PON1 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	PON1
Entrez Gene ID	523798
Full Name	paraoxonase 1
General protein information	Preferred Names paraoxonase 1 Names serum paraoxonase/arylesterase 1
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001046269.2	NP_001039734.1	serum paraoxonase/arylesterase 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PON1	XP_519211.2
Rattus norvegicus (Norway rat)	Pon1	NP_114466.1
	PON1	XP_001095992.1
Canis lupus familiaris (dog)	PON1	XP_850219.1
Bos taurus (cattle)	PON1	NP_001039734.1
Mus musculus (house mouse)	Pon1	NP_035264.2
Homo sapiens (human)	PON1	NP_000437.3

Gene Ontology
Bibliography

Related articles in PubMed

Effect of serum paraoxonase-1 (PON1) activity on follicular development and pregnancy rate in cattle.
Castro NA, Pfeifer LFM, Andrade JS, Rinc?n JAA, Pegoraro LMC, Schneider A
Animal reproduction science188130-136(2018 Jan)

Expression of paraoxonase types 1, 2 and 3 in reproductive tissues and activity of paraoxonase type 1 in the serum and seminal plasma of bulls.
Ferreira CER, Haas CS, Goularte KL, Rovani MT, Cardoso FF, Schneider A, Gasperin BG, Lucia T Jr
Andrologia(2017 Nov)

Serum paraoxonase 1 (PON1) activity and lipid metabolism parameters changes in different production cycle periods of Holstein-Friesian, Polish Red and Norwegian breeds.
Kulka M, Ko?odziejska-Lesisz J, Kluci?ski W
Polish journal of veterinary sciences19(1)165-73(2016)

Characterization of single nucleotide polymorphisms in the promoter region of the bovine paraoxonase 1 (PON1) gene affecting serum enzyme activity in dairy cows.
Silveira PA, Schwegler E, Montagner P, Krause AR, Acosta DA, Halfen J, Garlet T, Barros CC, Corr?a MN, Schneider A
Veterinary journal (London, England : 1997)205(1)101-3(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results suggest that PON1 might be a better parameter for minimal redox state changes in serum, shortly after labour in the examined breeds.
Title: Serum paraoxonase 1 (PON1) activity and lipid metabolism parameters changes in different production cycle periods of Holstein-Friesian, Polish Red and Norwegian breeds.

characterization the SNPs in the promoter region of the bovine PON1 gene, and to evaluation of association with serum PON1 activity in periparturient Holstein cows
Title: Characterization of single nucleotide polymorphisms in the promoter region of the bovine paraoxonase 1 (PON1) gene affecting serum enzyme activity in dairy cows.

Data indicate that Cu(2+), Mn(2+), Zn(2+), Ni(2+), and Pb(2+) were found to inhibite the paraoxonase 1 (PON1) enzyme activity in a concentration-dependent fashion.
Title: Purification of Holstein bull semen paraoxonase 1 (PON1) by hydrophobic interaction chromatography and investigation of its inhibition kinetics by heavy metals.

The results indicate that lower serum paraoxonase activity and higher concentration of uric acid are associated with oxidative character of transition period and lipid functional antioxidative protection during intensive milk production.
Title: Serum paraoxonase-1 activity of dairy Holstein-Fresian cows in different lactation stages--preliminary study.

The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1, 2 and 3 in granulosa cells and PON1 activity in follicular fluid and plasma of dairy cows.
Title: Paraoxonase (PON) 1, 2 and 3 expression in granulosa cells and PON1 activity in follicular fluid of dairy cows.

The following PON1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PON1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa01526	NM_001046269.2 Latest version!	Bos taurus paraoxonase 1 (PON1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PON1 ( NM_001046269.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001039734.1 Bos taurus paraoxonase 1 (PON1), mRNA.

Price & Availability↑

CloneID	OBa01526
Clone ID Related Accession (Same CDS sequence)	NM_001046269.2
Accession Version	NM_001046269.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1068bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-26
Organism	Bos taurus(cattle)
Product	serum paraoxonase/arylesterase 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC112488.1. On Aug 31, 2012 this sequence version replaced NM_001046269.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC112488.1, EU289337.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN03145416, SAMN03145418 [ECO:0000350] ##Evidence-Data-END##

ATGGCGAAGC TGTTGGTGCT CACCCTCTTG GGACTGGGGC TGGCATTCTT CAGGGATTAC 
CGGTCTTCTT ATCTAGCAAG AATGAACGCT TCCCGAGAAG TAAAATCGGT AGAACTTCCT 
AACTGTAAAT TAATAAAAGG AATAGAAACT GGTGCTGAAG ACCTGGAGAT ACTTCCTAAT 
GGACTCGCTT TCATTAGTTC CGGATTACGA TATCCTGGAG TAAAAAGCTT TGAACCTGAT 
AAGCCTGGAA AAATACTGCT GATGGACCTG AACAAAGAGG ATCCTACAGT GTTGGAATTG 
AAGATGACTG GAAGTAACTT TGATGCGTCT TCATTTAACC CTCACGGCAT TAGCACATTC 
ACAGATGAAG ATAATACTGT GTACCTGCTG GTGGTGAGCC ATCCAGACGT TAAGTCCACG 
GTTGAGTTGT TTAAATTTCA AGAAGAAGAA AAGTCACTTT TGCATCTGAA AACCATCAAA 
CATGAACTTC TGCCTAATTT GAATGACCTT GTCGCTGTGG GCCGTGAACA CTTCTATGCC 
ACCAATGACC ACTATTTTGT TGACCAGTAC ATGAGATCCT GGGAATTATA TTTGGGTCTA 
GCATGGTCAA ATGTTGTTTA CTACAGTCCA GATGACGTTC GAGTGGTGGC CAGTGGATTT 
GATTTTGCTA ATGGAATCAG CATGTCACCT GACCGCAAGT ATGTCTATAT AGCTGAACTT 
CTGGCTCATA AGATTCATGT GTATGAAAAG CATGCTAATT GGACTTTAAC TCCATTGAAG 
TCTCTGGACT GTGACACACT CGTGGATAAC ATATCTGTGG ATCCTGTGAC AGGGGACCTG 
TGGGTTGGCT GCCACCCCAA TGGCATGAAA ATCTTCTCCT ATGACCCAGA GAATCCTCCT 
GGATCAGAGG TGCTCCAAAT CCAGAATATT TTAGCAGAAG AACCCAAAGT TACGGTGGTT 
TATGCAGAAG ATGGTAAAGT GTTGCATGGA AGTACGGTTG CTTCTGTGTA CAAGGGGAAA 
ATGCTGGTTG GAACTGTGTT CCAGAAAGCT CTTTACTGTG AGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001039734.1
CDS	11..1078
Translation	MAKLLVLTLLGLGLAFFRDYRSSYLARMNASREVKSVELPNCKLIKGIETGAEDLEILPNGLAFISSGLRYPGVKSFEPDKPGKILLMDLNKEDPTVLELKMTGSNFDASSFNPHGISTFTDEDNTVYLLVVSHPDVKSTVELFKFQEEEKSLLHLKTIKHELLPNLNDLVAVGREHFYATNDHYFVDQYMRSWELYLGLAWSNVVYYSPDDVRVVASGFDFANGISMSPDRKYVYIAELLAHKIHVYEKHANWTLTPLKSLDCDTLVDNISVDPVTGDLWVGCHPNGMKIFSYDPENPPGSEVLQIQNILAEEPKVTVVYAEDGKVLHGSTVASVYKGKMLVGTVFQKALYCEF

Target ORF information:

RefSeq Version	NM_001046269.2
Organism	Bos taurus(cattle)
Definition	Bos taurus paraoxonase 1 (PON1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001046269.2

ORF Insert Sequence:

ATGGCGAAGC TGTTGGTGCT CACCCTCTTG GGACTGGGGC TGGCATTCTT CAGGGATTAC 
CGGTCTTCTT ATCTAGCAAG AATGAACGCT TCCCGAGAAG TAAAATCGGT AGAACTTCCT 
AACTGTAAAT TAATAAAAGG AATAGAAACT GGTGCTGAAG ACCTGGAGAT ACTTCCTAAT 
GGACTCGCTT TCATTAGTTC CGGATTACGA TATCCTGGAG TAAAAAGCTT TGAACCTGAT 
AAGCCTGGAA AAATACTGCT GATGGACCTG AACAAAGAGG ATCCTACAGT GTTGGAATTG 
AAGATGACTG GAAGTAACTT TGATGCGTCT TCATTTAACC CTCACGGCAT TAGCACATTC 
ACAGATGAAG ATAATACTGT GTACCTGCTG GTGGTGAGCC ATCCAGACGT TAAGTCCACG 
GTTGAGTTGT TTAAATTTCA AGAAGAAGAA AAGTCACTTT TGCATCTGAA AACCATCAAA 
CATGAACTTC TGCCTAATTT GAATGACCTT GTCGCTGTGG GCCGTGAACA CTTCTATGCC 
ACCAATGACC ACTATTTTGT TGACCAGTAC ATGAGATCCT GGGAATTATA TTTGGGTCTA 
GCATGGTCAA ATGTTGTTTA CTACAGTCCA GATGACGTTC GAGTGGTGGC CAGTGGATTT 
GATTTTGCTA ATGGAATCAG CATGTCACCT GACCGCAAGT ATGTCTATAT AGCTGAACTT 
CTGGCTCATA AGATTCATGT GTATGAAAAG CATGCTAATT GGACTTTAAC TCCATTGAAG 
TCTCTGGACT GTGACACACT CGTGGATAAC ATATCTGTGG ATCCTGTGAC AGGGGACCTG 
TGGGTTGGCT GCCACCCCAA TGGCATGAAA ATCTTCTCCT ATGACCCAGA GAATCCTCCT 
GGATCAGAGG TGCTCCAAAT CCAGAATATT TTAGCAGAAG AACCCAAAGT TACGGTGGTT 
TATGCAGAAG ATGGTAAAGT GTTGCATGGA AGTACGGTTG CTTCTGTGTA CAAGGGGAAA 
ATGCTGGTTG GAACTGTGTT CCAGAAAGCT CTTTACTGTG AGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effect of serum paraoxonase-1 (PON1) activity on follicular development and pregnancy rate in cattle.
Animal reproduction science188130-136(2018 Jan)
Castro NA,Pfeifer LFM,Andrade JS,Rinc?n JAA,Pegoraro LMC,Schneider A

Expression of paraoxonase types 1, 2 and 3 in reproductive tissues and activity of paraoxonase type 1 in the serum and seminal plasma of bulls.
Andrologia(2017 Nov)
Ferreira CER,Haas CS,Goularte KL,Rovani MT,Cardoso FF,Schneider A,Gasperin BG,Lucia T Jr

Serum paraoxonase 1 (PON1) activity and lipid metabolism parameters changes in different production cycle periods of Holstein-Friesian, Polish Red and Norwegian breeds.
Polish journal of veterinary sciences19(1)165-73(2016)
Kulka M,Ko?odziejska-Lesisz J,Kluci?ski W

Characterization of single nucleotide polymorphisms in the promoter region of the bovine paraoxonase 1 (PON1) gene affecting serum enzyme activity in dairy cows.
Veterinary journal (London, England : 1997)205(1)101-3(2015 Jul)
Silveira PA,Schwegler E,Montagner P,Krause AR,Acosta DA,Halfen J,Garlet T,Barros CC,Corr?a MN,Schneider A

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PON1 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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