Pon1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pon1
Entrez Gene ID	84024
Full Name	paraoxonase 1
General protein information	Preferred Names paraoxonase 1 Names serum paraoxonase/arylesterase 1 A-esterase 1 PON 1 aromatic esterase 1 serum aryldialkylphosphatase 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q13
Summary	may protect LDL and HDL from oxidation and provide protection against atherosclerosis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_032077.1	NP_114466.1	serum paraoxonase/arylesterase 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PON1	XP_519211.2
Rattus norvegicus (Norway rat)	Pon1	NP_114466.1
	PON1	XP_001095992.1
Canis lupus familiaris (dog)	PON1	XP_850219.1
Bos taurus (cattle)	PON1	NP_001039734.1
Mus musculus (house mouse)	Pon1	NP_035264.2
Homo sapiens (human)	PON1	NP_000437.3

Gene Ontology
Bibliography

Related articles in PubMed

Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia.
Mero?o T, Dauteuille C, Tetzlaff W, Mart?n M, Botta E, Lhomme M, Saez MS, Sorroche P, Boero L, Arbelbide J, Chapman MJ, Kontush A, Brites F
Clinical nutrition (Edinburgh, Scotland)36(2)552-558(2017 Apr)

Involvement of xanthine oxidase and paraoxonase 1 in the process of oxidative stress in nonalcoholic fatty liver disease.
Wang B, Yang RN, Zhu YR, Xing JC, Lou XW, He YJ, Ding QL, Zhang MY, Qiu H
Molecular medicine reports15(1)387-395(2017 Jan)

18?-Glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2/ARE/HO-1 pathway and endogenous antioxidants.
Abd El-Twab SM, Hozayen WG, Hussein OE, Mahmoud AM
Renal failure38(9)1516-1527(2016 Oct)

A?ai (Euterpe oleracea Mart.) Upregulates Paraoxonase 1 Gene Expression and Activity with Concomitant Reduction of Hepatic Steatosis in High-Fat Diet-Fed Rats.
Pereira RR, de Abreu IC, Guerra JF, Lage NN, Lopes JM, Silva M, de Lima WG, Silva ME, Pedrosa ML
Oxidative medicine and cellular longevity20168379105(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Compared with the rats in the control group, the serum activity of xanthine oxidase was significantly higher and that of PON1 was significantly lower in the rats in the model nonalcoholic fatty liver disease group (P<0.01).
Title: Involvement of xanthine oxidase and paraoxonase 1 in the process of oxidative stress in nonalcoholic fatty liver disease.

18beta-GA has a protective effect on MTX-induced nephrotoxicity with possible mechanisms of attenuating oxidative stress and inflammation through up-regulating the Nrf2/ARE signaling
Title: 18?-Glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2/ARE/HO-1 pathway and endogenous antioxidants.

Acai extract increased serum PON1 activity and reduced hepatic steatosis and hepatic injury in rats fed a high fat diet.
Title: A?ai (Euterpe oleracea Mart.) Upregulates Paraoxonase 1 Gene Expression and Activity with Concomitant Reduction of Hepatic Steatosis in High-Fat Diet-Fed Rats.

investigated the changes in plasma PON1 activity, LDL oxidation, radical scavenging activity and lipid peroxidation in D-galactose-induced aging model and also compared the results with 24-month naturally aged rats
Title: Plasma paraoxonase 1 arylesterase activity in D-galactose-induced aged rat model: correlation with LDL oxidation and redox status.

High omega-3 PUFA and ethanol decreased liver PON1 mRNA expression. Betaine restored liver PON1 mRNA expressions in low and high omega-3 PUFA ETOH groups.
Title: Betaine protects chronic alcohol and omega-3 PUFA-mediated down-regulations of PON1 gene, serum PON1 and homocysteine thiolactonase activities with restoration of liver GSH.

The following Pon1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pon1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08993	NM_032077.1 Latest version!	Rattus norvegicus paraoxonase 1 (Pon1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pon1 ( NM_032077.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_114466.1 Rattus norvegicus paraoxonase 1 (Pon1), mRNA.

Price & Availability↑

CloneID	ORa08993
Clone ID Related Accession (Same CDS sequence)	NM_032077.1
Accession Version	NM_032077.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1068bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	serum paraoxonase/arylesterase 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CO570909.1, U94856.1 and CO562983.1. On Oct 22, 2004 this sequence version replaced XM_342639.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC091403.1, FQ209429.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906357 [ECO:0000348] ##Evidence-Data-END##

ATGGCGAAAC TGCTAGGGCT CACCCTCGTG GGACTGGTGT TGGCACTTTA CAAGAACCAT 
CGGTCTTCCT ATCAAACAAG ATTAAATGCT TTCCGTGAAG TAACACCGGT AGATCTTCCT 
AACTGTACTT TAGTTAAAGG AATCGAAGCG GGTGCTGAAG ACTTAGAGAT TCTGCCTAAT 
GGACTAACTT TCTTTAGCAC AGGGTTAAAG TATCCTGGAA TAAAAAGTTT CGATCCCAGT 
AAGCCTGGAA AAATACTTCT GATGGACTTG AATGAGAAGG AGCCAGCAGT GTCAGAATTA 
GCAATTATGG GAAATACGTT GGATATGTCT TCATTTAACC CTCATGGGAT TAGCACATTC 
ATAGATGAAG ATAACACTGT GTACCTACTG GTGGTAAGCC ACCCAGACTC CTCGTCCACC 
GTGGAGGTGT TTAAATTTCA AGAAGAGGAA AGATCACTTT TGCATCTGAA AACCATCACC 
CATGAACTTC TGCCTAGCAT CAACGATATA GCTGCTGTTG GACCTGAGAG CTTCTATGCC 
ACAAATGATC ACTATTTTGC TGACCCATAC TTACGGTCCT GGGAAATGTA CTTGGGCCTG 
TCATGGTCCA ATGTTGTATA CTACAGTCCA GATAAAGTCC GAGTGGTAGC AGATGGATTT 
GATTTCGCTA ATGGCATTGG CATTTCCCTT GATGGCAAGT ATGTCTATAT CGCTGAATTG 
CTGGCTCACA AGATTCACGT GTATGAAAAG CATGCTAATT GGACTTTAAC GCCATTGAAG 
GTCCTCAGCT TTGACACCCT TGTGGATAAC ATCTCTGTGG ATCCTGTGAC AGGGGACCTC 
TGGGTTGGAT GCCATCCCAA TGGGATGAGG ATTTTTTTCT ATGACTCGGA GAATCCTCCT 
GGCTCAGAGG TGCTTCGGAT CCAGAGCATT TTATCCGAAG ACCCCAAAGT AACTGTAGTT 
TATGCAGAGA ATGGCACGGT GTTGCAAGGT ACGACAGTCG CTGCTGTGTA CAAAGGAAAA 
CTGCTGATTG GAACGGTGTT CCACAGAGCT CTTTGTTGTG ACCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114466.1
CDS	13..1080
Translation	MAKLLGLTLVGLVLALYKNHRSSYQTRLNAFREVTPVDLPNCTLVKGIEAGAEDLEILPNGLTFFSTGLKYPGIKSFDPSKPGKILLMDLNEKEPAVSELAIMGNTLDMSSFNPHGISTFIDEDNTVYLLVVSHPDSSSTVEVFKFQEEERSLLHLKTITHELLPSINDIAAVGPESFYATNDHYFADPYLRSWEMYLGLSWSNVVYYSPDKVRVVADGFDFANGIGISLDGKYVYIAELLAHKIHVYEKHANWTLTPLKVLSFDTLVDNISVDPVTGDLWVGCHPNGMRIFFYDSENPPGSEVLRIQSILSEDPKVTVVYAENGTVLQGTTVAAVYKGKLLIGTVFHRALCCDL

Target ORF information:

RefSeq Version	NM_032077.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus paraoxonase 1 (Pon1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032077.1

ORF Insert Sequence:

ATGGCGAAAC TGCTAGGGCT CACCCTCGTG GGACTGGTGT TGGCACTTTA CAAGAACCAT 
CGGTCTTCCT ATCAAACAAG ATTAAATGCT TTCCGTGAAG TAACACCGGT AGATCTTCCT 
AACTGTACTT TAGTTAAAGG AATCGAAGCG GGTGCTGAAG ACTTAGAGAT TCTGCCTAAT 
GGACTAACTT TCTTTAGCAC AGGGTTAAAG TATCCTGGAA TAAAAAGTTT CGATCCCAGT 
AAGCCTGGAA AAATACTTCT GATGGACTTG AATGAGAAGG AGCCAGCAGT GTCAGAATTA 
GCAATTATGG GAAATACGTT GGATATGTCT TCATTTAACC CTCATGGGAT TAGCACATTC 
ATAGATGAAG ATAACACTGT GTACCTACTG GTGGTAAGCC ACCCAGACTC CTCGTCCACC 
GTGGAGGTGT TTAAATTTCA AGAAGAGGAA AGATCACTTT TGCATCTGAA AACCATCACC 
CATGAACTTC TGCCTAGCAT CAACGATATA GCTGCTGTTG GACCTGAGAG CTTCTATGCC 
ACAAATGATC ACTATTTTGC TGACCCATAC TTACGGTCCT GGGAAATGTA CTTGGGCCTG 
TCATGGTCCA ATGTTGTATA CTACAGTCCA GATAAAGTCC GAGTGGTAGC AGATGGATTT 
GATTTCGCTA ATGGCATTGG CATTTCCCTT GATGGCAAGT ATGTCTATAT CGCTGAATTG 
CTGGCTCACA AGATTCACGT GTATGAAAAG CATGCTAATT GGACTTTAAC GCCATTGAAG 
GTCCTCAGCT TTGACACCCT TGTGGATAAC ATCTCTGTGG ATCCTGTGAC AGGGGACCTC 
TGGGTTGGAT GCCATCCCAA TGGGATGAGG ATTTTTTTCT ATGACTCGGA GAATCCTCCT 
GGCTCAGAGG TGCTTCGGAT CCAGAGCATT TTATCCGAAG ACCCCAAAGT AACTGTAGTT 
TATGCAGAGA ATGGCACGGT GTTGCAAGGT ACGACAGTCG CTGCTGTGTA CAAAGGAAAA 
CTGCTGATTG GAACGGTGTT CCACAGAGCT CTTTGTTGTG ACCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Oxidative stress, HDL functionality and effects of intravenous iron administration in women with iron deficiency anemia.
Clinical nutrition (Edinburgh, Scotland)36(2)552-558(2017 Apr)
Mero?o T,Dauteuille C,Tetzlaff W,Mart?n M,Botta E,Lhomme M,Saez MS,Sorroche P,Boero L,Arbelbide J,Chapman MJ,Kontush A,Brites F

Involvement of xanthine oxidase and paraoxonase 1 in the process of oxidative stress in nonalcoholic fatty liver disease.
Molecular medicine reports15(1)387-395(2017 Jan)
Wang B,Yang RN,Zhu YR,Xing JC,Lou XW,He YJ,Ding QL,Zhang MY,Qiu H

18?-Glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2/ARE/HO-1 pathway and endogenous antioxidants.
Renal failure38(9)1516-1527(2016 Oct)
Abd El-Twab SM,Hozayen WG,Hussein OE,Mahmoud AM

A?ai (Euterpe oleracea Mart.) Upregulates Paraoxonase 1 Gene Expression and Activity with Concomitant Reduction of Hepatic Steatosis in High-Fat Diet-Fed Rats.
Oxidative medicine and cellular longevity20168379105(2016)
Pereira RR,de Abreu IC,Guerra JF,Lage NN,Lopes JM,Silva M,de Lima WG,Silva ME,Pedrosa ML

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Pon1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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