TFAM cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TFAM
Entrez Gene ID	7019
Full Name	transcription factor A, mitochondrial
Synonyms	MTDPS15,MTTF1,MTTFA,TCF6,TCF6L1,TCF6L2,TCF6L3
General protein information	Preferred Names transcription factor A, mitochondrial Names transcription factor A, mitochondrial mitochondrial transcription factor 1 mitochondrial transcription factor A transcription factor 6 transcription factor 6-like 1 transcription factor 6-like 2 (mitochondrial transcription factor) transcription factor 6-like 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q21.1
Summary	This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Disorder MIM:	600438
Disorder Html:	?Mitochondrial DNA depletion syndrome 15 (hepatocerebral type), 617156 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011540120.2	XP_011538422.1	transcription factor A, mitochondrial isoform X1
NM_003201.2	NP_003192.1	transcription factor A, mitochondrial isoform 1 precursor
NM_001270782.1	NP_001257711.1	transcription factor A, mitochondrial isoform 2 precursor
XM_011540121.3	XP_011538423.1	transcription factor A, mitochondrial isoform X1
XM_011540121.2	XP_011538423.1	transcription factor A, mitochondrial isoform X2
NM_003201.3	NP_003192.1	transcription factor A, mitochondrial isoform 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	TFAM	NP_003192.1
Danio rerio (zebrafish)	tfam	NP_001070857.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008499	XP_316944.3
Xenopus tropicalis (tropical clawed frog)	tfam	XP_002937148.2
Canis lupus familiaris (dog)	TFAM	XP_546107.2
Mus musculus (house mouse)	Tfam	NP_033386.1
Rattus norvegicus (Norway rat)	Tfam	NP_112616.1
	TFAM	XP_001097656.1
Bos taurus (cattle)	TFAM	NP_001029188.2
Gallus gallus (chicken)	TFAM	NP_989431.1
Pan troglodytes (chimpanzee)	TFAM	NP_001181871.1
Drosophila melanogaster (fruit fly)	TFAM	NP_524415.1

Gene Ontology
Bibliography

Related articles in PubMed

New isoforms of human mitochondrial transcription factor A detected in normal and tumoral cells.
De Virgilio C, Pousis C, Bruno S, Gadaleta G
Mitochondrion11(2)287-95(2011 Mar)

The smaller isoform of the mitochondrial transcription factor A has a role in the mitochondrial transcription.
Bruno S, De Virgilio C, Gadaleta G
The Italian journal of biochemistry56(4)315-8(2007 Dec)

Human mitochondrial transcription factor A possesses multiple subcellular targeting signals.
Pastukh V, Shokolenko I, Wang B, Wilson G, Alexeyev M
The FEBS journal274(24)6488-99(2007 Dec)

Mitochondrial transcription factor A in the maintenance of mitochondrial DNA: overview of its multiple roles.
Kang D, Hamasaki N
Annals of the New York Academy of Sciences1042101-8(2005 May)

Human mitochondrial transcription factor A (mtTFA): gene structure and characterization of related pseudogenes.
Reyes A, Mezzina M, Gadaleta G
Gene291(1-2)223-32(2002 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results suggest that a high mtTFA expression is a useful marker for tumor progression and a poor prognosis in left-sided colorectal cancer patients.
Title: Prognostic Significance of Mitochondrial Transcription Factor A Expression in Patients with Right- or Left-sided Colorectal Cancer.

The authors did not find statistically significant differences in the genotype frequencies for the TFAM +35G/C polymorphism between women with polycystic ovary syndrome and controls and found that mtDNA copy number is not associated with TFAM+35G/C SNP in polycystic ovary syndrome patients.
Title: Polymorphisms in the TFAM and PGC1-? genes and their association with polycystic ovary syndrome among South Indian women.

Study reports crystal structures of human mitochondrial transcription initiation complexes assembled on both light and heavy strand promoters. The structures reveal how transcription factors TFAM and TFB2M assist mitochondrial RNA polymerase to achieve promoter-dependent initiation.
Title: Structural Basis of Mitochondrial Transcription Initiation.

Alleles in mitochondrial transcription factor A (TFAM) and AP endonuclease 1 (APE1) are associated with reduced cognitive performance.
Title: Mitochondrial transcription factor A (TFAM) rs1937 and AP endonuclease 1 (APE1) rs1130409 alleles are associated with reduced cognitive performance.

miR-199a-3p is able to attenuate cisplatin resistance in breast cancer cells through inhibiting TFAM expression.
Title: MiR-199a-3p enhances breast cancer cell sensitivity to cisplatin by downregulating TFAM (TFAM).

The following TFAM gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TFAM cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08546	NM_003201.3 Latest version!	Homo sapiens transcription factor A, mitochondrial (TFAM), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu08564	NM_001270782.1 Latest version!	Homo sapiens transcription factor A, mitochondrial (TFAM), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu60955	XM_011540120.2 Latest version!	Homo sapiens transcription factor A, mitochondrial (TFAM), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu60956	XM_011540121.3 Latest version!	Homo sapiens transcription factor A, mitochondrial (TFAM), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu60956	XM_011540121.2	Homo sapiens transcription factor A, mitochondrial (TFAM), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu08546	NM_003201.2	Homo sapiens transcription factor A, mitochondrial (TFAM), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TFAM ( NM_003201.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003192.1 Homo sapiens transcription factor A, mitochondrial (TFAM), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu08546
Clone ID Related Accession (Same CDS sequence)	NM_003201.2 , NM_003201.3
Accession Version	NM_003201.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 741bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	transcription factor A, mitochondrial isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB456976.3, AC023170.10, M62810.1 and CN478914.1. This sequence is a reference standard in the RefSeqGene project. On Aug 4, 2012 this sequence version replaced NM_003201.1. Transcript Variant: This variant (1, also known as ref) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.231383.1, SRR1660805.215267.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGTTTC TCCGAAGCAT GTGGGGCGTG CTGAGTGCCC TGGGAAGGTC TGGAGCAGAG 
CTGTGCACCG GCTGTGGAAG TCGACTGCGC TCCCCCTTCA GTTTTGTGTA TTTACCGAGG 
TGGTTTTCAT CTGTCTTGGC AAGTTGTCCA AAGAAACCTG TAAGTTCTTA CCTTCGATTT 
TCTAAAGAAC AACTACCCAT ATTTAAAGCT CAGAACCCAG ATGCAAAAAC TACAGAACTA 
ATTAGAAGAA TTGCCCAGCG TTGGAGGGAA CTTCCTGATT CAAAGAAAAA AATATATCAA 
GATGCTTATA GGGCGGAGTG GCAGGTATAT AAAGAAGAGA TAAGCAGATT TAAAGAACAG 
CTAACTCCAA GTCAGATTAT GTCTTTGGAA AAAGAAATCA TGGACAAACA TTTAAAAAGG 
AAAGCTATGA CAAAAAAAAA AGAGTTAACA CTGCTTGGAA AACCAAAAAG ACCTCGTTCA 
GCTTATAACG TTTATGTAGC TGAAAGATTC CAAGAAGCTA AGGGTGATTC ACCGCAGGAA 
AAGCTGAAGA CTGTAAAGGA AAACTGGAAA AATCTGTCTG ACTCTGAAAA GGAATTATAT 
ATTCAGCATG CTAAAGAGGA CGAAACTCGT TATCATAATG AAATGAAGTC TTGGGAAGAA 
CAAATGATTG AAGTTGGACG AAAGGATCTT CTACGTCGCA CAATAAAGAA ACAACGAAAA 
TATGGTGCTG AGGAGTGTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003192.1
CDS	406..1146
Translation	MAFLRSMWGVLSALGRSGAELCTGCGSRLRSPFSFVYLPRWFSSVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELPDSKKKIYQDAYRAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKAMTKKKELTLLGKPKRPRSAYNVYVAERFQEAKGDSPQEKLKTVKENWKNLSDSEKELYIQHAKEDETRYHNEMKSWEEQMIEVGRKDLLRRTIKKQRKYGAEEC

Target ORF information:

RefSeq Version	NM_003201.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transcription factor A, mitochondrial (TFAM), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003201.2

ORF Insert Sequence:

ATGGCGTTTC TCCGAAGCAT GTGGGGCGTG CTGAGTGCCC TGGGAAGGTC TGGAGCAGAG 
CTGTGCACCG GCTGTGGAAG TCGACTGCGC TCCCCCTTCA GTTTTGTGTA TTTACCGAGG 
TGGTTTTCAT CTGTCTTGGC AAGTTGTCCA AAGAAACCTG TAAGTTCTTA CCTTCGATTT 
TCTAAAGAAC AACTACCCAT ATTTAAAGCT CAGAACCCAG ATGCAAAAAC TACAGAACTA 
ATTAGAAGAA TTGCCCAGCG TTGGAGGGAA CTTCCTGATT CAAAGAAAAA AATATATCAA 
GATGCTTATA GGGCGGAGTG GCAGGTATAT AAAGAAGAGA TAAGCAGATT TAAAGAACAG 
CTAACTCCAA GTCAGATTAT GTCTTTGGAA AAAGAAATCA TGGACAAACA TTTAAAAAGG 
AAAGCTATGA CAAAAAAAAA AGAGTTAACA CTGCTTGGAA AACCAAAAAG ACCTCGTTCA 
GCTTATAACG TTTATGTAGC TGAAAGATTC CAAGAAGCTA AGGGTGATTC ACCGCAGGAA 
AAGCTGAAGA CTGTAAAGGA AAACTGGAAA AATCTGTCTG ACTCTGAAAA GGAATTATAT 
ATTCAGCATG CTAAAGAGGA CGAAACTCGT TATCATAATG AAATGAAGTC TTGGGAAGAA 
CAAATGATTG AAGTTGGACG AAAGGATCTT CTACGTCGCA CAATAAAGAA ACAACGAAAA 
TATGGTGCTG AGGAGTGTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TFAM ( NM_003201.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003192.1 Homo sapiens transcription factor A, mitochondrial (TFAM), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu08546
Clone ID Related Accession (Same CDS sequence)	NM_003201.2 , NM_003201.3
Accession Version	NM_003201.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 741bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	transcription factor A, mitochondrial isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC023170.10, M62810.1 and CN478914.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_003201.2. Transcript Variant: This variant (1, also known as ref) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.231383.1, SRR1660805.215267.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000487519.6/ ENSP00000420588.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGTTTC TCCGAAGCAT GTGGGGCGTG CTGAGTGCCC TGGGAAGGTC TGGAGCAGAG 
CTGTGCACCG GCTGTGGAAG TCGACTGCGC TCCCCCTTCA GTTTTGTGTA TTTACCGAGG 
TGGTTTTCAT CTGTCTTGGC AAGTTGTCCA AAGAAACCTG TAAGTTCTTA CCTTCGATTT 
TCTAAAGAAC AACTACCCAT ATTTAAAGCT CAGAACCCAG ATGCAAAAAC TACAGAACTA 
ATTAGAAGAA TTGCCCAGCG TTGGAGGGAA CTTCCTGATT CAAAGAAAAA AATATATCAA 
GATGCTTATA GGGCGGAGTG GCAGGTATAT AAAGAAGAGA TAAGCAGATT TAAAGAACAG 
CTAACTCCAA GTCAGATTAT GTCTTTGGAA AAAGAAATCA TGGACAAACA TTTAAAAAGG 
AAAGCTATGA CAAAAAAAAA AGAGTTAACA CTGCTTGGAA AACCAAAAAG ACCTCGTTCA 
GCTTATAACG TTTATGTAGC TGAAAGATTC CAAGAAGCTA AGGGTGATTC ACCGCAGGAA 
AAGCTGAAGA CTGTAAAGGA AAACTGGAAA AATCTGTCTG ACTCTGAAAA GGAATTATAT 
ATTCAGCATG CTAAAGAGGA CGAAACTCGT TATCATAATG AAATGAAGTC TTGGGAAGAA 
CAAATGATTG AAGTTGGACG AAAGGATCTT CTACGTCGCA CAATAAAGAA ACAACGAAAA 
TATGGTGCTG AGGAGTGTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003192.1
CDS	139..879
Translation	MAFLRSMWGVLSALGRSGAELCTGCGSRLRSPFSFVYLPRWFSSVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELPDSKKKIYQDAYRAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKAMTKKKELTLLGKPKRPRSAYNVYVAERFQEAKGDSPQEKLKTVKENWKNLSDSEKELYIQHAKEDETRYHNEMKSWEEQMIEVGRKDLLRRTIKKQRKYGAEEC

Target ORF information:

RefSeq Version	NM_003201.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transcription factor A, mitochondrial (TFAM), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003201.3

ORF Insert Sequence:

ATGGCGTTTC TCCGAAGCAT GTGGGGCGTG CTGAGTGCCC TGGGAAGGTC TGGAGCAGAG 
CTGTGCACCG GCTGTGGAAG TCGACTGCGC TCCCCCTTCA GTTTTGTGTA TTTACCGAGG 
TGGTTTTCAT CTGTCTTGGC AAGTTGTCCA AAGAAACCTG TAAGTTCTTA CCTTCGATTT 
TCTAAAGAAC AACTACCCAT ATTTAAAGCT CAGAACCCAG ATGCAAAAAC TACAGAACTA 
ATTAGAAGAA TTGCCCAGCG TTGGAGGGAA CTTCCTGATT CAAAGAAAAA AATATATCAA 
GATGCTTATA GGGCGGAGTG GCAGGTATAT AAAGAAGAGA TAAGCAGATT TAAAGAACAG 
CTAACTCCAA GTCAGATTAT GTCTTTGGAA AAAGAAATCA TGGACAAACA TTTAAAAAGG 
AAAGCTATGA CAAAAAAAAA AGAGTTAACA CTGCTTGGAA AACCAAAAAG ACCTCGTTCA 
GCTTATAACG TTTATGTAGC TGAAAGATTC CAAGAAGCTA AGGGTGATTC ACCGCAGGAA 
AAGCTGAAGA CTGTAAAGGA AAACTGGAAA AATCTGTCTG ACTCTGAAAA GGAATTATAT 
ATTCAGCATG CTAAAGAGGA CGAAACTCGT TATCATAATG AAATGAAGTC TTGGGAAGAA 
CAAATGATTG AAGTTGGACG AAAGGATCTT CTACGTCGCA CAATAAAGAA ACAACGAAAA 
TATGGTGCTG AGGAGTGTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TFAM ( NM_001270782.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001257711.1 Homo sapiens transcription factor A, mitochondrial (TFAM), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08564
Clone ID Related Accession (Same CDS sequence)	NM_001270782.1
Accession Version	NM_001270782.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 645bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	transcription factor A, mitochondrial isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB456976.3, AC023170.10, BM455062.1 and CN478914.1. Transcript Variant: This variant (2, also known as tr6 or delta 5TFam) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.196647.1, SRR1660809.193841.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGTTTC TCCGAAGCAT GTGGGGCGTG CTGAGTGCCC TGGGAAGGTC TGGAGCAGAG 
CTGTGCACCG GCTGTGGAAG TCGACTGCGC TCCCCCTTCA GTTTTGTGTA TTTACCGAGG 
TGGTTTTCAT CTGTCTTGGC AAGTTGTCCA AAGAAACCTG TAAGTTCTTA CCTTCGATTT 
TCTAAAGAAC AACTACCCAT ATTTAAAGCT CAGAACCCAG ATGCAAAAAC TACAGAACTA 
ATTAGAAGAA TTGCCCAGCG TTGGAGGGAA CTTCCTGATT CAAAGAAAAA AATATATCAA 
GATGCTTATA GGGCGGAGTG GCAGGTATAT AAAGAAGAGA TAAGCAGATT TAAAGAACAG 
CTAACTCCAA GTCAGATTAT GTCTTTGGAA AAAGAAATCA TGGACAAACA TTTAAAAAGG 
AAAGCTATGA CAAAAAAAAA AGAAAAGCTG AAGACTGTAA AGGAAAACTG GAAAAATCTG 
TCTGACTCTG AAAAGGAATT ATATATTCAG CATGCTAAAG AGGACGAAAC TCGTTATCAT 
AATGAAATGA AGTCTTGGGA AGAACAAATG ATTGAAGTTG GACGAAAGGA TCTTCTACGT 
CGCACAATAA AGAAACAACG AAAATATGGT GCTGAGGAGT GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001257711.1
CDS	406..1050
Translation	MAFLRSMWGVLSALGRSGAELCTGCGSRLRSPFSFVYLPRWFSSVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELPDSKKKIYQDAYRAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKAMTKKKEKLKTVKENWKNLSDSEKELYIQHAKEDETRYHNEMKSWEEQMIEVGRKDLLRRTIKKQRKYGAEEC

Target ORF information:

RefSeq Version	NM_001270782.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transcription factor A, mitochondrial (TFAM), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001270782.1

ORF Insert Sequence:

ATGGCGTTTC TCCGAAGCAT GTGGGGCGTG CTGAGTGCCC TGGGAAGGTC TGGAGCAGAG 
CTGTGCACCG GCTGTGGAAG TCGACTGCGC TCCCCCTTCA GTTTTGTGTA TTTACCGAGG 
TGGTTTTCAT CTGTCTTGGC AAGTTGTCCA AAGAAACCTG TAAGTTCTTA CCTTCGATTT 
TCTAAAGAAC AACTACCCAT ATTTAAAGCT CAGAACCCAG ATGCAAAAAC TACAGAACTA 
ATTAGAAGAA TTGCCCAGCG TTGGAGGGAA CTTCCTGATT CAAAGAAAAA AATATATCAA 
GATGCTTATA GGGCGGAGTG GCAGGTATAT AAAGAAGAGA TAAGCAGATT TAAAGAACAG 
CTAACTCCAA GTCAGATTAT GTCTTTGGAA AAAGAAATCA TGGACAAACA TTTAAAAAGG 
AAAGCTATGA CAAAAAAAAA AGAAAAGCTG AAGACTGTAA AGGAAAACTG GAAAAATCTG 
TCTGACTCTG AAAAGGAATT ATATATTCAG CATGCTAAAG AGGACGAAAC TCGTTATCAT 
AATGAAATGA AGTCTTGGGA AGAACAAATG ATTGAAGTTG GACGAAAGGA TCTTCTACGT 
CGCACAATAA AGAAACAACG AAAATATGGT GCTGAGGAGT GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TFAM ( XM_011540120.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011538422.1 Homo sapiens transcription factor A, mitochondrial (TFAM), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu60955
Clone ID Related Accession (Same CDS sequence)	XM_011540120.2
Accession Version	XM_011540120.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 450bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	transcription factor A, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011540120.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGTTTC TCCGAAGCAT GTGGGGCGTG CTGAGTGCCC TGGGAAGGTC TGGAGCAGAG 
CTGTGCACCG GCTGTGGAAG TCGACTGCGC TCCCCCTTCA GTTTTGTGTA TTTACCGAGG 
TGGTTTTCAT CTGTCTTGGC AAGTTGTCCA AAGAAACCTG TAAGTTCTTA CCTTCGATTT 
TCTAAAGAAC AACTACCCAT ATTTAAAGCT CAGAACCCAG ATGCAAAAAC TACAGAACTA 
ATTAGAAGAA TTGCCCAGCG TTGGAGGGAA CTTCCTGATT CAAAGAAAAA AATATATCAA 
GATGCTTATA GGGCGGAGTG GCAGGTATAT AAAGAAGAGA TAAGCAGATT TAAAGAACAG 
CTAACTCCAA GTCAGATTAT GTCTTTGGAA AAAGAAATCA TGGACAAACA TTTAAAAAGG 
AAAGCTATGA CAAAAAAAAA AAAGAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011538422.1
CDS	139..588
Translation	MAFLRSMWGVLSALGRSGAELCTGCGSRLRSPFSFVYLPRWFSSVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELPDSKKKIYQDAYRAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKAMTKKKKS

Target ORF information:

RefSeq Version	XM_011540120.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transcription factor A, mitochondrial (TFAM), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011540120.2

ORF Insert Sequence:

ATGGCGTTTC TCCGAAGCAT GTGGGGCGTG CTGAGTGCCC TGGGAAGGTC TGGAGCAGAG 
CTGTGCACCG GCTGTGGAAG TCGACTGCGC TCCCCCTTCA GTTTTGTGTA TTTACCGAGG 
TGGTTTTCAT CTGTCTTGGC AAGTTGTCCA AAGAAACCTG TAAGTTCTTA CCTTCGATTT 
TCTAAAGAAC AACTACCCAT ATTTAAAGCT CAGAACCCAG ATGCAAAAAC TACAGAACTA 
ATTAGAAGAA TTGCCCAGCG TTGGAGGGAA CTTCCTGATT CAAAGAAAAA AATATATCAA 
GATGCTTATA GGGCGGAGTG GCAGGTATAT AAAGAAGAGA TAAGCAGATT TAAAGAACAG 
CTAACTCCAA GTCAGATTAT GTCTTTGGAA AAAGAAATCA TGGACAAACA TTTAAAAAGG 
AAAGCTATGA CAAAAAAAAA AAAGAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TFAM ( XM_011540121.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011538423.1 Homo sapiens transcription factor A, mitochondrial (TFAM), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu60956
Clone ID Related Accession (Same CDS sequence)	XM_011540121.3 , XM_011540121.2
Accession Version	XM_011540121.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	transcription factor A, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011540121.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGTTTC TCCGAAGCAT GTGGGGCGTG CTGAGTGCCC TGGGAAGGTC TGGAGCAGAG 
CTGTGCACCG GCTGTGGAAG TCGACTGCGC TCCCCCTTCA GTTTTGTGTA TTTACCGAGG 
TGGTTTTCAT CTGTCTTGGC AAGTTGTCCA AAGAAACCTG TAAGTTCTTA CCTTCGATTT 
TCTAAAGAAC AACTACCCAT ATTTAAAGCT CAGAACCCAG ATGCAAAAAC TACAGAACTA 
ATTAGAAGAA TTGCCCAGCG TTGGAGGGAA CTTCCTGATT CAAAGAAAAA AATATATCAA 
GATGCTTATA GGGCGGAGTG GCAGGTATAT AAAGAAGAGA TAAGCAGATT TAAAGAACAG 
CTAACTCCAA GTCAGATTAT GTCTTTGGAA AAAGAAATCA TGGACAAACA TTTAAAAAGG 
AAAGCTATGA CAAAAAAAAA GAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011538423.1
CDS	140..586
Translation	MAFLRSMWGVLSALGRSGAELCTGCGSRLRSPFSFVYLPRWFSSVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELPDSKKKIYQDAYRAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKAMTKKKS

Target ORF information:

RefSeq Version	XM_011540121.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transcription factor A, mitochondrial (TFAM), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011540121.3

ORF Insert Sequence:

ATGGCGTTTC TCCGAAGCAT GTGGGGCGTG CTGAGTGCCC TGGGAAGGTC TGGAGCAGAG 
CTGTGCACCG GCTGTGGAAG TCGACTGCGC TCCCCCTTCA GTTTTGTGTA TTTACCGAGG 
TGGTTTTCAT CTGTCTTGGC AAGTTGTCCA AAGAAACCTG TAAGTTCTTA CCTTCGATTT 
TCTAAAGAAC AACTACCCAT ATTTAAAGCT CAGAACCCAG ATGCAAAAAC TACAGAACTA 
ATTAGAAGAA TTGCCCAGCG TTGGAGGGAA CTTCCTGATT CAAAGAAAAA AATATATCAA 
GATGCTTATA GGGCGGAGTG GCAGGTATAT AAAGAAGAGA TAAGCAGATT TAAAGAACAG 
CTAACTCCAA GTCAGATTAT GTCTTTGGAA AAAGAAATCA TGGACAAACA TTTAAAAAGG 
AAAGCTATGA CAAAAAAAAA GAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TFAM ( XM_011540121.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011538423.1 Homo sapiens transcription factor A, mitochondrial (TFAM), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu60956
Clone ID Related Accession (Same CDS sequence)	XM_011540121.3 , XM_011540121.2
Accession Version	XM_011540121.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	transcription factor A, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011540121.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGTTTC TCCGAAGCAT GTGGGGCGTG CTGAGTGCCC TGGGAAGGTC TGGAGCAGAG 
CTGTGCACCG GCTGTGGAAG TCGACTGCGC TCCCCCTTCA GTTTTGTGTA TTTACCGAGG 
TGGTTTTCAT CTGTCTTGGC AAGTTGTCCA AAGAAACCTG TAAGTTCTTA CCTTCGATTT 
TCTAAAGAAC AACTACCCAT ATTTAAAGCT CAGAACCCAG ATGCAAAAAC TACAGAACTA 
ATTAGAAGAA TTGCCCAGCG TTGGAGGGAA CTTCCTGATT CAAAGAAAAA AATATATCAA 
GATGCTTATA GGGCGGAGTG GCAGGTATAT AAAGAAGAGA TAAGCAGATT TAAAGAACAG 
CTAACTCCAA GTCAGATTAT GTCTTTGGAA AAAGAAATCA TGGACAAACA TTTAAAAAGG 
AAAGCTATGA CAAAAAAAAA GAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011538423.1
CDS	139..585
Translation	MAFLRSMWGVLSALGRSGAELCTGCGSRLRSPFSFVYLPRWFSSVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELPDSKKKIYQDAYRAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKAMTKKKS

Target ORF information:

RefSeq Version	XM_011540121.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transcription factor A, mitochondrial (TFAM), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011540121.2

ORF Insert Sequence:

ATGGCGTTTC TCCGAAGCAT GTGGGGCGTG CTGAGTGCCC TGGGAAGGTC TGGAGCAGAG 
CTGTGCACCG GCTGTGGAAG TCGACTGCGC TCCCCCTTCA GTTTTGTGTA TTTACCGAGG 
TGGTTTTCAT CTGTCTTGGC AAGTTGTCCA AAGAAACCTG TAAGTTCTTA CCTTCGATTT 
TCTAAAGAAC AACTACCCAT ATTTAAAGCT CAGAACCCAG ATGCAAAAAC TACAGAACTA 
ATTAGAAGAA TTGCCCAGCG TTGGAGGGAA CTTCCTGATT CAAAGAAAAA AATATATCAA 
GATGCTTATA GGGCGGAGTG GCAGGTATAT AAAGAAGAGA TAAGCAGATT TAAAGAACAG 
CTAACTCCAA GTCAGATTAT GTCTTTGGAA AAAGAAATCA TGGACAAACA TTTAAAAAGG 
AAAGCTATGA CAAAAAAAAA GAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

New isoforms of human mitochondrial transcription factor A detected in normal and tumoral cells.
Mitochondrion11(2)287-95(2011 Mar)
De Virgilio C,Pousis C,Bruno S,Gadaleta G

The smaller isoform of the mitochondrial transcription factor A has a role in the mitochondrial transcription.
The Italian journal of biochemistry56(4)315-8(2007 Dec)
Bruno S,De Virgilio C,Gadaleta G

Human mitochondrial transcription factor A possesses multiple subcellular targeting signals.
The FEBS journal274(24)6488-99(2007 Dec)
Pastukh V,Shokolenko I,Wang B,Wilson G,Alexeyev M

Mitochondrial transcription factor A in the maintenance of mitochondrial DNA: overview of its multiple roles.
Annals of the New York Academy of Sciences1042101-8(2005 May)
Kang D,Hamasaki N

Human mitochondrial transcription factor A (mtTFA): gene structure and characterization of related pseudogenes.
Gene291(1-2)223-32(2002 May)
Reyes A,Mezzina M,Gadaleta G

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TFAM cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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