Gene Symbol | VPS74 |
Entrez Gene ID | 851978 |
Full Name | Vps74p |
Synonyms | API1,MNN3 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » VPS74 cDNA ORF clone
Gene Symbol | VPS74 |
Entrez Gene ID | 851978 |
Full Name | Vps74p |
Synonyms | API1,MNN3 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001180680.1 | NP_010660.1 | Vps74p |
Bos taurus (cattle) | GOLPH3L | NP_001092522.1 |
Rattus norvegicus (Norway rat) | Golph3l | NP_001007699.1 |
Eremothecium gossypii | AGOS_ACL165C | NP_983239.1 |
Schizosaccharomyces pombe (fission yeast) | SPAC5D6.13 | XP_001713053.1 |
Pan troglodytes (chimpanzee) | GOLPH3L | XP_003949582.1 |
Danio rerio (zebrafish) | golph3l | NP_001032788.1 |
Saccharomyces cerevisiae (baker's yeast) | VPS74 | NP_010660.1 |
Kluyveromyces lactis | KLLA0E02355g | XP_454054.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_00839 | XP_003718140.1 |
Xenopus tropicalis (tropical clawed frog) | golph3l | NP_001011166.1 |
Homo sapiens (human) | GOLPH3L | NP_060648.2 |
GOLPH3L | XP_001102836.2 | |
Canis lupus familiaris (dog) | GOLPH3L | XP_005630819.1 |
Gallus gallus (chicken) | GOLPH3L | XP_004948347.1 |
Mus musculus (house mouse) | Golph3l | NP_666245.2 |
Neurospora crassa | NCU06091 | XP_959553.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Jacq C, Alt-M?rbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Bl?cker H, Blugeon C, Boskovic J, Brandt P, Br?ckner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P
Nature387(6632 Suppl)75-8(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Disruption of the Sac1-Vps74 interface results in a broader distribution of phosphatidylinositol 4-phosphate within the Golgi apparatus and failure to maintain residence of a medial Golgi mannosyltransferase.
Title: Sac1-Vps74 structure reveals a mechanism to terminate phosphoinositide signaling in the Golgi apparatus.
propose that Vps74p may use different domains to interact with specific effectors thereby differentially modulating a variety of cellular functions
Title: The N-terminus of Vps74p is essential for the retention of glycosyltransferases in the Golgi but not for the modulation of apical polarized growth in Saccharomyces cerevisiae.
Vps74 Arg-rich N terminus binds directly to coatomer.
Title: A conserved N-terminal arginine-motif in GOLPH3-family proteins mediates binding to coatomer.
additive roles of Vps74-mediated and sphingolipid-dependent sorting of Golgi residents.
Title: Local control of phosphatidylinositol 4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase.
Targeting of Vps74 to the Golgi apparatus requires ongoing synthesis of phosphatidylinositol (PtdIns) 4-phosphate (PtdIns4P) by the Pik1 PtdIns 4-kinase and that modulation of the levels and cellular location of PtdIns4P leads to mislocalization.
Title: PtdIns4P recognition by Vps74/GOLPH3 links PtdIns 4-kinase signaling to retrograde Golgi trafficking.
The following VPS74 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VPS74 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi01450 | |
Clone ID Related Accession (Same CDS sequence) | NM_001180680.1 | |
Accession Version | NM_001180680.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | Vps74p | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001136). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGTCTACTT TACAACGTCG TAGAGTCAAT AGGGCGGATT CTGGAGATAC TTCCTCCATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_010660.1 |
CDS | 1..1038 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001180680.1 |
1 | ATGTCTACTT TACAACGTCG TAGAGTCAAT AGGGCGGATT CTGGAGATAC TTCCTCCATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. |
Life with 6000 genes. |