HEH2 cDNA ORF clone, Saccharomyces cerevisiae S288C

Gene
Clones
gRNAs

Summary

Gene Symbol	HEH2
Entrez Gene ID	852069
Full Name	Heh2p
Gene Type	protein-coding
Organism	Saccharomyces cerevisiae S288C

mRNA and Protein(s)

mRNA	Protein	Name
NM_001180766.1	NP_010746.1	Heh2p

Pathways from BioSystems

Homologies

Kluyveromyces lactis	KLLA0B01826g	XP_451612.1
Saccharomyces cerevisiae (baker's yeast)	HEH2	NP_010746.1

Gene Ontology
Bibliography

Related articles in PubMed

The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Jacq C, Alt-M?rbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Bl?cker H, Blugeon C, Boskovic J, Brandt P, Br?ckner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P
Nature387(6632 Suppl)75-8(1997 May)

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The conserved features of the NLSs of ScHeh1, ScHeh2, and RnPom121 and the effective sorting of Heh2-derived reporters in human cells suggest that active import is conserved but confined to a small subset of INM proteins.
Title: Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins.

Heh2 and Src1/Heh1 contain bipartite import sequences that associate intimately with the minor nuclear localization sequence-binding pocket of yeast importin alpha.
Title: Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2.

study found that at least a 120-residue-long intrinsically disordered linker was required for the import of membrane proteins carrying a nuclear localization signal for the transport factor karyopherin-alpha
Title: Long unfolded linkers facilitate membrane protein import through the nuclear pore complex.

In the absence of the Kap60-44, Kap60-30 and Kap60-10 isoforms, Heh2 localized to cytoplasmic membranes, whereas its wild-type localization at the nuclear periphery was restored when the Kap60-44 isoform was reintroduced.
Title: Truncated isoforms of Kap60 facilitate trafficking of Heh2 to the nuclear envelope.

The following HEH2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HEH2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSi01528	NM_001180766.1 Latest version!	Saccharomyces cerevisiae S288C Heh2p (HEH2), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HEH2 ( NM_001180766.1 ) cDNA ORF clone, Saccharomyces cerevisiae S288C -> NP_010746.1 Saccharomyces cerevisiae S288C Heh2p (HEH2), partial mRNA.

Price & Availability↑

CloneID	OSi01528
Clone ID Related Accession (Same CDS sequence)	NM_001180766.1
Accession Version	NM_001180766.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1992bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-31
Organism	Saccharomyces cerevisiae S288C
Product	Heh2p
Comment	Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001136). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends.

ATGGATCACA GAAACCTTGA TCCGAAAACG CTGAAGGTCA GCCAATTGAG AAGAGTTTTG 
GTAGAAAATG ATGTTGCGTT CCCTGCCAAC GCTAGGAAGC CTGTCTTGGT GAAATTGTTT 
GAGGAGAAAG TGAGGCAACG TCTCCAATCT TCACCTGAGG CCTCAAAGGT TAGAACTAGC 
ATTCAAAAGG TTGTGAAGTC TGGGGCAAAA AACGCAGATC GCAAAAAGAC ATTAAAGAGT 
AAAAAGCTTG AATCAAGTTC TAGTGAGAGT AAAACTGTCA AAGATGAAAA TGTTGAAACT 
AACAAGAGGA AAAGGGAACA AATTAGTACG GATAATGAAG CGAAGATGCA AATACAGGAA 
GAGAAGTCTC CTAAAAAGAA AAGAAAGAAA AGATCTAGTA AGGCCAATAA ACCACCAGAG 
TCTCCTCCAC AATCTAAGTC AGATGGGAAA GCAACTTCTG CTGATTTAAC TTCTGAACTG 
GAAACTGTAG AAGAACTTCA TAAGAAAGAT TCTTCGGATG ACAAACCAAG GGTAAAAGAG 
CTTCCAAAAC CAGAATTGCC GAATTTAAAA GTATCAAACG AATTTTTAGC TCAACTAAAT 
AAAGAGTTAG CTAGTGCAGC TACGGAGAAT TATGATCATT CTATAAAATC CACGGACTTA 
TCGTCTATCA GAATCGAAAC AGAAGAGCCT GTTGGTCCTT CAACTGGAGC AGAAACAAGA 
AATGAAAGTG AGGTGATGGA GAATATCAAT TTGGAAGTCC AACCTGAGGT GAAGGAAGCA 
AAAGAAGAAC TAACAAAAAT ATCAGAAACT TTTGATAATC AAGACGAAGA GGATACTAGT 
AGGTTATCGT CGAAAAAAAA TATACGAAGT CCAAAAGGTC GCACCAGGCA CTTCATTGCC 
AACAAAACTA AAAGAGGGAT AGATATTATG AAACCGTTTA TTGCACATCT CTTCATTTGG 
TTATGGAATG GTGCTATTTT CCTTTCAATA ATATGTCCTA TTCTTTTTGG TCTTTGGTAT 
CGAGAACAGA GAATTCAAGT AGGATATTGC GGTCATGAAA AGCCCCTGAA ATCTCTTGCA 
ATCTCAGCTT TCCCTCAGAC TGAAAGGGTA GATTCAGTGT TGCAAGCTTA TCGACCAAAT 
TGTCTCGAAT GTCCTGAGCA TGGAATATGT TCTTCTTTTA TGAATGTTGA GTGTGAACCA 
GGCTATGAGC CTAAAAGTTC TATTTTAGAA ACGTATGGTA TTATTCCTTT TCCAAAATAT 
TGTGCCAAAG ATGAAAGTAA AGAAAAGGAG GTTGATGAAC TGGTTTGGAA AGTAAATGAA 
TATCTTAAAA AGAAGAATGC ACAACATGAA TGTGGTGAAG GAGAGAATCT CTTTGAGAGT 
GGTGAAACGG AAACCAAATT ATATGATATA TTCTCTCATT CTAGACCGTC ATGGGAAAGT 
CAAAGGGAAT TCAATGATCA TTGGAAAAAT GTGCTTGAAA TATTAAAGAA AAAAGATGAT 
ATTATCTGGC TGCCATTAGA TTTTGAAACT AATGGAAAAA GAGAGAAATC TAAATCTAAT 
AACACTAACT ATATTTATCG TTCAACTTCA AAAAAATGGG TTACGTTGCA ATGTCATTTA 
GAAGGGGATA TACAGGAGTA TATAACGAAA TATGGTGGTT CTTTATTTAT CACCCTAGGC 
GTCCTTTTCC TTATCAAAAA AATACAATCG ACACTTGACA ATTACGTTCA AGGAGAGCAG 
ATAATTGAGA AATTGGTAAA AGAGGCAATT GATAAATTGA AAGATGTAAA GAAGAACAAA 
GGTGAAGAAC CTTTTCTGAC AACAGTTCAA CTAAGAGCTA CTTTATTGAG CGACATACCA 
AATATAAAAG AACAGAATAA TCTATGGGCT CAAACGAAAG AAAAAATCAT GAAAGAGCAA 
TCAGAGAATA TAGAATTATA TCTTCTTGAA GAAAATGGAG AGATCATGAC ATGTTGGGAA 
TGGAAAGAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_010746.1
CDS	1..1992
Translation	MDHRNLDPKTLKVSQLRRVLVENDVAFPANARKPVLVKLFEEKVRQRLQSSPEASKVRTSIQKVVKSGAKNADRKKTLKSKKLESSSSESKTVKDENVETNKRKREQISTDNEAKMQIQEEKSPKKKRKKRSSKANKPPESPPQSKSDGKATSADLTSELETVEELHKKDSSDDKPRVKELPKPELPNLKVSNEFLAQLNKELASAATENYDHSIKSTDLSSIRIETEEPVGPSTGAETRNESEVMENINLEVQPEVKEAKEELTKISETFDNQDEEDTSRLSSKKNIRSPKGRTRHFIANKTKRGIDIMKPFIAHLFIWLWNGAIFLSIICPILFGLWYREQRIQVGYCGHEKPLKSLAISAFPQTERVDSVLQAYRPNCLECPEHGICSSFMNVECEPGYEPKSSILETYGIIPFPKYCAKDESKEKEVDELVWKVNEYLKKKNAQHECGEGENLFESGETETKLYDIFSHSRPSWESQREFNDHWKNVLEILKKKDDIIWLPLDFETNGKREKSKSNNTNYIYRSTSKKWVTLQCHLEGDIQEYITKYGGSLFITLGVLFLIKKIQSTLDNYVQGEQIIEKLVKEAIDKLKDVKKNKGEEPFLTTVQLRATLLSDIPNIKEQNNLWAQTKEKIMKEQSENIELYLLEENGEIMTCWEWKE

Target ORF information:

RefSeq Version	NM_001180766.1
Organism	Saccharomyces cerevisiae S288C
Definition	Saccharomyces cerevisiae S288C Heh2p (HEH2), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001180766.1

ORF Insert Sequence:

ATGGATCACA GAAACCTTGA TCCGAAAACG CTGAAGGTCA GCCAATTGAG AAGAGTTTTG 
GTAGAAAATG ATGTTGCGTT CCCTGCCAAC GCTAGGAAGC CTGTCTTGGT GAAATTGTTT 
GAGGAGAAAG TGAGGCAACG TCTCCAATCT TCACCTGAGG CCTCAAAGGT TAGAACTAGC 
ATTCAAAAGG TTGTGAAGTC TGGGGCAAAA AACGCAGATC GCAAAAAGAC ATTAAAGAGT 
AAAAAGCTTG AATCAAGTTC TAGTGAGAGT AAAACTGTCA AAGATGAAAA TGTTGAAACT 
AACAAGAGGA AAAGGGAACA AATTAGTACG GATAATGAAG CGAAGATGCA AATACAGGAA 
GAGAAGTCTC CTAAAAAGAA AAGAAAGAAA AGATCTAGTA AGGCCAATAA ACCACCAGAG 
TCTCCTCCAC AATCTAAGTC AGATGGGAAA GCAACTTCTG CTGATTTAAC TTCTGAACTG 
GAAACTGTAG AAGAACTTCA TAAGAAAGAT TCTTCGGATG ACAAACCAAG GGTAAAAGAG 
CTTCCAAAAC CAGAATTGCC GAATTTAAAA GTATCAAACG AATTTTTAGC TCAACTAAAT 
AAAGAGTTAG CTAGTGCAGC TACGGAGAAT TATGATCATT CTATAAAATC CACGGACTTA 
TCGTCTATCA GAATCGAAAC AGAAGAGCCT GTTGGTCCTT CAACTGGAGC AGAAACAAGA 
AATGAAAGTG AGGTGATGGA GAATATCAAT TTGGAAGTCC AACCTGAGGT GAAGGAAGCA 
AAAGAAGAAC TAACAAAAAT ATCAGAAACT TTTGATAATC AAGACGAAGA GGATACTAGT 
AGGTTATCGT CGAAAAAAAA TATACGAAGT CCAAAAGGTC GCACCAGGCA CTTCATTGCC 
AACAAAACTA AAAGAGGGAT AGATATTATG AAACCGTTTA TTGCACATCT CTTCATTTGG 
TTATGGAATG GTGCTATTTT CCTTTCAATA ATATGTCCTA TTCTTTTTGG TCTTTGGTAT 
CGAGAACAGA GAATTCAAGT AGGATATTGC GGTCATGAAA AGCCCCTGAA ATCTCTTGCA 
ATCTCAGCTT TCCCTCAGAC TGAAAGGGTA GATTCAGTGT TGCAAGCTTA TCGACCAAAT 
TGTCTCGAAT GTCCTGAGCA TGGAATATGT TCTTCTTTTA TGAATGTTGA GTGTGAACCA 
GGCTATGAGC CTAAAAGTTC TATTTTAGAA ACGTATGGTA TTATTCCTTT TCCAAAATAT 
TGTGCCAAAG ATGAAAGTAA AGAAAAGGAG GTTGATGAAC TGGTTTGGAA AGTAAATGAA 
TATCTTAAAA AGAAGAATGC ACAACATGAA TGTGGTGAAG GAGAGAATCT CTTTGAGAGT 
GGTGAAACGG AAACCAAATT ATATGATATA TTCTCTCATT CTAGACCGTC ATGGGAAAGT 
CAAAGGGAAT TCAATGATCA TTGGAAAAAT GTGCTTGAAA TATTAAAGAA AAAAGATGAT 
ATTATCTGGC TGCCATTAGA TTTTGAAACT AATGGAAAAA GAGAGAAATC TAAATCTAAT 
AACACTAACT ATATTTATCG TTCAACTTCA AAAAAATGGG TTACGTTGCA ATGTCATTTA 
GAAGGGGATA TACAGGAGTA TATAACGAAA TATGGTGGTT CTTTATTTAT CACCCTAGGC 
GTCCTTTTCC TTATCAAAAA AATACAATCG ACACTTGACA ATTACGTTCA AGGAGAGCAG 
ATAATTGAGA AATTGGTAAA AGAGGCAATT GATAAATTGA AAGATGTAAA GAAGAACAAA 
GGTGAAGAAC CTTTTCTGAC AACAGTTCAA CTAAGAGCTA CTTTATTGAG CGACATACCA 
AATATAAAAG AACAGAATAA TCTATGGGCT CAAACGAAAG AAAAAATCAT GAAAGAGCAA 
TCAGAGAATA TAGAATTATA TCTTCTTGAA GAAAATGGAG AGATCATGAC ATGTTGGGAA 
TGGAAAGAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Nature387(6632 Suppl)75-8(1997 May)
Jacq C,Alt-M?rbe J,Andre B,Arnold W,Bahr A,Ballesta JP,Bargues M,Baron L,Becker A,Biteau N,Bl?cker H,Blugeon C,Boskovic J,Brandt P,Br?ckner M,Buitrago MJ,Coster F,Delaveau T,del Rey F,Dujon B,Eide LG,Garcia-Cantalejo JM,Goffeau A,Gomez-Peris A,Zaccaria P

Life with 6000 genes.
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Goffeau A,Barrell BG,Bussey H,Davis RW,Dujon B,Feldmann H,Galibert F,Hoheisel JD,Jacq C,Johnston M,Louis EJ,Mewes HW,Murakami Y,Philippsen P,Tettelin H,Oliver SG

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HEH2 cDNA ORF clone, Saccharomyces cerevisiae S288C

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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