nse2 cDNA ORF clone, Schizosaccharomyces pombe(fission yeast)

The genome sequence of Schizosaccharomyces pombe.
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Nature415(6874)871-80(2002 Feb)

role in protecting genome stability against spontaneous Top1-mediated DNA damage
Title: SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.

Nse2-dependent sumoylation activity has a role in DNA damage responses but not in the essential function of the Smc5-6 complex. [Nse2]
Title: Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage.

Nse1, Nse2, and Nse3 are crucial for meiosis. They also play an important role in mitigating the genome destabilizing effects of replication fork stalling. [Nse2]
Title: Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.

Nse1 and Nse2 are non-SMC subunits of the Smc5-6 DNA repair complex. They both interact with Smc5. Nse1 and Nse2 function together with Rhp51 in the homologous recombination repair of DNA double-strand breaks. They are essential proteins. [Nse2]
Title: Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.