xenopus left-right development.

Data show that Wnt11b signaling can rescue reduced cardiac differentiation resulting from loss of function of GATA4 and 6 but not GATA5.
Title: Different requirements for GATA factors in cardiogenesis are mediated by non-canonical Wnt signaling.

The following wnt11b.L gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the wnt11b.L cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OAf01396	NM_001090858.1 Latest version!	Xenopus laevis wingless-type MMTV integration site family, member 11B L homeolog (wnt11b.L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	Quote Price

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

wnt11b.L ( NM_001090858.1 ) cDNA ORF clone, Xenopus laevis(African clawed frog) -> NP_001084327.1 Xenopus laevis wingless-type MMTV integration site family, member 11B L homeolog (wnt11b.L), mRNA.

Price & Availability↑

CloneID	OAf01396
Clone ID Related Accession (Same CDS sequence)	NM_001090858.1
Accession Version	NM_001090858.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1062bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Xenopus laevis(African clawed frog)
Product	protein Wnt-11b precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC084745.1. On Jul 25, 2007 this sequence version replaced NM_001090859.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC084745.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00012418, SAMD00012419 [ECO:0000348] ##Evidence-Data-END##

ATGGCTCCGA CCCGTCACTG GGTTACCCCC CTGCTCCTCT TGTGTTGCTC CGGGATCTGT 
GGCGCCATCC AGTGGCTTGG GCTCACCGTA AATGGCAGCC GGGTGGCCTG GAATGAGAGC 
GAACACTGTC GCTTGCTGGA CGGTCTAGTC CCTGACCAGT CGCAACTCTG CAAGAGGAAT 
CTTGAACTGA TGCAAAGTGT CGTTAATGCT GCCAAACAGA CCAAGCTAAC CTGCCAAATG 
ACCTTATCTG ACATGCGCTG GAACTGCTCT TCAGTAGAGA ATGCACCAAG CTTCACCCCT 
GACTTGAGCA AAGGTACCAG GGAGTCTGCC TTTGTCTATG CTCTGGCCTC TGCCACTCTC 
AGCCATACCA TTGCGCGTGC CTGTGCCTCG GGGGAGCTGC CCACATGCTC TTGTGGTGCC 
ACCCCAGCTG AGGTGCCCGG AACAGGCTTC CGATGGGGAG GGTGTGGGGA CAACCTACAT 
TACGGCCTTA ACATGGGCTC TGCTTTTGTT GACGCTCCAA TGAAGTCAAG CAAGTCTGCT 
GGGACCCAGG CCACTAAAAT TATGAATCTA CACAACAATG CAGTTGGCAG ACAGGTACTG 
ATGGACTCTT TGGAGACAAA ATGCAAGTGC CACGGAGTGT CTGGATCTTG CTCCGTGAAG 
ACCTGTTGGA AGGGCCTGCA GGATCTTCCC CATATTGCTA ATGAGCTTAA ATCCAAATAC 
CTTGGTGCCA CTAAAGTCAT CCACAGACAG ACCGGCACTC GGAGGCAGCT TGTTCCCAGG 
GAGCTAGACA TCAGGCCAGT GAGAGAGTCT GAGCTGGTGT ACCTGGTTAG TTCCCCTGAC 
TACTGCACAA AGAATCCCAA GTTGGGTTCA TATGGGACAC AGGACAGGCT GTGCAACAAG 
ACCTCCGTTG GTAGTGACAG CTGCAACCTC ATGTGCTGTG GGCGGGGATA CAACGCCTAC 
ACCGAAACCA TCGTGGAACG CTGTCAATGC AAGTACCACT GGTGCTGCTA TGTCATGTGC 
AAGAAATGTG AGCGGACAGT GGAGAGGTAT GTCTGCAAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001084327.1
CDS	289..1350
Translation	MAPTRHWVTPLLLLCCSGICGAIQWLGLTVNGSRVAWNESEHCRLLDGLVPDQSQLCKRNLELMQSVVNAAKQTKLTCQMTLSDMRWNCSSVENAPSFTPDLSKGTRESAFVYALASATLSHTIARACASGELPTCSCGATPAEVPGTGFRWGGCGDNLHYGLNMGSAFVDAPMKSSKSAGTQATKIMNLHNNAVGRQVLMDSLETKCKCHGVSGSCSVKTCWKGLQDLPHIANELKSKYLGATKVIHRQTGTRRQLVPRELDIRPVRESELVYLVSSPDYCTKNPKLGSYGTQDRLCNKTSVGSDSCNLMCCGRGYNAYTETIVERCQCKYHWCCYVMCKKCERTVERYVCK

Target ORF information:

RefSeq Version	NM_001090858.1
Organism	Xenopus laevis(African clawed frog)
Definition	Xenopus laevis wingless-type MMTV integration site family, member 11B L homeolog (wnt11b.L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001090858.1

ORF Insert Sequence:

ATGGCTCCGA CCCGTCACTG GGTTACCCCC CTGCTCCTCT TGTGTTGCTC CGGGATCTGT 
GGCGCCATCC AGTGGCTTGG GCTCACCGTA AATGGCAGCC GGGTGGCCTG GAATGAGAGC 
GAACACTGTC GCTTGCTGGA CGGTCTAGTC CCTGACCAGT CGCAACTCTG CAAGAGGAAT 
CTTGAACTGA TGCAAAGTGT CGTTAATGCT GCCAAACAGA CCAAGCTAAC CTGCCAAATG 
ACCTTATCTG ACATGCGCTG GAACTGCTCT TCAGTAGAGA ATGCACCAAG CTTCACCCCT 
GACTTGAGCA AAGGTACCAG GGAGTCTGCC TTTGTCTATG CTCTGGCCTC TGCCACTCTC 
AGCCATACCA TTGCGCGTGC CTGTGCCTCG GGGGAGCTGC CCACATGCTC TTGTGGTGCC 
ACCCCAGCTG AGGTGCCCGG AACAGGCTTC CGATGGGGAG GGTGTGGGGA CAACCTACAT 
TACGGCCTTA ACATGGGCTC TGCTTTTGTT GACGCTCCAA TGAAGTCAAG CAAGTCTGCT 
GGGACCCAGG CCACTAAAAT TATGAATCTA CACAACAATG CAGTTGGCAG ACAGGTACTG 
ATGGACTCTT TGGAGACAAA ATGCAAGTGC CACGGAGTGT CTGGATCTTG CTCCGTGAAG 
ACCTGTTGGA AGGGCCTGCA GGATCTTCCC CATATTGCTA ATGAGCTTAA ATCCAAATAC 
CTTGGTGCCA CTAAAGTCAT CCACAGACAG ACCGGCACTC GGAGGCAGCT TGTTCCCAGG 
GAGCTAGACA TCAGGCCAGT GAGAGAGTCT GAGCTGGTGT ACCTGGTTAG TTCCCCTGAC 
TACTGCACAA AGAATCCCAA GTTGGGTTCA TATGGGACAC AGGACAGGCT GTGCAACAAG 
ACCTCCGTTG GTAGTGACAG CTGCAACCTC ATGTGCTGTG GGCGGGGATA CAACGCCTAC 
ACCGAAACCA TCGTGGAACG CTGTCAATGC AAGTACCACT GGTGCTGCTA TGTCATGTGC 
AAGAAATGTG AGCGGACAGT GGAGAGGTAT GTCTGCAAGT AA