Ralbp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ralbp1
Entrez Gene ID	84014
Full Name	ralA binding protein 1
Synonyms	RIP1,RLIP76
General protein information	Preferred Names ralA binding protein 1 Names ralA-binding protein 1 DNP-SG ATPase cytocentrin dinitrophenyl S-glutathione ATPase ral-interacting protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q37
Summary	binds the GTP-bound form of Ras-related GTPase RalA; also interacts with Rho family member CDC42 via a specific Rho-GTPase activating domain [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_032067.1	NP_114456.1	ralA-binding protein 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	RALBP1	XP_005224360.1
Danio rerio (zebrafish)	ralbp1	NP_996963.1
Pan troglodytes (chimpanzee)	RALBP1	XP_001138420.1
Homo sapiens (human)	RALBP1	NP_006779.1
	RALBP1	XP_001107087.2
Canis lupus familiaris (dog)	RALBP1	XP_547670.1
Mus musculus (house mouse)	Ralbp1	NP_001185878.1
Rattus norvegicus (Norway rat)	Ralbp1	NP_114456.1
Gallus gallus (chicken)	RALBP1	NP_001026746.1
Xenopus tropicalis (tropical clawed frog)	ralbp1	XP_002937519.1

Gene Ontology
Bibliography

Related articles in PubMed

RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage.
Zhou K, Shi L, Wang Z, Zhou J, Manaenko A, Reis C, Chen S, Zhang J
Experimental neurology295116-124(2017 Sep)

Role for RIP1 in mediating necroptosis in experimental intracerebral hemorrhage model both in vivo and in vitro.
Shen H, Liu C, Zhang D, Yao X, Zhang K, Li H, Chen G
Cell death & disease8(3)e2641(2017 Mar)

Indole-3-Carbinol Induces Apoptosis of Hepatic Stellate Cells through K63 De-Ubiquitination of RIP1 in Rats.
Li B, Cong M, Zhu Y, Xiong Y, Jin W, Wan Y, Zhou Y, Ao Y, Wang H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology41(4)1481-1490(2017)

The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
Simicek M, Lievens S, Laga M, Guzenko D, Aushev VN, Kalev P, Baietti MF, Strelkov SV, Gevaert K, Tavernier J, Sablina AA
Nature cell biology15(10)1220-30(2013 Oct)

Eleostearic acid induces RIP1-mediated atypical apoptosis in a kinase-independent manner via ERK phosphorylation, ROS generation and mitochondrial dysfunction.
Obitsu S, Sakata K, Teshima R, Kondo K
Cell death & disease4e674(2013 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

subarachnoid hemorrhage led to the upregulation of RIP1, RIP3, phosphorylated DRP1 and NLRP3 inflammasome
Title: RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage.

Phosphorylation of RIP1 is the essential molecular mechanism of necroptosis.
Title: Role for RIP1 in mediating necroptosis in experimental intracerebral hemorrhage model both in vivo and in vitro.

These results demonstrated that indole-3-carbinol could induce apoptosis of hepatic stellate cells through RIP1 K63 de-ubiquitination by upregulating deubiquitinase CYLD.
Title: Indole-3-Carbinol Induces Apoptosis of Hepatic Stellate Cells through K63 De-Ubiquitination of RIP1 in Rats.

We propose that NMDAR activation brings RalBP1 close to PSD-95 to promote the interaction of RalBP1-associated endocytic proteins with PSD-95-associated AMPARs.
Title: Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTD.

The following Ralbp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ralbp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08955	NM_032067.1 Latest version!	Rattus norvegicus ralA binding protein 1 (Ralbp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$405.30 $579.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ralbp1 ( NM_032067.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_114456.1 Rattus norvegicus ralA binding protein 1 (Ralbp1), mRNA.

Price & Availability↑

CloneID	ORa08955
Clone ID Related Accession (Same CDS sequence)	NM_032067.1
Accession Version	NM_032067.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2082bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	ralA-binding protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U82623.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U82623.1, U28830.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906350, SAMN01906352 [ECO:0000348] ##Evidence-Data-END##

ATGACTGAGT GCTTCCTGCC CCCCACCAGC AGCCCTAGTG AACACCGCAG GGCCGAGCAC 
GGCAGCGGGC TGACCCGGAC CCCCAGCTCC GAGGAGATCA GCCCTACAAA ATTTCCTGGA 
TTGTACCGGA CGGGTGAGCC TTCACCTCCC CATGACATCC TCCACGAGCC TCCTGATATC 
GTGTCAGATG ATGAGAAAGA CCATGGAAAG AAAAAAGGAA AATTTAAGAA AAAGGAGAAA 
AGGACTGAAG GCTACGCTGC CTTCCAGGAA GACAGCTCTG GAGATGAGGC TGAAAGTCCT 
TCCAAGATGA AGAGGTCCAA GGGCATCCAT GTGTTCAAAA AGCCCAGCTT CTCTAAAAAG 
AAGGAAAAGG ATTTTAAAAT CAAAGAAAAG CCCAAAGAAG AAAAGCACAA AGAAGAAAAG 
CATAAAGAGG AAAAGCATAA AGAAAAGAAA TGTAAAGACT TGACGGCCGC CGATGTTGTT 
AAACAGTGGA AGGAAAAGAA GAAAAAGAAG AAGCCAACTC AGGAGCCAGA GGTGCCTCAG 
ACGGACGCCC CGAGTCTCAG ACCCATTTTC GGCGCTCCCT TGGCTGACGC AGTAGAGAGG 
ACCATGATGT ACGACGGCAT CCGGCTGCCA GCTGTCTTCC GGGAGTGCGT GGACTACATG 
GAGAAGCACG GCATGAAATG TGAAGGCATC TACCGAGTGT CAGGAATCAA ATCAAAGGTA 
GATGAGCTGA AAGCAGCCTA TGACCGAGAG GAGTCTCCAA ACTTGGAAGA ATATGAACCT 
AACACTGTAG CCAGCTTGCT GAAGCAGTAT CTGCGAGACC TTCCCGAGAA TTTGCTTACC 
AAAGAGCTTA TGCCCCGATT TGAAGAGGCT TGTGGGAGGA CCACAGAGGT GGAGAAAGTG 
CAGGAGTTCC AGCGCTTGCT CAGGGAACTG CCGGAGTACA ACCATCTTCT GCTCTCCTGG 
CTCATTGTGC ACATGGACCA CGTCATCGCG AAGGAGCTGG AAACCAAGAT GAACATCCAG 
AACATCTCCA TAGTGCTGAG CCCAACCGTC CAGATCAGCA ACCGGGTCCT GTATGTGCTT 
TTCACACACG TGCAAGAGCT CTTTGGCACC GTGGTCCTGA AGCAAGTAAC GAGACCTCTG 
CGTTGGTCCA ACATGGCCAC AATGCCTACA CTGCCAGAGA CCCAAGCAGG CATCAAGGAA 
GAAATCAGGA GACAGGAGTT CCTTTTGAAC TGTTTACATC GAGATCTGCA GGGCGGGATA 
AAGGACTTGT CTAAAGAAGA AAGATTATGG GAAGTACAGA GGATTCTGAC TGCCCTCAAG 
AGAAAGCTGA GGGAAGCTAA AAGACAAGAG TGTGAGACCA AGATTGCACA GGAGATAGCC 
AGCCTTTCGA AGGAGGATGT TTCCAAAGAA GAAACGAACG AAAACGAGGA GGTCATAAAT 
ATCCTCCTTG CCCAGGAGAA TGAGATCCTG ACTGAGCAGG AGGAGCTCCT GGCCATGGAG 
CAGTTTCTGC GTCGTCAGAT CGCCTCGGAG AAAGAAGAGA TTGACCCCCT CCGAGCTGAG 
ATTGCGGAGA TCCAGAGTCG CCAGCATGGC CGCAGCGAGA CAGAGGAGTA CTCCTCTGAC 
AGCGAGAGCG AGAGCGAGGA TGAGGAGGAG CTGCAGATCA TTCTGGAAGA CTTACAGAGG 
CAGAATGAAG AGTTAGAAAT AAAGAACAAT CACTTGAACC AGGCAGTCCA TGAAGAGCGG 
GAGGCCATCG TTGAGCTCCG AGTGCAGCTC CGGCTGCTCC AGATGCTGCG AGCCAAGTCT 
GAGCAGCAGC TCCAGGAGGA GGAGGAGCCC GAGAGGCGAG GGGGCACAGG CCCACTACCC 
TGTGAAGGTG TCCTCGAGGT GAGAGCAGCC AAGGAGCAGG CGAAGCCTCG CCCAGCAAAG 
ACCGGAAGGA GACGCCCATC TGAACTGCCC CGGCCCTGTG CATCGTACTG TAAGCGAGAG 
TCCGCTGCCT GTCCTGCCAG GCAGCGTTCT GTGAAGGCTC TCAGAGACGC TCGCTCTTGC 
ACACGTCTGA CTCCGTGTCA GGCTCAGGTC CTGGGAGAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114456.1
CDS	120..2201
Translation	MTECFLPPTSSPSEHRRAEHGSGLTRTPSSEEISPTKFPGLYRTGEPSPPHDILHEPPDIVSDDEKDHGKKKGKFKKKEKRTEGYAAFQEDSSGDEAESPSKMKRSKGIHVFKKPSFSKKKEKDFKIKEKPKEEKHKEEKHKEEKHKEKKCKDLTAADVVKQWKEKKKKKKPTQEPEVPQTDAPSLRPIFGAPLADAVERTMMYDGIRLPAVFRECVDYMEKHGMKCEGIYRVSGIKSKVDELKAAYDREESPNLEEYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTEVEKVQEFQRLLRELPEYNHLLLSWLIVHMDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVLFTHVQELFGTVVLKQVTRPLRWSNMATMPTLPETQAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLREAKRQECETKIAQEIASLSKEDVSKEETNENEEVINILLAQENEILTEQEELLAMEQFLRRQIASEKEEIDPLRAEIAEIQSRQHGRSETEEYSSDSESESEDEEELQIILEDLQRQNEELEIKNNHLNQAVHEEREAIVELRVQLRLLQMLRAKSEQQLQEEEEPERRGGTGPLPCEGVLEVRAAKEQAKPRPAKTGRRRPSELPRPCASYCKRESAACPARQRSVKALRDARSCTRLTPCQAQVLGE

Target ORF information:

RefSeq Version	NM_032067.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ralA binding protein 1 (Ralbp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032067.1

ORF Insert Sequence:

ATGACTGAGT GCTTCCTGCC CCCCACCAGC AGCCCTAGTG AACACCGCAG GGCCGAGCAC 
GGCAGCGGGC TGACCCGGAC CCCCAGCTCC GAGGAGATCA GCCCTACAAA ATTTCCTGGA 
TTGTACCGGA CGGGTGAGCC TTCACCTCCC CATGACATCC TCCACGAGCC TCCTGATATC 
GTGTCAGATG ATGAGAAAGA CCATGGAAAG AAAAAAGGAA AATTTAAGAA AAAGGAGAAA 
AGGACTGAAG GCTACGCTGC CTTCCAGGAA GACAGCTCTG GAGATGAGGC TGAAAGTCCT 
TCCAAGATGA AGAGGTCCAA GGGCATCCAT GTGTTCAAAA AGCCCAGCTT CTCTAAAAAG 
AAGGAAAAGG ATTTTAAAAT CAAAGAAAAG CCCAAAGAAG AAAAGCACAA AGAAGAAAAG 
CATAAAGAGG AAAAGCATAA AGAAAAGAAA TGTAAAGACT TGACGGCCGC CGATGTTGTT 
AAACAGTGGA AGGAAAAGAA GAAAAAGAAG AAGCCAACTC AGGAGCCAGA GGTGCCTCAG 
ACGGACGCCC CGAGTCTCAG ACCCATTTTC GGCGCTCCCT TGGCTGACGC AGTAGAGAGG 
ACCATGATGT ACGACGGCAT CCGGCTGCCA GCTGTCTTCC GGGAGTGCGT GGACTACATG 
GAGAAGCACG GCATGAAATG TGAAGGCATC TACCGAGTGT CAGGAATCAA ATCAAAGGTA 
GATGAGCTGA AAGCAGCCTA TGACCGAGAG GAGTCTCCAA ACTTGGAAGA ATATGAACCT 
AACACTGTAG CCAGCTTGCT GAAGCAGTAT CTGCGAGACC TTCCCGAGAA TTTGCTTACC 
AAAGAGCTTA TGCCCCGATT TGAAGAGGCT TGTGGGAGGA CCACAGAGGT GGAGAAAGTG 
CAGGAGTTCC AGCGCTTGCT CAGGGAACTG CCGGAGTACA ACCATCTTCT GCTCTCCTGG 
CTCATTGTGC ACATGGACCA CGTCATCGCG AAGGAGCTGG AAACCAAGAT GAACATCCAG 
AACATCTCCA TAGTGCTGAG CCCAACCGTC CAGATCAGCA ACCGGGTCCT GTATGTGCTT 
TTCACACACG TGCAAGAGCT CTTTGGCACC GTGGTCCTGA AGCAAGTAAC GAGACCTCTG 
CGTTGGTCCA ACATGGCCAC AATGCCTACA CTGCCAGAGA CCCAAGCAGG CATCAAGGAA 
GAAATCAGGA GACAGGAGTT CCTTTTGAAC TGTTTACATC GAGATCTGCA GGGCGGGATA 
AAGGACTTGT CTAAAGAAGA AAGATTATGG GAAGTACAGA GGATTCTGAC TGCCCTCAAG 
AGAAAGCTGA GGGAAGCTAA AAGACAAGAG TGTGAGACCA AGATTGCACA GGAGATAGCC 
AGCCTTTCGA AGGAGGATGT TTCCAAAGAA GAAACGAACG AAAACGAGGA GGTCATAAAT 
ATCCTCCTTG CCCAGGAGAA TGAGATCCTG ACTGAGCAGG AGGAGCTCCT GGCCATGGAG 
CAGTTTCTGC GTCGTCAGAT CGCCTCGGAG AAAGAAGAGA TTGACCCCCT CCGAGCTGAG 
ATTGCGGAGA TCCAGAGTCG CCAGCATGGC CGCAGCGAGA CAGAGGAGTA CTCCTCTGAC 
AGCGAGAGCG AGAGCGAGGA TGAGGAGGAG CTGCAGATCA TTCTGGAAGA CTTACAGAGG 
CAGAATGAAG AGTTAGAAAT AAAGAACAAT CACTTGAACC AGGCAGTCCA TGAAGAGCGG 
GAGGCCATCG TTGAGCTCCG AGTGCAGCTC CGGCTGCTCC AGATGCTGCG AGCCAAGTCT 
GAGCAGCAGC TCCAGGAGGA GGAGGAGCCC GAGAGGCGAG GGGGCACAGG CCCACTACCC 
TGTGAAGGTG TCCTCGAGGT GAGAGCAGCC AAGGAGCAGG CGAAGCCTCG CCCAGCAAAG 
ACCGGAAGGA GACGCCCATC TGAACTGCCC CGGCCCTGTG CATCGTACTG TAAGCGAGAG 
TCCGCTGCCT GTCCTGCCAG GCAGCGTTCT GTGAAGGCTC TCAGAGACGC TCGCTCTTGC 
ACACGTCTGA CTCCGTGTCA GGCTCAGGTC CTGGGAGAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage.
Experimental neurology295116-124(2017 Sep)
Zhou K,Shi L,Wang Z,Zhou J,Manaenko A,Reis C,Chen S,Zhang J

Role for RIP1 in mediating necroptosis in experimental intracerebral hemorrhage model both in vivo and in vitro.
Cell death & disease8(3)e2641(2017 Mar)
Shen H,Liu C,Zhang D,Yao X,Zhang K,Li H,Chen G

Indole-3-Carbinol Induces Apoptosis of Hepatic Stellate Cells through K63 De-Ubiquitination of RIP1 in Rats.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology41(4)1481-1490(2017)
Li B,Cong M,Zhu Y,Xiong Y,Jin W,Wan Y,Zhou Y,Ao Y,Wang H

The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
Nature cell biology15(10)1220-30(2013 Oct)
Simicek M,Lievens S,Laga M,Guzenko D,Aushev VN,Kalev P,Baietti MF,Strelkov SV,Gevaert K,Tavernier J,Sablina AA

Eleostearic acid induces RIP1-mediated atypical apoptosis in a kinase-independent manner via ERK phosphorylation, ROS generation and mitochondrial dysfunction.
Cell death & disease4e674(2013 Jun)
Obitsu S,Sakata K,Teshima R,Kondo K

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Ralbp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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