Renbp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Renbp
Entrez Gene ID	81759
Full Name	renin binding protein
General protein information	Preferred Names renin binding protein Names N-acylglucosamine 2-epimerase AGE N-acetyl-D-glucosamine 2-epimerase glcNAc 2-epimerase rnBP
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq37
Summary	has N-acetyl-D-glucosamine 2-epimerase activity; inhibits renin activity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006229615.3	XP_006229677.1	N-acylglucosamine 2-epimerase isoform X1
NM_031095.1	NP_112357.1	N-acylglucosamine 2-epimerase

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	renbp	NP_001106581.1
Pan troglodytes (chimpanzee)	RENBP	XP_003317823.1
Homo sapiens (human)	RENBP	NP_002901.2
Canis lupus familiaris (dog)	RENBP	XP_855355.4
Mus musculus (house mouse)	Renbp	NP_075621.3
Bos taurus (cattle)	RENBP	NP_001039688.1
Rattus norvegicus (Norway rat)	Renbp	NP_112357.1
Danio rerio (zebrafish)	renbp	NP_001119915.1

Gene Ontology
Bibliography

Related articles in PubMed

Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid.
Bergfeld AK, Pearce OM, Diaz SL, Pham T, Varki A
The Journal of biological chemistry287(34)28865-81(2012 Aug)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

Amino acid residues conferring the nucleotide binding properties of N-acetyl-D-glucosamine 2-epimerase (renin binding protein).
Takahashi S, Ogasawara H, Hiwatashi K, Hata K, Hori K, Koizumi Y, Sugiyama T
Biomedical research (Tokyo, Japan)26(3)117-21(2005 Jun)

Identification of a domain conferring nucleotide binding to the N-acetyl-d-glucosamine 2-epimerase (Renin binding protein).
Takahashi S, Ogasawara H, Takahashi K, Hori K, Saito K, Mori K
Journal of biochemistry131(4)605-10(2002 Apr)

Assignment of the gene encoding renin binding protein (Renbp) to rat chromosome Xq37 by in situ hybridization and radiation hybrid mapping.
Z?rcher H, Van Vooren P, Szpirer J, Szpirer C, Kreutz R
Cytogenetic and genome research97(3-4)277H(2002)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

domain structure of renin binding protein
Title: Identification of a domain conferring nucleotide binding to the N-acetyl-d-glucosamine 2-epimerase (Renin binding protein).

The gene encoding renin binding protein (Renbp) has been assigned to rat chromosome Xq37.
Title: Assignment of the gene encoding renin binding protein (Renbp) to rat chromosome Xq37 by in situ hybridization and radiation hybrid mapping.

The following Renbp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Renbp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07582	NM_031095.1 Latest version!	Rattus norvegicus renin binding protein (Renbp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa23047	XM_006229615.3 Latest version!	Rattus norvegicus renin binding protein (Renbp), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Renbp ( NM_031095.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112357.1 Rattus norvegicus renin binding protein (Renbp), mRNA.

Price & Availability↑

CloneID	ORa07582
Clone ID Related Accession (Same CDS sequence)	NM_031095.1
Accession Version	NM_031095.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	N-acylglucosamine 2-epimerase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D10233.1. ##Evidence-Data-START## Transcript exon combination :: D10233.1, FQ228819.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGAAGG AACGGGAGAC ACTGCAGGTC TGGAAGCAAC GTGTGGGACA AGAGCTCGAT 
TCTGTGATCG CTTTCTGGAT GGAGCATTCC CATGACCAGG AACACGGGGG CTTCTTCACA 
TGCCTTGGCC GCGATGGGCA GGTATATGAT CACCTCAAAT ATGTCTGGCT GCAGGGGAGG 
CAGGTATGGA TGTATTGTCG CTTATACCGC ACTTTTGAGC GCTTCCGCCG TGTCGAGCTT 
CTGGATGCAG CAAAAGCAGG TGGTGAATTT TTGTTGAGTT ATGCCCGGGT GGCACCGCCT 
GGCAAGAAAT GTGCTTTTGT GCTGACCCAG GACGGCCGTC CAGTGAAGGT GCAGCGGACC 
ATTTTCAGCG AGTGCTTTTA CACCATGGCC ATGAATGAAC TGTGGAAAGT AACAGGGGAA 
ATGCATTATC AGAGAGAAGC CGTAGAGATG ATGGATCAGA TCATCCACTG GGTAAGGGAG 
GACCCAGCTG GGCTGGGCCG GCCTCAGCTC TCGGGAACAC TGGCCACAGA GCCCATGGCA 
GTGCCCATGA TGCTGCTCAA CCTGGTGGAG CAGCTTGGAG AAGAAGATGA GGAGATGACC 
GACAAGTATG CAGAACTAGG GGACTGGTGT GCCCATAGGA TTCTTCAGCA TGTCCAGAGG 
GATGGACAAG TTGTACTGGA GAATGTATCA GAGGATGGCA AAGAGCTCCC TGGTTGCCTT 
GGAAGACATC AGAACCCAGG CCACACACTG GAAGCTGGCT GGTTTCTGCT CCAGTATGCC 
CTCAGGAAAG GTGATCCCAA ACTTCAAAGG CACATTATTG ACAAGTTTCT CTTACTGCCT 
TTCCACTCTG GATGGGACCC TGAGCACGGA GGCCTCTTCT ACTTCCAGGA TGCTGATGAT 
CTCTGCCCTA CCCAGCTGGA ATGGAACATG AAGCTGTGGT GGCCACACAC TGAAGCCATG 
ATTGCCTTCC TCATGGGTTA CAGGGACAGC GGGGACCCAG CCTTGCTGAA CCTCTTCTAC 
CAAGTGGCTG AATACACCTT CCACCAGTTT CGTGATCCTG AGTACGGGGA ATGGTTTGGC 
TACCTGAACC AAGAGGGAAA GGTGGCCCTT ACCATCAAAG GAGGTCCTTT TAAAGGCTGC 
TTCCATGTGC CGCGGTGCCT GGCCATGTGC GAGCAGATTT TGGGAGCCCT ACTCCAACGC 
CTTGGGCCCG CCCCCCTCGG CTCCTTGCCC GCTGTCCCCA CTCGCGAAGG CTCGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112357.1
CDS	18..1277
Translation	MEKERETLQVWKQRVGQELDSVIAFWMEHSHDQEHGGFFTCLGRDGQVYDHLKYVWLQGRQVWMYCRLYRTFERFRRVELLDAAKAGGEFLLSYARVAPPGKKCAFVLTQDGRPVKVQRTIFSECFYTMAMNELWKVTGEMHYQREAVEMMDQIIHWVREDPAGLGRPQLSGTLATEPMAVPMMLLNLVEQLGEEDEEMTDKYAELGDWCAHRILQHVQRDGQVVLENVSEDGKELPGCLGRHQNPGHTLEAGWFLLQYALRKGDPKLQRHIIDKFLLLPFHSGWDPEHGGLFYFQDADDLCPTQLEWNMKLWWPHTEAMIAFLMGYRDSGDPALLNLFYQVAEYTFHQFRDPEYGEWFGYLNQEGKVALTIKGGPFKGCFHVPRCLAMCEQILGALLQRLGPAPLGSLPAVPTREGSK

Target ORF information:

RefSeq Version	NM_031095.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus renin binding protein (Renbp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031095.1

ORF Insert Sequence:

ATGGAGAAGG AACGGGAGAC ACTGCAGGTC TGGAAGCAAC GTGTGGGACA AGAGCTCGAT 
TCTGTGATCG CTTTCTGGAT GGAGCATTCC CATGACCAGG AACACGGGGG CTTCTTCACA 
TGCCTTGGCC GCGATGGGCA GGTATATGAT CACCTCAAAT ATGTCTGGCT GCAGGGGAGG 
CAGGTATGGA TGTATTGTCG CTTATACCGC ACTTTTGAGC GCTTCCGCCG TGTCGAGCTT 
CTGGATGCAG CAAAAGCAGG TGGTGAATTT TTGTTGAGTT ATGCCCGGGT GGCACCGCCT 
GGCAAGAAAT GTGCTTTTGT GCTGACCCAG GACGGCCGTC CAGTGAAGGT GCAGCGGACC 
ATTTTCAGCG AGTGCTTTTA CACCATGGCC ATGAATGAAC TGTGGAAAGT AACAGGGGAA 
ATGCATTATC AGAGAGAAGC CGTAGAGATG ATGGATCAGA TCATCCACTG GGTAAGGGAG 
GACCCAGCTG GGCTGGGCCG GCCTCAGCTC TCGGGAACAC TGGCCACAGA GCCCATGGCA 
GTGCCCATGA TGCTGCTCAA CCTGGTGGAG CAGCTTGGAG AAGAAGATGA GGAGATGACC 
GACAAGTATG CAGAACTAGG GGACTGGTGT GCCCATAGGA TTCTTCAGCA TGTCCAGAGG 
GATGGACAAG TTGTACTGGA GAATGTATCA GAGGATGGCA AAGAGCTCCC TGGTTGCCTT 
GGAAGACATC AGAACCCAGG CCACACACTG GAAGCTGGCT GGTTTCTGCT CCAGTATGCC 
CTCAGGAAAG GTGATCCCAA ACTTCAAAGG CACATTATTG ACAAGTTTCT CTTACTGCCT 
TTCCACTCTG GATGGGACCC TGAGCACGGA GGCCTCTTCT ACTTCCAGGA TGCTGATGAT 
CTCTGCCCTA CCCAGCTGGA ATGGAACATG AAGCTGTGGT GGCCACACAC TGAAGCCATG 
ATTGCCTTCC TCATGGGTTA CAGGGACAGC GGGGACCCAG CCTTGCTGAA CCTCTTCTAC 
CAAGTGGCTG AATACACCTT CCACCAGTTT CGTGATCCTG AGTACGGGGA ATGGTTTGGC 
TACCTGAACC AAGAGGGAAA GGTGGCCCTT ACCATCAAAG GAGGTCCTTT TAAAGGCTGC 
TTCCATGTGC CGCGGTGCCT GGCCATGTGC GAGCAGATTT TGGGAGCCCT ACTCCAACGC 
CTTGGGCCCG CCCCCCTCGG CTCCTTGCCC GCTGTCCCCA CTCGCGAAGG CTCGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Renbp ( XM_006229615.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006229677.1 Rattus norvegicus renin binding protein (Renbp), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa23047
Clone ID Related Accession (Same CDS sequence)	XM_006229615.3
Accession Version	XM_006229615.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1293bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	N-acylglucosamine 2-epimerase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005120.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006229615.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGGACC CAGGACTCCT AGTGTTACAG GACATGGAGA AGGAACGGGA GACACTGCAG 
GTCTGGAAGC AACGTGTGGG ACAAGAGCTC GATTCTGTGA TCGCTTTCTG GATGGAGCAT 
TCCCATGACC AGGAACACGG GGGCTTCTTC ACATGCCTTG GCCGCGATGG GCAGGTATAT 
GATCACCTCA AATATGTCTG GCTGCAGGGG AGGCAGGTAT GGATGTATTG TCGCTTATAC 
CGCACTTTTG AGCGCTTCCG CCGTGTCGAG CTTCTGGATG CAGCAAAAGC AGGTGGTGAA 
TTTTTGTTGA GTTATGCCCG GGTGGCACCG CCTGGCAAGA AATGTGCTTT TGTGCTGACC 
CAGGACGGCC GTCCAGTGAA GGTGCAGCGG ACCATTTTCA GCGAGTGCTT TTACACCATG 
GCCATGAATG AACTGTGGAA AGTAACAGGG GAAATGCATT ATCAGAGAGA AGCCGTAGAG 
ATGATGGATC AGATCATCCA CTGGGTAAGG GAGGACCCAG CTGGGCTGGG CCGGCCTCAG 
CTCTCGGGAA CACTGGCCAC AGAGCCCATG GCAGTGCCCA TGATGCTGCT CAACCTGGTG 
GAGCAGCTTG GAGAAGAAGA TGAGGAGATG ACCGACAAGT ATGCAGAACT AGGGGACTGG 
TGTGCCCATA GGATTCTTCA GCATGTCCAG AGGGATGGAC AAGTTGTACT GGAGAATGTA 
TCAGAGGATG GCAAAGAGCT CCCTGGTTGC CTTGGAAGAC ATCAGAACCC AGGCCACACA 
CTGGAAGCTG GCTGGTTTCT GCTCCAGTAT GCCCTCAGGA AAGGTGATCC CAAACTTCAA 
AGGCACATTA TTGACAAGTT TCTCTTACTG CCTTTCCACT CTGGATGGGA CCCTGAGCAC 
GGAGGCCTCT TCTACTTCCA GGATGCTGAT GATCTCTGCC CTACCCAGCT GGAATGGAAC 
ATGAAGCTGT GGTGGCCACA CACTGAAGCC ATGATTGCCT TCCTCATGGG TTACAGGGAC 
AGCGGGGACC CAGCCTTGCT GAACCTCTTC TACCAAGTGG CTGAATACAC CTTCCACCAG 
TTTCGTGATC CTGAGTACGG GGAATGGTTT GGCTACCTGA ACCAAGAGGG AAAGGTGGCC 
CTTACCATCA AAGGAGGTCC TTTTAAAGGC TGCTTCCATG TGCCGCGGTG CCTGGCCATG 
TGCGAGCAGA TTTTGGGAGC CCTACTCCAA CGCCTTGGGC CCGCCCCCCT CGGCTCCTTG 
CCCGCTGTCC CCACTCGCGA AGGCTCGAAA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006229677.1
CDS	105..1397
Translation	MMDPGLLVLQDMEKERETLQVWKQRVGQELDSVIAFWMEHSHDQEHGGFFTCLGRDGQVYDHLKYVWLQGRQVWMYCRLYRTFERFRRVELLDAAKAGGEFLLSYARVAPPGKKCAFVLTQDGRPVKVQRTIFSECFYTMAMNELWKVTGEMHYQREAVEMMDQIIHWVREDPAGLGRPQLSGTLATEPMAVPMMLLNLVEQLGEEDEEMTDKYAELGDWCAHRILQHVQRDGQVVLENVSEDGKELPGCLGRHQNPGHTLEAGWFLLQYALRKGDPKLQRHIIDKFLLLPFHSGWDPEHGGLFYFQDADDLCPTQLEWNMKLWWPHTEAMIAFLMGYRDSGDPALLNLFYQVAEYTFHQFRDPEYGEWFGYLNQEGKVALTIKGGPFKGCFHVPRCLAMCEQILGALLQRLGPAPLGSLPAVPTREGSK

Target ORF information:

RefSeq Version	XM_006229615.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus renin binding protein (Renbp), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006229615.3

ORF Insert Sequence:

ATGATGGACC CAGGACTCCT AGTGTTACAG GACATGGAGA AGGAACGGGA GACACTGCAG 
GTCTGGAAGC AACGTGTGGG ACAAGAGCTC GATTCTGTGA TCGCTTTCTG GATGGAGCAT 
TCCCATGACC AGGAACACGG GGGCTTCTTC ACATGCCTTG GCCGCGATGG GCAGGTATAT 
GATCACCTCA AATATGTCTG GCTGCAGGGG AGGCAGGTAT GGATGTATTG TCGCTTATAC 
CGCACTTTTG AGCGCTTCCG CCGTGTCGAG CTTCTGGATG CAGCAAAAGC AGGTGGTGAA 
TTTTTGTTGA GTTATGCCCG GGTGGCACCG CCTGGCAAGA AATGTGCTTT TGTGCTGACC 
CAGGACGGCC GTCCAGTGAA GGTGCAGCGG ACCATTTTCA GCGAGTGCTT TTACACCATG 
GCCATGAATG AACTGTGGAA AGTAACAGGG GAAATGCATT ATCAGAGAGA AGCCGTAGAG 
ATGATGGATC AGATCATCCA CTGGGTAAGG GAGGACCCAG CTGGGCTGGG CCGGCCTCAG 
CTCTCGGGAA CACTGGCCAC AGAGCCCATG GCAGTGCCCA TGATGCTGCT CAACCTGGTG 
GAGCAGCTTG GAGAAGAAGA TGAGGAGATG ACCGACAAGT ATGCAGAACT AGGGGACTGG 
TGTGCCCATA GGATTCTTCA GCATGTCCAG AGGGATGGAC AAGTTGTACT GGAGAATGTA 
TCAGAGGATG GCAAAGAGCT CCCTGGTTGC CTTGGAAGAC ATCAGAACCC AGGCCACACA 
CTGGAAGCTG GCTGGTTTCT GCTCCAGTAT GCCCTCAGGA AAGGTGATCC CAAACTTCAA 
AGGCACATTA TTGACAAGTT TCTCTTACTG CCTTTCCACT CTGGATGGGA CCCTGAGCAC 
GGAGGCCTCT TCTACTTCCA GGATGCTGAT GATCTCTGCC CTACCCAGCT GGAATGGAAC 
ATGAAGCTGT GGTGGCCACA CACTGAAGCC ATGATTGCCT TCCTCATGGG TTACAGGGAC 
AGCGGGGACC CAGCCTTGCT GAACCTCTTC TACCAAGTGG CTGAATACAC CTTCCACCAG 
TTTCGTGATC CTGAGTACGG GGAATGGTTT GGCTACCTGA ACCAAGAGGG AAAGGTGGCC 
CTTACCATCA AAGGAGGTCC TTTTAAAGGC TGCTTCCATG TGCCGCGGTG CCTGGCCATG 
TGCGAGCAGA TTTTGGGAGC CCTACTCCAA CGCCTTGGGC CCGCCCCCCT CGGCTCCTTG 
CCCGCTGTCC CCACTCGCGA AGGCTCGAAA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid.
The Journal of biological chemistry287(34)28865-81(2012 Aug)
Bergfeld AK,Pearce OM,Diaz SL,Pham T,Varki A

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

Amino acid residues conferring the nucleotide binding properties of N-acetyl-D-glucosamine 2-epimerase (renin binding protein).
Biomedical research (Tokyo, Japan)26(3)117-21(2005 Jun)
Takahashi S,Ogasawara H,Hiwatashi K,Hata K,Hori K,Koizumi Y,Sugiyama T

Identification of a domain conferring nucleotide binding to the N-acetyl-d-glucosamine 2-epimerase (Renin binding protein).
Journal of biochemistry131(4)605-10(2002 Apr)
Takahashi S,Ogasawara H,Takahashi K,Hori K,Saito K,Mori K

Assignment of the gene encoding renin binding protein (Renbp) to rat chromosome Xq37 by in situ hybridization and radiation hybrid mapping.
Cytogenetic and genome research97(3-4)277H(2002)
Z?rcher H,Van Vooren P,Szpirer J,Szpirer C,Kreutz R