| Gene Symbol | SPP1 |
| Entrez Gene ID | 397087 |
| Full Name | secreted phosphoprotein 1 |
| Synonyms | Opn |
| Gene Type | protein-coding |
| Organism | Sus scrofa(pig) |
| Genome |
ORF » Species Summary » Sus scrofa » SPP1 cDNA ORF clone
| Gene Symbol | SPP1 |
| Entrez Gene ID | 397087 |
| Full Name | secreted phosphoprotein 1 |
| Synonyms | Opn |
| Gene Type | protein-coding |
| Organism | Sus scrofa(pig) |
| Genome |
| mRNA | Protein | Name |
|---|---|---|
| XM_005667004.3 | XP_005667061.1 | osteopontin isoform X1 |
| XM_021100464.1 | XP_020956123.1 | osteopontin isoform X1 |
| XM_005667004.2 | XP_005667061.1 | osteopontin isoform X1 |
| XM_005667005.2 | XP_005667062.1 | osteopontin isoform X2 |
| XM_005667005.3 | XP_005667062.1 | osteopontin isoform X2 |
| NM_214023.1 | NP_999188.1 | osteopontin precursor |
Osteoponin promoter controlled by DNA methylation: aberrant methylation in cloned porcine genome.
Shen CJ, Tsou YA, Chen HL, Huang HJ, Wu SC, Cheng WT, Chen CY, Chen CM
BioMed research international2014327538(2014)
Secreted phosphoprotein 1 expression in endometrium and placental tissues of hyperprolific large white and meishan gilts.
Hernandez SC, Hogg CO, Billon Y, Sanchez MP, Bidanel JP, Haley CS, Archibald AL, Ashworth CJ
Biology of reproduction88(5)120(2013 May)
Porcine SPP1 gene polymorphism association with phenotypic traits in the Landrace ? Jeju (Korea) Black pig F2 population.
Han SH, Shin KY, Lee SS, Ko MS, Oh HS, Cho IC
Molecular biology reports39(7)7705-9(2012 Jul)
Role of osteopontin in the development of neointimal hyperplasia in vein grafts.
Kang N, Ng CS, Hu J, Qiu ZB, Underwood MJ, Jeremy JY, Wan S
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery41(6)1384-9(2012 Jun)
Osteopontin alters the functional profile of porcine microglia in vitro.
Tambuyzer BR, Casteleyn C, Vergauwen H, Van Cruchten S, Van Ginneken C
Cell biology international36(12)1233-8(2012)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These data suggested that methylation in the OPN promoter plays a crucial role in the regulation of OPN expression that we found in cloned pigs genome.
Title: Osteoponin promoter controlled by DNA methylation: aberrant methylation in cloned porcine genome.
The striking breed differences between hyperprolific Large White and Meishanin pigs of secreted phospoprotein 1 expression in endometrium suggest that SPP1 may be associated with placental efficiency.
Title: Secreted phosphoprotein 1 expression in endometrium and placental tissues of hyperprolific large white and meishan gilts.
results of this study reveal faster growth rate and differences in pig productivity according to genotypes of the SPP1 gene
Title: Porcine SPP1 gene polymorphism association with phenotypic traits in the Landrace ? Jeju (Korea) Black pig F2 population.
Osteopontin could play an important role in the development of neointimal hyperplasia in venous conduits after coronary artery bypass grafting.
Title: Role of osteopontin in the development of neointimal hyperplasia in vein grafts.
Microglia incubated in vitro with different concentrations (0.1 fM-1 nM) of recombinant osteopontin showed increased proliferation at 10 fM.
Title: Osteopontin alters the functional profile of porcine microglia in vitro.
The following SPP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OSe15594 | |
| Clone ID Related Accession (Same CDS sequence) | XM_005667004.3 , XM_021100464.1 , XM_005667004.2 , NM_214023.1 | |
| Accession Version | NM_214023.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-24 | |
| Organism | Sus scrofa(pig) | |
| Product | osteopontin precursor | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from X16575.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X16575.1, AK234564.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01048247, SAMN01048300 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGAGAATTG CAGTGATAGC CTTCTGCCTC TGGGGCTTCG CCTCTGCCCT TCCAGTTAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_999188.1 |
| CDS | 98..1009 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_214023.1 |
1 | ATGAGAATTG CAGTGATAGC CTTCTGCCTC TGGGGCTTCG CCTCTGCCCT TCCAGTTAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSe15594 | |
| Clone ID Related Accession (Same CDS sequence) | XM_005667004.3 , XM_021100464.1 , XM_005667004.2 , NM_214023.1 | |
| Accession Version | XM_005667004.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-05-12 | |
| Organism | Sus scrofa(pig) | |
| Product | osteopontin isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_010450.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 13, 2017 this sequence version replaced XM_005667004.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Sus scrofa Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGAGAATTG CAGTGATAGC CTTCTGCCTC TGGGGCTTCG CCTCTGCCCT TCCAGTTAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_005667061.1 |
| CDS | 201..1112 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_005667004.3 |
1 | ATGAGAATTG CAGTGATAGC CTTCTGCCTC TGGGGCTTCG CCTCTGCCCT TCCAGTTAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSe15594 | |
| Clone ID Related Accession (Same CDS sequence) | XM_005667004.3 , XM_021100464.1 , XM_005667004.2 , NM_214023.1 | |
| Accession Version | XM_021100464.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-05-12 | |
| Organism | Sus scrofa(pig) | |
| Product | osteopontin isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_010450.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Sus scrofa Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGAGAATTG CAGTGATAGC CTTCTGCCTC TGGGGCTTCG CCTCTGCCCT TCCAGTTAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_020956123.1 |
| CDS | 172..1083 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_021100464.1 |
1 | ATGAGAATTG CAGTGATAGC CTTCTGCCTC TGGGGCTTCG CCTCTGCCCT TCCAGTTAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSe15594 | |
| Clone ID Related Accession (Same CDS sequence) | XM_005667004.3 , XM_021100464.1 , XM_005667004.2 , NM_214023.1 | |
| Accession Version | XM_005667004.2 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-09-10 | |
| Organism | Sus scrofa(Pig) | |
| Product | osteopontin isoform X1 | |
| Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003610971.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 11, 2015 this sequence version replaced XM_005667004.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Sus scrofa Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGAGAATTG CAGTGATAGC CTTCTGCCTC TGGGGCTTCG CCTCTGCCCT TCCAGTTAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_005667061.1 |
| CDS | 142..1053 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_005667004.2 |
1 | ATGAGAATTG CAGTGATAGC CTTCTGCCTC TGGGGCTTCG CCTCTGCCCT TCCAGTTAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSe15595 | |
| Clone ID Related Accession (Same CDS sequence) | XM_005667005.2 , XM_005667005.3 | |
| Accession Version | XM_005667005.2 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 909bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-09-10 | |
| Organism | Sus scrofa(Pig) | |
| Product | osteopontin isoform X2 | |
| Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003610971.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 11, 2015 this sequence version replaced XM_005667005.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Sus scrofa Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGAGAATTG CAGTGATAGC CTTCTGCCTC TGGGGCTTCG CCTCTGCCCT TCCAGTTAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_005667062.1 |
| CDS | 136..1044 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_005667005.2 |
1 | ATGAGAATTG CAGTGATAGC CTTCTGCCTC TGGGGCTTCG CCTCTGCCCT TCCAGTTAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSe15595 | |
| Clone ID Related Accession (Same CDS sequence) | XM_005667005.2 , XM_005667005.3 | |
| Accession Version | XM_005667005.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 909bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-05-12 | |
| Organism | Sus scrofa(pig) | |
| Product | osteopontin isoform X2 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_010450.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 13, 2017 this sequence version replaced XM_005667005.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Sus scrofa Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGAGAATTG CAGTGATAGC CTTCTGCCTC TGGGGCTTCG CCTCTGCCCT TCCAGTTAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_005667062.1 |
| CDS | 168..1076 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_005667005.3 |
1 | ATGAGAATTG CAGTGATAGC CTTCTGCCTC TGGGGCTTCG CCTCTGCCCT TCCAGTTAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Osteoponin promoter controlled by DNA methylation: aberrant methylation in cloned porcine genome. |
Secreted phosphoprotein 1 expression in endometrium and placental tissues of hyperprolific large white and meishan gilts. |
Porcine SPP1 gene polymorphism association with phenotypic traits in the Landrace ? Jeju (Korea) Black pig F2 population. |
Role of osteopontin in the development of neointimal hyperplasia in vein grafts. |
Osteopontin alters the functional profile of porcine microglia in vitro. |