Tfam cDNA ORF clone, Rattus norvegicus(Norway rat)

Nkx6.1 decline accompanies mitochondrial DNA reduction but subtle nucleoid size decrease in pancreatic islet ?-cells of diabetic Goto Kakizaki rats.
?pa?ek T, Pavluch V, Al?n L, Capkov? N, Engstov? H, Dlaskov? A, Berkov? Z, Saudek F, Je?ek P
Scientific reports7(1)15674(2017 Nov)

Impaired Nrf2 regulation of mitochondrial biogenesis in rostral ventrolateral medulla on hypertension induced by systemic inflammation.
Wu KLH, Wu CW, Chao YM, Hung CY, Chan JYH
Free radical biology & medicine9758-74(2016 08)

Regulation of mitochondrial genome replication by hypoxia: The role of DNA oxidation in D-loop region.
Pastukh VM, Gorodnya OM, Gillespie MN, Ruchko MV
Free radical biology & medicine9678-88(2016 07)

these results indicate that defect mitochondrial biogenesis in RVLM neurons entailing redox-sensitive and IL-1beta-dependent suppression of TFAM because of the increase in the formation of Keap1/Nrf2 complex, reductions in nuclear translocation of the activated Nrf2 and its binding to the Tfam gene promoter may underlie hypertension developed under the LPS-induced systemic inflammation
Title: Impaired Nrf2 regulation of mitochondrial biogenesis in rostral ventrolateral medulla on hypertension induced by systemic inflammation.

Ogg1 overexpression also reduced binding of mitochondrial transcription factor A (TFAM) to both regulatory and coding regions of the mitochondrial genome without altering total abundance of TFAM in either control or hypoxic cells. These observations suggest that oxidative DNA modifications in the D-loop region during hypoxia are important for increased TFAM binding and ensuing replication of the mitochondrial genome.
Title: Regulation of mitochondrial genome replication by hypoxia: The role of DNA oxidation in D-loop region.

Following skeletal muscle denervation, import of Tfam into the mitochondrion is the critical point of regulation for this protein.
Title: Effect of denervation on the regulation of mitochondrial transcription factor A expression in skeletal muscle.

The modulation of TFAM expression, TFAM-binding to mtDNA and mtDNA content with aging and CR showed a trend shared by the skeletal muscle and liver, but not by the frontal cortex counterpart.
Title: A comparison among the tissue-specific effects of aging and calorie restriction on TFAM amount and TFAM-binding activity to mtDNA in rat.

An age-related decrease in mitochondrial DNA (mtDNA) content and mitochondrial transcription factor A (TFAM) amount, fully prevented by calorie restriction.
Title: Aging and calorie restriction oppositely affect mitochondrial biogenesis through TFAM binding at both origins of mitochondrial DNA replication in rat liver.