Cxcr3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cxcr3
Entrez Gene ID	84475
Full Name	C-X-C motif chemokine receptor 3
Synonyms	Gpr9
General protein information	Preferred Names C-X-C motif chemokine receptor 3 Names C-X-C chemokine receptor type 3 CXC-R3 CXCR-3 G protein-coupled receptor 9 IP-10 receptor chemokine (C-X-C motif) receptor 3 interferon-inducible protein 10 receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq22
Summary	binds interferon-inducible protein-10 and induces intracellular calcium mobilization; increased expression occurs in response to focal stroke [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053415.1	NP_445867.1	C-X-C chemokine receptor type 3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Cxcr3	NP_034040.1
Danio rerio (zebrafish)	cxcr3.1	NP_001082899.2
Xenopus tropicalis (tropical clawed frog)	LOC100485636	XP_002938579.2
Homo sapiens (human)	CXCR3	NP_001136269.1
Canis lupus familiaris (dog)	CXCR3	NP_001011887.1
	CXCR3	NP_001138512.1
Pan troglodytes (chimpanzee)	CXCR3	XP_001137964.1
Bos taurus (cattle)	CXCR3	NP_001011673.1
Rattus norvegicus (Norway rat)	Cxcr3	NP_445867.1

Gene Ontology
Bibliography

Related articles in PubMed

CXCL10/IP-10 Neutralization Can Ameliorate Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats.
Lang S, Li L, Wang X, Sun J, Xue X, Xiao Y, Zhang M, Ao T, Wang J
PloS one12(1)e0169100(2017)

CXCL10/CXCR3 signaling mediates inhibitory action by interferon-gamma on CRF-stimulated adrenocorticotropic hormone (ACTH) release.
Horiguchi K, Fujiwara K, Tsukada T, Yoshida S, Higuchi M, Tateno K, Hasegawa R, Takigami S, Ohsako S, Yashiro T, Kato T, Kato Y
Cell and tissue research364(2)395-404(2016 05)

The CXCL10/CXCR3 axis promotes cardiac microvascular endothelial cell migration via the p38/FAK pathway in a proliferation-independent manner.
Xia JB, Mao CZ, Chen ZY, Liu GH, Wu HY, Zhou DC, Park KS, Zhao H, Kim SK, Cai DQ, Qi XF
Experimental and molecular pathology100(2)257-65(2016 Apr)

Activation of spinal chemokine receptor CXCR3 mediates bone cancer pain through an Akt-ERK crosstalk pathway in rats.
Guan XH, Fu QC, Shi D, Bu HL, Song ZP, Xiong BR, Shu B, Xiang HB, Xu B, Manyande A, Cao F, Tian YK
Experimental neurology26339-49(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

chemokine CXCL10 promotes the development of experimental acute respiratory distress syndrome by binding to its receptor CXCR3
Title: CXCL10/IP-10 Neutralization Can Ameliorate Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats.

the present study leads to an assumption that CXCL10/CXCR3 signaling mediates inhibition of the corticotropin-releasing factor-stimulated adrenocorticotropin-release by interferon-gamma.
Title: CXCL10/CXCR3 signaling mediates inhibitory action by interferon-gamma on CRF-stimulated adrenocorticotropic hormone (ACTH) release.

Dats show that CXCL10 chemokine treatment promoted the activation of p38 MAPK pathway through CXCR3 receptor signaling, thereby up-regulating focal adhesion kinase (FAK) activation and promoted cardiac microvascular endothelial cell migration.
Title: The CXCL10/CXCR3 axis promotes cardiac microvascular endothelial cell migration via the p38/FAK pathway in a proliferation-independent manner.

Our results demonstrated that the activation of spinal chemokine receptor CXCR3 mediated bone cancer pain through Akt and ERK 1/2 kinase
Title: Activation of spinal chemokine receptor CXCR3 mediates bone cancer pain through an Akt-ERK crosstalk pathway in rats.

The chemokine CXCL12, its truncated form SDF-1(5-67), and the receptors CXCR4 and CXCR3 are expressed in human glaucomatous trabecular tissue and a human trabecular cell line.
Title: CXCR3 antagonism of SDF-1(5-67) restores trabecular function and prevents retinal neurodegeneration in a rat model of ocular hypertension.

The following Cxcr3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cxcr3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09487	NM_053415.1 Latest version!	Rattus norvegicus C-X-C motif chemokine receptor 3 (Cxcr3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cxcr3 ( NM_053415.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445867.1 Rattus norvegicus C-X-C motif chemokine receptor 3 (Cxcr3), mRNA.

Price & Availability↑

CloneID	ORa09487
Clone ID Related Accession (Same CDS sequence)	NM_053415.1
Accession Version	NM_053415.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	C-X-C chemokine receptor type 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF223642.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF223642.1, FQ125480.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689596 [ECO:0000348] ##Evidence-Data-END##

ATGTACCTTG AGGTCAGTGA ACGTCAAGTG CTAGATGCCT CGGACATTGC CTTTCTTCTG 
GAAAACAGCA CATCTCCCTA CGATTATGGG GAAAACGAAA GCGACTTCTC TGACTCCCCG 
CCCTGCCCAC AGGACTTCAG CCTGAACTTT GACAGAACCT TCCTGCCAGT CCTCTACAGC 
CTCCTCTTTT TGCTGGGGCT GCTAGGCAAT GGGGCAGTGG CTGCTGTGCT ACTGAGCCAG 
CGCACTGCCC TGAGCAGCAC AGACACCTTC CTGCTCCACC TGGCTGTGGC CGATGTACTG 
CTGGTACTAA CCCTCCCACT GTGGGCAGTA GATGCTGCTG CCCAGTGGGT TTTCGGCTCT 
GGTCTCTGCA AAGTGGCAGG TGCCCTGTTC AACATCAACT TCTACGCAGG GGCCTTCCTG 
CTGGCCTGTA TAAGCTTTGA CCGCTACCTG AGCATAGTGC ATGCCACCCA GATCTACCGC 
AGGGACCCCT GGGTACGTGT AGCCCTCACC TGCATTGTTG TGTGGGGTCT CTGTGTGCTC 
TTTGCCCTCC CAGATTTCAT CTTCCTGTCA GCCAGCCATG ATCAGCGCCT CAATGCCACC 
CATTGCCAGT ACAACTTCCC ACAGGTGGGT CGGACTGCTC TGCGTGTACT GCAGCTAGTG 
GCTGGTTTCC TGATGCCCCT TCTAGTCATG GCCTACTGCT ATGCCCATAT CCTGGCTGTG 
CTGCTGGTCT CCAGAGGCCA GAGGCGCTTT CGAGCTATGA GGCTAGTGGT GGTGGTGGTG 
GTGGCCTTTG CCGTCTGCTG GACCCCCTAT CACCTGGTGG TGTTAGTGGA TATCCTTATG 
GACGTGGGAG TTTTGGCCCG CAACTGTGGT CGAGAAAGCC ATGTGGACGT AGCCAAGTCA 
GTCACCTCAG GCATGGGCTA CATGCACTGC TGCCTCAATC CACTGCTCTA TGCCTTTGTG 
GGAGTGAAGT TCAAAGAACA AATGTGGATG TTGCTCATGC GCCTGGGCCG CTCTGACCAG 
AGAGGACCGC AGCGGCAGCC TTCATCTTCA CGGAGAGAAT CATCCTGGTC TGAGACAACT 
GAGGCCTCCT ACTTGGGCTT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445867.1
CDS	149..1252
Translation	MYLEVSERQVLDASDIAFLLENSTSPYDYGENESDFSDSPPCPQDFSLNFDRTFLPVLYSLLFLLGLLGNGAVAAVLLSQRTALSSTDTFLLHLAVADVLLVLTLPLWAVDAAAQWVFGSGLCKVAGALFNINFYAGAFLLACISFDRYLSIVHATQIYRRDPWVRVALTCIVVWGLCVLFALPDFIFLSASHDQRLNATHCQYNFPQVGRTALRVLQLVAGFLMPLLVMAYCYAHILAVLLVSRGQRRFRAMRLVVVVVVAFAVCWTPYHLVVLVDILMDVGVLARNCGRESHVDVAKSVTSGMGYMHCCLNPLLYAFVGVKFKEQMWMLLMRLGRSDQRGPQRQPSSSRRESSWSETTEASYLGL

Target ORF information:

RefSeq Version	NM_053415.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-X-C motif chemokine receptor 3 (Cxcr3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053415.1

ORF Insert Sequence:

ATGTACCTTG AGGTCAGTGA ACGTCAAGTG CTAGATGCCT CGGACATTGC CTTTCTTCTG 
GAAAACAGCA CATCTCCCTA CGATTATGGG GAAAACGAAA GCGACTTCTC TGACTCCCCG 
CCCTGCCCAC AGGACTTCAG CCTGAACTTT GACAGAACCT TCCTGCCAGT CCTCTACAGC 
CTCCTCTTTT TGCTGGGGCT GCTAGGCAAT GGGGCAGTGG CTGCTGTGCT ACTGAGCCAG 
CGCACTGCCC TGAGCAGCAC AGACACCTTC CTGCTCCACC TGGCTGTGGC CGATGTACTG 
CTGGTACTAA CCCTCCCACT GTGGGCAGTA GATGCTGCTG CCCAGTGGGT TTTCGGCTCT 
GGTCTCTGCA AAGTGGCAGG TGCCCTGTTC AACATCAACT TCTACGCAGG GGCCTTCCTG 
CTGGCCTGTA TAAGCTTTGA CCGCTACCTG AGCATAGTGC ATGCCACCCA GATCTACCGC 
AGGGACCCCT GGGTACGTGT AGCCCTCACC TGCATTGTTG TGTGGGGTCT CTGTGTGCTC 
TTTGCCCTCC CAGATTTCAT CTTCCTGTCA GCCAGCCATG ATCAGCGCCT CAATGCCACC 
CATTGCCAGT ACAACTTCCC ACAGGTGGGT CGGACTGCTC TGCGTGTACT GCAGCTAGTG 
GCTGGTTTCC TGATGCCCCT TCTAGTCATG GCCTACTGCT ATGCCCATAT CCTGGCTGTG 
CTGCTGGTCT CCAGAGGCCA GAGGCGCTTT CGAGCTATGA GGCTAGTGGT GGTGGTGGTG 
GTGGCCTTTG CCGTCTGCTG GACCCCCTAT CACCTGGTGG TGTTAGTGGA TATCCTTATG 
GACGTGGGAG TTTTGGCCCG CAACTGTGGT CGAGAAAGCC ATGTGGACGT AGCCAAGTCA 
GTCACCTCAG GCATGGGCTA CATGCACTGC TGCCTCAATC CACTGCTCTA TGCCTTTGTG 
GGAGTGAAGT TCAAAGAACA AATGTGGATG TTGCTCATGC GCCTGGGCCG CTCTGACCAG 
AGAGGACCGC AGCGGCAGCC TTCATCTTCA CGGAGAGAAT CATCCTGGTC TGAGACAACT 
GAGGCCTCCT ACTTGGGCTT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CXCL10/IP-10 Neutralization Can Ameliorate Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats.
PloS one12(1)e0169100(2017)
Lang S,Li L,Wang X,Sun J,Xue X,Xiao Y,Zhang M,Ao T,Wang J

CXCL10/CXCR3 signaling mediates inhibitory action by interferon-gamma on CRF-stimulated adrenocorticotropic hormone (ACTH) release.
Cell and tissue research364(2)395-404(2016 05)
Horiguchi K,Fujiwara K,Tsukada T,Yoshida S,Higuchi M,Tateno K,Hasegawa R,Takigami S,Ohsako S,Yashiro T,Kato T,Kato Y

The CXCL10/CXCR3 axis promotes cardiac microvascular endothelial cell migration via the p38/FAK pathway in a proliferation-independent manner.
Experimental and molecular pathology100(2)257-65(2016 Apr)
Xia JB,Mao CZ,Chen ZY,Liu GH,Wu HY,Zhou DC,Park KS,Zhao H,Kim SK,Cai DQ,Qi XF

Activation of spinal chemokine receptor CXCR3 mediates bone cancer pain through an Akt-ERK crosstalk pathway in rats.
Experimental neurology26339-49(2015 Jan)
Guan XH,Fu QC,Shi D,Bu HL,Song ZP,Xiong BR,Shu B,Xiang HB,Xu B,Manyande A,Cao F,Tian YK

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Cxcr3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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