Xpo1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Xpo1
Entrez Gene ID	85252
Full Name	exportin 1
General protein information	Preferred Names exportin 1 Names exportin-1 chromosome region maintenance 1 protein homolog exp1 exportin 1 (CRM1, yeast, homolog) exportin 1, CRM1 homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14q22
Summary	binds human T-cell leukemia virus type 1 Rex protein and exports it to the cytoplasm; however, does not have strong Rex protein cofactor activity which may account for poor replication of HTLV-1 in rats compared with humans [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006251578.3	XP_006251640.1	exportin-1 isoform X1
NM_053490.1	NP_445942.1	exportin-1

Pathways from BioSystems

Homologies

	XPO1	XP_001115623.1
Mus musculus (house mouse)	Xpo1	NP_001030303.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009929	XP_319051.2
Saccharomyces cerevisiae (baker's yeast)	CRM1	NP_011734.3
Eremothecium gossypii	AGOS_ADL128C	NP_983968.2
Neurospora crassa	NCU01820	XP_955917.2
Arabidopsis thaliana (thale cress)	XPO1B	NP_566193.2
Arabidopsis thaliana (thale cress)	XPO1A	NP_197204.1
Oryza sativa (rice)	Os03g0858100	NP_001051959.1
Bos taurus (cattle)	XPO1	NP_001179190.1
Kluyveromyces lactis	KLLA0E16061g	XP_454672.1
Magnaporthe oryzae (rice blast fungus)	MGG_02526	XP_003709336.1
Rattus norvegicus (Norway rat)	Xpo1	NP_445942.1
Drosophila melanogaster (fruit fly)	emb	NP_723391.2
Homo sapiens (human)	XPO1	NP_003391.1
Danio rerio (zebrafish)	xpo1b	XP_001919797.3
Caenorhabditis elegans (roundworm)	xpo-1	NP_741567.1
Xenopus tropicalis (tropical clawed frog)	xpo1	XP_002939551.2
Pan troglodytes (chimpanzee)	XPO1	XP_515727.2
Canis lupus familiaris (dog)	XPO1	XP_005626195.1
Gallus gallus (chicken)	XPO1	NP_001012887.2
Schizosaccharomyces pombe (fission yeast)	crm1	XP_001713070.1

Gene Ontology
Bibliography

Related articles in PubMed

Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein.
Ortega JF, de Conti A, Tryndyak V, Furtado KS, Heidor R, Horst MA, Fernandes LH, Tavares PE, Pogribna M, Shpyleva S, Beland FA, Pogribny IP, Moreno FS
Oncotarget7(17)24339-47(2016 Apr)

RNA Export through the NPC in Eukaryotes.
Okamura M, Inose H, Masuda S
Genes6(1)124-49(2015 Mar)

Upregulation of CRM1 relates to neuronal apoptosis after traumatic brain injury in adult rats.
Li A, Zou F, Fu H, Cui G, Yan Y, Wu Q, Gu X
Journal of molecular neuroscience : MN51(1)208-18(2013 Sep)

Postage for the messenger: designating routes for nuclear mRNA export.
Natalizio BJ, Wente SR
Trends in cell biology23(8)365-73(2013 Aug)

CRM1 and its ribosome export adaptor NMD3 localize to the nucleolus and affect rRNA synthesis.
Bai B, Moore HM, Laiho M
Nucleus (Austin, Tex.)4(4)315-25(2013 Jul-Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results suggest that the cancer-inhibitory activity of sodium butyrate and its derivatives on liver carcinogenesis may be attributed to retention of p53 and CRM1 proteins in the nucleus, an event that may trigger activation of p53-mediated apoptotic cell death in neoplastic cells.
Title: Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein.

CRM1 mRNA and protein expression in cortical neurons is upregulated after traumatic brin injury.
Title: Upregulation of CRM1 relates to neuronal apoptosis after traumatic brain injury in adult rats.

the mechanism underlying the function of human and rat CRM1 in HIV-1 replication was investigated in rat cells.
Title: Nuclear and cytoplasmic effects of human CRM1 on HIV-1 production in rat cells.

Phosphorylation of ChREBP was essential for its interaction with CRM1 for export to the cytosol, whereas nuclear import of ChREBP requires dephosphorylated ChREBP to interact with importin alpha.
Title: Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation.

Our results suggest that CRM 1-dependent NES-mediated mechanisms influence the degradation and agonist-mediated down-regulation of the beta1-AR mRNAs.
Title: CRM 1-mediated degradation and agonist-induced down-regulation of beta-adrenergic receptor mRNAs.

The following Xpo1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Xpo1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13770	NM_053490.1 Latest version!	Rattus norvegicus exportin 1 (Xpo1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00
ORa13770	XM_006251578.3 Latest version!	Rattus norvegicus exportin 1 (Xpo1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Xpo1 ( NM_053490.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445942.1 Rattus norvegicus exportin 1 (Xpo1), mRNA.

Price & Availability↑

CloneID	ORa13770
Clone ID Related Accession (Same CDS sequence)	XM_006251578.3 , NM_053490.1
Accession Version	NM_053490.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3216bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Rattus norvegicus(Norway rat)
Product	exportin-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB105193.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB105193.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCAGCAA TTATGACAAT GTTAGCAGAC CATGCAGCCC GTCAGCTGCT TGACTTCAGC 
CAGAAGCTGG ATATCAACCT TTTAGACAAT GTGGTGAACT GCTTGTACCA CGGGGAAGGA 
GCCCAGCAGA GAATGGCTCA AGAAGTACTG ACACATCTAA AGGAGCATCC TGATGCCTGG 
ACGCGCGTCG ACACCATTTT GGAGTTTTCG CAGAACATGA ACACAAAATA CTATGGACTA 
CAGATTTTGG AAAATGTGAT CAAAACAAGG TGGAAGATCC TTCCAAGGAA CCAGTGTGAA 
GGAATAAAAA AATACGTTGT TGGTCTCATC ATCAAGACAT CCTCTGACCC AACTTGTGTA 
GAGAAAGAAA AGGTGTATAT TGGGAAGTTG AATATGATTC TTGTTCAGAT ACTTAAGCAA 
GAGTGGCCCA AACATTGGCC AACTTTTATC AGTGACATTG TTGGAGCAAG TAGGACCAGT 
GAAAGCCTAT GTCAAAATAA TATGGTGATT CTTAAACTCT TGAGTGAAGA AGTGTTTGAT 
TTCTCTAGTG GACAGATAAC CCAAGTTAAA GCCAAGCATT TAAAAGACAG CATGTGCAAT 
GAGTTTTCAC AAATATTCCA GCTTTGCCAG TTTGTGATGG AAAACTCCCA GAATGCTCCC 
CTTGTACATG CTACATTAGA AACGCTGCTG AGATTTCTGA ACTGGATTCC CCTGGGATAC 
ATCTTCGAGA CTAAGTTAAT CAGCACCTTG ATTTACAAGT TCCTGAATGT TCCGATGTTC 
CGAAACGTGT CTCTAAAGTG CCTCACGGAG ATTGCTGGTG TGAGTGTGAG CCAGTATGAG 
GAGCAGTTTG AAACTCTGTT TACACTTACA ATGATGCAGC TAAAACAGAT GCTTCCTTTA 
AACACTAATA TCCGACTTGC ATATTCGAAT GGGAAAGATG ATGAACAGAA CTTTATTCAA 
AATCTCAGTC TGTTTCTCTG CACCTTCCTA AAGGAGCATG GTCAACTTCT AGAGAAAAGG 
CTGAATCTCA GGGAAGCACT CATGGAGGCT CTTCATTACA TGTTGTTGGT GTCTGAAGTG 
GAAGAAACTG AAATTTTTAA AATCTGTCTT GAGTACTGGA ATCACTTGGC AGCTGAGCTC 
TACAGAGAGA GTCCATTTTC TACATCTGCT TCTCCATTGT TATCTGGAAG TCAGCACTTT 
GATATTCCTC CTCGGAGACA GCTGTACTTG ACCGTGTTAT CCAAGGTTCG TTTATTGATG 
GTTAGTCGCA TGGCTAAACC AGAGGAGGTA CTGGTTGTAG AAAATGATCA GGGAGAAGTT 
GTAAGAGAGT TCATGAAGGA TACTGATTCC ATAAATTTGT ATAAGAATAT GAGAGAAACA 
TTAGTTTATC TTACCCATCT GGATTATGTA GATACGGAAA TAATAATGAC TAAGAAACTT 
CAAAATCAAG TGAATGGTAC AGAATGGTCA TGGAAAAATT TGAATACACT GTGCTGGGCA 
ATAGGCTCCA TCAGTGGGGC GATGCACGAG GAGGATGAGA AGCGGTTCCT TGTCACTGTT 
ATCAAGGACC TCTTAGGATT ATGTGAGCAG AAGAGAGGCA AGGATAATAA AGCCATCATT 
GCATCGAATA TCATGTACAT AGTAGGCCAG TACCCACGGT TTCTGAGAGC ACACTGGAAA 
TTTTTGAAGA CAGTAGTAAA CAAGCTTTTC GAATTCATGC ATGAAACCCA TGATGGAGTC 
CAGGACATGG CTTGTGACAC ATTTATTAAA ATAGCTCAAA AATGCCGTAG ACATTTTGTT 
CAGGTTCAAG TTGGAGAAGT AATGCCGTTT ATTGATGAGA TTTTAAACAA CATAAATACT 
ATAATTTGTG ATCTTCAGCC TCAGCAGGTT CATACCTTTT ATGAAGCAGT GGGGTACATG 
ATTGGTGCAC AGACAGACCA GACAGTTCAA GAGCATTTGA TAGAAAAATA CATGCTACTC 
CCTAATCAAG TATGGGACAG TATAATTCAA CAGGCAACCA AAAATGTGGA TATCCTGAAA 
GACCCCGAGA CAGTCAAGCA GCTGGGGAGC ATACTAAAAA CTAATGTGAG AGCCTGCAAG 
GCTGTTGGCC ACCCCTTTGT GATTCAGCTG GGGAGGATTT ACTTAGACAT GCTCAATGTG 
TACAAGTGCC TCAGTGAAAA CATTTCTGCA GCCATTCAAG CTAACGGTGA GATGGTTACA 
AAGCAACCAC TGATTAGAAG TATGCGAACA GTAAAAAGGG AAACTTTAAA GTTAATATCT 
GGTTGGGTGA GCCGTTCCAA TGATCCTCAG ATGGTAGCTG AAAACTTTGT TCCTCCTCTG 
TTGGATGCGG TTCTTATTGA TTACCAGAGA AATGTTCCAG CTGCTAGAGA GCCAGAAGTG 
CTCAGTACTA TGGCCATTAT TGTCAACAAG CTCGGTGGAC ATATAACAGC TGAAATACCT 
CAGATTTTTG ATGCAGTTTT TGAGTGCACA TTGAATATGA TAAATAAGGA TTTTGAAGAG 
TATCCAGAAC ACAGAACCAA CTTTTTCTTG TTACTTCAAG CTGTCAATTC TCACTGTTTC 
CCAGCATTCC TTGCTATTCC ACCTGCCCAG TTCAAGCTTG TTTTGGATTC TATTATTTGG 
GCTTTTAAAC ATACTATGAG GAATGTCGCA GATACAGGCT TACAGATACT TTTTACACTT 
TTACAAAATG TTGCACAAGA AGAAGCTGCA GCGCAGAGTT TTTACCAAAC GTACTTTTGT 
GACATTCTTC AGCATATCTT TTCTGTTGTG ACAGACACCT CACATACTGC GGGTCTAACA 
ATGCATGCAT CAATTCTCGC ATATATGTTT AATTTGGTTG AAGAAGGAAA GATAAGCACA 
CCGCTAAATC CCGGAAGTCC AGTTAGCAAC CAGATGTTTA TTCAAGACTA CGTGGCTAAT 
CTCCTTAAGT CTGCGTTCCC TCACCTACAA GATGCTCAAG TAAAGCTCTT TGTGACAGGA 
CTTTTCAGCT TAAATCAAGA TATTCCTGCT TTCAAAGAAC ATCTAAGGGA TTTCTTAGTT 
CAAATAAAGG AGTTTGCAGG TGAAGACACA TCGGATCTAT TTTTGGAAGA GAGAGAAACA 
GCTCTTCGAC AGGCTCAGGA GGAGAAACAT AAACTTCAAA TGTCTGTACC TGGAATCCTT 
AACCCACATG AAATCCCAGA AGAAATGTGT GACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445942.1
CDS	1..3216
Translation	MPAIMTMLADHAARQLLDFSQKLDINLLDNVVNCLYHGEGAQQRMAQEVLTHLKEHPDAWTRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCEGIKKYVVGLIIKTSSDPTCVEKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNNMVILKLLSEEVFDFSSGQITQVKAKHLKDSMCNEFSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGYIFETKLISTLIYKFLNVPMFRNVSLKCLTEIAGVSVSQYEEQFETLFTLTMMQLKQMLPLNTNIRLAYSNGKDDEQNFIQNLSLFLCTFLKEHGQLLEKRLNLREALMEALHYMLLVSEVEETEIFKICLEYWNHLAAELYRESPFSTSASPLLSGSQHFDIPPRRQLYLTVLSKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYVDTEIIMTKKLQNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKAIIASNIMYIVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFVQVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTVQEHLIEKYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNVYKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDYQRNVPAAREPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFLLLQAVNSHCFPAFLAIPPAQFKLVLDSIIWAFKHTMRNVADTGLQILFTLLQNVAQEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKISTPLNPGSPVSNQMFIQDYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLVQIKEFAGEDTSDLFLEERETALRQAQEEKHKLQMSVPGILNPHEIPEEMCD

Target ORF information:

RefSeq Version	NM_053490.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus exportin 1 (Xpo1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053490.1

ORF Insert Sequence:

ATGCCAGCAA TTATGACAAT GTTAGCAGAC CATGCAGCCC GTCAGCTGCT TGACTTCAGC 
CAGAAGCTGG ATATCAACCT TTTAGACAAT GTGGTGAACT GCTTGTACCA CGGGGAAGGA 
GCCCAGCAGA GAATGGCTCA AGAAGTACTG ACACATCTAA AGGAGCATCC TGATGCCTGG 
ACGCGCGTCG ACACCATTTT GGAGTTTTCG CAGAACATGA ACACAAAATA CTATGGACTA 
CAGATTTTGG AAAATGTGAT CAAAACAAGG TGGAAGATCC TTCCAAGGAA CCAGTGTGAA 
GGAATAAAAA AATACGTTGT TGGTCTCATC ATCAAGACAT CCTCTGACCC AACTTGTGTA 
GAGAAAGAAA AGGTGTATAT TGGGAAGTTG AATATGATTC TTGTTCAGAT ACTTAAGCAA 
GAGTGGCCCA AACATTGGCC AACTTTTATC AGTGACATTG TTGGAGCAAG TAGGACCAGT 
GAAAGCCTAT GTCAAAATAA TATGGTGATT CTTAAACTCT TGAGTGAAGA AGTGTTTGAT 
TTCTCTAGTG GACAGATAAC CCAAGTTAAA GCCAAGCATT TAAAAGACAG CATGTGCAAT 
GAGTTTTCAC AAATATTCCA GCTTTGCCAG TTTGTGATGG AAAACTCCCA GAATGCTCCC 
CTTGTACATG CTACATTAGA AACGCTGCTG AGATTTCTGA ACTGGATTCC CCTGGGATAC 
ATCTTCGAGA CTAAGTTAAT CAGCACCTTG ATTTACAAGT TCCTGAATGT TCCGATGTTC 
CGAAACGTGT CTCTAAAGTG CCTCACGGAG ATTGCTGGTG TGAGTGTGAG CCAGTATGAG 
GAGCAGTTTG AAACTCTGTT TACACTTACA ATGATGCAGC TAAAACAGAT GCTTCCTTTA 
AACACTAATA TCCGACTTGC ATATTCGAAT GGGAAAGATG ATGAACAGAA CTTTATTCAA 
AATCTCAGTC TGTTTCTCTG CACCTTCCTA AAGGAGCATG GTCAACTTCT AGAGAAAAGG 
CTGAATCTCA GGGAAGCACT CATGGAGGCT CTTCATTACA TGTTGTTGGT GTCTGAAGTG 
GAAGAAACTG AAATTTTTAA AATCTGTCTT GAGTACTGGA ATCACTTGGC AGCTGAGCTC 
TACAGAGAGA GTCCATTTTC TACATCTGCT TCTCCATTGT TATCTGGAAG TCAGCACTTT 
GATATTCCTC CTCGGAGACA GCTGTACTTG ACCGTGTTAT CCAAGGTTCG TTTATTGATG 
GTTAGTCGCA TGGCTAAACC AGAGGAGGTA CTGGTTGTAG AAAATGATCA GGGAGAAGTT 
GTAAGAGAGT TCATGAAGGA TACTGATTCC ATAAATTTGT ATAAGAATAT GAGAGAAACA 
TTAGTTTATC TTACCCATCT GGATTATGTA GATACGGAAA TAATAATGAC TAAGAAACTT 
CAAAATCAAG TGAATGGTAC AGAATGGTCA TGGAAAAATT TGAATACACT GTGCTGGGCA 
ATAGGCTCCA TCAGTGGGGC GATGCACGAG GAGGATGAGA AGCGGTTCCT TGTCACTGTT 
ATCAAGGACC TCTTAGGATT ATGTGAGCAG AAGAGAGGCA AGGATAATAA AGCCATCATT 
GCATCGAATA TCATGTACAT AGTAGGCCAG TACCCACGGT TTCTGAGAGC ACACTGGAAA 
TTTTTGAAGA CAGTAGTAAA CAAGCTTTTC GAATTCATGC ATGAAACCCA TGATGGAGTC 
CAGGACATGG CTTGTGACAC ATTTATTAAA ATAGCTCAAA AATGCCGTAG ACATTTTGTT 
CAGGTTCAAG TTGGAGAAGT AATGCCGTTT ATTGATGAGA TTTTAAACAA CATAAATACT 
ATAATTTGTG ATCTTCAGCC TCAGCAGGTT CATACCTTTT ATGAAGCAGT GGGGTACATG 
ATTGGTGCAC AGACAGACCA GACAGTTCAA GAGCATTTGA TAGAAAAATA CATGCTACTC 
CCTAATCAAG TATGGGACAG TATAATTCAA CAGGCAACCA AAAATGTGGA TATCCTGAAA 
GACCCCGAGA CAGTCAAGCA GCTGGGGAGC ATACTAAAAA CTAATGTGAG AGCCTGCAAG 
GCTGTTGGCC ACCCCTTTGT GATTCAGCTG GGGAGGATTT ACTTAGACAT GCTCAATGTG 
TACAAGTGCC TCAGTGAAAA CATTTCTGCA GCCATTCAAG CTAACGGTGA GATGGTTACA 
AAGCAACCAC TGATTAGAAG TATGCGAACA GTAAAAAGGG AAACTTTAAA GTTAATATCT 
GGTTGGGTGA GCCGTTCCAA TGATCCTCAG ATGGTAGCTG AAAACTTTGT TCCTCCTCTG 
TTGGATGCGG TTCTTATTGA TTACCAGAGA AATGTTCCAG CTGCTAGAGA GCCAGAAGTG 
CTCAGTACTA TGGCCATTAT TGTCAACAAG CTCGGTGGAC ATATAACAGC TGAAATACCT 
CAGATTTTTG ATGCAGTTTT TGAGTGCACA TTGAATATGA TAAATAAGGA TTTTGAAGAG 
TATCCAGAAC ACAGAACCAA CTTTTTCTTG TTACTTCAAG CTGTCAATTC TCACTGTTTC 
CCAGCATTCC TTGCTATTCC ACCTGCCCAG TTCAAGCTTG TTTTGGATTC TATTATTTGG 
GCTTTTAAAC ATACTATGAG GAATGTCGCA GATACAGGCT TACAGATACT TTTTACACTT 
TTACAAAATG TTGCACAAGA AGAAGCTGCA GCGCAGAGTT TTTACCAAAC GTACTTTTGT 
GACATTCTTC AGCATATCTT TTCTGTTGTG ACAGACACCT CACATACTGC GGGTCTAACA 
ATGCATGCAT CAATTCTCGC ATATATGTTT AATTTGGTTG AAGAAGGAAA GATAAGCACA 
CCGCTAAATC CCGGAAGTCC AGTTAGCAAC CAGATGTTTA TTCAAGACTA CGTGGCTAAT 
CTCCTTAAGT CTGCGTTCCC TCACCTACAA GATGCTCAAG TAAAGCTCTT TGTGACAGGA 
CTTTTCAGCT TAAATCAAGA TATTCCTGCT TTCAAAGAAC ATCTAAGGGA TTTCTTAGTT 
CAAATAAAGG AGTTTGCAGG TGAAGACACA TCGGATCTAT TTTTGGAAGA GAGAGAAACA 
GCTCTTCGAC AGGCTCAGGA GGAGAAACAT AAACTTCAAA TGTCTGTACC TGGAATCCTT 
AACCCACATG AAATCCCAGA AGAAATGTGT GACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Xpo1 ( XM_006251578.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006251640.1 Rattus norvegicus exportin 1 (Xpo1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa13770
Clone ID Related Accession (Same CDS sequence)	XM_006251578.3 , NM_053490.1
Accession Version	XM_006251578.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3216bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	exportin-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006251578.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCAGCAA TTATGACAAT GTTAGCAGAC CATGCAGCCC GTCAGCTGCT TGACTTCAGC 
CAGAAGCTGG ATATCAACCT TTTAGACAAT GTGGTGAACT GCTTGTACCA CGGGGAAGGA 
GCCCAGCAGA GAATGGCTCA AGAAGTACTG ACACATCTAA AGGAGCATCC TGATGCCTGG 
ACGCGCGTCG ACACCATTTT GGAGTTTTCG CAGAACATGA ACACAAAATA CTATGGACTA 
CAGATTTTGG AAAATGTGAT CAAAACAAGG TGGAAGATCC TTCCAAGGAA CCAGTGTGAA 
GGAATAAAAA AATACGTTGT TGGTCTCATC ATCAAGACAT CCTCTGACCC AACTTGTGTA 
GAGAAAGAAA AGGTGTATAT TGGGAAGTTG AATATGATTC TTGTTCAGAT ACTTAAGCAA 
GAGTGGCCCA AACATTGGCC AACTTTTATC AGTGACATTG TTGGAGCAAG TAGGACCAGT 
GAAAGCCTAT GTCAAAATAA TATGGTGATT CTTAAACTCT TGAGTGAAGA AGTGTTTGAT 
TTCTCTAGTG GACAGATAAC CCAAGTTAAA GCCAAGCATT TAAAAGACAG CATGTGCAAT 
GAGTTTTCAC AAATATTCCA GCTTTGCCAG TTTGTGATGG AAAACTCCCA GAATGCTCCC 
CTTGTACATG CTACATTAGA AACGCTGCTG AGATTTCTGA ACTGGATTCC CCTGGGATAC 
ATCTTCGAGA CTAAGTTAAT CAGCACCTTG ATTTACAAGT TCCTGAATGT TCCGATGTTC 
CGAAACGTGT CTCTAAAGTG CCTCACGGAG ATTGCTGGTG TGAGTGTGAG CCAGTATGAG 
GAGCAGTTTG AAACTCTGTT TACACTTACA ATGATGCAGC TAAAACAGAT GCTTCCTTTA 
AACACTAATA TCCGACTTGC ATATTCGAAT GGGAAAGATG ATGAACAGAA CTTTATTCAA 
AATCTCAGTC TGTTTCTCTG CACCTTCCTA AAGGAGCATG GTCAACTTCT AGAGAAAAGG 
CTGAATCTCA GGGAAGCACT CATGGAGGCT CTTCATTACA TGTTGTTGGT GTCTGAAGTG 
GAAGAAACTG AAATTTTTAA AATCTGTCTT GAGTACTGGA ATCACTTGGC AGCTGAGCTC 
TACAGAGAGA GTCCATTTTC TACATCTGCT TCTCCATTGT TATCTGGAAG TCAGCACTTT 
GATATTCCTC CTCGGAGACA GCTGTACTTG ACCGTGTTAT CCAAGGTTCG TTTATTGATG 
GTTAGTCGCA TGGCTAAACC AGAGGAGGTA CTGGTTGTAG AAAATGATCA GGGAGAAGTT 
GTAAGAGAGT TCATGAAGGA TACTGATTCC ATAAATTTGT ATAAGAATAT GAGAGAAACA 
TTAGTTTATC TTACCCATCT GGATTATGTA GATACGGAAA TAATAATGAC TAAGAAACTT 
CAAAATCAAG TGAATGGTAC AGAATGGTCA TGGAAAAATT TGAATACACT GTGCTGGGCA 
ATAGGCTCCA TCAGTGGGGC GATGCACGAG GAGGATGAGA AGCGGTTCCT TGTCACTGTT 
ATCAAGGACC TCTTAGGATT ATGTGAGCAG AAGAGAGGCA AGGATAATAA AGCCATCATT 
GCATCGAATA TCATGTACAT AGTAGGCCAG TACCCACGGT TTCTGAGAGC ACACTGGAAA 
TTTTTGAAGA CAGTAGTAAA CAAGCTTTTC GAATTCATGC ATGAAACCCA TGATGGAGTC 
CAGGACATGG CTTGTGACAC ATTTATTAAA ATAGCTCAAA AATGCCGTAG ACATTTTGTT 
CAGGTTCAAG TTGGAGAAGT AATGCCGTTT ATTGATGAGA TTTTAAACAA CATAAATACT 
ATAATTTGTG ATCTTCAGCC TCAGCAGGTT CATACCTTTT ATGAAGCAGT GGGGTACATG 
ATTGGTGCAC AGACAGACCA GACAGTTCAA GAGCATTTGA TAGAAAAATA CATGCTACTC 
CCTAATCAAG TATGGGACAG TATAATTCAA CAGGCAACCA AAAATGTGGA TATCCTGAAA 
GACCCCGAGA CAGTCAAGCA GCTGGGGAGC ATACTAAAAA CTAATGTGAG AGCCTGCAAG 
GCTGTTGGCC ACCCCTTTGT GATTCAGCTG GGGAGGATTT ACTTAGACAT GCTCAATGTG 
TACAAGTGCC TCAGTGAAAA CATTTCTGCA GCCATTCAAG CTAACGGTGA GATGGTTACA 
AAGCAACCAC TGATTAGAAG TATGCGAACA GTAAAAAGGG AAACTTTAAA GTTAATATCT 
GGTTGGGTGA GCCGTTCCAA TGATCCTCAG ATGGTAGCTG AAAACTTTGT TCCTCCTCTG 
TTGGATGCGG TTCTTATTGA TTACCAGAGA AATGTTCCAG CTGCTAGAGA GCCAGAAGTG 
CTCAGTACTA TGGCCATTAT TGTCAACAAG CTCGGTGGAC ATATAACAGC TGAAATACCT 
CAGATTTTTG ATGCAGTTTT TGAGTGCACA TTGAATATGA TAAATAAGGA TTTTGAAGAG 
TATCCAGAAC ACAGAACCAA CTTTTTCTTG TTACTTCAAG CTGTCAATTC TCACTGTTTC 
CCAGCATTCC TTGCTATTCC ACCTGCCCAG TTCAAGCTTG TTTTGGATTC TATTATTTGG 
GCTTTTAAAC ATACTATGAG GAATGTCGCA GATACAGGCT TACAGATACT TTTTACACTT 
TTACAAAATG TTGCACAAGA AGAAGCTGCA GCGCAGAGTT TTTACCAAAC GTACTTTTGT 
GACATTCTTC AGCATATCTT TTCTGTTGTG ACAGACACCT CACATACTGC GGGTCTAACA 
ATGCATGCAT CAATTCTCGC ATATATGTTT AATTTGGTTG AAGAAGGAAA GATAAGCACA 
CCGCTAAATC CCGGAAGTCC AGTTAGCAAC CAGATGTTTA TTCAAGACTA CGTGGCTAAT 
CTCCTTAAGT CTGCGTTCCC TCACCTACAA GATGCTCAAG TAAAGCTCTT TGTGACAGGA 
CTTTTCAGCT TAAATCAAGA TATTCCTGCT TTCAAAGAAC ATCTAAGGGA TTTCTTAGTT 
CAAATAAAGG AGTTTGCAGG TGAAGACACA TCGGATCTAT TTTTGGAAGA GAGAGAAACA 
GCTCTTCGAC AGGCTCAGGA GGAGAAACAT AAACTTCAAA TGTCTGTACC TGGAATCCTT 
AACCCACATG AAATCCCAGA AGAAATGTGT GACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006251640.1
CDS	759..3974
Translation	MPAIMTMLADHAARQLLDFSQKLDINLLDNVVNCLYHGEGAQQRMAQEVLTHLKEHPDAWTRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCEGIKKYVVGLIIKTSSDPTCVEKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNNMVILKLLSEEVFDFSSGQITQVKAKHLKDSMCNEFSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGYIFETKLISTLIYKFLNVPMFRNVSLKCLTEIAGVSVSQYEEQFETLFTLTMMQLKQMLPLNTNIRLAYSNGKDDEQNFIQNLSLFLCTFLKEHGQLLEKRLNLREALMEALHYMLLVSEVEETEIFKICLEYWNHLAAELYRESPFSTSASPLLSGSQHFDIPPRRQLYLTVLSKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYVDTEIIMTKKLQNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKAIIASNIMYIVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFVQVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTVQEHLIEKYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNVYKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDYQRNVPAAREPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFLLLQAVNSHCFPAFLAIPPAQFKLVLDSIIWAFKHTMRNVADTGLQILFTLLQNVAQEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKISTPLNPGSPVSNQMFIQDYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLVQIKEFAGEDTSDLFLEERETALRQAQEEKHKLQMSVPGILNPHEIPEEMCD

Target ORF information:

RefSeq Version	XM_006251578.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus exportin 1 (Xpo1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006251578.3

ORF Insert Sequence:

ATGCCAGCAA TTATGACAAT GTTAGCAGAC CATGCAGCCC GTCAGCTGCT TGACTTCAGC 
CAGAAGCTGG ATATCAACCT TTTAGACAAT GTGGTGAACT GCTTGTACCA CGGGGAAGGA 
GCCCAGCAGA GAATGGCTCA AGAAGTACTG ACACATCTAA AGGAGCATCC TGATGCCTGG 
ACGCGCGTCG ACACCATTTT GGAGTTTTCG CAGAACATGA ACACAAAATA CTATGGACTA 
CAGATTTTGG AAAATGTGAT CAAAACAAGG TGGAAGATCC TTCCAAGGAA CCAGTGTGAA 
GGAATAAAAA AATACGTTGT TGGTCTCATC ATCAAGACAT CCTCTGACCC AACTTGTGTA 
GAGAAAGAAA AGGTGTATAT TGGGAAGTTG AATATGATTC TTGTTCAGAT ACTTAAGCAA 
GAGTGGCCCA AACATTGGCC AACTTTTATC AGTGACATTG TTGGAGCAAG TAGGACCAGT 
GAAAGCCTAT GTCAAAATAA TATGGTGATT CTTAAACTCT TGAGTGAAGA AGTGTTTGAT 
TTCTCTAGTG GACAGATAAC CCAAGTTAAA GCCAAGCATT TAAAAGACAG CATGTGCAAT 
GAGTTTTCAC AAATATTCCA GCTTTGCCAG TTTGTGATGG AAAACTCCCA GAATGCTCCC 
CTTGTACATG CTACATTAGA AACGCTGCTG AGATTTCTGA ACTGGATTCC CCTGGGATAC 
ATCTTCGAGA CTAAGTTAAT CAGCACCTTG ATTTACAAGT TCCTGAATGT TCCGATGTTC 
CGAAACGTGT CTCTAAAGTG CCTCACGGAG ATTGCTGGTG TGAGTGTGAG CCAGTATGAG 
GAGCAGTTTG AAACTCTGTT TACACTTACA ATGATGCAGC TAAAACAGAT GCTTCCTTTA 
AACACTAATA TCCGACTTGC ATATTCGAAT GGGAAAGATG ATGAACAGAA CTTTATTCAA 
AATCTCAGTC TGTTTCTCTG CACCTTCCTA AAGGAGCATG GTCAACTTCT AGAGAAAAGG 
CTGAATCTCA GGGAAGCACT CATGGAGGCT CTTCATTACA TGTTGTTGGT GTCTGAAGTG 
GAAGAAACTG AAATTTTTAA AATCTGTCTT GAGTACTGGA ATCACTTGGC AGCTGAGCTC 
TACAGAGAGA GTCCATTTTC TACATCTGCT TCTCCATTGT TATCTGGAAG TCAGCACTTT 
GATATTCCTC CTCGGAGACA GCTGTACTTG ACCGTGTTAT CCAAGGTTCG TTTATTGATG 
GTTAGTCGCA TGGCTAAACC AGAGGAGGTA CTGGTTGTAG AAAATGATCA GGGAGAAGTT 
GTAAGAGAGT TCATGAAGGA TACTGATTCC ATAAATTTGT ATAAGAATAT GAGAGAAACA 
TTAGTTTATC TTACCCATCT GGATTATGTA GATACGGAAA TAATAATGAC TAAGAAACTT 
CAAAATCAAG TGAATGGTAC AGAATGGTCA TGGAAAAATT TGAATACACT GTGCTGGGCA 
ATAGGCTCCA TCAGTGGGGC GATGCACGAG GAGGATGAGA AGCGGTTCCT TGTCACTGTT 
ATCAAGGACC TCTTAGGATT ATGTGAGCAG AAGAGAGGCA AGGATAATAA AGCCATCATT 
GCATCGAATA TCATGTACAT AGTAGGCCAG TACCCACGGT TTCTGAGAGC ACACTGGAAA 
TTTTTGAAGA CAGTAGTAAA CAAGCTTTTC GAATTCATGC ATGAAACCCA TGATGGAGTC 
CAGGACATGG CTTGTGACAC ATTTATTAAA ATAGCTCAAA AATGCCGTAG ACATTTTGTT 
CAGGTTCAAG TTGGAGAAGT AATGCCGTTT ATTGATGAGA TTTTAAACAA CATAAATACT 
ATAATTTGTG ATCTTCAGCC TCAGCAGGTT CATACCTTTT ATGAAGCAGT GGGGTACATG 
ATTGGTGCAC AGACAGACCA GACAGTTCAA GAGCATTTGA TAGAAAAATA CATGCTACTC 
CCTAATCAAG TATGGGACAG TATAATTCAA CAGGCAACCA AAAATGTGGA TATCCTGAAA 
GACCCCGAGA CAGTCAAGCA GCTGGGGAGC ATACTAAAAA CTAATGTGAG AGCCTGCAAG 
GCTGTTGGCC ACCCCTTTGT GATTCAGCTG GGGAGGATTT ACTTAGACAT GCTCAATGTG 
TACAAGTGCC TCAGTGAAAA CATTTCTGCA GCCATTCAAG CTAACGGTGA GATGGTTACA 
AAGCAACCAC TGATTAGAAG TATGCGAACA GTAAAAAGGG AAACTTTAAA GTTAATATCT 
GGTTGGGTGA GCCGTTCCAA TGATCCTCAG ATGGTAGCTG AAAACTTTGT TCCTCCTCTG 
TTGGATGCGG TTCTTATTGA TTACCAGAGA AATGTTCCAG CTGCTAGAGA GCCAGAAGTG 
CTCAGTACTA TGGCCATTAT TGTCAACAAG CTCGGTGGAC ATATAACAGC TGAAATACCT 
CAGATTTTTG ATGCAGTTTT TGAGTGCACA TTGAATATGA TAAATAAGGA TTTTGAAGAG 
TATCCAGAAC ACAGAACCAA CTTTTTCTTG TTACTTCAAG CTGTCAATTC TCACTGTTTC 
CCAGCATTCC TTGCTATTCC ACCTGCCCAG TTCAAGCTTG TTTTGGATTC TATTATTTGG 
GCTTTTAAAC ATACTATGAG GAATGTCGCA GATACAGGCT TACAGATACT TTTTACACTT 
TTACAAAATG TTGCACAAGA AGAAGCTGCA GCGCAGAGTT TTTACCAAAC GTACTTTTGT 
GACATTCTTC AGCATATCTT TTCTGTTGTG ACAGACACCT CACATACTGC GGGTCTAACA 
ATGCATGCAT CAATTCTCGC ATATATGTTT AATTTGGTTG AAGAAGGAAA GATAAGCACA 
CCGCTAAATC CCGGAAGTCC AGTTAGCAAC CAGATGTTTA TTCAAGACTA CGTGGCTAAT 
CTCCTTAAGT CTGCGTTCCC TCACCTACAA GATGCTCAAG TAAAGCTCTT TGTGACAGGA 
CTTTTCAGCT TAAATCAAGA TATTCCTGCT TTCAAAGAAC ATCTAAGGGA TTTCTTAGTT 
CAAATAAAGG AGTTTGCAGG TGAAGACACA TCGGATCTAT TTTTGGAAGA GAGAGAAACA 
GCTCTTCGAC AGGCTCAGGA GGAGAAACAT AAACTTCAAA TGTCTGTACC TGGAATCCTT 
AACCCACATG AAATCCCAGA AGAAATGTGT GACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein.
Oncotarget7(17)24339-47(2016 Apr)
Ortega JF,de Conti A,Tryndyak V,Furtado KS,Heidor R,Horst MA,Fernandes LH,Tavares PE,Pogribna M,Shpyleva S,Beland FA,Pogribny IP,Moreno FS

RNA Export through the NPC in Eukaryotes.
Genes6(1)124-49(2015 Mar)
Okamura M,Inose H,Masuda S

Upregulation of CRM1 relates to neuronal apoptosis after traumatic brain injury in adult rats.
Journal of molecular neuroscience : MN51(1)208-18(2013 Sep)
Li A,Zou F,Fu H,Cui G,Yan Y,Wu Q,Gu X

Postage for the messenger: designating routes for nuclear mRNA export.
Trends in cell biology23(8)365-73(2013 Aug)
Natalizio BJ,Wente SR

CRM1 and its ribosome export adaptor NMD3 localize to the nucleolus and affect rRNA synthesis.
Nucleus (Austin, Tex.)4(4)315-25(2013 Jul-Aug)
Bai B,Moore HM,Laiho M

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Xpo1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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