Gnb2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gnb2
Entrez Gene ID	81667
Full Name	G protein subunit beta 2
General protein information	Preferred Names G protein subunit beta 2 Names guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 g protein subunit beta-2 guanine nucleotide binding protein (G protein), beta 2 guanine nucleotide binding protein (G protein), beta polypeptide 2 guanine nucleotide binding protein beta 2 subunit guanine nucleotide binding protein, beta polypeptide 2 guanine nucleotide-binding protein, beta 2 transducin beta chain 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q12
Summary	modulates calcium channel activity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031037.2	NP_112299.1	guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	gnb2	NP_001013515.1
Homo sapiens (human)	GNB2	NP_005264.2
Pan troglodytes (chimpanzee)	GNB2	XP_001152250.1
Canis lupus familiaris (dog)	GNB2	XP_536861.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005913	XP_315943.3
Rattus norvegicus (Norway rat)	Gnb2	NP_112299.1
Bos taurus (cattle)	GNB2	NP_001091030.1
Mus musculus (house mouse)	Gnb2	NP_034442.1

Gene Ontology
Bibliography

Related articles in PubMed

G?? mimics activation kinetic slowing of CaV2.2 channels by noradrenaline in rat sympathetic neurons.
Hern?ndez-Castellanos JM, Vivas O, Gardu?o J, De la Cruz L, Arenas I, El?as-Vi?as D, Mackie K, Garc?a DE
Biochemical and biophysical research communications445(1)250-4(2014 Feb)

KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.
Ahmed SM, Th?riault BL, Uppalapati M, Chiu CW, Gallie BL, Sidhu SS, Angers S
The Journal of cell biology199(6)951-67(2012 Dec)

G?2 and G?4 participate in the opioid and adrenergic receptor-mediated Ca2+ channel modulation in rat sympathetic neurons.
Mahmoud S, Yun JK, Ruiz-Velasco V
The Journal of physiology590(19)4673-89(2012 Oct)

G?? and the C terminus of SNAP-25 are necessary for long-term depression of transmitter release.
Zhang XL, Upreti C, Stanton PK
PloS one6(5)e20500(2011)

Enhanced expression of heterotrimeric GTP-binding protein subunits in Zajdela ascitic hepatoma.
Sharma SK, Das MR
Indian journal of biochemistry & biophysics39(3)148-54(2002 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that verexpression of Gbeta2 subunit mimics CaV2.2 kinetic slowing by noradrenaline.
Title: G?? mimics activation kinetic slowing of CaV2.2 channels by noradrenaline in rat sympathetic neurons.

Gnb2 and Gnb4 participate in the opioid and adrenergic receptor-mediated Ca2+ channel modulation in rat sympathetic neurons
Title: G?2 and G?4 participate in the opioid and adrenergic receptor-mediated Ca2+ channel modulation in rat sympathetic neurons.

Data show that the C-terminus of SNAP-25 is a binding target for Gbetagamma necessary for both transient transmitter-mediated presynaptic inhibition, and the induction of presynaptic LTD.
Title: G?? and the C terminus of SNAP-25 are necessary for long-term depression of transmitter release.

analysis of enhanced expression of heterotrimeric GTP-binding protein subunits in Zajdela ascitic hepatoma
Title: Enhanced expression of heterotrimeric GTP-binding protein subunits in Zajdela ascitic hepatoma.

The following Gnb2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gnb2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13196	NM_031037.2 Latest version!	Rattus norvegicus G protein subunit beta 2 (Gnb2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gnb2 ( NM_031037.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112299.1 Rattus norvegicus G protein subunit beta 2 (Gnb2), mRNA.

Price & Availability↑

CloneID	ORa13196
Clone ID Related Accession (Same CDS sequence)	NM_031037.2
Accession Version	NM_031037.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1023bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065579.1. On Feb 1, 2004 this sequence version replaced NM_031037.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC065579.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGTGAGC TGGAGCAACT GAGACAGGAG GCTGAGCAGC TCCGGAACCA GATCCGGGAC 
GCCAGAAAAG CATGCGGGGA TTCCACACTG ACCCAGATCA CAGCTGGGCT GGACCCAGTG 
GGGCGAATTC AGATGAGAAC ACGGAGGACC CTCCGTGGAC ACCTGGCAAA AATCTATGCC 
ATGCACTGGG GGACAGACTC AAGGCTGCTG GTCAGCGCCT CCCAGGACGG AAAGCTCATC 
ATTTGGGACA GCTACACCAC TAACAAGGTC CACGCCATCC CTCTGCGCTC CTCCTGGGTC 
ATGACCTGTG CCTACGCCCC CTCGGGGAAC TTCGTGGCCT GTGGGGGTTT GGACAACATC 
TGCTCCATCT ATAGTCTCAA GACCCGAGAG GGCAATGTCA GGGTCAGCAG AGAGCTGCCT 
GGCCATACTG GGTACCTCTC CTGCTGCCGC TTCCTGGACG ACAACCAAAT CATCACCAGC 
TCTGGGGACA CCACCTGTGC CCTGTGGGAC ATTGAGACAG GCCAGCAGAC AGTGGGATTT 
GCTGGACACA GTGGGGATGT GATGTCCCTG TCCCTGGCCC CCGATGGCCG CACCTTTGTG 
TCAGGTGCCT GCGATGCCTC CATCAAGCTG TGGGATGTTC GGGATTCCAT GTGCCGACAG 
ACATTCATAG GTCACGAATC GGACATCAAT GCTGTGGCTT TCTTCCCCAA TGGTTATGCC 
TTCACCACGG GATCAGATGA TGCCACATGT CGCCTGTTTG ACCTGCGGGC TGATCAGGAG 
CTGCTCATGT ATTCCCACGA CAACATCATC TGCGGCATCA CCTCGGTTGC CTTCTCACGC 
AGCGGCCGGC TGCTGCTCGC TGGCTATGAC GACTTCAACT GCAACATCTG GGATGCCATG 
AAGGGTGACC GTGCAGGTGT CCTCGCTGGC CATGATAACC GTGTGAGCTG CCTTGGGGTC 
ACAGATGATG GGATGGCTGT GGCTACAGGC TCCTGGGACT CCTTCCTCAA GATCTGGAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112299.1
CDS	229..1251
Translation	MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Target ORF information:

RefSeq Version	NM_031037.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus G protein subunit beta 2 (Gnb2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031037.2

ORF Insert Sequence:

ATGAGTGAGC TGGAGCAACT GAGACAGGAG GCTGAGCAGC TCCGGAACCA GATCCGGGAC 
GCCAGAAAAG CATGCGGGGA TTCCACACTG ACCCAGATCA CAGCTGGGCT GGACCCAGTG 
GGGCGAATTC AGATGAGAAC ACGGAGGACC CTCCGTGGAC ACCTGGCAAA AATCTATGCC 
ATGCACTGGG GGACAGACTC AAGGCTGCTG GTCAGCGCCT CCCAGGACGG AAAGCTCATC 
ATTTGGGACA GCTACACCAC TAACAAGGTC CACGCCATCC CTCTGCGCTC CTCCTGGGTC 
ATGACCTGTG CCTACGCCCC CTCGGGGAAC TTCGTGGCCT GTGGGGGTTT GGACAACATC 
TGCTCCATCT ATAGTCTCAA GACCCGAGAG GGCAATGTCA GGGTCAGCAG AGAGCTGCCT 
GGCCATACTG GGTACCTCTC CTGCTGCCGC TTCCTGGACG ACAACCAAAT CATCACCAGC 
TCTGGGGACA CCACCTGTGC CCTGTGGGAC ATTGAGACAG GCCAGCAGAC AGTGGGATTT 
GCTGGACACA GTGGGGATGT GATGTCCCTG TCCCTGGCCC CCGATGGCCG CACCTTTGTG 
TCAGGTGCCT GCGATGCCTC CATCAAGCTG TGGGATGTTC GGGATTCCAT GTGCCGACAG 
ACATTCATAG GTCACGAATC GGACATCAAT GCTGTGGCTT TCTTCCCCAA TGGTTATGCC 
TTCACCACGG GATCAGATGA TGCCACATGT CGCCTGTTTG ACCTGCGGGC TGATCAGGAG 
CTGCTCATGT ATTCCCACGA CAACATCATC TGCGGCATCA CCTCGGTTGC CTTCTCACGC 
AGCGGCCGGC TGCTGCTCGC TGGCTATGAC GACTTCAACT GCAACATCTG GGATGCCATG 
AAGGGTGACC GTGCAGGTGT CCTCGCTGGC CATGATAACC GTGTGAGCTG CCTTGGGGTC 
ACAGATGATG GGATGGCTGT GGCTACAGGC TCCTGGGACT CCTTCCTCAA GATCTGGAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

G?? mimics activation kinetic slowing of CaV2.2 channels by noradrenaline in rat sympathetic neurons.
Biochemical and biophysical research communications445(1)250-4(2014 Feb)
Hern?ndez-Castellanos JM,Vivas O,Gardu?o J,De la Cruz L,Arenas I,El?as-Vi?as D,Mackie K,Garc?a DE

KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.
The Journal of cell biology199(6)951-67(2012 Dec)
Ahmed SM,Th?riault BL,Uppalapati M,Chiu CW,Gallie BL,Sidhu SS,Angers S

G?2 and G?4 participate in the opioid and adrenergic receptor-mediated Ca2+ channel modulation in rat sympathetic neurons.
The Journal of physiology590(19)4673-89(2012 Oct)
Mahmoud S,Yun JK,Ruiz-Velasco V

G?? and the C terminus of SNAP-25 are necessary for long-term depression of transmitter release.
PloS one6(5)e20500(2011)
Zhang XL,Upreti C,Stanton PK

Enhanced expression of heterotrimeric GTP-binding protein subunits in Zajdela ascitic hepatoma.
Indian journal of biochemistry & biophysics39(3)148-54(2002 Jun)
Sharma SK,Das MR

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Gnb2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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